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Q92104

- CP11B_LITCT

UniProt

Q92104 - CP11B_LITCT

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Protein

Cytochrome P450 11B, mitochondrial

Gene

CYP11B

Organism
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Has 11 beta-hydroxylation, 18-hydroxylation activities and aldosterone synthetic activity. Catalyzes the final steps of glucocorticoid and mineralocorticoid biosynthesis.

Catalytic activityi

A steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11-beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi465 – 4651Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. steroid 11-beta-monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. steroid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 11B, mitochondrial
Alternative name(s):
CYPXIB
Cytochrome P450C11
P-450(11 beta,aldo)
Steroid 11-beta-hydroxylase (EC:1.14.15.4)
Gene namesi
Name:CYP11B
OrganismiLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Taxonomic identifieri8400 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4545MitochondrionSequence AnalysisAdd
BLAST
Chaini46 – 517472Cytochrome P450 11B, mitochondrialPRO_0000003607Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051098.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92104-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEKTAARQI GSCLMRCRTL DTTSPLWTGF SRLSTAPLIH EAREDGSLAS
60 70 80 90 100
QTLPYEAIPT TGRSAWFNLF QFWRKNSFQH MHLAMEENFQ NLGPIYREKL
110 120 130 140 150
GTHNSVNIML PQDVARLFQS EGIFPRRMTM EAWSKHRELR NHKQGVFLLN
160 170 180 190 200
GEAWRSDRII LNKEVLSLAG VKKFLPFLDE AAADFVTFMK KRMSKNTRGS
210 220 230 240 250
LTVDLYADLF RFTLEASSYV LYGQRLGLLE EHPNADTLRF ISAVETVLKT
260 270 280 290 300
TLPLLYYPHQ ILQLFQTRLW NEHMHAWDVI FEQADRCIQN IYQEYCLGQE
310 320 330 340 350
RGYSGIMAEL LLQAELPLDS IKANITELMA GGVDTTAMPL LFTLFELARN
360 370 380 390 400
PSVQRELREE IRKAEAQNPN DLNQLLNSLP LLKGAIKETL RLYPVGITVQ
410 420 430 440 450
RHLIKDIVLH NYHIPAGTLV QVGLYPMGRS PLLFQDALRY DPARWLKRED
460 470 480 490 500
TNFKALAFGF GSRQCIGRRI AETEITLFLM HMLKNFQIDT VSKDDIKTVF
510
GFILMPEKPP LLTFRPI
Length:517
Mass (Da):59,539
Last modified:November 1, 1996 - v1
Checksum:i8F94DCD66BA6370B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10984 mRNA. Translation: BAA01756.1.
PIRiS69347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10984 mRNA. Translation: BAA01756.1 .
PIRi S69347.

3D structure databases

ProteinModelPortali Q92104.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG051098.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Frog cytochrome P-450 (11 beta,aldo), a single enzyme involved in the final steps of glucocorticoid and mineralocorticoid biosynthesis."
    Nonaka Y., Takemori H., Halder S.K., Sun T., Ohta M., Hatano O., Takakusu A., Okamoto M.
    Eur. J. Biochem. 229:249-256(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adrenal gland.

Entry informationi

Entry nameiCP11B_LITCT
AccessioniPrimary (citable) accession number: Q92104
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3