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Protein

L-xylulose reductase

Gene

Dcxr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.

Catalytic activityi

Xylitol + NADP+ = L-xylulose + NADPH.3 Publications

Kineticsi

  1. KM=0.11 mM for L-xylulose (at 25 degrees Celsius)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei136SubstrateBy similarity1
    Active sitei149Proton acceptor1
    Active sitei1531

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi11 – 39NADPBy similarityAdd BLAST29

    GO - Molecular functioni

    GO - Biological processi

    • D-xylose metabolic process Source: UniProtKB-KW
    • glucose metabolic process Source: UniProtKB
    • NADP metabolic process Source: Ensembl
    • protein homotetramerization Source: UniProtKB
    • xylulose metabolic process Source: UniProtKB

    Keywordsi

    Molecular functionOxidoreductase
    Biological processCarbohydrate metabolism, Glucose metabolism, Xylose metabolism
    LigandNADP

    Enzyme and pathway databases

    BRENDAi1.1.1.10 5301
    ReactomeiR-RNO-5661270 Catabolism of glucuronate to xylulose-5-phosphate
    SABIO-RKQ920P0

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-xylulose reductase (EC:1.1.1.103 Publications)
    Short name:
    XR
    Alternative name(s):
    Dicarbonyl/L-xylulose reductase
    Gene namesi
    Name:Dcxr
    Synonyms:Glb
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
    Proteomesi
    • UP000002494 Componenti: Chromosome 10

    Organism-specific databases

    RGDi620031 Dcxr

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi136S → A: Loss of activity. 1 Publication1
    Mutagenesisi137Q → M: Slightly reduced activity. Loss of activity for sugars; when associated with F-143 and L-146. 1 Publication1
    Mutagenesisi143L → F: Slightly reduced activity. Loss of activity for sugars; when associated with M-137 and L-146. 1 Publication1
    Mutagenesisi146H → L: Slightly reduced activity. Loss of activity for sugars; when associated with M-137; F-143 and L-146. 1 Publication1
    Mutagenesisi149Y → F: Loss of activity. 1 Publication1
    Mutagenesisi153K → M: Loss of activity. 1 Publication1
    Mutagenesisi190N → V: Slightly reduced activity. Loss of activity for sugars; when associated with S-191. 1 Publication1
    Mutagenesisi191W → F: Slightly reduced activity. 1 Publication1
    Mutagenesisi191W → S: Slightly reduced activity. Loss of activity for sugars; when associated with V-190. 1 Publication1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000545571 – 244L-xylulose reductaseAdd BLAST244

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei1N-acetylmethionineBy similarity1
    Modified residuei21Omega-N-methylarginineBy similarity1
    Modified residuei46PhosphoserineBy similarity1

    Keywords - PTMi

    Acetylation, Methylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ920P0
    PRIDEiQ920P0

    PTM databases

    iPTMnetiQ920P0
    PhosphoSitePlusiQ920P0

    Expressioni

    Tissue specificityi

    Highly expressed in kidney and liver. Weakly or not expressed in brain, heart, lung, spleen, epididymis and testis.1 Publication

    Gene expression databases

    BgeeiENSRNOG00000050315
    ExpressionAtlasiQ920P0 baseline and differential
    GenevisibleiQ920P0 RN

    Interactioni

    Subunit structurei

    Homotetramer.

    GO - Molecular functioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000064161

    Structurei

    3D structure databases

    ProteinModelPortaliQ920P0
    SMRiQ920P0
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiKOG1207 Eukaryota
    ENOG410XQCY LUCA
    GeneTreeiENSGT00910000144022
    HOVERGENiHBG105069
    InParanoidiQ920P0
    KOiK03331
    OMAiRECPGIE
    OrthoDBiEOG091G0GV2
    PhylomeDBiQ920P0

    Family and domain databases

    InterProiView protein in InterPro
    IPR036291 NAD(P)-bd_dom_sf
    IPR020904 Sc_DH/Rdtase_CS
    IPR002347 SDR_fam
    PRINTSiPR00081 GDHRDH
    PR00080 SDRFAMILY
    SUPFAMiSSF51735 SSF51735, 1 hit
    PROSITEiView protein in PROSITE
    PS00061 ADH_SHORT, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q920P0-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MDLGLAGRRA LVTGAGKGIG RSTVLALQAA GAQVVAVSRT REDLDSLVRE
    60 70 80 90 100
    CPGVEPVCVD LADWEATEQA LSNVGPVDLL VNNAAVATLQ PFLEVTKEAC
    110 120 130 140 150
    DTSFNVNFRA VVQVSQIVAR GMIARGVPGA IVNVSSQASQ RALTNHTVYC
    160 170 180 190 200
    STKGALDMLT KVMALELGPH KIRVNAVNPT VVMTPMGRAN WSDPHKAKVM
    210 220 230 240
    LDRIPLGKFA EVENVVDTIL FLLSNRSSMT TGSALPVDGG FLAT
    Length:244
    Mass (Da):25,720
    Last modified:December 1, 2001 - v1
    Checksum:i7BAEE7E7BB404057
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB061719 mRNA Translation: BAB64340.1
    RefSeqiNP_599214.1, NM_134387.1
    XP_008766687.1, XM_008768465.2
    UniGeneiRn.177518

    Genome annotation databases

    EnsembliENSRNOT00000074362; ENSRNOP00000064161; ENSRNOG00000050315
    GeneIDi171408
    KEGGirno:171408

    Similar proteinsi

    Entry informationi

    Entry nameiDCXR_RAT
    AccessioniPrimary (citable) accession number: Q920P0
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: December 1, 2001
    Last modified: May 23, 2018
    This is version 109 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

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