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Protein

Synaptotagmin-12

Gene

Syt12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-12
Alternative name(s):
Synaptotagmin XII
Short name:
SytXII
Gene namesi
Name:Syt12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2159601. Syt12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18VesicularSequence analysisAdd BLAST18
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 421CytoplasmicSequence analysisAdd BLAST382

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839731 – 421Synaptotagmin-12Add BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97PhosphoserineBy similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei214PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ920N7.
PaxDbiQ920N7.
PRIDEiQ920N7.

PTM databases

iPTMnetiQ920N7.
PhosphoSitePlusiQ920N7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049303.
CleanExiMM_SYT12.
ExpressionAtlasiQ920N7. baseline and differential.
GenevisibleiQ920N7. MM.

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055237.

Structurei

3D structure databases

ProteinModelPortaliQ920N7.
SMRiQ920N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 272C2 1PROSITE-ProRule annotationAdd BLAST105
Domaini285 – 388C2 2PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3K. Eukaryota.
ENOG411011E. LUCA.
GeneTreeiENSGT00830000128339.
HOGENOMiHOG000063703.
HOVERGENiHBG057176.
InParanoidiQ920N7.
KOiK19912.
OMAiWTSGSFP.
OrthoDBiEOG091G07FE.
PhylomeDBiQ920N7.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR030537. SYT12.
[Graphical view]
PANTHERiPTHR10024:SF252. PTHR10024:SF252. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q920N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDVTEYHL SVIKSPPGWE VGVYAAGALA LLGIAAVSLW KLWTSGSFPS
60 70 80 90 100
PSPFPNYDYR YLQQKYGEAY VEAKLKRVPP WNDQRTTTRG PPSRKGSLSI
110 120 130 140 150
EDTFESISEL GPLELMGREL DLAPYGTLRK SQSADSLNSI SSVSNTFGQD
160 170 180 190 200
FTLGQVEVSM DYDGASHTLH VAVLQGKDLL EREEATFESC FMRVSLLPDE
210 220 230 240 250
QIVGISRIQR NAYSIFFDEK FSVPLDPTAL EEKSLRFSVF GIDEDERNVS
260 270 280 290 300
TGVVELKLSV LDLPLQPFSG WLYLQDQNKA ADAVGEILLS LSYLPTAERL
310 320 330 340 350
TVVVVKAKNL IWTNEKSTAD PFVKVYLLQD GRKMSKKKTA VKRDDPNPVF
360 370 380 390 400
NEAMIFSVPA IVLQDLSLRV TVAESSSDGR GDNVGHVIIG PGVSGMGTTH
410 420
WNQMLATLRR PVSMWHPVRR N
Length:421
Mass (Da):46,680
Last modified:December 1, 2001 - v1
Checksum:i4E854C7B2089597C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062804 mRNA. Translation: BAB69674.1.
AK046627 mRNA. Translation: BAC32812.1.
AK083139 mRNA. Translation: BAC38779.1.
CCDSiCCDS29428.1.
RefSeqiNP_598925.1. NM_134164.5.
UniGeneiMm.262270.

Genome annotation databases

EnsembliENSMUST00000059295; ENSMUSP00000055237; ENSMUSG00000049303.
GeneIDi171180.
KEGGimmu:171180.
UCSCiuc008gad.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062804 mRNA. Translation: BAB69674.1.
AK046627 mRNA. Translation: BAC32812.1.
AK083139 mRNA. Translation: BAC38779.1.
CCDSiCCDS29428.1.
RefSeqiNP_598925.1. NM_134164.5.
UniGeneiMm.262270.

3D structure databases

ProteinModelPortaliQ920N7.
SMRiQ920N7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055237.

PTM databases

iPTMnetiQ920N7.
PhosphoSitePlusiQ920N7.

Proteomic databases

MaxQBiQ920N7.
PaxDbiQ920N7.
PRIDEiQ920N7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059295; ENSMUSP00000055237; ENSMUSG00000049303.
GeneIDi171180.
KEGGimmu:171180.
UCSCiuc008gad.1. mouse.

Organism-specific databases

CTDi91683.
MGIiMGI:2159601. Syt12.

Phylogenomic databases

eggNOGiENOG410IT3K. Eukaryota.
ENOG411011E. LUCA.
GeneTreeiENSGT00830000128339.
HOGENOMiHOG000063703.
HOVERGENiHBG057176.
InParanoidiQ920N7.
KOiK19912.
OMAiWTSGSFP.
OrthoDBiEOG091G07FE.
PhylomeDBiQ920N7.
TreeFamiTF315600.

Miscellaneous databases

PROiQ920N7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049303.
CleanExiMM_SYT12.
ExpressionAtlasiQ920N7. baseline and differential.
GenevisibleiQ920N7. MM.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR030537. SYT12.
[Graphical view]
PANTHERiPTHR10024:SF252. PTHR10024:SF252. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT12_MOUSE
AccessioniPrimary (citable) accession number: Q920N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.