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Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei229SubstrateBy similarity1
Metal bindingi463Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • oxidative deethylation Source: AgBase

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYP1A2
CYPIA1
Gene namesi
Name:cyp1a1
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516411 – 522Cytochrome P450 1A1Add BLAST522

Proteomic databases

PRIDEiQ92110

Expressioni

Tissue specificityi

Liver.

Inductioni

By 3-methylcholanthrene (3MC).

Structurei

3D structure databases

ProteinModelPortaliQ92110
SMRiQ92110
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008066 Cyt_P450_E_grp-I_CYP1
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01683 EP450ICYP1A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q92110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLMILPIIG SVSVSEGLVA IVTLCLVYML MKYKHTEIPE GLKRLPGPKP
60 70 80 90 100
LPIIGNVLEV YNNPHLSLTA MSERYGSVFQ IQIGMRPVVV LSGNETVRQA
110 120 130 140 150
LIKQGEDFAG RPDLYSFKFI NDGKSLAFST DKAGVWRARR KLAMSALRSF
160 170 180 190 200
ATLEGTTPEY SCALEEHVCK EGEYLVKQLT SVMDVSGSFD PFRHIVVSVA
210 220 230 240 250
NVICGMCFGR RYSHDDQELL GLVNMSDEFG QVVGSGNPAD FIPILRYLPN
260 270 280 290 300
RTMKRFMDIN DRFNNFVQKI VSEHYESYDK DNIRDITDSL IDHCEDRKLD
310 320 330 340 350
ENANIQVSDE KIVGIVNDLF GAGFDTISTA LSWAVVYLVA YPEIQERLHQ
360 370 380 390 400
ELKEKVGMIR TPRLSDKINL PLLEAFILEI FRHSSFLPFT IPHCTIKDTS
410 420 430 440 450
LNGYFIPKDT CVFINQWQVN HDPELWKEPS SFNPDRFLSA DGTELNKLEG
460 470 480 490 500
EKVLVFGMDK RRCIGEAIGR NEVYLFLAIL LQRLRFQEKP GHPLDMTPEY
510 520
GLTMKHKRCQ LKASMRPWGQ EE
Length:522
Mass (Da):59,344
Last modified:May 30, 2000 - v2
Checksum:i9D063B5891102CE9
GO

Sequence cautioni

The sequence AAA49550 differs from that shown. Chimera. Its N-terminal part has been shown to be derived from what is now known as the CYP1A3. CYP1A1 has also been called CYP1A2.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51L → P in AAB69383 (Ref. 3) Curated1
Sequence conflicti97V → D in AAB69383 (Ref. 3) Curated1
Sequence conflicti124K → N in AAB69383 (Ref. 3) Curated1
Sequence conflicti306Q → H in AAB69383 (Ref. 3) Curated1
Sequence conflicti390T → I in AAB69383 (Ref. 3) Curated1
Sequence conflicti459D → G in AAB40627 (Ref. 2) Curated1
Sequence conflicti470R → H in AAB69383 (Ref. 3) Curated1
Sequence conflicti474Y → F in AAD14036 (PubMed:8161204).Curated1
Sequence conflicti474Y → F in AAA49550 (PubMed:8161204).Curated1
Sequence conflicti483R → K in AAB40627 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69278 Genomic DNA Translation: AAD14036.1
U62797 mRNA Translation: AAB40627.1
AF015660 mRNA Translation: AAB69383.1
M21310 mRNA Translation: AAA49550.1 Sequence problems.
PIRiA28789
S51557
UniGeneiOmy.11738

Similar proteinsi

Entry informationi

Entry nameiCP1A1_ONCMY
AccessioniPrimary (citable) accession number: Q92110
Secondary accession number(s): O42195, P10609, P79830
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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