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Q92100

- CP1A1_PLEPL

UniProt

Q92100 - CP1A1_PLEPL

Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Pleuronectes platessa (European plaice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei229 – 2291SubstrateBy similarity
    Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:cyp1a1
    OrganismiPleuronectes platessa (European plaice)
    Taxonomic identifieri8262 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataCarangimorphariaePleuronectiformesPleuronectoideiPleuronectidaePleuronectinaePleuronectes

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Cytochrome P450 1A1PRO_0000051646Add
    BLAST

    Expressioni

    Inductioni

    By 3-methylcholanthrene (3MC) and isosafrole (ISF).

    Structurei

    3D structure databases

    ProteinModelPortaliQ92100.
    SMRiQ92100. Positions 38-513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92100-1 [UniParc]FASTAAdd to Basket

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    MMLMMLPFIG SVSVSESLVA MTTMCLVYLI LKFFQTEIPE GLRRLPGPKP    50
    LPIIGNVLGL GSKPYLSLTA MSKRYGHVFQ IQIGMRPVVV LSGTGTVRQA 100
    LIKQGDEFAG RPDLYSFRFI NAGKSLAFST DQAGVWRARR KLAYSALRSF 150
    STLEGTTPEY SCVLEEHICK EGEYLIKQLN TVMKADGSFD PFRHIVVSVA 200
    NVICGMCFGR RYDHDDQELV SLVTLSDEFG RVVGSGNPAD FIPILQYLPS 250
    AEMKNFLRIN EHFTEFVQKI VTEHYTTFNK DNIRDITDSL IDHCEDRKLD 300
    ENSNVQMSDE KIVGIVNDLF GAGFDTVSTA LSWSVMYLVA HPEIQERLYQ 350
    EIEDKVGLDR MPLLSDKPNL PFLEAFILEI LRHSSFLPFT IPHCTTKDTS 400
    LNGYFIPKDT CVFINQWQIN HDPELWKDPS SFNPDRFLSA DGSEVNKLDG 450
    EKVMAFGMGK RRCIGEVIAR NEVYLFLAII IQKLHFLPIP GEKLDMTPEY 500
    GLTMKHKRCH LKATMRARNE H 521
    Length:521
    Mass (Da):59,061
    Last modified:November 1, 1996 - v1
    Checksum:iAA7A97CB4578F9E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73631 mRNA. Translation: CAA52010.1.
    PIRiS34184.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73631 mRNA. Translation: CAA52010.1 .
    PIRi S34184.

    3D structure databases

    ProteinModelPortali Q92100.
    SMRi Q92100. Positions 38-513.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cytochrome P450 1A1 cDNA from plaice (Pleuronectes platessa) and induction of P450 1A1 mRNA in various tissues by 3-methylcholanthrene and isosafrole."
      Leaver M.J., Pirrit L., George S.G.
      Mol. Mar. Biol. Biotechnol. 2:338-345(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_PLEPL
    AccessioniPrimary (citable) accession number: Q92100
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3