Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Synaptotagmin-12

Gene

Syt12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-12
Alternative name(s):
Synaptotagmin XII
Short name:
SytXII
Gene namesi
Name:Syt12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2159601 Syt12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18VesicularSequence analysisAdd BLAST18
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 421CytoplasmicSequence analysisAdd BLAST382

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839731 – 421Synaptotagmin-12Add BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97PhosphoserineBy similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei214PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ920N7
PaxDbiQ920N7
PRIDEiQ920N7

PTM databases

iPTMnetiQ920N7
PhosphoSitePlusiQ920N7

Expressioni

Gene expression databases

BgeeiENSMUSG00000049303
CleanExiMM_SYT12
ExpressionAtlasiQ920N7 baseline and differential
GenevisibleiQ920N7 MM

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ920N7
SMRiQ920N7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 272C2 1PROSITE-ProRule annotationAdd BLAST105
Domaini285 – 388C2 2PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3K Eukaryota
ENOG411011E LUCA
GeneTreeiENSGT00910000144119
HOGENOMiHOG000063703
HOVERGENiHBG057176
InParanoidiQ920N7
KOiK19912
OMAiWTSGSFP
OrthoDBiEOG091G07FE
PhylomeDBiQ920N7
TreeFamiTF315600

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR030537 SYT12
PANTHERiPTHR10024:SF252 PTHR10024:SF252, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequencei

Sequence statusi: Complete.

Q920N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDVTEYHL SVIKSPPGWE VGVYAAGALA LLGIAAVSLW KLWTSGSFPS
60 70 80 90 100
PSPFPNYDYR YLQQKYGEAY VEAKLKRVPP WNDQRTTTRG PPSRKGSLSI
110 120 130 140 150
EDTFESISEL GPLELMGREL DLAPYGTLRK SQSADSLNSI SSVSNTFGQD
160 170 180 190 200
FTLGQVEVSM DYDGASHTLH VAVLQGKDLL EREEATFESC FMRVSLLPDE
210 220 230 240 250
QIVGISRIQR NAYSIFFDEK FSVPLDPTAL EEKSLRFSVF GIDEDERNVS
260 270 280 290 300
TGVVELKLSV LDLPLQPFSG WLYLQDQNKA ADAVGEILLS LSYLPTAERL
310 320 330 340 350
TVVVVKAKNL IWTNEKSTAD PFVKVYLLQD GRKMSKKKTA VKRDDPNPVF
360 370 380 390 400
NEAMIFSVPA IVLQDLSLRV TVAESSSDGR GDNVGHVIIG PGVSGMGTTH
410 420
WNQMLATLRR PVSMWHPVRR N
Length:421
Mass (Da):46,680
Last modified:December 1, 2001 - v1
Checksum:i4E854C7B2089597C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062804 mRNA Translation: BAB69674.1
AK046627 mRNA Translation: BAC32812.1
AK083139 mRNA Translation: BAC38779.1
CCDSiCCDS29428.1
RefSeqiNP_598925.1, NM_134164.5
UniGeneiMm.262270

Genome annotation databases

EnsembliENSMUST00000059295; ENSMUSP00000055237; ENSMUSG00000049303
GeneIDi171180
KEGGimmu:171180
UCSCiuc008gad.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSYT12_MOUSE
AccessioniPrimary (citable) accession number: Q920N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health