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Q920R0

- ALS2_MOUSE

UniProt

Q920R0 - ALS2_MOUSE

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Protein
Alsin
Gene
Als2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a GTPase regulator By similarity. Controls survival and growth of spinal motoneurons By similarity.By similarity

GO - Molecular functioni

  1. Rab GTPase binding Source: UniProtKB
  2. Rab guanyl-nucleotide exchange factor activity Source: UniProtKB
  3. Rac guanyl-nucleotide exchange factor activity Source: UniProtKB
  4. protein binding Source: MGI
  5. protein homodimerization activity Source: UniProtKB
  6. protein serine/threonine kinase activator activity Source: UniProtKB

GO - Biological processi

  1. behavioral fear response Source: MGI
  2. endosomal transport Source: MGI
  3. locomotory behavior Source: MGI
  4. neuromuscular junction development Source: MGI
  5. neuron projection morphogenesis Source: UniProtKB
  6. positive regulation of Rac GTPase activity Source: UniProtKB
  7. positive regulation of protein kinase activity Source: UniProtKB
  8. protein localization Source: MGI
  9. receptor recycling Source: MGI
  10. regulation of Rab GTPase activity Source: MGI
  11. regulation of Rac GTPase activity Source: GOC
  12. regulation of endosome size Source: UniProtKB
  13. response to oxidative stress Source: MGI
  14. synaptic transmission, glutamatergic Source: MGI
  15. vesicle organization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Alsin
Alternative name(s):
Amyotrophic lateral sclerosis 2 protein homolog
Gene namesi
Name:Als2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1921268. Als2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: UniProtKB
  3. dendrite Source: UniProtKB
  4. dendritic spine Source: MGI
  5. early endosome Source: UniProtKB
  6. growth cone Source: UniProtKB
  7. lamellipodium Source: UniProtKB
  8. postsynaptic density Source: MGI
  9. protein complex Source: UniProtKB
  10. ruffle Source: UniProtKB
  11. vesicle Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16511651Alsin
PRO_0000080904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei477 – 4771Phosphoserine1 Publication
Modified residuei486 – 4861Phosphoserine1 Publication
Modified residuei527 – 5271N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ920R0.
PaxDbiQ920R0.
PRIDEiQ920R0.

PTM databases

PhosphoSiteiQ920R0.

Expressioni

Gene expression databases

GenevestigatoriQ920R0.

Interactioni

Subunit structurei

Forms a heteromeric complex with ALS2CL. Interacts with ALS2CL By similarity.

Protein-protein interaction databases

BioGridi216427. 4 interactions.
STRINGi10090.ENSMUSP00000027178.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati59 – 10850RCC1 1
Add
BLAST
Repeati109 – 16759RCC1 2
Add
BLAST
Repeati169 – 21850RCC1 3
Add
BLAST
Repeati519 – 57052RCC1 4
Add
BLAST
Repeati572 – 62150RCC1 5
Add
BLAST
Domaini684 – 879196DH
Add
BLAST
Domaini895 – 1001107PH
Add
BLAST
Repeati1043 – 106523MORN 1
Add
BLAST
Repeati1066 – 108823MORN 2
Add
BLAST
Repeati1094 – 111623MORN 3
Add
BLAST
Repeati1117 – 113923MORN 4
Add
BLAST
Repeati1145 – 116723MORN 5
Add
BLAST
Repeati1169 – 119123MORN 6
Add
BLAST
Repeati1192 – 121423MORN 7
Add
BLAST
Repeati1215 – 123824MORN 8
Add
BLAST
Domaini1507 – 1651145VPS9
Add
BLAST

