Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q920L2

- SDHA_RAT

UniProt

Q920L2 - SDHA_RAT

Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

Sdha

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor.By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei267 – 2671FADBy similarity
    Binding sitei288 – 2881SubstrateBy similarity
    Binding sitei300 – 3001SubstrateBy similarity
    Active sitei332 – 3321Proton acceptorBy similarity
    Binding sitei399 – 3991SubstrateBy similarity
    Binding sitei432 – 4321FADBy similarity
    Binding sitei443 – 4431SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi60 – 656FADBy similarity
    Nucleotide bindingi83 – 9816FADBy similarityAdd
    BLAST
    Nucleotide bindingi448 – 4492FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. succinate dehydrogenase (ubiquinone) activity Source: RGD

    GO - Biological processi

    1. nervous system development Source: Ensembl
    2. respiratory electron transport chain Source: UniProtKB
    3. succinate metabolic process Source: UniProtKB
    4. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    ReactomeiREACT_216424. Citric acid cycle (TCA cycle).
    SABIO-RKQ920L2.
    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Flavoprotein subunit of complex II
    Short name:
    Fp
    Gene namesi
    Name:Sdha
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi621557. Sdha.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB
    2. mitochondrial respiratory chain complex II Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3535MitochondrionBy similarityAdd
    BLAST
    Chaini36 – 656621Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialPRO_0000010338Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei91 – 911Tele-8alpha-FAD histidineBy similarity
    Modified residuei171 – 1711N6-acetyllysine; alternateBy similarity
    Modified residuei171 – 1711N6-succinyllysine; alternateBy similarity
    Modified residuei174 – 1741N6-acetyllysineBy similarity
    Modified residuei207 – 2071Phosphotyrosine; by SRCBy similarity
    Modified residuei242 – 2421N6-acetyllysine; alternateBy similarity
    Modified residuei242 – 2421N6-succinyllysine; alternateBy similarity
    Modified residuei327 – 3271N6-acetyllysine; alternateBy similarity
    Modified residuei327 – 3271N6-succinyllysine; alternateBy similarity
    Modified residuei415 – 4151N6-acetyllysineBy similarity
    Modified residuei472 – 4721N6-acetyllysineBy similarity
    Modified residuei477 – 4771N6-acetyllysine; alternateBy similarity
    Modified residuei477 – 4771N6-succinyllysine; alternateBy similarity
    Modified residuei490 – 4901N6-acetyllysine; alternateBy similarity
    Modified residuei490 – 4901N6-succinyllysine; alternateBy similarity
    Modified residuei509 – 5091N6-acetyllysineBy similarity
    Modified residuei530 – 5301N6-acetyllysine; alternateBy similarity
    Modified residuei530 – 5301N6-succinyllysine; alternateBy similarity
    Modified residuei542 – 5421N6-acetyllysineBy similarity
    Modified residuei590 – 5901N6-acetyllysineBy similarity
    Modified residuei600 – 6001N6-acetyllysineBy similarity
    Modified residuei607 – 6071N6-succinyllysineBy similarity
    Modified residuei616 – 6161N6-acetyllysineBy similarity
    Modified residuei625 – 6251N6-acetyllysineBy similarity
    Modified residuei628 – 6281N6-acetyllysineBy similarity
    Modified residuei639 – 6391N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylation at Tyr-207 is important for efficient electron transfer in complex II and the prevention of ROS generation.By similarity
    Deacetylated by SIRT3.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ920L2.
    PRIDEiQ920L2.

    2D gel databases

    World-2DPAGE0004:Q920L2.

    PTM databases

    PhosphoSiteiQ920L2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ920L2.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF2/SDH5; interaction is required for FAD attachment By similarity. Interacts with TRAP1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ920L2. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ920L2.
    SMRiQ920L2. Positions 44-656.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1053.
    GeneTreeiENSGT00390000010046.
    HOGENOMiHOG000160475.
    HOVERGENiHBG001461.
    KOiK00234.
    OMAiRDGPILQ.
    OrthoDBiEOG7MH0XJ.
    PhylomeDBiQ920L2.

