Reviewed,
UniProtKB/Swiss-Prot Q920N9 (DCXR_CAVPO)
Last modified
November 25, 2008.
Version 35.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: L-xylulose reductase Short name=XR EC=1.1.1.10 Alternative name(s): Dicarbonyl/L-xylulose reductase Protein P26h | ||||
| Gene names |
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| Organism | Cavia porcellus (Guinea pig) | ||||
| Taxonomic identifier | 10141 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia |
Protein attributes
| Sequence length | 244 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. |
| Catalytic activity | Xylitol + NADP(+) = L-xylulose + NADPH. |
| Subunit structure | Homotetramer. |
| Subcellular location | Membrane; Peripheral membrane proteinBy similarity. Note= Probably recruited to membranes via an interaction with phosphatidylinositol By similarity. |
| Tissue specificity | Highly expressed in kidney and liver. Expressed in epididymis. Expressed at intermediate level in lung. Weakly expressed in brain, heart, spleen and testis. |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism Glucose metabolism Xylose metabolism |
| Cellular component | Membrane |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW glucose metabolic processInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | L-xylulose reductase activity Inferred from electronic annotation. Source: EC bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 244 | 244 | L-xylulose reductase | PRO_0000054553 | |||||
Regions | |||||||||
| Nucleotide binding | 11 – 39 | 29 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 149 | 1 | Proton acceptor By similarity | ||||||
| Active site | 153 | 1 | By similarity | ||||||
| Binding site | 136 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 149 | 1 | Phosphotyrosine By similarity | ||||||
Sequences
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References
| [1] | "Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney." Nakagawa J., Ishikura S., Asami J., Isaji T., Usami N., Hara A., Sakurai T., Tsuritani K., Oda K., Takahashi M., Yoshimoto M., Otsuka N., Kitamura K. J. Biol. Chem. 277:17883-17891(2002) [PubMed: 11882650] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ENZYME ACTIVITY, TISSUE SPECIFICITY. Strain: Hartley. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| AB061720 mRNA. Translation: BAB64341.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1CYD based on UniProtKB P08074. |
| SMR | Q920N9. Positions 1-243. |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | Q920N9. |
Family and domain databases | |
| InterPro | IPR002198. DHase_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DHase. IPR016040. NAD(P)-bd. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR19410. ADH_short_C2. 1 hit. |
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] |
| PRINTS | PR00081. GDHRDH. PR00080. SDRFAMILY. |
| PROSITE | PS00061. ADH_SHORT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DCXR_CAVPO | ||||||||
| Accession | Primary (citable) accession number: Q920N9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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