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Q92109

- CP1A3_ONCMY

UniProt

Q92109 - CP1A3_ONCMY

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Protein
Cytochrome P450 1A3
Gene
cyp1a3
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei229 – 2291Substrate By similarity
Metal bindingi463 – 4631Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A3 (EC:1.14.14.1)
Short name:
CYP1A3
Alternative name(s):
CYP1A1
Gene namesi
Name:cyp1a3
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Cytochrome P450 1A3
PRO_0000051642Add
BLAST

Expressioni

Tissue specificityi

Liver.

Inductioni

By 3-methylcholanthrene (3MC).

Structurei

3D structure databases

ProteinModelPortaliQ92109.
SMRiQ92109. Positions 38-514.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92109-1 [UniParc]FASTAAdd to Basket

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MVLMILPIIG SVSASEGLVA MVTLCLVYMI MKYMHTEIPE GLKRLPGPKP    50
LPIIGNMLEV HNNPHLSLTA MSERYGSVFQ IQIGMRPVVV LSGNETVRQA 100
LIKQGEDFAG RSDLYSFKFI NDGKSLAFST DKAGVWRARR KLAMSALRSF 150
ATLEGTTPEY SCALEEHVLK EGEYLVKQLT SVMDVSGSFD PFRHIVVSVA 200
NVICGMCFGR RYSHDDQELL GLVNMSDEFG QVVGSGNPAD FIPILRYLPN 250
RTMKRFMDIN DRFNNFVQKI VSEHYESYDK DNIRDITDSL IDHCEDRKLD 300
ENANIQVSDE KIVGIVNDLF GAGFDTISTA LSWAVVYLVA YPETQERLHQ 350
ELKEKVGMIR TPRLSDKINL PLLEAFILEI FRHSSFLPFT IPHCTIKDTS 400
LNGYFIPKDT CVFINQWQVN HDPELWKEPS SFNPDRFLSA DGTELNKLEG 450
EKVLVFGMGK RRCIGEAIGR NEVYLFLAIL LQRLRFQEKP GHPLDMTPEY 500
GLTMKHKRCQ LKASMRPWGQ EE 522
Length:522
Mass (Da):59,273
Last modified:May 30, 2000 - v2
Checksum:i0E83F2A5EEFE3202
GO

Sequence cautioni

The sequence AAA49550.1 differs from that shown. Reason: Chimera cDNA. Its C-terminal part has been shown to be derived from what is now known as the CYP1A1. CYP1A3 has also been called CYP1A1.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571M → V in AAD14035. 1 Publication
Sequence conflicti57 – 571M → V in AAA49550. 1 Publication
Sequence conflicti94 – 941N → S in AAD14035. 1 Publication
Sequence conflicti94 – 941N → S in AAA49550. 1 Publication
Sequence conflicti112 – 1121S → P in AAD14035. 1 Publication
Sequence conflicti112 – 1121S → P in AAA49550. 1 Publication
Sequence conflicti156 – 1561T → S in AAD14035. 1 Publication
Sequence conflicti169 – 1691L → C in AAD14035. 1 Publication
Sequence conflicti169 – 1691L → C in AAA49550. 1 Publication
Sequence conflicti265 – 2651N → T in AAD14035. 1 Publication
Sequence conflicti265 – 2651N → T in AAA49550. 1 Publication
Sequence conflicti276 – 2761E → D in AAD14035. 1 Publication
Sequence conflicti305 – 3051I → V in AAD14035. 1 Publication
Sequence conflicti344 – 3441T → I in AAD14035. 1 Publication
Sequence conflicti344 – 3441T → I in AAA49550. 1 Publication
Sequence conflicti396 – 3961I → V in AAD14035. 1 Publication
Sequence conflicti485 – 4851R → C in AAD14035. 1 Publication
Sequence conflicti515 – 5228MRPWGQEE → LRHGGRKSEGHGHIYDSQHH YN in AAD14035. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S69277 Genomic DNA. Translation: AAD14035.1.
U62796 mRNA. Translation: AAB40626.1.
M21310 mRNA. Translation: AAA49550.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S69277 Genomic DNA. Translation: AAD14035.1 .
U62796 mRNA. Translation: AAB40626.1 .
M21310 mRNA. Translation: AAA49550.1 . Sequence problems.

3D structure databases

ProteinModelPortali Q92109.
SMRi Q92109. Positions 38-514.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two unique CYP1 genes are expressed in response to 3-methylcholanthrene treatment in rainbow trout."
    Berndtson A.K., Chen T.T.
    Arch. Biochem. Biophys. 310:187-195(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "Cloning, sequencing and functional expression of two trout CYP1A cDNAs in yeast."
    Bailey G., You L., Harttig U.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Trout P450IA1: cDNA and deduced protein sequence, expression in liver, and evolutionary significance."
    Heilmann L.J., Sheen Y.-Y., Bigelow S.W., Nebert D.W.
    DNA 7:379-387(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A3_ONCMY
AccessioniPrimary (citable) accession number: Q92109
Secondary accession number(s): P10609, P79829
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: June 11, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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