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Q92110

- CP1A1_ONCMY

UniProt

Q92110 - CP1A1_ONCMY

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Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei229 – 2291SubstrateBy similarity
Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYP1A2
CYPIA1
Gene namesi
Name:cyp1a1
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Cytochrome P450 1A1PRO_0000051641Add
BLAST

Expressioni

Tissue specificityi

Liver.

Inductioni

By 3-methylcholanthrene (3MC).

Structurei

3D structure databases

ProteinModelPortaliQ92110.
SMRiQ92110. Positions 38-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92110-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLMILPIIG SVSVSEGLVA IVTLCLVYML MKYKHTEIPE GLKRLPGPKP
60 70 80 90 100
LPIIGNVLEV YNNPHLSLTA MSERYGSVFQ IQIGMRPVVV LSGNETVRQA
110 120 130 140 150
LIKQGEDFAG RPDLYSFKFI NDGKSLAFST DKAGVWRARR KLAMSALRSF
160 170 180 190 200
ATLEGTTPEY SCALEEHVCK EGEYLVKQLT SVMDVSGSFD PFRHIVVSVA
210 220 230 240 250
NVICGMCFGR RYSHDDQELL GLVNMSDEFG QVVGSGNPAD FIPILRYLPN
260 270 280 290 300
RTMKRFMDIN DRFNNFVQKI VSEHYESYDK DNIRDITDSL IDHCEDRKLD
310 320 330 340 350
ENANIQVSDE KIVGIVNDLF GAGFDTISTA LSWAVVYLVA YPEIQERLHQ
360 370 380 390 400
ELKEKVGMIR TPRLSDKINL PLLEAFILEI FRHSSFLPFT IPHCTIKDTS
410 420 430 440 450
LNGYFIPKDT CVFINQWQVN HDPELWKEPS SFNPDRFLSA DGTELNKLEG
460 470 480 490 500
EKVLVFGMDK RRCIGEAIGR NEVYLFLAIL LQRLRFQEKP GHPLDMTPEY
510 520
GLTMKHKRCQ LKASMRPWGQ EE
Length:522
Mass (Da):59,344
Last modified:May 30, 2000 - v2
Checksum:i9D063B5891102CE9
GO

Sequence cautioni

The sequence AAA49550.1 differs from that shown. Reason: Chimera. Its N-terminal part has been shown to be derived from what is now known as the CYP1A3. CYP1A1 has also been called CYP1A2.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511L → P in AAB69383. 1 PublicationCurated
Sequence conflicti97 – 971V → D in AAB69383. 1 PublicationCurated
Sequence conflicti124 – 1241K → N in AAB69383. 1 PublicationCurated
Sequence conflicti306 – 3061Q → H in AAB69383. 1 PublicationCurated
Sequence conflicti390 – 3901T → I in AAB69383. 1 PublicationCurated
Sequence conflicti459 – 4591D → G in AAB40627. 1 PublicationCurated
Sequence conflicti470 – 4701R → H in AAB69383. 1 PublicationCurated
Sequence conflicti474 – 4741Y → F in AAD14036. (PubMed:8161204)Curated
Sequence conflicti474 – 4741Y → F in AAA49550. (PubMed:8161204)Curated
Sequence conflicti483 – 4831R → K in AAB40627. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69278 Genomic DNA. Translation: AAD14036.1.
U62797 mRNA. Translation: AAB40627.1.
AF015660 mRNA. Translation: AAB69383.1.
M21310 mRNA. Translation: AAA49550.1. Sequence problems.
PIRiA28789.
S51557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69278 Genomic DNA. Translation: AAD14036.1 .
U62797 mRNA. Translation: AAB40627.1 .
AF015660 mRNA. Translation: AAB69383.1 .
M21310 mRNA. Translation: AAA49550.1 . Sequence problems.
PIRi A28789.
S51557.

3D structure databases

ProteinModelPortali Q92110.
SMRi Q92110. Positions 38-514.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two unique CYP1 genes are expressed in response to 3-methylcholanthrene treatment in rainbow trout."
    Berndtson A.K., Chen T.T.
    Arch. Biochem. Biophys. 310:187-195(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "Cloning, sequencing and functional expression of two trout CYP1A cDNAs in yeast."
    Bailey G., You L., Harttig U.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning, sequencing and aflatoxin B1 metabolism by multiple rainbow trout CYP1A cDNAs expressed in yeast."
    Bailey G., You L., Harttig U.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Trout P450IA1: cDNA and deduced protein sequence, expression in liver, and evolutionary significance."
    Heilmann L.J., Sheen Y.-Y., Bigelow S.W., Nebert D.W.
    DNA 7:379-387(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A1_ONCMY
AccessioniPrimary (citable) accession number: Q92110
Secondary accession number(s): O42195, P10609, P79830
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 26, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3