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Protein

Aromatase

Gene

cyp19a1

Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi457 – 4571Iron (heme axial ligand)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:cyp19a1
Synonyms:cyp19
OrganismiIctalurus punctatus (Channel catfish) (Silurus punctatus)
Taxonomic identifieri7998 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524AromatasePRO_0000051970Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG050750.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHVFPMCE RTRKPVHFSE TVMEILLREA RNGTDPRYEN PRGITLLLLL
60 70 80 90 100
CLVLLLTVWN RHEKKCSIPG PSFCLGLGPL MSYCRFIWMG IGTASNYYNE
110 120 130 140 150
KYGDMVRVWI SGEETLVLSR PSAVYHVLKH SQYTSRFGSK LGLQCIGMHE
160 170 180 190 200
QGIIFNSNVT LWRKVRTYFA KALTGPGLQR TLEICTMSTN THLDGLSRLT
210 220 230 240 250
DAQGHVDVLN LLRCIVVDIS NRLFLDVPLN EQNLLFKIHR YFETWQTVLI
260 270 280 290 300
KPDFYFRLKW LHDKHRNAAQ ELHDAIEDLI EQKRTELQQA EKLDNLNFTE
310 320 330 340 350
ELIFAQSHGE LTAENVRQCV LEMVIAAPDT LSISVFFMLL LLKQNAEVER
360 370 380 390 400
RILTEIHTVL GDTELQHSHL SQLHVLECFI NEALRFHPVV DFSYRRALDD
410 420 430 440 450
DVIEGFRVPR GTNIILNVGR MHRSEFYPKP ADFSLDNFNK PVPSRFFQPF
460 470 480 490 500
GSGPRSCVGK HIAMVMMKAV LLMVLSRFSV CPEESCTVEN IAHTNDLSQQ
510 520
PVEDKHTLSV RFIPRNTHTR NRKA
Length:524
Mass (Da):60,346
Last modified:November 1, 1996 - v1
Checksum:iEB3DE1458F81F5C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75715 mRNA. Translation: AAB32613.1.
PIRiI51268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75715 mRNA. Translation: AAB32613.1.
PIRiI51268.

3D structure databases

ProteinModelPortaliQ92111.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG050750.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of the cDNA encoding the channel catfish (Ictalurus punctatus) form of cytochrome P450arom."
    Trant J.M.
    Gen. Comp. Endocrinol. 95:155-168(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiCP19A_ICTPU
AccessioniPrimary (citable) accession number: Q92111
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1, Met-8 or Met-23 is the initiator.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.