Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aromatase

Gene

cyp19a1

Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Caution

It is uncertain whether Met-1, Met-8 or Met-23 is the initiator.Curated

Catalytic activityi

Testosterone + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = 17-beta-estradiol + formate + 4 H2O + 3 [oxidized NADPH--hemoprotein reductase].By similarity
Androst-4-ene-3,17-dione + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = estrone + formate + 4 H2O + 3 [oxidized NADPH--hemoprotein reductase].By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi457Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14By similarity)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:cyp19a1
Synonyms:cyp19
OrganismiIctalurus punctatus (Channel catfish) (Silurus punctatus)
Taxonomic identifieri7998 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus
Proteomesi
  • UP000221080 Componenti: Genome assembly

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519701 – 524AromataseAdd BLAST524

Structurei

3D structure databases

ProteinModelPortaliQ92111
SMRiQ92111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG050750
KOiK07434

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q92111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHVFPMCE RTRKPVHFSE TVMEILLREA RNGTDPRYEN PRGITLLLLL
60 70 80 90 100
CLVLLLTVWN RHEKKCSIPG PSFCLGLGPL MSYCRFIWMG IGTASNYYNE
110 120 130 140 150
KYGDMVRVWI SGEETLVLSR PSAVYHVLKH SQYTSRFGSK LGLQCIGMHE
160 170 180 190 200
QGIIFNSNVT LWRKVRTYFA KALTGPGLQR TLEICTMSTN THLDGLSRLT
210 220 230 240 250
DAQGHVDVLN LLRCIVVDIS NRLFLDVPLN EQNLLFKIHR YFETWQTVLI
260 270 280 290 300
KPDFYFRLKW LHDKHRNAAQ ELHDAIEDLI EQKRTELQQA EKLDNLNFTE
310 320 330 340 350
ELIFAQSHGE LTAENVRQCV LEMVIAAPDT LSISVFFMLL LLKQNAEVER
360 370 380 390 400
RILTEIHTVL GDTELQHSHL SQLHVLECFI NEALRFHPVV DFSYRRALDD
410 420 430 440 450
DVIEGFRVPR GTNIILNVGR MHRSEFYPKP ADFSLDNFNK PVPSRFFQPF
460 470 480 490 500
GSGPRSCVGK HIAMVMMKAV LLMVLSRFSV CPEESCTVEN IAHTNDLSQQ
510 520
PVEDKHTLSV RFIPRNTHTR NRKA
Length:524
Mass (Da):60,346
Last modified:November 1, 1996 - v1
Checksum:iEB3DE1458F81F5C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75715 mRNA Translation: AAB32613.1
PIRiI51268
RefSeqiNP_001316189.1, NM_001329260.1
UniGeneiIpu.44083

Genome annotation databases

GeneIDi108264511
KEGGiipu:108264511

Similar proteinsi

Entry informationi

Entry nameiCP19A_ICTPU
AccessioniPrimary (citable) accession number: Q92111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health