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Q92110

- CP1A1_ONCMY

UniProt

Q92110 - CP1A1_ONCMY

Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei229 – 2291SubstrateBy similarity
    Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYP1A2
    CYPIA1
    Gene namesi
    Name:cyp1a1
    OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
    Taxonomic identifieri8022 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Cytochrome P450 1A1PRO_0000051641Add
    BLAST

    Expressioni

    Tissue specificityi

    Liver.

    Inductioni

    By 3-methylcholanthrene (3MC).

    Structurei

    3D structure databases

    ProteinModelPortaliQ92110.
    SMRiQ92110. Positions 38-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92110-1 [UniParc]FASTAAdd to Basket

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    MVLMILPIIG SVSVSEGLVA IVTLCLVYML MKYKHTEIPE GLKRLPGPKP    50
    LPIIGNVLEV YNNPHLSLTA MSERYGSVFQ IQIGMRPVVV LSGNETVRQA 100
    LIKQGEDFAG RPDLYSFKFI NDGKSLAFST DKAGVWRARR KLAMSALRSF 150
    ATLEGTTPEY SCALEEHVCK EGEYLVKQLT SVMDVSGSFD PFRHIVVSVA 200
    NVICGMCFGR RYSHDDQELL GLVNMSDEFG QVVGSGNPAD FIPILRYLPN 250
    RTMKRFMDIN DRFNNFVQKI VSEHYESYDK DNIRDITDSL IDHCEDRKLD 300
    ENANIQVSDE KIVGIVNDLF GAGFDTISTA LSWAVVYLVA YPEIQERLHQ 350
    ELKEKVGMIR TPRLSDKINL PLLEAFILEI FRHSSFLPFT IPHCTIKDTS 400
    LNGYFIPKDT CVFINQWQVN HDPELWKEPS SFNPDRFLSA DGTELNKLEG 450
    EKVLVFGMDK RRCIGEAIGR NEVYLFLAIL LQRLRFQEKP GHPLDMTPEY 500
    GLTMKHKRCQ LKASMRPWGQ EE 522
    Length:522
    Mass (Da):59,344
    Last modified:May 30, 2000 - v2
    Checksum:i9D063B5891102CE9
    GO

    Sequence cautioni

    The sequence AAA49550.1 differs from that shown. Reason: Chimera. Its N-terminal part has been shown to be derived from what is now known as the CYP1A3. CYP1A1 has also been called CYP1A2.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti51 – 511L → P in AAB69383. 1 PublicationCurated
    Sequence conflicti97 – 971V → D in AAB69383. 1 PublicationCurated
    Sequence conflicti124 – 1241K → N in AAB69383. 1 PublicationCurated
    Sequence conflicti306 – 3061Q → H in AAB69383. 1 PublicationCurated
    Sequence conflicti390 – 3901T → I in AAB69383. 1 PublicationCurated
    Sequence conflicti459 – 4591D → G in AAB40627. 1 PublicationCurated
    Sequence conflicti470 – 4701R → H in AAB69383. 1 PublicationCurated
    Sequence conflicti474 – 4741Y → F in AAD14036. (PubMed:8161204)Curated
    Sequence conflicti474 – 4741Y → F in AAA49550. (PubMed:8161204)Curated
    Sequence conflicti483 – 4831R → K in AAB40627. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S69278 Genomic DNA. Translation: AAD14036.1.
    U62797 mRNA. Translation: AAB40627.1.
    AF015660 mRNA. Translation: AAB69383.1.
    M21310 mRNA. Translation: AAA49550.1. Sequence problems.
    PIRiA28789.
    S51557.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S69278 Genomic DNA. Translation: AAD14036.1 .
    U62797 mRNA. Translation: AAB40627.1 .
    AF015660 mRNA. Translation: AAB69383.1 .
    M21310 mRNA. Translation: AAA49550.1 . Sequence problems.
    PIRi A28789.
    S51557.

    3D structure databases

    ProteinModelPortali Q92110.
    SMRi Q92110. Positions 38-514.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two unique CYP1 genes are expressed in response to 3-methylcholanthrene treatment in rainbow trout."
      Berndtson A.K., Chen T.T.
      Arch. Biochem. Biophys. 310:187-195(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    2. "Cloning, sequencing and functional expression of two trout CYP1A cDNAs in yeast."
      Bailey G., You L., Harttig U.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning, sequencing and aflatoxin B1 metabolism by multiple rainbow trout CYP1A cDNAs expressed in yeast."
      Bailey G., You L., Harttig U.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Trout P450IA1: cDNA and deduced protein sequence, expression in liver, and evolutionary significance."
      Heilmann L.J., Sheen Y.-Y., Bigelow S.W., Nebert D.W.
      DNA 7:379-387(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_ONCMY
    AccessioniPrimary (citable) accession number: Q92110
    Secondary accession number(s): O42195, P10609, P79830
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3