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Q92110 (CP1A1_ONCMY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A1

EC=1.14.14.1
Alternative name(s):
CYP1A2
CYPIA1
Gene names
Name:cyp1a1
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifier8022 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Liver.

Induction

By 3-methylcholanthrene (3MC).

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence caution

The sequence AAA49550.1 differs from that shown. Reason: Chimera. Its N-terminal part has been shown to be derived from what is now known as the CYP1A3. CYP1A1 has also been called CYP1A2.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Cytochrome P450 1A1
PRO_0000051641

Sites

Metal binding4631Iron (heme axial ligand) By similarity
Binding site2291Substrate By similarity

Experimental info

Sequence conflict511L → P in AAB69383. Ref.3
Sequence conflict971V → D in AAB69383. Ref.3
Sequence conflict1241K → N in AAB69383. Ref.3
Sequence conflict3061Q → H in AAB69383. Ref.3
Sequence conflict3901T → I in AAB69383. Ref.3
Sequence conflict4591D → G in AAB40627. Ref.2
Sequence conflict4701R → H in AAB69383. Ref.3
Sequence conflict4741Y → F in AAD14036. Ref.1
Sequence conflict4741Y → F in AAA49550. Ref.1
Sequence conflict4831R → K in AAB40627. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q92110 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 9D063B5891102CE9

FASTA52259,344
        10         20         30         40         50         60 
MVLMILPIIG SVSVSEGLVA IVTLCLVYML MKYKHTEIPE GLKRLPGPKP LPIIGNVLEV 

        70         80         90        100        110        120 
YNNPHLSLTA MSERYGSVFQ IQIGMRPVVV LSGNETVRQA LIKQGEDFAG RPDLYSFKFI 

       130        140        150        160        170        180 
NDGKSLAFST DKAGVWRARR KLAMSALRSF ATLEGTTPEY SCALEEHVCK EGEYLVKQLT 

       190        200        210        220        230        240 
SVMDVSGSFD PFRHIVVSVA NVICGMCFGR RYSHDDQELL GLVNMSDEFG QVVGSGNPAD 

       250        260        270        280        290        300 
FIPILRYLPN RTMKRFMDIN DRFNNFVQKI VSEHYESYDK DNIRDITDSL IDHCEDRKLD 

       310        320        330        340        350        360 
ENANIQVSDE KIVGIVNDLF GAGFDTISTA LSWAVVYLVA YPEIQERLHQ ELKEKVGMIR 

       370        380        390        400        410        420 
TPRLSDKINL PLLEAFILEI FRHSSFLPFT IPHCTIKDTS LNGYFIPKDT CVFINQWQVN 

       430        440        450        460        470        480 
HDPELWKEPS SFNPDRFLSA DGTELNKLEG EKVLVFGMDK RRCIGEAIGR NEVYLFLAIL 

       490        500        510        520 
LQRLRFQEKP GHPLDMTPEY GLTMKHKRCQ LKASMRPWGQ EE 

« Hide

References

[1]"Two unique CYP1 genes are expressed in response to 3-methylcholanthrene treatment in rainbow trout."
Berndtson A.K., Chen T.T.
Arch. Biochem. Biophys. 310:187-195(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[2]"Cloning, sequencing and functional expression of two trout CYP1A cDNAs in yeast."
Bailey G., You L., Harttig U.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning, sequencing and aflatoxin B1 metabolism by multiple rainbow trout CYP1A cDNAs expressed in yeast."
Bailey G., You L., Harttig U.
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Trout P450IA1: cDNA and deduced protein sequence, expression in liver, and evolutionary significance."
Heilmann L.J., Sheen Y.-Y., Bigelow S.W., Nebert D.W.
DNA 7:379-387(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S69278 Genomic DNA. Translation: AAD14036.1.
U62797 mRNA. Translation: AAB40627.1.
AF015660 mRNA. Translation: AAB69383.1.
M21310 mRNA. Translation: AAA49550.1. Sequence problems.
PIRA28789.
S51557.

3D structure databases

ProteinModelPortalQ92110.
SMRQ92110. Positions 38-514.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106944.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A1_ONCMY
AccessionPrimary (citable) accession number: Q92110
Secondary accession number(s): O42195, P10609, P79830
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: June 11, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families