Reviewed, UniProtKB/Swiss-Prot Q920P6 (ADA_RAT)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:

Ada

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion By similarity.
Catalytic activity	Adenosine + H2O = inosine + NH3.
Subunit structure	Interacts with DPP4 (extracellular domain) By similarity.
Subcellular location	Cell membrane By similarity. Cell junction By similarity. Note: Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion By similarity.
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Cell adhesion Nucleotide metabolism
Cellular component	Cell junction Cell membrane Membrane
Molecular function	Hydrolase
PTM	Acetylation
Gene Ontology (GO)
Biological process	aging Inferred from expression pattern. Source: RGD purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro regulation of circadian sleep/wake cycle, sleep Inferred from expression pattern. Source: RGD response to hydrogen peroxide Inferred from expression pattern. Source: RGD
Cellular component	cell soma Inferred from direct assay. Source: RGD dendrite cytoplasm Inferred from direct assay. Source: RGD extracellular space Inferred from direct assay. Source: RGD
Molecular function	adenosine deaminase activity Inferred from direct assay. Source: RGD purine nucleoside binding Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 352	351	Adenosine deaminase		PRO_0000194354
Sites
	Active site	214	1	Potential
	Active site	262	1	Potential
	Active site	295	1	Potential
	Active site	296	1	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	54	1	N6-acetyllysine By similarity
	Modified residue	232	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q920P6-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: F689ADFD39682FC6	FASTA	352	39,899
	10 20 30 40 50 60 MAQTPAFNKP KVELHVHLDG AIKPETILYY GKKRGIDLPA DTVEGLRNII GMDKPLSLPD 70 80 90 100 110 120 FLAKFDYYMP AIAGCREAIK RIAYEFVEMK AKEGVVYVEV RYSPHLLANS KVDPIPWNQA 130 140 150 160 170 180 EGDLTPDEVV DLVNQGLQEG EQAFGIKVRS ILCCMRHQPS WSPEVLELCK KYHQKTVVAM 190 200 210 220 230 240 DLAGDETIEG SSLFPGHVEA YEGAVKDGIH RTVHAGEVGS AEVVREAVDI LKTERVGHGY 250 260 270 280 290 300 HTIEDEALYN RLLKENMHFE VCPWSSYLTG AWNPKTTHAV VRFKDDQANY SLNSDDPLIF 310 320 330 340 350 KSTVDTDYQM VKKDMGFTEE EFKRLNINAA KSSFLPEDEK KELLERLYKE YQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Restricted expression of adenosine deaminase in rat leptomeninges and its role in the regulation of sleep." Okada T., Mochizuki T., Huag Z., Sugita Y., Urade Y., Hayaishi O. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Leptomeninges.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB059655 mRNA. Translation: BAB69691.1. BC088116 mRNA. Translation: AAH88116.1.
IPI	IPI00200806.
RefSeq	NP_569083.1.
UniGene	Rn.12689
3D structure databases
SMR	Q920P6. Positions 4-352.
ModBase	Search...
Protein-protein interaction databases
STRING	Q920P6.
Genome annotation databases
Ensembl	ENSRNOT00000014151; ENSRNOP00000014151; ENSRNOG00000010265; Rattus norvegicus. [Genome view]
GeneID	24165.
KEGG	rno:24165.
NMPDR	fig|10116.3.peg.20213.
UCSC	NM_130399. rat.
Organism-specific databases
CTD	24165.
RGD	2031. Ada.
Phylogenomic databases
eggNOG	roNOG04750.
HOVERGEN	Q920P6.
InParanoid	Q920P6.
OMA	CMRHQPS.
OrthoDB	EOG97M4HX.
PhylomeDB	Q920P6.
Enzyme and pathway databases
BRENDA	3.5.4.4. 248.
Gene expression databases
ArrayExpress	Q920P6.
Genevestigator	Q920P6.
GermOnline	ENSRNOG00000010265. Rattus norvegicus.
Family and domain databases
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	602469.

Entry information

Entry name

ADA_RAT

Accession

Primary (citable) accession number: Q920P6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	January 23, 2007
Last modified:	February 9, 2010
This is version 55 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)