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Protein

UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

Gene

B3galnt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transfers N-acetylgalactosamine onto globotriaosylceramide.1 Publication

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.By similarity

Cofactori

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • oligosaccharide biosynthetic process Source: MGI
  • protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

ReactomeiR-MMU-1660662. Glycosphingolipid metabolism.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (EC:2.4.1.79By similarity)
Short name:
Beta-1,3-GalNAc-T1
Alternative name(s):
Beta-1,3-galactosyltransferase 3
Short name:
Beta-1,3-GalTase 3
Short name:
Beta3Gal-T3
Short name:
Beta3GalT3
Short name:
b3Gal-T3
Beta-3-Gx-T3
Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase
Globoside synthase
UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
Gene namesi
Name:B3galnt1
Synonyms:B3galt3, B3gt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1349405. B3galnt1.

Subcellular locationi

  • Golgi apparatus membrane By similarity; Single-pass type II membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 43Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini44 – 331LumenalSequence analysisAdd BLAST288

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191541 – 331UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi154N-linked (GlcNAc...)Sequence analysis1
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Glycosylationi212N-linked (GlcNAc...)Sequence analysis1
Glycosylationi326N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ920V1.
PaxDbiQ920V1.
PeptideAtlasiQ920V1.
PRIDEiQ920V1.

PTM databases

PhosphoSitePlusiQ920V1.

Expressioni

Tissue specificityi

Detected in brain, ovary, uterus and stomach.1 Publication

Gene expression databases

BgeeiENSMUSG00000043300.
GenevisibleiQ920V1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058363.

Structurei

3D structure databases

ProteinModelPortaliQ920V1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
GeneTreeiENSGT00760000118879.
HOGENOMiHOG000059604.
HOVERGENiHBG101817.
InParanoidiQ920V1.
KOiK00719.
OMAiRFTLREH.
OrthoDBiEOG091G0AXM.
PhylomeDBiQ920V1.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q920V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAVLTALP NRMSLRSLKW SLLLLSLLSF LVIWYLSLPH YNVIERVNWM
60 70 80 90 100
YFYEYEPIYR QDFRFTLREH SNCSHQNPFL VILVTSRPSD VKARQAIRVT
110 120 130 140 150
WGEKKSWWGY EVLTFFLLGQ QAEREDKTLA LSLEDEHVLY GDIIRQDFLD
160 170 180 190 200
TYNNLTLKTI MAFRWVMEFC PNAKYIMKTD TDVFINTGNL VKYLLNLNHS
210 220 230 240 250
EKFFTGYPLI DNYSYRGFFH KNHISYQEYP FKVFPPYCSG LGYIMSGDLV
260 270 280 290 300
PRVYEMMSHV KPIKFEDVYV GICLNLLKVD IHIPEDTNLF FLYRIHLDVC
310 320 330
QLRRVIAAHG FSSKEIITFW QVMLRNTTCH Y
Length:331
Mass (Da):39,371
Last modified:July 5, 2005 - v2
Checksum:i387E8B0C75FC282D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti4A → T in strain: NJL/Msf, BLG2/Msf, MSM/Msf and SWN/Msf. 1 Publication1
Natural varianti87R → H in strain: SWN/Msf. 1 Publication1
Natural varianti128T → M in strain: CAST/Ei. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039154 Genomic DNA. Translation: BAB68678.1.
AB039155 Genomic DNA. Translation: BAB68679.1.
AB039156 Genomic DNA. Translation: BAB68680.1.
AB039157 Genomic DNA. Translation: BAB68681.1.
AB039158 Genomic DNA. Translation: BAB68682.1.
AB039159 Genomic DNA. Translation: BAB68683.1.
AB039160 Genomic DNA. Translation: BAB68684.1.
AB039161 Genomic DNA. Translation: BAB68685.1.
AB039162 Genomic DNA. Translation: BAB68686.1.
AF029792 Genomic DNA. Translation: AAC53525.1.
AK003837 mRNA. Translation: BAB23028.1.
AK088407 mRNA. Translation: BAC40336.1.
BC003835 mRNA. Translation: AAH03835.3.
CCDSiCCDS17406.1.
RefSeqiNP_064410.1. NM_020026.4.
XP_006501592.1. XM_006501529.3.
UniGeneiMm.153710.

Genome annotation databases

EnsembliENSMUST00000061826; ENSMUSP00000058363; ENSMUSG00000043300.
GeneIDi26879.
KEGGimmu:26879.
UCSCiuc008pmj.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

b3GalT3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039154 Genomic DNA. Translation: BAB68678.1.
AB039155 Genomic DNA. Translation: BAB68679.1.
AB039156 Genomic DNA. Translation: BAB68680.1.
AB039157 Genomic DNA. Translation: BAB68681.1.
AB039158 Genomic DNA. Translation: BAB68682.1.
AB039159 Genomic DNA. Translation: BAB68683.1.
AB039160 Genomic DNA. Translation: BAB68684.1.
AB039161 Genomic DNA. Translation: BAB68685.1.
AB039162 Genomic DNA. Translation: BAB68686.1.
AF029792 Genomic DNA. Translation: AAC53525.1.
AK003837 mRNA. Translation: BAB23028.1.
AK088407 mRNA. Translation: BAC40336.1.
BC003835 mRNA. Translation: AAH03835.3.
CCDSiCCDS17406.1.
RefSeqiNP_064410.1. NM_020026.4.
XP_006501592.1. XM_006501529.3.
UniGeneiMm.153710.

3D structure databases

ProteinModelPortaliQ920V1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058363.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSitePlusiQ920V1.

Proteomic databases

MaxQBiQ920V1.
PaxDbiQ920V1.
PeptideAtlasiQ920V1.
PRIDEiQ920V1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061826; ENSMUSP00000058363; ENSMUSG00000043300.
GeneIDi26879.
KEGGimmu:26879.
UCSCiuc008pmj.2. mouse.

Organism-specific databases

CTDi8706.
MGIiMGI:1349405. B3galnt1.

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
GeneTreeiENSGT00760000118879.
HOGENOMiHOG000059604.
HOVERGENiHBG101817.
InParanoidiQ920V1.
KOiK00719.
OMAiRFTLREH.
OrthoDBiEOG091G0AXM.
PhylomeDBiQ920V1.
TreeFamiTF318639.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiR-MMU-1660662. Glycosphingolipid metabolism.

Miscellaneous databases

PROiQ920V1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043300.
GenevisibleiQ920V1. MM.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3GL1_MOUSE
AccessioniPrimary (citable) accession number: Q920V1
Secondary accession number(s): O54906
, Q91V72, Q920V0, Q9CTE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.