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Q920N7 (SYT12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptotagmin-12
Alternative name(s):
Synaptotagmin XII
Short name=SytXII
Gene names
Name:Syt12
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis By similarity.

Subunit structure

Homodimer. Can also form heterodimers By similarity.

Subcellular location

Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the synaptotagmin family.

Contains 2 C2 domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421Synaptotagmin-12
PRO_0000183973

Regions

Topological domain1 – 1818Vesicular Potential
Transmembrane19 – 3921Helical; Potential
Topological domain40 – 421382Cytoplasmic Potential
Domain168 – 272105C2 1
Domain285 – 388104C2 2

Sequences

Sequence LengthMass (Da)Tools
Q920N7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 4E854C7B2089597C

FASTA42146,680
        10         20         30         40         50         60 
MAVDVTEYHL SVIKSPPGWE VGVYAAGALA LLGIAAVSLW KLWTSGSFPS PSPFPNYDYR 

        70         80         90        100        110        120 
YLQQKYGEAY VEAKLKRVPP WNDQRTTTRG PPSRKGSLSI EDTFESISEL GPLELMGREL 

       130        140        150        160        170        180 
DLAPYGTLRK SQSADSLNSI SSVSNTFGQD FTLGQVEVSM DYDGASHTLH VAVLQGKDLL 

       190        200        210        220        230        240 
EREEATFESC FMRVSLLPDE QIVGISRIQR NAYSIFFDEK FSVPLDPTAL EEKSLRFSVF 

       250        260        270        280        290        300 
GIDEDERNVS TGVVELKLSV LDLPLQPFSG WLYLQDQNKA ADAVGEILLS LSYLPTAERL 

       310        320        330        340        350        360 
TVVVVKAKNL IWTNEKSTAD PFVKVYLLQD GRKMSKKKTA VKRDDPNPVF NEAMIFSVPA 

       370        380        390        400        410        420 
IVLQDLSLRV TVAESSSDGR GDNVGHVIIG PGVSGMGTTH WNQMLATLRR PVSMWHPVRR 


N

« Hide

References

« Hide 'large scale' references
[1]"Mechanism of the SDS-resistant synaptotagmin clustering mediated by the cysteine cluster at the interface between the transmembrane and spacer domains."
Fukuda M., Kanno E., Ogata Y., Mikoshiba K.
J. Biol. Chem. 276:40319-40325(2001) [PubMed: 11514560] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Adipose tissue and Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB062804 mRNA. Translation: BAB69674.1.
AK046627 mRNA. Translation: BAC32812.1.
AK083139 mRNA. Translation: BAC38779.1.
IPIIPI00120798.
RefSeqNP_598925.1. NM_134164.5.
UniGeneMm.262270.

3D structure databases

ProteinModelPortalQ920N7.
SMRQ920N7. Positions 152-420.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ920N7.

PTM databases

PhosphoSiteQ920N7.

Proteomic databases

PRIDEQ920N7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000059295; ENSMUSP00000055237; ENSMUSG00000049303.
GeneID171180.
KEGGmmu:171180.

Organism-specific databases

CTD91683.
MGIMGI:2159601. Syt12.

Phylogenomic databases

GeneTreeENSGT00600000084331.
HOGENOMHBG445851.
HOVERGENHBG057176.
InParanoidQ920N7.
OMAEYHLSVI.
OrthoDBEOG4DV5MC.
PhylomeDBQ920N7.

Gene expression databases

ArrayExpressQ920N7.
BgeeQ920N7.
CleanExMM_SYT12.
GenevestigatorQ920N7.
GermOnlineENSMUSG00000049303. Mus musculus.

Family and domain databases

InterProIPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR018029. C2_membr_targeting.
IPR001565. Synaptotagmin.
[Graphical view]
PfamPF00168. C2. 2 hits.
[Graphical view]
PRINTSPR00399. SYNAPTOTAGMN.
SMARTSM00239. C2. 2 hits.
[Graphical view]
SUPFAMSSF49562. C2_CaLB. 2 hits.
PROSITEPS50004. C2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio370588.
SOURCESearch...

Entry information

Entry nameSYT12_MOUSE
AccessionPrimary (citable) accession number: Q920N7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: December 1, 2001
Last modified: September 21, 2011
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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