Cytochrome P450 1A1 - Oncorhynchus mykiss (Rainbow trout)

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Q92110 (CP1A1_ONCMY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 80. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome P450 1A1
EC=1.14.14.1

Alternative name(s):
CYP1A2
CYPIA1

Gene names

Name:

cyp1a1

Organism

Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

Taxonomic identifier

8022 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Oncorhynchus

Protein attributes

Sequence length	522 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O₂ = ROH + oxidized flavoprotein + H₂O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue specificity	Liver.
Induction	By 3-methylcholanthrene (3MC).
Sequence similarities	Belongs to the cytochrome P450 family.
Sequence caution	The sequence AAA49550.1 differs from that shown. Reason: Chimera. Its N-terminal part has been shown to be derived from what is now known as the CYP1A3. CYP1A1 has also been called CYP1A2.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 522

522

Cytochrome P450 1A1

PRO_0000051641

Sites

Metal binding

463

Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict

L → P in AAB69383. Ref.3

Sequence conflict

V → D in AAB69383. Ref.3

Sequence conflict

124

K → N in AAB69383. Ref.3

Sequence conflict

306

Q → H in AAB69383. Ref.3

Sequence conflict

390

T → I in AAB69383. Ref.3

Sequence conflict

459

D → G in AAB40627. Ref.2

Sequence conflict

470

R → H in AAB69383. Ref.3

Sequence conflict

474

Y → F in AAD14036. Ref.1

Sequence conflict

474

Y → F in AAA49550. Ref.1

Sequence conflict

483

R → K in AAB40627. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q92110 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 9D063B5891102CE9
Show »

FASTA

522

59,344

        10         20         30         40         50         60 
MVLMILPIIG SVSVSEGLVA IVTLCLVYML MKYKHTEIPE GLKRLPGPKP LPIIGNVLEV 

        70         80         90        100        110        120 
YNNPHLSLTA MSERYGSVFQ IQIGMRPVVV LSGNETVRQA LIKQGEDFAG RPDLYSFKFI 

       130        140        150        160        170        180 
NDGKSLAFST DKAGVWRARR KLAMSALRSF ATLEGTTPEY SCALEEHVCK EGEYLVKQLT 

       190        200        210        220        230        240 
SVMDVSGSFD PFRHIVVSVA NVICGMCFGR RYSHDDQELL GLVNMSDEFG QVVGSGNPAD 

       250        260        270        280        290        300 
FIPILRYLPN RTMKRFMDIN DRFNNFVQKI VSEHYESYDK DNIRDITDSL IDHCEDRKLD 

       310        320        330        340        350        360 
ENANIQVSDE KIVGIVNDLF GAGFDTISTA LSWAVVYLVA YPEIQERLHQ ELKEKVGMIR 

       370        380        390        400        410        420 
TPRLSDKINL PLLEAFILEI FRHSSFLPFT IPHCTIKDTS LNGYFIPKDT CVFINQWQVN 

       430        440        450        460        470        480 
HDPELWKEPS SFNPDRFLSA DGTELNKLEG EKVLVFGMDK RRCIGEAIGR NEVYLFLAIL 

       490        500        510        520 
LQRLRFQEKP GHPLDMTPEY GLTMKHKRCQ LKASMRPWGQ EE

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References

[1]	"Two unique CYP1 genes are expressed in response to 3-methylcholanthrene treatment in rainbow trout." Berndtson A.K., Chen T.T. Arch. Biochem. Biophys. 310:187-195(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver.
[2]	"Cloning, sequencing and functional expression of two trout CYP1A cDNAs in yeast." Bailey G., You L., Harttig U. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning, sequencing and aflatoxin B1 metabolism by multiple rainbow trout CYP1A cDNAs expressed in yeast." Bailey G., You L., Harttig U. Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Trout P450IA1: cDNA and deduced protein sequence, expression in liver, and evolutionary significance." Heilmann L.J., Sheen Y.-Y., Bigelow S.W., Nebert D.W. DNA 7:379-387(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S69278 Genomic DNA. Translation: AAD14036.1. U62797 mRNA. Translation: AAB40627.1. AF015660 mRNA. Translation: AAB69383.1. M21310 mRNA. Translation: AAA49550.1. Sequence problems.
PIR	A28789. S51557.
3D structure databases
ProteinModelPortal	Q92110.
SMR	Q92110. Positions 38-514.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG106944.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008066. Cyt_P450_E_grp-I_CYP1. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01683. EP450ICYP1A. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP1A1_ONCMY

Accession

Primary (citable) accession number: Q92110
Secondary accession number(s): O42195, P10609, P79830

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	April 3, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents