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Protein

GATA zinc finger domain-containing protein 1

Gene

Gatad1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri9 – 33GATA-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
GATA zinc finger domain-containing protein 1
Alternative name(s):
Ocular development-associated gene protein
Gene namesi
Name:Gatad1
Synonyms:Odag
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914460. Gatad1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889101 – 266GATA zinc finger domain-containing protein 1Add BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki259Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ920S3.
PeptideAtlasiQ920S3.
PRIDEiQ920S3.

PTM databases

iPTMnetiQ920S3.
PhosphoSitePlusiQ920S3.

Expressioni

Tissue specificityi

Expressed in the eye (lens, ciliary body, retina, sclera and conjunctiva) at postnatal day 2 and 10. Not detected anywhere at postnatal day 14.1 Publication

Developmental stagei

Expressed in embryo at 13 dpc onwards. Expressed in embryonic heart at all stages of development.2 Publications

Gene expression databases

BgeeiENSMUSG00000007415.
CleanExiMM_GATAD1.
ExpressionAtlasiQ920S3. baseline and differential.
GenevisibleiQ920S3. MM.

Interactioni

Subunit structurei

Component of a chromatin complex, at least composed of KDM5A, GATAD1 and EMSY.By similarity

Protein-protein interaction databases

IntActiQ920S3. 1 interactor.
MINTiMINT-4122397.
STRINGi10090.ENSMUSP00000007559.

Structurei

3D structure databases

ProteinModelPortaliQ920S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 78Gly-richAdd BLAST44

Sequence similaritiesi

Contains 1 GATA-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri9 – 33GATA-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGNZ. Eukaryota.
ENOG410XR16. LUCA.
GeneTreeiENSGT00390000018554.
HOGENOMiHOG000039281.
HOVERGENiHBG067032.
InParanoidiQ920S3.
OMAiYIVGPEE.
OrthoDBiEOG091G0KSX.
PhylomeDBiQ920S3.
TreeFamiTF325354.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PROSITEiPS50114. GATA_ZN_FINGER_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q920S3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLGLKPTCS MCKTTSSSMW KKSPQGEILC HHCTGRGGGG AGVAGGTGGG
60 70 80 90 100
GGGGGGFGTT TFATTSAGPS QSNGGGGGKQ SKQEIHRRSA RLRNTKYKSA
110 120 130 140 150
PAAEKKVSTK GKGRRHIFKL KNPIKAPESV STIVTAESIF YKGVYYQIGD
160 170 180 190 200
VVSVIDEQDG KPYYAQIRGF IQDQYCEKSA ALTWLIPTLA SPRDQFDPAS
210 220 230 240 250
YIIGPEEDLP RKMEYLEFVC HAPSEYFKSR SSPFPTVPTR PEKGYIWTHV
260
GPTPAITIKE TVANHL
Length:266
Mass (Da):28,535
Last modified:May 29, 2007 - v2
Checksum:i23A09267763A37CE
GO
Isoform 2 (identifier: Q920S3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-218: PEEDLPRKMEYLEF → EAQHLRFTSFFSAL
     219-266: Missing.

Show »
Length:218
Mass (Da):23,062
Checksum:i2E6F810CEEAD36B9
GO

Sequence cautioni

The sequence BAB28550 differs from that shown. Reason: Erroneous termination at position 247. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60T → A in BAB69047 (PubMed:12062807).Curated1
Sequence conflicti194D → G in BAB28550 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025823205 – 218PEEDL…EYLEF → EAQHLRFTSFFSAL in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_025824219 – 266Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047921 mRNA. Translation: BAB69047.1.
AK012921 mRNA. Translation: BAB28550.2. Sequence problems.
BC019449 mRNA. Translation: AAH19449.1.
CCDSiCCDS19066.1. [Q920S3-1]
RefSeqiNP_080309.2. NM_026033.2. [Q920S3-1]
UniGeneiMm.178424.
Mm.482994.

Genome annotation databases

EnsembliENSMUST00000007559; ENSMUSP00000007559; ENSMUSG00000007415. [Q920S3-1]
ENSMUST00000119783; ENSMUSP00000113271; ENSMUSG00000007415. [Q920S3-2]
GeneIDi67210.
KEGGimmu:67210.
UCSCiuc008whh.2. mouse. [Q920S3-1]
uc008whi.2. mouse. [Q920S3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047921 mRNA. Translation: BAB69047.1.
AK012921 mRNA. Translation: BAB28550.2. Sequence problems.
BC019449 mRNA. Translation: AAH19449.1.
CCDSiCCDS19066.1. [Q920S3-1]
RefSeqiNP_080309.2. NM_026033.2. [Q920S3-1]
UniGeneiMm.178424.
Mm.482994.

3D structure databases

ProteinModelPortaliQ920S3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ920S3. 1 interactor.
MINTiMINT-4122397.
STRINGi10090.ENSMUSP00000007559.

PTM databases

iPTMnetiQ920S3.
PhosphoSitePlusiQ920S3.

Proteomic databases

PaxDbiQ920S3.
PeptideAtlasiQ920S3.
PRIDEiQ920S3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007559; ENSMUSP00000007559; ENSMUSG00000007415. [Q920S3-1]
ENSMUST00000119783; ENSMUSP00000113271; ENSMUSG00000007415. [Q920S3-2]
GeneIDi67210.
KEGGimmu:67210.
UCSCiuc008whh.2. mouse. [Q920S3-1]
uc008whi.2. mouse. [Q920S3-2]

Organism-specific databases

CTDi57798.
MGIiMGI:1914460. Gatad1.

Phylogenomic databases

eggNOGiENOG410IGNZ. Eukaryota.
ENOG410XR16. LUCA.
GeneTreeiENSGT00390000018554.
HOGENOMiHOG000039281.
HOVERGENiHBG067032.
InParanoidiQ920S3.
OMAiYIVGPEE.
OrthoDBiEOG091G0KSX.
PhylomeDBiQ920S3.
TreeFamiTF325354.

Miscellaneous databases

ChiTaRSiGatad1. mouse.
PROiQ920S3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007415.
CleanExiMM_GATAD1.
ExpressionAtlasiQ920S3. baseline and differential.
GenevisibleiQ920S3. MM.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PROSITEiPS50114. GATA_ZN_FINGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGATD1_MOUSE
AccessioniPrimary (citable) accession number: Q920S3
Secondary accession number(s): Q8VCQ2, Q9CSG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.