Sequence similaritiesi

Contains 8 MORN repeats.
Contains 1 PH domain.
Contains 5 RCC1 repeats.
Contains 1 VPS9 domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG4642.
GeneTreeiENSGT00730000110297.
HOGENOMiHOG000033908.
HOVERGENiHBG037320.
InParanoidiQ920R0.
KOiK04575.
OMAiKLATCFE.
OrthoDBiEOG7C5M7B.
TreeFamiTF331793.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.130.10.30. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR003409. MORN.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003123. VPS9.
[Graphical view]
PfamiPF02493. MORN. 7 hits.
PF00415. RCC1. 4 hits.
PF00621. RhoGEF. 1 hit.
PF02204. VPS9. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00698. MORN. 8 hits.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50985. SSF50985. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 4 hits.
PS51205. VPS9. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q920R0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDSKKKSSTE AEGSKERGLV HVWQAGSFSL TPERLPGWGG KTVLQAALGV     50
RHGVLLTEDG EVYSFGTLPW KSESAEICPS SPLLESALVG HHVITVATGS 100
FHSGAVTESG VVYMWGENAA GQCAVANQQY VPEPSPVSIS DSETSPSLAV 150
RILQLACGEE HTLALSLSRE IWAWGTGCQL GLITTTFPVT KPQKVEHLAG 200
RVVLQVACGA FHSLALVQCL PPQDLKPVPE RCNQCSQLLI TMTDKEDHVI 250
ISDSHCCPLG VTLSESQAEK HASPAPSPHP EALDEQGEVF ENTVVEAELN 300
MGSSQTTSGS AISTQQNVVG TAEVSSARTA PSYPDTHAVT AYLQKLSEHS 350
MRENHEPGEK PPQVQPLVEE AVPDLHSPPT TSTSALNSLV VSCASAVGVR 400
VAATYEAGAL SLKKVMNFYS TAPCETAAQS GSASTGPESL KDLREEQVKQ 450
ESLQGKKSSS LMDIREEELE GGSRRLSLPG LLSQVSPRLL RKAARVKTRT 500
VVLTPTYSGE ADALLPSLRT EVWTWGKGKE GQLGHGDVLP RLQPLCVKCL 550
DGKEVIHLEA GGSHSLALTA KSQVYSWGSN TFGQLGHSEF PTTVPRLSKV 600
SSENGVWSVA AGQDYSLFLV DTEDFQPGLY YSGRQDRAEG DTLPENPSGT 650
KTPVLLSCSK LGYISRVTAG KDSYLALVDK NIMGYIASLH ELASTERRFY 700
SKLSEIKSQI LRPLLSLENL GTVTTVQLLQ EVASRFSKLC YLIGQHGASL 750
SSYLQGMKEA SSLVIMKHSS LFLDSYTEYC TSVSNFLVMG GFQLLAKPAI 800
DFLNKNQELL QDLSEVNDEN TQLMEILNML FFLPIRRLHN YAKVLLKLAT 850
CFEVTSPEYQ KLQDSSSCYE SLALHLGKKR KEAEYTLSFW KTFPGKMTDS 900
LRKPERRLLC ESSNRALSLQ HAGRFSVNWF ILFNDALVHA QFSTHHVFPL 950
ATLWAEPLSE EAGSVNGLKI TTPEEQFTLI SSTPQEKTKW LRAISQAVDQ 1000
ALRGTSDFPL YGGGSSVQRQ EPPISRSAKY TFYKDTRLKD ATYDGRWLSG 1050
KPHGRGVLKW PDGKMYSGMF RNGLEDGYGE YRIPNKALNK EDHYVGHWKE 1100
GKMCGQGVYS YASGEVFEGC FQDNMRHGHG LLRSGKLTSS SPSMFIGQWV 1150
MDKKAGYGVF DDITRGEKYM GMWQDDVCQG NGVVVTQFGL YYEGNFHLNK 1200
MMGNGVLLSE DDTIYEGEFS DDWTLSGKGT LTMPHGDYIE GYFSGEWGSG 1250
IKITGTYFKP SLYESDKDKP KAFRKLGNLA VAADEKWRAV FEECWRQLGC 1300
ESPGQGEVWK AWDNIAVALT TNRRQHKDSP EILSRSQTQT LESLEYIPQH 1350
IGAFSVEKYD DIKKYLIKAC DTPLHPLGRL VETLVAVYRM TYVGVGANRR 1400
LLQEAVKEIK SYLKRIFQLV RFLFPELPEE GSTIPLSAPL PTGRRSFCTG 1450
KSDSRSESPE PGYVVTSSGL LLPVLLPRLY PPLFMLYALD NDREEDIYWE 1500
CVLRLNKQPD IALLGFLGVQ KKFWPATLSI LGESKKVLST TKDACFASAV 1550
ECLQQISTTF TPSDKLKVIQ QTFEEISQSV LASLQEDFLW SMDDLFPVFL 1600
YVVLRARIRN LGSEVHLIED LMDPFLQHGE QGIMFTTLKA CYFQIQREKL 1650
N 1651
Length:1,651
Mass (Da):182,566
Last modified:October 3, 2012 - v3
Checksum:iF9A9DBCA1ED423B2
GO
Isoform 2 (identifier: Q920R0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     855-928: TSPEYQKLQD...LQHAGRFSVN → VGFVCAPPNT...MRSDALFWSV
     929-1651: Missing.

Note: No experimental confirmation available.

Show »
Length:928
Mass (Da):100,103
Checksum:iF4EF20522FF88C32
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei855 – 92874TSPEY…RFSVN → VGFVCAPPNTREAKSQSSLF ALSLLKMLGPGAGEMAQWVR APDCSSEGLEFKSQQPHGGS QPPVMRSDALFWSV in isoform 2.
VSP_050525Add
BLAST
Alternative sequencei929 – 1651723Missing in isoform 2.
VSP_050526Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti318 – 3181V → I in BAB69016. 1 Publication
Sequence conflicti318 – 3181V → I in AAH31479. 1 Publication
Sequence conflicti469 – 4691L → S in BAB69016. 1 Publication
Sequence conflicti469 – 4691L → S in AAH31479. 1 Publication
Sequence conflicti764 – 7641V → F in AAH46828. 1 Publication
Sequence conflicti1206 – 12061V → L in BAB29271. 1 Publication
Sequence conflicti1296 – 12961R → H in BAB69016. 1 Publication
Sequence conflicti1452 – 14521S → L in BAB69016. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB053307 mRNA. Translation: BAB69016.1.
AC153652 Genomic DNA. No translation available.
CH466548 Genomic DNA. Translation: EDL00124.1.
BC031479 mRNA. Translation: AAH31479.1.
BC046828 mRNA. Translation: AAH46828.1.
AK014320 mRNA. Translation: BAB29271.2.
CCDSiCCDS35583.1. [Q920R0-1]
RefSeqiNP_001153420.2. NM_001159948.2. [Q920R0-1]
NP_082993.4. NM_028717.6. [Q920R0-1]
NP_666221.1. NM_146109.3.
UniGeneiMm.272078.
Mm.474049.

Genome annotation databases

EnsembliENSMUST00000027178; ENSMUSP00000027178; ENSMUSG00000026024. [Q920R0-1]
ENSMUST00000163058; ENSMUSP00000125753; ENSMUSG00000026024. [Q920R0-1]
GeneIDi74018.
KEGGimmu:74018.
UCSCiuc007bdm.2. mouse.
uc007bdn.2. mouse. [Q920R0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB053307 mRNA. Translation: BAB69016.1 .
AC153652 Genomic DNA. No translation available.
CH466548 Genomic DNA. Translation: EDL00124.1 .
BC031479 mRNA. Translation: AAH31479.1 .
BC046828 mRNA. Translation: AAH46828.1 .
AK014320 mRNA. Translation: BAB29271.2 .
CCDSi CCDS35583.1. [Q920R0-1 ]
RefSeqi NP_001153420.2. NM_001159948.2. [Q920R0-1 ]
NP_082993.4. NM_028717.6. [Q920R0-1 ]
NP_666221.1. NM_146109.3.
UniGenei Mm.272078.
Mm.474049.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 216427. 4 interactions.
STRINGi 10090.ENSMUSP00000027178.

PTM databases

PhosphoSitei Q920R0.

Proteomic databases

MaxQBi Q920R0.
PaxDbi Q920R0.
PRIDEi Q920R0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027178 ; ENSMUSP00000027178 ; ENSMUSG00000026024 . [Q920R0-1 ]
ENSMUST00000163058 ; ENSMUSP00000125753 ; ENSMUSG00000026024 . [Q920R0-1 ]
GeneIDi 74018.
KEGGi mmu:74018.
UCSCi uc007bdm.2. mouse.
uc007bdn.2. mouse. [Q920R0-2 ]

Organism-specific databases

CTDi 57679.
MGIi MGI:1921268. Als2.

Phylogenomic databases

eggNOGi COG4642.
GeneTreei ENSGT00730000110297.
HOGENOMi HOG000033908.
HOVERGENi HBG037320.
InParanoidi Q920R0.
KOi K04575.
OMAi KLATCFE.
OrthoDBi EOG7C5M7B.
TreeFami TF331793.

Miscellaneous databases

ChiTaRSi ALS2. mouse.
NextBioi 339546.
PROi Q920R0.
SOURCEi Search...

Gene expression databases

Genevestigatori Q920R0.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.130.10.30. 2 hits.
2.30.29.30. 1 hit.
InterProi IPR000219. DH-domain.
IPR003409. MORN.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003123. VPS9.
[Graphical view ]
Pfami PF02493. MORN. 7 hits.
PF00415. RCC1. 4 hits.
PF00621. RhoGEF. 1 hit.
PF02204. VPS9. 1 hit.
[Graphical view ]
PRINTSi PR00633. RCCNDNSATION.
SMARTi SM00698. MORN. 8 hits.
SM00233. PH. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF50985. SSF50985. 2 hits.
PROSITEi PS50010. DH_2. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 4 hits.
PS51205. VPS9. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Brain and Mammary gland.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 847-1651 (ISOFORM 1).
    Strain: C57BL/6J.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-477 AND SER-486, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-527, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiALS2_MOUSE
AccessioniPrimary (citable) accession number: Q920R0
Secondary accession number(s): G5E868, Q8JZR1, Q9CXJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi