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Q92111

- CP19A_ICTPU

UniProt

Q92111 - CP19A_ICTPU

Protein

Aromatase

Gene

cyp19a1

Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi457 – 4571Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIX
    Cytochrome P-450AROM
    Cytochrome P450 19A1
    Estrogen synthase
    Gene namesi
    Name:cyp19a1
    Synonyms:cyp19
    OrganismiIctalurus punctatus (Channel catfish) (Silurus punctatus)
    Taxonomic identifieri7998 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 524524AromatasePRO_0000051970Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ92111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG050750.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92111-1 [UniParc]FASTAAdd to Basket

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    MAAHVFPMCE RTRKPVHFSE TVMEILLREA RNGTDPRYEN PRGITLLLLL    50
    CLVLLLTVWN RHEKKCSIPG PSFCLGLGPL MSYCRFIWMG IGTASNYYNE 100
    KYGDMVRVWI SGEETLVLSR PSAVYHVLKH SQYTSRFGSK LGLQCIGMHE 150
    QGIIFNSNVT LWRKVRTYFA KALTGPGLQR TLEICTMSTN THLDGLSRLT 200
    DAQGHVDVLN LLRCIVVDIS NRLFLDVPLN EQNLLFKIHR YFETWQTVLI 250
    KPDFYFRLKW LHDKHRNAAQ ELHDAIEDLI EQKRTELQQA EKLDNLNFTE 300
    ELIFAQSHGE LTAENVRQCV LEMVIAAPDT LSISVFFMLL LLKQNAEVER 350
    RILTEIHTVL GDTELQHSHL SQLHVLECFI NEALRFHPVV DFSYRRALDD 400
    DVIEGFRVPR GTNIILNVGR MHRSEFYPKP ADFSLDNFNK PVPSRFFQPF 450
    GSGPRSCVGK HIAMVMMKAV LLMVLSRFSV CPEESCTVEN IAHTNDLSQQ 500
    PVEDKHTLSV RFIPRNTHTR NRKA 524
    Length:524
    Mass (Da):60,346
    Last modified:November 1, 1996 - v1
    Checksum:iEB3DE1458F81F5C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S75715 mRNA. Translation: AAB32613.1.
    PIRiI51268.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S75715 mRNA. Translation: AAB32613.1 .
    PIRi I51268.

    3D structure databases

    ProteinModelPortali Q92111.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG050750.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the cDNA encoding the channel catfish (Ictalurus punctatus) form of cytochrome P450arom."
      Trant J.M.
      Gen. Comp. Endocrinol. 95:155-168(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiCP19A_ICTPU
    AccessioniPrimary (citable) accession number: Q92111
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1, Met-8 or Met-23 is the initiator.Curated

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3