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Reviewed, UniProtKB/Swiss-Prot Q920P6 (ADA_RAT)

Last modified February 9, 2010. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase
Gene names
Name: Ada
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion By similarity.

Catalytic activity

Adenosine + H2O = inosine + NH3.

Subunit structure

Interacts with DPP4 (extracellular domain) By similarity.

Subcellular location

Cell membrane By similarity. Cell junction By similarity. Note: Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion By similarity.

Sequence similarities

Belongs to the adenosine and AMP deaminases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 352351Adenosine deaminase
PRO_0000194354

Sites

Active site2141 Potential
Active site2621 Potential
Active site2951 Potential
Active site2961 Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue541N6-acetyllysine By similarity
Modified residue2321N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q920P6-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: F689ADFD39682FC6

FASTA35239,899
        10         20         30         40         50         60 
MAQTPAFNKP KVELHVHLDG AIKPETILYY GKKRGIDLPA DTVEGLRNII GMDKPLSLPD 

        70         80         90        100        110        120 
FLAKFDYYMP AIAGCREAIK RIAYEFVEMK AKEGVVYVEV RYSPHLLANS KVDPIPWNQA 

       130        140        150        160        170        180 
EGDLTPDEVV DLVNQGLQEG EQAFGIKVRS ILCCMRHQPS WSPEVLELCK KYHQKTVVAM 

       190        200        210        220        230        240 
DLAGDETIEG SSLFPGHVEA YEGAVKDGIH RTVHAGEVGS AEVVREAVDI LKTERVGHGY 

       250        260        270        280        290        300 
HTIEDEALYN RLLKENMHFE VCPWSSYLTG AWNPKTTHAV VRFKDDQANY SLNSDDPLIF 

       310        320        330        340        350 
KSTVDTDYQM VKKDMGFTEE EFKRLNINAA KSSFLPEDEK KELLERLYKE YQ 

« Hide

References

« Hide 'large scale' references
[1]"Restricted expression of adenosine deaminase in rat leptomeninges and its role in the regulation of sleep."
Okada T., Mochizuki T., Huag Z., Sugita Y., Urade Y., Hayaishi O.
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Leptomeninges.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB059655 mRNA. Translation: BAB69691.1.
BC088116 mRNA. Translation: AAH88116.1.
IPIIPI00200806.
RefSeqNP_569083.1.
UniGeneRn.12689

3D structure databases

SMRQ920P6. Positions 4-352.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ920P6.

Genome annotation databases

EnsemblENSRNOT00000014151; ENSRNOP00000014151; ENSRNOG00000010265; Rattus norvegicus. [Genome view]
GeneID24165.
KEGGrno:24165.
NMPDRfig|10116.3.peg.20213.
UCSCNM_130399. rat.

Organism-specific databases

CTD24165.
RGD2031. Ada.

Phylogenomic databases

eggNOGroNOG04750.
HOVERGENQ920P6.
InParanoidQ920P6.
OMACMRHQPS.
OrthoDBEOG97M4HX.
PhylomeDBQ920P6.

Enzyme and pathway databases

BRENDA3.5.4.4. 248.

Gene expression databases

ArrayExpressQ920P6.
GenevestigatorQ920P6.
GermOnlineENSRNOG00000010265. Rattus norvegicus.

Family and domain databases

InterProIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase.
IPR006330. A_deaminase.
[Graphical view]
PANTHERPTHR11409. A/AMP_deaminase. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio602469.

Entry information

Entry nameADA_RAT
AccessionPrimary (citable) accession number: Q920P6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: January 23, 2007
Last modified: February 9, 2010
This is version 55 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents