Reviewed, UniProtKB/Swiss-Prot Q92111 (CP19A_ICTPU)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 19A1
    EC=1.14.14.1
Alternative name(s):
    CYPXIX
    Aromatase
    Estrogen synthase
    Cytochrome P-450AROM

Gene names

Name:	cyp19a1
Synonyms:	cyp19

Organism

Ictalurus punctatus (Channel catfish)

Taxonomic identifier

7998 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Siluriformes › Ictaluridae › Ictalurus

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.
Caution	It is uncertain whether Met-1, Met-8 or Met-23 is the initiator.

Ontologies

Keywords
Cellular component	Membrane
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 524	524	Cytochrome P450 19A1		PRO_0000051970
Sites
	Metal binding	457	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92111-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: EB3DE1458F81F5C0	FASTA	524	60,346
	10 20 30 40 50 60 MAAHVFPMCE RTRKPVHFSE TVMEILLREA RNGTDPRYEN PRGITLLLLL CLVLLLTVWN 70 80 90 100 110 120 RHEKKCSIPG PSFCLGLGPL MSYCRFIWMG IGTASNYYNE KYGDMVRVWI SGEETLVLSR 130 140 150 160 170 180 PSAVYHVLKH SQYTSRFGSK LGLQCIGMHE QGIIFNSNVT LWRKVRTYFA KALTGPGLQR 190 200 210 220 230 240 TLEICTMSTN THLDGLSRLT DAQGHVDVLN LLRCIVVDIS NRLFLDVPLN EQNLLFKIHR 250 260 270 280 290 300 YFETWQTVLI KPDFYFRLKW LHDKHRNAAQ ELHDAIEDLI EQKRTELQQA EKLDNLNFTE 310 320 330 340 350 360 ELIFAQSHGE LTAENVRQCV LEMVIAAPDT LSISVFFMLL LLKQNAEVER RILTEIHTVL 370 380 390 400 410 420 GDTELQHSHL SQLHVLECFI NEALRFHPVV DFSYRRALDD DVIEGFRVPR GTNIILNVGR 430 440 450 460 470 480 MHRSEFYPKP ADFSLDNFNK PVPSRFFQPF GSGPRSCVGK HIAMVMMKAV LLMVLSRFSV 490 500 510 520 CPEESCTVEN IAHTNDLSQQ PVEDKHTLSV RFIPRNTHTR NRKA

References

[1]	"Isolation and characterization of the cDNA encoding the channel catfish (Ictalurus punctatus) form of cytochrome P450arom." Trant J.M. Gen. Comp. Endocrinol. 95:155-168(1994) [PubMed: 7958747] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S75715 mRNA. Translation: AAB32613.1.
PIR	I51268.
3D structure databases
SMR	Q92111. Positions 69-516.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q92111.
Enzyme and pathway databases
BRENDA	1.14.14.1. 142888.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP19A_ICTPU

Accession

Primary (citable) accession number: Q92111

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)