Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q92111 (CP19A_ICTPU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatase

EC=1.14.14.14
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene names
Name:cyp19a1
Synonyms:cyp19
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
Taxonomic identifier7998 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus

Protein attributes

Sequence length524 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Caution

It is uncertain whether Met-1, Met-8 or Met-23 is the initiator.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 524524Aromatase
PRO_0000051970

Sites

Metal binding4571Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92111 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: EB3DE1458F81F5C0

FASTA52460,346
        10         20         30         40         50         60 
MAAHVFPMCE RTRKPVHFSE TVMEILLREA RNGTDPRYEN PRGITLLLLL CLVLLLTVWN 

        70         80         90        100        110        120 
RHEKKCSIPG PSFCLGLGPL MSYCRFIWMG IGTASNYYNE KYGDMVRVWI SGEETLVLSR 

       130        140        150        160        170        180 
PSAVYHVLKH SQYTSRFGSK LGLQCIGMHE QGIIFNSNVT LWRKVRTYFA KALTGPGLQR 

       190        200        210        220        230        240 
TLEICTMSTN THLDGLSRLT DAQGHVDVLN LLRCIVVDIS NRLFLDVPLN EQNLLFKIHR 

       250        260        270        280        290        300 
YFETWQTVLI KPDFYFRLKW LHDKHRNAAQ ELHDAIEDLI EQKRTELQQA EKLDNLNFTE 

       310        320        330        340        350        360 
ELIFAQSHGE LTAENVRQCV LEMVIAAPDT LSISVFFMLL LLKQNAEVER RILTEIHTVL 

       370        380        390        400        410        420 
GDTELQHSHL SQLHVLECFI NEALRFHPVV DFSYRRALDD DVIEGFRVPR GTNIILNVGR 

       430        440        450        460        470        480 
MHRSEFYPKP ADFSLDNFNK PVPSRFFQPF GSGPRSCVGK HIAMVMMKAV LLMVLSRFSV 

       490        500        510        520 
CPEESCTVEN IAHTNDLSQQ PVEDKHTLSV RFIPRNTHTR NRKA 

« Hide

References

[1]"Isolation and characterization of the cDNA encoding the channel catfish (Ictalurus punctatus) form of cytochrome P450arom."
Trant J.M.
Gen. Comp. Endocrinol. 95:155-168(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S75715 mRNA. Translation: AAB32613.1.
PIRI51268.

3D structure databases

ProteinModelPortalQ92111.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG050750.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP19A_ICTPU
AccessionPrimary (citable) accession number: Q92111
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: January 22, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families