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Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei229SubstrateBy similarity1
Metal bindingi463Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • oxidative deethylation Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYP1A2
CYPIA1
Gene namesi
Name:cyp1a1
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

  • basal plasma membrane Source: AgBase
  • cell Source: AgBase
  • cytoplasm Source: AgBase
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • microvillus membrane Source: AgBase
  • nuclear heterochromatin Source: AgBase
  • nuclear membrane Source: AgBase
  • perinuclear region of cytoplasm Source: AgBase
  • rough endoplasmic reticulum Source: AgBase
  • smooth endoplasmic reticulum Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516411 – 522Cytochrome P450 1A1Add BLAST522

Expressioni

Tissue specificityi

Liver.

Inductioni

By 3-methylcholanthrene (3MC).

Structurei

3D structure databases

ProteinModelPortaliQ92110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLMILPIIG SVSVSEGLVA IVTLCLVYML MKYKHTEIPE GLKRLPGPKP
60 70 80 90 100
LPIIGNVLEV YNNPHLSLTA MSERYGSVFQ IQIGMRPVVV LSGNETVRQA
110 120 130 140 150
LIKQGEDFAG RPDLYSFKFI NDGKSLAFST DKAGVWRARR KLAMSALRSF
160 170 180 190 200
ATLEGTTPEY SCALEEHVCK EGEYLVKQLT SVMDVSGSFD PFRHIVVSVA
210 220 230 240 250
NVICGMCFGR RYSHDDQELL GLVNMSDEFG QVVGSGNPAD FIPILRYLPN
260 270 280 290 300
RTMKRFMDIN DRFNNFVQKI VSEHYESYDK DNIRDITDSL IDHCEDRKLD
310 320 330 340 350
ENANIQVSDE KIVGIVNDLF GAGFDTISTA LSWAVVYLVA YPEIQERLHQ
360 370 380 390 400
ELKEKVGMIR TPRLSDKINL PLLEAFILEI FRHSSFLPFT IPHCTIKDTS
410 420 430 440 450
LNGYFIPKDT CVFINQWQVN HDPELWKEPS SFNPDRFLSA DGTELNKLEG
460 470 480 490 500
EKVLVFGMDK RRCIGEAIGR NEVYLFLAIL LQRLRFQEKP GHPLDMTPEY
510 520
GLTMKHKRCQ LKASMRPWGQ EE
Length:522
Mass (Da):59,344
Last modified:May 30, 2000 - v2
Checksum:i9D063B5891102CE9
GO

Sequence cautioni

The sequence AAA49550 differs from that shown. Chimera. Its N-terminal part has been shown to be derived from what is now known as the CYP1A3. CYP1A1 has also been called CYP1A2.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51L → P in AAB69383 (Ref. 3) Curated1
Sequence conflicti97V → D in AAB69383 (Ref. 3) Curated1
Sequence conflicti124K → N in AAB69383 (Ref. 3) Curated1
Sequence conflicti306Q → H in AAB69383 (Ref. 3) Curated1
Sequence conflicti390T → I in AAB69383 (Ref. 3) Curated1
Sequence conflicti459D → G in AAB40627 (Ref. 2) Curated1
Sequence conflicti470R → H in AAB69383 (Ref. 3) Curated1
Sequence conflicti474Y → F in AAD14036 (PubMed:8161204).Curated1
Sequence conflicti474Y → F in AAA49550 (PubMed:8161204).Curated1
Sequence conflicti483R → K in AAB40627 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69278 Genomic DNA. Translation: AAD14036.1.
U62797 mRNA. Translation: AAB40627.1.
AF015660 mRNA. Translation: AAB69383.1.
M21310 mRNA. Translation: AAA49550.1. Sequence problems.
PIRiA28789.
S51557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69278 Genomic DNA. Translation: AAD14036.1.
U62797 mRNA. Translation: AAB40627.1.
AF015660 mRNA. Translation: AAB69383.1.
M21310 mRNA. Translation: AAA49550.1. Sequence problems.
PIRiA28789.
S51557.

3D structure databases

ProteinModelPortaliQ92110.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP1A1_ONCMY
AccessioniPrimary (citable) accession number: Q92110
Secondary accession number(s): O42195, P10609, P79830
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: October 5, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.