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Q92109

- CP1A3_ONCMY

UniProt

Q92109 - CP1A3_ONCMY

Protein

Cytochrome P450 1A3

Gene

cyp1a3

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei229 – 2291SubstrateBy similarity
    Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A3 (EC:1.14.14.1)
    Short name:
    CYP1A3
    Alternative name(s):
    CYP1A1
    Gene namesi
    Name:cyp1a3
    OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
    Taxonomic identifieri8022 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Cytochrome P450 1A3PRO_0000051642Add
    BLAST

    Expressioni

    Tissue specificityi

    Liver.

    Inductioni

    By 3-methylcholanthrene (3MC).

    Structurei

    3D structure databases

    ProteinModelPortaliQ92109.
    SMRiQ92109. Positions 38-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92109-1 [UniParc]FASTAAdd to Basket

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    MVLMILPIIG SVSASEGLVA MVTLCLVYMI MKYMHTEIPE GLKRLPGPKP    50
    LPIIGNMLEV HNNPHLSLTA MSERYGSVFQ IQIGMRPVVV LSGNETVRQA 100
    LIKQGEDFAG RSDLYSFKFI NDGKSLAFST DKAGVWRARR KLAMSALRSF 150
    ATLEGTTPEY SCALEEHVLK EGEYLVKQLT SVMDVSGSFD PFRHIVVSVA 200
    NVICGMCFGR RYSHDDQELL GLVNMSDEFG QVVGSGNPAD FIPILRYLPN 250
    RTMKRFMDIN DRFNNFVQKI VSEHYESYDK DNIRDITDSL IDHCEDRKLD 300
    ENANIQVSDE KIVGIVNDLF GAGFDTISTA LSWAVVYLVA YPETQERLHQ 350
    ELKEKVGMIR TPRLSDKINL PLLEAFILEI FRHSSFLPFT IPHCTIKDTS 400
    LNGYFIPKDT CVFINQWQVN HDPELWKEPS SFNPDRFLSA DGTELNKLEG 450
    EKVLVFGMGK RRCIGEAIGR NEVYLFLAIL LQRLRFQEKP GHPLDMTPEY 500
    GLTMKHKRCQ LKASMRPWGQ EE 522
    Length:522
    Mass (Da):59,273
    Last modified:May 30, 2000 - v2
    Checksum:i0E83F2A5EEFE3202
    GO

    Sequence cautioni

    The sequence AAA49550.1 differs from that shown. Reason: Chimera cDNA. Its C-terminal part has been shown to be derived from what is now known as the CYP1A1. CYP1A3 has also been called CYP1A1.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571M → V in AAD14035. (PubMed:8161204)Curated
    Sequence conflicti57 – 571M → V in AAA49550. (PubMed:8161204)Curated
    Sequence conflicti94 – 941N → S in AAD14035. (PubMed:8161204)Curated
    Sequence conflicti94 – 941N → S in AAA49550. (PubMed:8161204)Curated
    Sequence conflicti112 – 1121S → P in AAD14035. (PubMed:8161204)Curated
    Sequence conflicti112 – 1121S → P in AAA49550. (PubMed:8161204)Curated
    Sequence conflicti156 – 1561T → S in AAD14035. (PubMed:8161204)Curated
    Sequence conflicti169 – 1691L → C in AAD14035. (PubMed:8161204)Curated
    Sequence conflicti169 – 1691L → C in AAA49550. (PubMed:8161204)Curated
    Sequence conflicti265 – 2651N → T in AAD14035. (PubMed:8161204)Curated
    Sequence conflicti265 – 2651N → T in AAA49550. (PubMed:8161204)Curated
    Sequence conflicti276 – 2761E → D in AAD14035. (PubMed:8161204)Curated
    Sequence conflicti305 – 3051I → V in AAD14035. (PubMed:8161204)Curated
    Sequence conflicti344 – 3441T → I in AAD14035. (PubMed:8161204)Curated
    Sequence conflicti344 – 3441T → I in AAA49550. (PubMed:8161204)Curated
    Sequence conflicti396 – 3961I → V in AAD14035. (PubMed:8161204)Curated
    Sequence conflicti485 – 4851R → C in AAD14035. (PubMed:8161204)Curated
    Sequence conflicti515 – 5228MRPWGQEE → LRHGGRKSEGHGHIYDSQHH YN in AAD14035. (PubMed:8161204)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S69277 Genomic DNA. Translation: AAD14035.1.
    U62796 mRNA. Translation: AAB40626.1.
    M21310 mRNA. Translation: AAA49550.1. Sequence problems.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S69277 Genomic DNA. Translation: AAD14035.1 .
    U62796 mRNA. Translation: AAB40626.1 .
    M21310 mRNA. Translation: AAA49550.1 . Sequence problems.

    3D structure databases

    ProteinModelPortali Q92109.
    SMRi Q92109. Positions 38-514.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two unique CYP1 genes are expressed in response to 3-methylcholanthrene treatment in rainbow trout."
      Berndtson A.K., Chen T.T.
      Arch. Biochem. Biophys. 310:187-195(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    2. "Cloning, sequencing and functional expression of two trout CYP1A cDNAs in yeast."
      Bailey G., You L., Harttig U.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Trout P450IA1: cDNA and deduced protein sequence, expression in liver, and evolutionary significance."
      Heilmann L.J., Sheen Y.-Y., Bigelow S.W., Nebert D.W.
      DNA 7:379-387(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A3_ONCMY
    AccessioniPrimary (citable) accession number: Q92109
    Secondary accession number(s): P10609, P79829
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3