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q920L2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGVGAVSRL LRGRRLALAG ATRGFHFSVG ESKKASAKVS DAISTQYPVV    50
    DHEFDAVVVG AGGAGLRAAF GLSEAGFNTA CLTKLFPTRS HTVAAQGGIN 100
    AALGNMEEDN WRWHFYDTVK GSDWLGDQDA IHYMTEQAPA SVVELENYGM 150
    PFSRTEDGRI YQRAFGGQSL KFGKGGQAHR CCCVADRTGH SLLHTLYGRS 200
    LRYDTSYFVE YFALDLLMEN GECRGVIALC IEDGSIHRIR AKNTIIATGG 250
    YGRTYFSCTS AHTSTGDGTA MVTRAGLPCQ DLEFVQFHPT GIYGAGCLIT 300
    EGCRGEGGIL INSQGERFME RYAPVAKDLA SRDVVSRSMT LEIREGRGCG 350
    PEKDHVYLQL HHLPPEQLAT RLPGISETAM IFAGVDVTKE PIPVLPTVHY 400
    NMGGIPTNYK GQVLKHVNGQ DQIVPGLYAC GEAACASVHG ANRLGANSLL 450
    DLVVFGRACA LSIAESCRPG DKVPPIKANA GEESVMNLDK LRFADGSVRT 500
    SELRLSMQKS MQSHAAVFRV GSVLQEGCEK VSQLYGDLQH LKTFDRGMVW 550
    NTDLVETLEL QNLMLCALQT IYGAEARKES RGAHAREDYK VRIDEYDYSK 600
    PIEGQQKKPF AEHWRKHTLS YVDTKTGKVT LDYRPVIDKT LNEADCATVP 650
    PAIRSY 656
    Length:656
    Mass (Da):71,615
    Last modified:December 1, 2001 - v1
    Checksum:i9E820F7FF7EC3B36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB072907 mRNA. Translation: BAB69818.1.
    RefSeqiNP_569112.1. NM_130428.1.
    UniGeneiRn.228607.

    Genome annotation databases

    EnsembliENSRNOT00000018336; ENSRNOP00000018336; ENSRNOG00000013331.
    GeneIDi157074.
    KEGGirno:157074.
    UCSCiRGD:621557. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB072907 mRNA. Translation: BAB69818.1 .
    RefSeqi NP_569112.1. NM_130428.1.
    UniGenei Rn.228607.

    3D structure databases

    ProteinModelPortali Q920L2.
    SMRi Q920L2. Positions 44-656.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q920L2. 1 interaction.

    PTM databases

    PhosphoSitei Q920L2.

    2D gel databases

    World-2DPAGE 0004:Q920L2.

    Proteomic databases

    PaxDbi Q920L2.
    PRIDEi Q920L2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000018336 ; ENSRNOP00000018336 ; ENSRNOG00000013331 .
    GeneIDi 157074.
    KEGGi rno:157074.
    UCSCi RGD:621557. rat.

    Organism-specific databases

    CTDi 6389.
    RGDi 621557. Sdha.

    Phylogenomic databases

    eggNOGi COG1053.
    GeneTreei ENSGT00390000010046.
    HOGENOMi HOG000160475.
    HOVERGENi HBG001461.
    KOi K00234.
    OMAi RDGPILQ.
    OrthoDBi EOG7MH0XJ.
    PhylomeDBi Q920L2.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .
    Reactomei REACT_216424. Citric acid cycle (TCA cycle).
    SABIO-RK Q920L2.

    Miscellaneous databases

    NextBioi 620967.
    PROi Q920L2.

    Gene expression databases

    Genevestigatori Q920L2.

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complex II from rat mitochondria."
      Tomitsuka E., Kita K.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Lubec G., Afjehi-Sadat L.
      Submitted (NOV-2006) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 39-67; 225-238; 354-371 AND 444-457, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Spinal cord.

    Entry informationi

    Entry nameiSDHA_RAT
    AccessioniPrimary (citable) accession number: Q920L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3