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Reviewed, UniProtKB/Swiss-Prot Q920L2 (DHSA_RAT)

Last modified February 9, 2010. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
    EC=1.3.5.1
Alternative name(s):
    Flavoprotein subunit of complex II
      Short name=Fp
Gene names
Name: Sdha
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length656 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activity

Succinate + ubiquinone = fumarate + ubiquinol.

Cofactor

FAD By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF2/SDH5; interaction is required for FAD attachment By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Miscellaneous

The complex, present in mitochondria, can be degraded to form EC 1.3.99.1, which no longer reacts with ubiquinone.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3535Mitochondrion By similarity
Chain36 – 656621Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
PRO_0000010338

Regions

Nucleotide binding83 – 9816FAD By similarity

Sites

Active site3321Proton acceptor By similarity
Binding site2881Substrate By similarity
Binding site3001Substrate By similarity
Binding site3991Substrate By similarity
Binding site4431Substrate By similarity

Amino acid modifications

Modified residue911Tele-8alpha-FAD histidine By similarity
Modified residue1711N6-acetyllysine By similarity
Modified residue2441Phosphothreonine By similarity
Modified residue3271N6-acetyllysine By similarity
Modified residue4151N6-acetyllysine By similarity
Modified residue4771N6-acetyllysine By similarity
Modified residue4901N6-acetyllysine By similarity
Modified residue5301N6-acetyllysine By similarity
Modified residue6001N6-acetyllysine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q920L2-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 9E820F7FF7EC3B36

FASTA65671,615
        10         20         30         40         50         60 
MAGVGAVSRL LRGRRLALAG ATRGFHFSVG ESKKASAKVS DAISTQYPVV DHEFDAVVVG 

        70         80         90        100        110        120 
AGGAGLRAAF GLSEAGFNTA CLTKLFPTRS HTVAAQGGIN AALGNMEEDN WRWHFYDTVK 

       130        140        150        160        170        180 
GSDWLGDQDA IHYMTEQAPA SVVELENYGM PFSRTEDGRI YQRAFGGQSL KFGKGGQAHR 

       190        200        210        220        230        240 
CCCVADRTGH SLLHTLYGRS LRYDTSYFVE YFALDLLMEN GECRGVIALC IEDGSIHRIR 

       250        260        270        280        290        300 
AKNTIIATGG YGRTYFSCTS AHTSTGDGTA MVTRAGLPCQ DLEFVQFHPT GIYGAGCLIT 

       310        320        330        340        350        360 
EGCRGEGGIL INSQGERFME RYAPVAKDLA SRDVVSRSMT LEIREGRGCG PEKDHVYLQL 

       370        380        390        400        410        420 
HHLPPEQLAT RLPGISETAM IFAGVDVTKE PIPVLPTVHY NMGGIPTNYK GQVLKHVNGQ 

       430        440        450        460        470        480 
DQIVPGLYAC GEAACASVHG ANRLGANSLL DLVVFGRACA LSIAESCRPG DKVPPIKANA 

       490        500        510        520        530        540 
GEESVMNLDK LRFADGSVRT SELRLSMQKS MQSHAAVFRV GSVLQEGCEK VSQLYGDLQH 

       550        560        570        580        590        600 
LKTFDRGMVW NTDLVETLEL QNLMLCALQT IYGAEARKES RGAHAREDYK VRIDEYDYSK 

       610        620        630        640        650 
PIEGQQKKPF AEHWRKHTLS YVDTKTGKVT LDYRPVIDKT LNEADCATVP PAIRSY

« Hide

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References

[1]"Complex II from rat mitochondria."
Tomitsuka E., Kita K.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Lubec G., Afjehi-Sadat L.
Submitted (NOV-2006) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 39-67; 225-238; 354-371 AND 444-457, MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Spinal cord.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB072907 mRNA. Translation: BAB69818.1.
IPIIPI00200659.
RefSeqNP_569112.1.
UniGeneRn.101725

3D structure databases

SMRQ920L2. Positions 44-656.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ920L2.

PTM databases

PhosphoSiteQ920L2.

Proteomic databases

PRIDEQ920L2.

Genome annotation databases

EnsemblENSRNOT00000018336; ENSRNOP00000018336; ENSRNOG00000013331; Rattus norvegicus. [Genome view]
GeneID157074.
KEGGrno:157074.
NMPDRfig|10116.3.peg.337.
UCSCNM_130428. rat.

Organism-specific databases

CTD157074.
RGD621557. Sdha.

Phylogenomic databases

HOVERGENQ920L2.
PhylomeDBQ920L2.

Enzyme and pathway databases

BRENDA1.3.5.1. 248.

Gene expression databases

ArrayExpressQ920L2.
GenevestigatorQ920L2.
GermOnlineENSRNOG00000013331. Rattus norvegicus.

Family and domain databases

InterProIPR003953. FAD_bind2_N.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR004112. Fum_Rdtase/Succ_DH_flav_C.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_frdA_Gneg.
[Graphical view]
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
TIGRFAMsTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio620967.

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Entry information

Entry nameDHSA_RAT
AccessionPrimary (citable) accession number: Q920L2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: February 9, 2010
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents