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Q92104

- CP11B_LITCT

UniProt

Q92104 - CP11B_LITCT

Protein

Cytochrome P450 11B, mitochondrial

Gene

CYP11B

Organism
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Has 11 beta-hydroxylation, 18-hydroxylation activities and aldosterone synthetic activity. Catalyzes the final steps of glucocorticoid and mineralocorticoid biosynthesis.

    Catalytic activityi

    A steroid + reduced adrenodoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenodoxin + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi465 – 4651Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. steroid 11-beta-monooxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. steroid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Steroidogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 11B, mitochondrial
    Alternative name(s):
    CYPXIB
    Cytochrome P450C11
    P-450(11 beta,aldo)
    Steroid 11-beta-hydroxylase (EC:1.14.15.4)
    Gene namesi
    Name:CYP11B
    OrganismiLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
    Taxonomic identifieri8400 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4545MitochondrionSequence AnalysisAdd
    BLAST
    Chaini46 – 517472Cytochrome P450 11B, mitochondrialPRO_0000003607Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ92104.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG051098.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q92104-1 [UniParc]FASTAAdd to Basket

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    MLEKTAARQI GSCLMRCRTL DTTSPLWTGF SRLSTAPLIH EAREDGSLAS    50
    QTLPYEAIPT TGRSAWFNLF QFWRKNSFQH MHLAMEENFQ NLGPIYREKL 100
    GTHNSVNIML PQDVARLFQS EGIFPRRMTM EAWSKHRELR NHKQGVFLLN 150
    GEAWRSDRII LNKEVLSLAG VKKFLPFLDE AAADFVTFMK KRMSKNTRGS 200
    LTVDLYADLF RFTLEASSYV LYGQRLGLLE EHPNADTLRF ISAVETVLKT 250
    TLPLLYYPHQ ILQLFQTRLW NEHMHAWDVI FEQADRCIQN IYQEYCLGQE 300
    RGYSGIMAEL LLQAELPLDS IKANITELMA GGVDTTAMPL LFTLFELARN 350
    PSVQRELREE IRKAEAQNPN DLNQLLNSLP LLKGAIKETL RLYPVGITVQ 400
    RHLIKDIVLH NYHIPAGTLV QVGLYPMGRS PLLFQDALRY DPARWLKRED 450
    TNFKALAFGF GSRQCIGRRI AETEITLFLM HMLKNFQIDT VSKDDIKTVF 500
    GFILMPEKPP LLTFRPI 517
    Length:517
    Mass (Da):59,539
    Last modified:November 1, 1996 - v1
    Checksum:i8F94DCD66BA6370B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10984 mRNA. Translation: BAA01756.1.
    PIRiS69347.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10984 mRNA. Translation: BAA01756.1 .
    PIRi S69347.

    3D structure databases

    ProteinModelPortali Q92104.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG051098.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Frog cytochrome P-450 (11 beta,aldo), a single enzyme involved in the final steps of glucocorticoid and mineralocorticoid biosynthesis."
      Nonaka Y., Takemori H., Halder S.K., Sun T., Ohta M., Hatano O., Takakusu A., Okamoto M.
      Eur. J. Biochem. 229:249-256(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Adrenal gland.

    Entry informationi

    Entry nameiCP11B_LITCT
    AccessioniPrimary (citable) accession number: Q92104
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3