Reviewed, UniProtKB/Swiss-Prot Q92100 (CP1A1_PLEPL)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 1A1
    EC=1.14.14.1
Alternative name(s):
    CYPIA1

Gene names

Name:

cyp1a1

Organism

Pleuronectes platessa (Plaice)

Taxonomic identifier

8262 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Pleuronectiformes › Pleuronectoidei › Pleuronectidae › Pleuronectinae › Pleuronectes

Protein attributes

Sequence length	521 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	By 3-methylcholanthrene (3MC) and isosafrole (ISF).
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 521	521	Cytochrome P450 1A1		PRO_0000051646
Sites
	Metal binding	463	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92100-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: AA7A97CB4578F9E6	FASTA	521	59,061
	10 20 30 40 50 60 MMLMMLPFIG SVSVSESLVA MTTMCLVYLI LKFFQTEIPE GLRRLPGPKP LPIIGNVLGL 70 80 90 100 110 120 GSKPYLSLTA MSKRYGHVFQ IQIGMRPVVV LSGTGTVRQA LIKQGDEFAG RPDLYSFRFI 130 140 150 160 170 180 NAGKSLAFST DQAGVWRARR KLAYSALRSF STLEGTTPEY SCVLEEHICK EGEYLIKQLN 190 200 210 220 230 240 TVMKADGSFD PFRHIVVSVA NVICGMCFGR RYDHDDQELV SLVTLSDEFG RVVGSGNPAD 250 260 270 280 290 300 FIPILQYLPS AEMKNFLRIN EHFTEFVQKI VTEHYTTFNK DNIRDITDSL IDHCEDRKLD 310 320 330 340 350 360 ENSNVQMSDE KIVGIVNDLF GAGFDTVSTA LSWSVMYLVA HPEIQERLYQ EIEDKVGLDR 370 380 390 400 410 420 MPLLSDKPNL PFLEAFILEI LRHSSFLPFT IPHCTTKDTS LNGYFIPKDT CVFINQWQIN 430 440 450 460 470 480 HDPELWKDPS SFNPDRFLSA DGSEVNKLDG EKVMAFGMGK RRCIGEVIAR NEVYLFLAII 490 500 510 520 IQKLHFLPIP GEKLDMTPEY GLTMKHKRCH LKATMRARNE H

References

[1]

"Cytochrome P450 1A1 cDNA from plaice (Pleuronectes platessa) and induction of P450 1A1 mRNA in various tissues by 3-methylcholanthrene and isosafrole." Leaver M.J., Pirrit L., George S.G. Mol. Mar. Biol. Biotechnol. 2:338-345(1993) [PubMed: 8193668] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X73631 mRNA. Translation: CAA52010.1.
PIR	S34184.
3D structure databases
HSSP	HSSP built from PDB template 1DT6 based on UniProtKB P00179.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q92100.
Enzyme and pathway databases
BRENDA	1.14.14.1. 74156.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008066. Cyt_P450_E_grp-I_CYP1. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit. PTHR19383:SF63. Cyt_P450_E_grp-I_CYP1. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01683. EP450ICYP1A. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP1A1_PLEPL

Accession

Primary (citable) accession number: Q92100

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	October 13, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)