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Q920V1

- B3GL1_MOUSE

UniProt

Q920V1 - B3GL1_MOUSE

Protein

UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

Gene

B3galnt1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Transfers N-acetylgalactosamine onto globotriaosylceramide.1 Publication

    Catalytic activityi

    UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

    Cofactori

    Magnesium.

    Pathwayi

    GO - Molecular functioni

    1. galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity Source: UniProtKB-EC
    2. UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Source: MGI

    GO - Biological processi

    1. oligosaccharide biosynthetic process Source: MGI
    2. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT31. Glycosyltransferase Family 31.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (EC:2.4.1.79)
    Short name:
    Beta-1,3-GalNAc-T1
    Alternative name(s):
    Beta-1,3-galactosyltransferase 3
    Short name:
    Beta-1,3-GalTase 3
    Short name:
    Beta3Gal-T3
    Short name:
    Beta3GalT3
    Short name:
    b3Gal-T3
    Beta-3-Gx-T3
    Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase
    Globoside synthase
    UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
    Gene namesi
    Name:B3galnt1
    Synonyms:B3galt3, B3gt3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1349405. B3galnt1.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1PRO_0000219154Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ920V1.
    PRIDEiQ920V1.

    PTM databases

    PhosphoSiteiQ920V1.

    Expressioni

    Tissue specificityi

    Detected in brain, ovary, uterus and stomach.1 Publication

    Gene expression databases

    BgeeiQ920V1.
    GenevestigatoriQ920V1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ920V1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini44 – 331288LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4323Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 31 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG269758.
    GeneTreeiENSGT00740000114871.
    HOGENOMiHOG000059604.
    HOVERGENiHBG101817.
    InParanoidiQ920V1.
    KOiK00719.
    OMAiCPNAKYI.
    OrthoDBiEOG7M3J0F.
    PhylomeDBiQ920V1.
    TreeFamiTF318639.

    Family and domain databases

    InterProiIPR002659. Glyco_trans_31.
    [Graphical view]
    PANTHERiPTHR11214. PTHR11214. 1 hit.
    PfamiPF01762. Galactosyl_T. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q920V1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPAVLTALP NRMSLRSLKW SLLLLSLLSF LVIWYLSLPH YNVIERVNWM    50
    YFYEYEPIYR QDFRFTLREH SNCSHQNPFL VILVTSRPSD VKARQAIRVT 100
    WGEKKSWWGY EVLTFFLLGQ QAEREDKTLA LSLEDEHVLY GDIIRQDFLD 150
    TYNNLTLKTI MAFRWVMEFC PNAKYIMKTD TDVFINTGNL VKYLLNLNHS 200
    EKFFTGYPLI DNYSYRGFFH KNHISYQEYP FKVFPPYCSG LGYIMSGDLV 250
    PRVYEMMSHV KPIKFEDVYV GICLNLLKVD IHIPEDTNLF FLYRIHLDVC 300
    QLRRVIAAHG FSSKEIITFW QVMLRNTTCH Y 331
    Length:331
    Mass (Da):39,371
    Last modified:July 5, 2005 - v2
    Checksum:i387E8B0C75FC282D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41A → T in strain: NJL/Msf, BLG2/Msf, MSM/Msf and SWN/Msf. 1 Publication
    Natural varianti87 – 871R → H in strain: SWN/Msf. 1 Publication
    Natural varianti128 – 1281T → M in strain: CAST/Ei. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039154 Genomic DNA. Translation: BAB68678.1.
    AB039155 Genomic DNA. Translation: BAB68679.1.
    AB039156 Genomic DNA. Translation: BAB68680.1.
    AB039157 Genomic DNA. Translation: BAB68681.1.
    AB039158 Genomic DNA. Translation: BAB68682.1.
    AB039159 Genomic DNA. Translation: BAB68683.1.
    AB039160 Genomic DNA. Translation: BAB68684.1.
    AB039161 Genomic DNA. Translation: BAB68685.1.
    AB039162 Genomic DNA. Translation: BAB68686.1.
    AF029792 Genomic DNA. Translation: AAC53525.1.
    AK003837 mRNA. Translation: BAB23028.1.
    AK088407 mRNA. Translation: BAC40336.1.
    BC003835 mRNA. Translation: AAH03835.3.
    CCDSiCCDS17406.1.
    RefSeqiNP_064410.1. NM_020026.4.
    XP_006501592.1. XM_006501529.1.
    UniGeneiMm.153710.

    Genome annotation databases

    EnsembliENSMUST00000061826; ENSMUSP00000058363; ENSMUSG00000043300.
    GeneIDi26879.
    KEGGimmu:26879.
    UCSCiuc008pmj.1. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - GTase

    b3GalT3

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039154 Genomic DNA. Translation: BAB68678.1 .
    AB039155 Genomic DNA. Translation: BAB68679.1 .
    AB039156 Genomic DNA. Translation: BAB68680.1 .
    AB039157 Genomic DNA. Translation: BAB68681.1 .
    AB039158 Genomic DNA. Translation: BAB68682.1 .
    AB039159 Genomic DNA. Translation: BAB68683.1 .
    AB039160 Genomic DNA. Translation: BAB68684.1 .
    AB039161 Genomic DNA. Translation: BAB68685.1 .
    AB039162 Genomic DNA. Translation: BAB68686.1 .
    AF029792 Genomic DNA. Translation: AAC53525.1 .
    AK003837 mRNA. Translation: BAB23028.1 .
    AK088407 mRNA. Translation: BAC40336.1 .
    BC003835 mRNA. Translation: AAH03835.3 .
    CCDSi CCDS17406.1.
    RefSeqi NP_064410.1. NM_020026.4.
    XP_006501592.1. XM_006501529.1.
    UniGenei Mm.153710.

    3D structure databases

    ProteinModelPortali Q920V1.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT31. Glycosyltransferase Family 31.

    PTM databases

    PhosphoSitei Q920V1.

    Proteomic databases

    PaxDbi Q920V1.
    PRIDEi Q920V1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061826 ; ENSMUSP00000058363 ; ENSMUSG00000043300 .
    GeneIDi 26879.
    KEGGi mmu:26879.
    UCSCi uc008pmj.1. mouse.

    Organism-specific databases

    CTDi 8706.
    MGIi MGI:1349405. B3galnt1.

    Phylogenomic databases

    eggNOGi NOG269758.
    GeneTreei ENSGT00740000114871.
    HOGENOMi HOG000059604.
    HOVERGENi HBG101817.
    InParanoidi Q920V1.
    KOi K00719.
    OMAi CPNAKYI.
    OrthoDBi EOG7M3J0F.
    PhylomeDBi Q920V1.
    TreeFami TF318639.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    NextBioi 304695.
    PROi Q920V1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q920V1.
    Genevestigatori Q920V1.

    Family and domain databases

    InterProi IPR002659. Glyco_trans_31.
    [Graphical view ]
    PANTHERi PTHR11214. PTHR11214. 1 hit.
    Pfami PF01762. Galactosyl_T. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
      Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-4; HIS-87 AND MET-128.
      Strain: BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, Pgn2 and SWN/Msf.
    2. "Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta1,3-galactosyltransferase genes."
      Hennet T., Dinter A., Kuhnert P., Mattu T.S., Rudd P.M., Berger E.G.
      J. Biol. Chem. 273:58-65(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: 129/SvJ.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Embryo and Thymus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.

    Entry informationi

    Entry nameiB3GL1_MOUSE
    AccessioniPrimary (citable) accession number: Q920V1
    Secondary accession number(s): O54906
    , Q91V72, Q920V0, Q9CTE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3