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Protein

UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

Gene

B3galnt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transfers N-acetylgalactosamine onto globotriaosylceramide.1 Publication

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.By similarity

Cofactori

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • oligosaccharide biosynthetic process Source: MGI
  • protein glycosylation Source: UniProtKB-UniPathway

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMagnesium

Enzyme and pathway databases

ReactomeiR-MMU-1660662 Glycosphingolipid metabolism
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (EC:2.4.1.79By similarity)
Short name:
Beta-1,3-GalNAc-T1
Alternative name(s):
Beta-1,3-galactosyltransferase 3
Short name:
Beta-1,3-GalTase 3
Short name:
Beta3Gal-T3
Short name:
Beta3GalT3
Short name:
b3Gal-T3
Beta-3-Gx-T3
Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase
Globoside synthase
UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
Gene namesi
Name:B3galnt1
Synonyms:B3galt3, B3gt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1349405 B3galnt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 43Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini44 – 331LumenalSequence analysisAdd BLAST288

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191541 – 331UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi326N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ920V1
PaxDbiQ920V1
PeptideAtlasiQ920V1
PRIDEiQ920V1

PTM databases

PhosphoSitePlusiQ920V1

Expressioni

Tissue specificityi

Detected in brain, ovary, uterus and stomach.1 Publication

Gene expression databases

BgeeiENSMUSG00000043300
GenevisibleiQ920V1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058363

Structurei

3D structure databases

ProteinModelPortaliQ920V1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287 Eukaryota
ENOG410ZZ1B LUCA
GeneTreeiENSGT00760000118879
HOGENOMiHOG000059604
HOVERGENiHBG101817
InParanoidiQ920V1
KOiK00719
OMAiRFTLREH
OrthoDBiEOG091G0AXM
PhylomeDBiQ920V1
TreeFamiTF318639

Family and domain databases

InterProiView protein in InterPro
IPR002659 Glyco_trans_31
PANTHERiPTHR11214 PTHR11214, 1 hit
PfamiView protein in Pfam
PF01762 Galactosyl_T, 1 hit

Sequencei

Sequence statusi: Complete.

Q920V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAVLTALP NRMSLRSLKW SLLLLSLLSF LVIWYLSLPH YNVIERVNWM
60 70 80 90 100
YFYEYEPIYR QDFRFTLREH SNCSHQNPFL VILVTSRPSD VKARQAIRVT
110 120 130 140 150
WGEKKSWWGY EVLTFFLLGQ QAEREDKTLA LSLEDEHVLY GDIIRQDFLD
160 170 180 190 200
TYNNLTLKTI MAFRWVMEFC PNAKYIMKTD TDVFINTGNL VKYLLNLNHS
210 220 230 240 250
EKFFTGYPLI DNYSYRGFFH KNHISYQEYP FKVFPPYCSG LGYIMSGDLV
260 270 280 290 300
PRVYEMMSHV KPIKFEDVYV GICLNLLKVD IHIPEDTNLF FLYRIHLDVC
310 320 330
QLRRVIAAHG FSSKEIITFW QVMLRNTTCH Y
Length:331
Mass (Da):39,371
Last modified:July 5, 2005 - v2
Checksum:i387E8B0C75FC282D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti4A → T in strain: NJL/Msf, BLG2/Msf, MSM/Msf and SWN/Msf. 1 Publication1
Natural varianti87R → H in strain: SWN/Msf. 1 Publication1
Natural varianti128T → M in strain: CAST/Ei. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039154 Genomic DNA Translation: BAB68678.1
AB039155 Genomic DNA Translation: BAB68679.1
AB039156 Genomic DNA Translation: BAB68680.1
AB039157 Genomic DNA Translation: BAB68681.1
AB039158 Genomic DNA Translation: BAB68682.1
AB039159 Genomic DNA Translation: BAB68683.1
AB039160 Genomic DNA Translation: BAB68684.1
AB039161 Genomic DNA Translation: BAB68685.1
AB039162 Genomic DNA Translation: BAB68686.1
AF029792 Genomic DNA Translation: AAC53525.1
AK003837 mRNA Translation: BAB23028.1
AK088407 mRNA Translation: BAC40336.1
BC003835 mRNA Translation: AAH03835.3
CCDSiCCDS17406.1
RefSeqiNP_064410.1, NM_020026.4
XP_006501592.1, XM_006501529.3
UniGeneiMm.153710

Genome annotation databases

EnsembliENSMUST00000061826; ENSMUSP00000058363; ENSMUSG00000043300
GeneIDi26879
KEGGimmu:26879
UCSCiuc008pmj.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiB3GL1_MOUSE
AccessioniPrimary (citable) accession number: Q920V1
Secondary accession number(s): O54906
, Q91V72, Q920V0, Q9CTE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: March 28, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health