Cytochrome P450 1A3 - Oncorhynchus mykiss (Rainbow trout)

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Reviewed, UniProtKB/Swiss-Prot Q92109 (CP1A3_ONCMY)

Last modified October 13, 2009. Version 63. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Cytochrome P450 1A3
      Short name=CYP1A3
    EC=1.14.14.1
Alternative name(s):
    CYP1A1

Gene names

Name:

cyp1a3

Organism

Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

Taxonomic identifier

8022 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Oncorhynchus

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Protein attributes

Sequence length	522 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O₂ = ROH + oxidized flavoprotein + H₂O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue specificity	Liver.
Induction	By 3-methylcholanthrene (3MC).
Sequence similarities	Belongs to the cytochrome P450 family.
Sequence caution	The sequence AAA49550.1 differs from that shown. Reason: Miscellaneous discrepancy. Chimera cDNA. Its C-terminal part has been shown to be derived from what is now known as the CYP1A1. CYP1A3 has also been called CYP1A1.

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Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 522

522

Cytochrome P450 1A3

PRO_0000051642

Sites

Metal binding

463

Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict

M → V in AAD14035. Ref.1

Sequence conflict

M → V in AAA49550. Ref.1

Sequence conflict

N → S in AAD14035. Ref.1

Sequence conflict

N → S in AAA49550. Ref.1

Sequence conflict

112

S → P in AAD14035. Ref.1

Sequence conflict

112

S → P in AAA49550. Ref.1

Sequence conflict

156

T → S in AAD14035. Ref.1

Sequence conflict

169

L → C in AAD14035. Ref.1

Sequence conflict

169

L → C in AAA49550. Ref.1

Sequence conflict

265

N → T in AAD14035. Ref.1

Sequence conflict

265

N → T in AAA49550. Ref.1

Sequence conflict

276

E → D in AAD14035. Ref.1

Sequence conflict

305

I → V in AAD14035. Ref.1

Sequence conflict

344

T → I in AAD14035. Ref.1

Sequence conflict

344

T → I in AAA49550. Ref.1

Sequence conflict

396

I → V in AAD14035. Ref.1

Sequence conflict

485

R → C in AAD14035. Ref.1

Sequence conflict

515 – 522

MRPWGQEE → LRHGGRKSEGHGHIYDSQHH YN in AAD14035. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

Q92109-1 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 0E83F2A5EEFE3202
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FASTA

522

59,273

        10         20         30         40         50         60 
MVLMILPIIG SVSASEGLVA MVTLCLVYMI MKYMHTEIPE GLKRLPGPKP LPIIGNMLEV 

        70         80         90        100        110        120 
HNNPHLSLTA MSERYGSVFQ IQIGMRPVVV LSGNETVRQA LIKQGEDFAG RSDLYSFKFI 

       130        140        150        160        170        180 
NDGKSLAFST DKAGVWRARR KLAMSALRSF ATLEGTTPEY SCALEEHVLK EGEYLVKQLT 

       190        200        210        220        230        240 
SVMDVSGSFD PFRHIVVSVA NVICGMCFGR RYSHDDQELL GLVNMSDEFG QVVGSGNPAD 

       250        260        270        280        290        300 
FIPILRYLPN RTMKRFMDIN DRFNNFVQKI VSEHYESYDK DNIRDITDSL IDHCEDRKLD 

       310        320        330        340        350        360 
ENANIQVSDE KIVGIVNDLF GAGFDTISTA LSWAVVYLVA YPETQERLHQ ELKEKVGMIR 

       370        380        390        400        410        420 
TPRLSDKINL PLLEAFILEI FRHSSFLPFT IPHCTIKDTS LNGYFIPKDT CVFINQWQVN 

       430        440        450        460        470        480 
HDPELWKEPS SFNPDRFLSA DGTELNKLEG EKVLVFGMGK RRCIGEAIGR NEVYLFLAIL 

       490        500        510        520 
LQRLRFQEKP GHPLDMTPEY GLTMKHKRCQ LKASMRPWGQ EE

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References

[1]	"Two unique CYP1 genes are expressed in response to 3-methylcholanthrene treatment in rainbow trout." Berndtson A.K., Chen T.T. Arch. Biochem. Biophys. 310:187-195(1994) [PubMed: 8161204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver.
[2]	"Cloning, sequencing and functional expression of two trout CYP1A cDNAs in yeast." Bailey G., You L., Harttig U. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Trout P450IA1: cDNA and deduced protein sequence, expression in liver, and evolutionary significance." Heilmann L.J., Sheen Y.-Y., Bigelow S.W., Nebert D.W. DNA 7:379-387(1988) [PubMed: 3203599] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

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Cross-references

Sequence databases
	S69277 Genomic DNA. Translation: AAD14035.1. U62796 mRNA. Translation: AAB40626.1. M21310 mRNA. Translation: AAA49550.1. Sequence problems.
3D structure databases
HSSP	HSSP built from PDB template 1DT6 based on UniProtKB P00179.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q92109.
Enzyme and pathway databases
BRENDA	1.14.14.1. 3435.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008066. Cyt_P450_E_grp-I_CYP1. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit. PTHR19383:SF63. Cyt_P450_E_grp-I_CYP1. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01683. EP450ICYP1A. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

CP1A3_ONCMY

Accession

Primary (citable) accession number: Q92109
Secondary accession number(s): P10609, P79829

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	October 13, 2009
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents