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Protein

BMP/retinoic acid-inducible neural-specific protein 1

Gene

Brinp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.1 Publication

GO - Biological processi

  • behavioral fear response Source: MGI
  • cell cycle arrest Source: UniProtKB-KW
  • cell death Source: UniProtKB
  • cellular response to retinoic acid Source: UniProtKB
  • exploration behavior Source: MGI
  • maternal behavior Source: MGI
  • negative regulation of cell cycle Source: UniProtKB
  • negative regulation of mitotic cell cycle Source: UniProtKB
  • negative regulation of neurogenesis Source: MGI
  • positive regulation of neuron differentiation Source: UniProtKB
  • short-term memory Source: MGI
  • social behavior Source: MGI
  • vocalization behavior Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
BMP/retinoic acid-inducible neural-specific protein 1
Alternative name(s):
Deleted in bladder cancer protein 1 homolog
Gene namesi
Name:Brinp1
Synonyms:Brinp, Dbc1, Dbccr1, Fam5a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1928478. Brinp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000004576717 – 760BMP/retinoic acid-inducible neural-specific protein 1Add BLAST744

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Glycosylationi433N-linked (GlcNAc...)Sequence analysis1
Glycosylationi443N-linked (GlcNAc...)Sequence analysis1
Glycosylationi553N-linked (GlcNAc...)Sequence analysis1
Glycosylationi599N-linked (GlcNAc...)Sequence analysis1
Glycosylationi630N-linked (GlcNAc...)Sequence analysis1
Glycosylationi676N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ920P3.
PeptideAtlasiQ920P3.
PRIDEiQ920P3.

PTM databases

PhosphoSitePlusiQ920P3.

Expressioni

Tissue specificityi

Expressed in brain. Weakly expressed in embryonic stem (ES) cells and in ES-derived neural stem cells (NSCs).2 Publications

Developmental stagei

Expressed from 9.5 dpc.1 Publication

Inductioni

Up-regulated upon differentiation into neuronal cells in the presence of retinoic acid and BDNF. Up-regulated upon differentiation into astroglial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000028351.
CleanExiMM_DBC1.
GenevisibleiQ920P3. MM.

Interactioni

Protein-protein interaction databases

BioGridi208138. 2 interactors.
IntActiQ920P3. 1 interactor.
STRINGi10090.ENSMUSP00000030036.

Structurei

3D structure databases

ProteinModelPortaliQ920P3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 251MACPFAdd BLAST184

Sequence similaritiesi

Belongs to the BRINP family.Curated
Contains 1 MACPF domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF4X. Eukaryota.
ENOG410XQ74. LUCA.
GeneTreeiENSGT00390000008571.
HOGENOMiHOG000049122.
HOVERGENiHBG081412.
InParanoidiQ920P3.
OMAiPNHQMPR.
OrthoDBiEOG091G02AS.
PhylomeDBiQ920P3.
TreeFamiTF331600.

Family and domain databases

InterProiIPR033237. BRINP.
IPR020864. MACPF.
[Graphical view]
PANTHERiPTHR15564. PTHR15564. 1 hit.
PfamiPF01823. MACPF. 1 hit.
[Graphical view]
SMARTiSM00457. MACPF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q920P3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNWRFVELLY FLFVWGRISV QPSRQEPAGT DQHVSKEFDW LISDRGPFHH
60 70 80 90 100
SRSYLSFVER HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE
110 120 130 140 150
FQRSIRLLGR RPTTQQFIDT IIKKYGTHLL ISATLGGEEA LTMYMDKSRL
160 170 180 190 200
DRKSGNATQS VEALHQLASS YFVDRDGTMR RLHEIQISTG AIKVTETRTG
210 220 230 240 250
PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE KFVQSALSYI
260 270 280 290 300
MCNGEGEYVC QNSQCRCQCA EEFPQCNCPI TDIQIMEFTL ANMAKAWTEA
310 320 330 340 350
YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQS RYKLLQSATE
360 370 380 390 400
AQRQKIQRTA RKLFGLSVRC RHNPNHQLPR ERTIQQWLAR VQSLLYCNEN
410 420 430 440 450
GFWGTFLESQ RSCVCHGSTT LCQRPIPCII GGNNSCAMCS LANISLCGSC
460 470 480 490 500
NKGYKLYRGR CEPQNVDSER SEQFISFETD LDFQDLELKY LLQKMDSRLY
510 520 530 540 550
VHTTFISNEI RLDTFFDPRW RKRMSLTLKS NKNRMDFIHM VIGMSMRICQ
560 570 580 590 600
MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EFGYPRWEKI RLQNSQCYNW
610 620 630 640 650
TLLLGNRWKT FFETVHIYLR SRTRLPTLRN ETGQGPVDLS DPSKRQFYIK
660 670 680 690 700
ISDVQVFGYS LRFNADLLRS AVQQVNQSYT QGGQFYSSSS VMLLMLDIRD
710 720 730 740 750
RINRLAPPVA PGKPQLDLFS CMLKHRLKLT NSEIIRVNHA LDLYNTEILK
760
QSDQMTAKLC
Length:760
Mass (Da):88,641
Last modified:December 1, 2001 - v1
Checksum:i746E954368F1E49A
GO
Isoform 2 (identifier: Q920P3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-320: DEFKSFMKRLPSN → GTQTTTVNASGQT
     321-760: Missing.

Note: No experimental confirmation available.
Show »
Length:320
Mass (Da):36,892
Checksum:iCA82A7C5F8C496EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62R → Q in BAC25879 (PubMed:16141072).Curated1
Sequence conflicti157 – 158AT → VP in AAF17579 (Ref. 2) Curated2
Sequence conflicti550 – 551QM → FQR in AAF17579 (Ref. 2) Curated2
Sequence conflicti608W → V in AAF17579 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017024308 – 320DEFKS…RLPSN → GTQTTTVNASGQT in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_017025321 – 760Missing in isoform 2. 1 PublicationAdd BLAST440

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060587 Genomic DNA. Translation: BAB70600.1.
AB060589 mRNA. Translation: BAB70601.1.
AB088118 Genomic DNA. Translation: BAC55204.1.
AF202896 mRNA. Translation: AAF17579.1.
AK028321 mRNA. Translation: BAC25879.1.
AK045420 mRNA. Translation: BAC32355.1.
BX088573, BX649413 Genomic DNA. Translation: CAI26033.1.
BX649413, BX088573 Genomic DNA. Translation: CAI24368.1.
BC048789 mRNA. Translation: AAH48789.1.
BC079630 mRNA. Translation: AAH79630.1.
CCDSiCCDS18272.1. [Q920P3-1]
RefSeqiNP_064351.2. NM_019967.2. [Q920P3-1]
UniGeneiMm.248788.

Genome annotation databases

EnsembliENSMUST00000030036; ENSMUSP00000030036; ENSMUSG00000028351. [Q920P3-1]
GeneIDi56710.
KEGGimmu:56710.
UCSCiuc008thw.1. mouse. [Q920P3-1]
uc008thx.1. mouse. [Q920P3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060587 Genomic DNA. Translation: BAB70600.1.
AB060589 mRNA. Translation: BAB70601.1.
AB088118 Genomic DNA. Translation: BAC55204.1.
AF202896 mRNA. Translation: AAF17579.1.
AK028321 mRNA. Translation: BAC25879.1.
AK045420 mRNA. Translation: BAC32355.1.
BX088573, BX649413 Genomic DNA. Translation: CAI26033.1.
BX649413, BX088573 Genomic DNA. Translation: CAI24368.1.
BC048789 mRNA. Translation: AAH48789.1.
BC079630 mRNA. Translation: AAH79630.1.
CCDSiCCDS18272.1. [Q920P3-1]
RefSeqiNP_064351.2. NM_019967.2. [Q920P3-1]
UniGeneiMm.248788.

3D structure databases

ProteinModelPortaliQ920P3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208138. 2 interactors.
IntActiQ920P3. 1 interactor.
STRINGi10090.ENSMUSP00000030036.

PTM databases

PhosphoSitePlusiQ920P3.

Proteomic databases

PaxDbiQ920P3.
PeptideAtlasiQ920P3.
PRIDEiQ920P3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030036; ENSMUSP00000030036; ENSMUSG00000028351. [Q920P3-1]
GeneIDi56710.
KEGGimmu:56710.
UCSCiuc008thw.1. mouse. [Q920P3-1]
uc008thx.1. mouse. [Q920P3-2]

Organism-specific databases

CTDi1620.
MGIiMGI:1928478. Brinp1.

Phylogenomic databases

eggNOGiENOG410IF4X. Eukaryota.
ENOG410XQ74. LUCA.
GeneTreeiENSGT00390000008571.
HOGENOMiHOG000049122.
HOVERGENiHBG081412.
InParanoidiQ920P3.
OMAiPNHQMPR.
OrthoDBiEOG091G02AS.
PhylomeDBiQ920P3.
TreeFamiTF331600.

Miscellaneous databases

PROiQ920P3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028351.
CleanExiMM_DBC1.
GenevisibleiQ920P3. MM.

Family and domain databases

InterProiIPR033237. BRINP.
IPR020864. MACPF.
[Graphical view]
PANTHERiPTHR15564. PTHR15564. 1 hit.
PfamiPF01823. MACPF. 1 hit.
[Graphical view]
SMARTiSM00457. MACPF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBRNP1_MOUSE
AccessioniPrimary (citable) accession number: Q920P3
Secondary accession number(s): Q80ZL2
, Q812F0, Q8C1C9, Q920P4, Q9QXL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.