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Q92109 (CP1A3_ONCMY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A3

Short name=CYP1A3
EC=1.14.14.1
Alternative name(s):
CYP1A1
Gene names
Name:cyp1a3
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifier8022 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Liver.

Induction

By 3-methylcholanthrene (3MC).

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence caution

The sequence AAA49550.1 differs from that shown. Reason: Chimera cDNA. Its C-terminal part has been shown to be derived from what is now known as the CYP1A1. CYP1A3 has also been called CYP1A1.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Cytochrome P450 1A3
PRO_0000051642

Sites

Metal binding4631Iron (heme axial ligand) By similarity
Binding site2291Substrate By similarity

Experimental info

Sequence conflict571M → V in AAD14035. Ref.1
Sequence conflict571M → V in AAA49550. Ref.1
Sequence conflict941N → S in AAD14035. Ref.1
Sequence conflict941N → S in AAA49550. Ref.1
Sequence conflict1121S → P in AAD14035. Ref.1
Sequence conflict1121S → P in AAA49550. Ref.1
Sequence conflict1561T → S in AAD14035. Ref.1
Sequence conflict1691L → C in AAD14035. Ref.1
Sequence conflict1691L → C in AAA49550. Ref.1
Sequence conflict2651N → T in AAD14035. Ref.1
Sequence conflict2651N → T in AAA49550. Ref.1
Sequence conflict2761E → D in AAD14035. Ref.1
Sequence conflict3051I → V in AAD14035. Ref.1
Sequence conflict3441T → I in AAD14035. Ref.1
Sequence conflict3441T → I in AAA49550. Ref.1
Sequence conflict3961I → V in AAD14035. Ref.1
Sequence conflict4851R → C in AAD14035. Ref.1
Sequence conflict515 – 5228MRPWGQEE → LRHGGRKSEGHGHIYDSQHH YN in AAD14035. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q92109 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 0E83F2A5EEFE3202

FASTA52259,273
        10         20         30         40         50         60 
MVLMILPIIG SVSASEGLVA MVTLCLVYMI MKYMHTEIPE GLKRLPGPKP LPIIGNMLEV 

        70         80         90        100        110        120 
HNNPHLSLTA MSERYGSVFQ IQIGMRPVVV LSGNETVRQA LIKQGEDFAG RSDLYSFKFI 

       130        140        150        160        170        180 
NDGKSLAFST DKAGVWRARR KLAMSALRSF ATLEGTTPEY SCALEEHVLK EGEYLVKQLT 

       190        200        210        220        230        240 
SVMDVSGSFD PFRHIVVSVA NVICGMCFGR RYSHDDQELL GLVNMSDEFG QVVGSGNPAD 

       250        260        270        280        290        300 
FIPILRYLPN RTMKRFMDIN DRFNNFVQKI VSEHYESYDK DNIRDITDSL IDHCEDRKLD 

       310        320        330        340        350        360 
ENANIQVSDE KIVGIVNDLF GAGFDTISTA LSWAVVYLVA YPETQERLHQ ELKEKVGMIR 

       370        380        390        400        410        420 
TPRLSDKINL PLLEAFILEI FRHSSFLPFT IPHCTIKDTS LNGYFIPKDT CVFINQWQVN 

       430        440        450        460        470        480 
HDPELWKEPS SFNPDRFLSA DGTELNKLEG EKVLVFGMGK RRCIGEAIGR NEVYLFLAIL 

       490        500        510        520 
LQRLRFQEKP GHPLDMTPEY GLTMKHKRCQ LKASMRPWGQ EE 

« Hide

References

[1]"Two unique CYP1 genes are expressed in response to 3-methylcholanthrene treatment in rainbow trout."
Berndtson A.K., Chen T.T.
Arch. Biochem. Biophys. 310:187-195(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[2]"Cloning, sequencing and functional expression of two trout CYP1A cDNAs in yeast."
Bailey G., You L., Harttig U.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Trout P450IA1: cDNA and deduced protein sequence, expression in liver, and evolutionary significance."
Heilmann L.J., Sheen Y.-Y., Bigelow S.W., Nebert D.W.
DNA 7:379-387(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S69277 Genomic DNA. Translation: AAD14035.1.
U62796 mRNA. Translation: AAB40626.1.
M21310 mRNA. Translation: AAA49550.1. Sequence problems.

3D structure databases

ProteinModelPortalQ92109.
SMRQ92109. Positions 38-514.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106944.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A3_ONCMY
AccessionPrimary (citable) accession number: Q92109
Secondary accession number(s): P10609, P79829
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: June 11, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families