Reviewed,
UniProtKB/Swiss-Prot Q920L2 (DHSA_RAT)
Last modified
February 9, 2010.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial EC=1.3.5.1 Alternative name(s): Flavoprotein subunit of complex II Short name=Fp | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 656 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity. |
| Catalytic activity | Succinate + ubiquinone = fumarate + ubiquinol. |
| Cofactor | FAD By similarity. |
| Pathway | |
| Subunit structure | Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF2/SDH5; interaction is required for FAD attachment By similarity. |
| Subcellular location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity. |
| Miscellaneous | The complex, present in mitochondria, can be degraded to form EC 1.3.99.1, which no longer reacts with ubiquinone. |
| Sequence similarities | Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 35 | 35 | Mitochondrion By similarity | ||||||
| Chain | 36 – 656 | 621 | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | PRO_0000010338 | |||||
Regions | |||||||||
| Nucleotide binding | 83 – 98 | 16 | FAD By similarity | ||||||
Sites | |||||||||
| Active site | 332 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 288 | 1 | Substrate By similarity | ||||||
| Binding site | 300 | 1 | Substrate By similarity | ||||||
| Binding site | 399 | 1 | Substrate By similarity | ||||||
| Binding site | 443 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 91 | 1 | Tele-8alpha-FAD histidine By similarity | ||||||
| Modified residue | 171 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 244 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 327 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 415 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 477 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 490 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 530 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 600 | 1 | N6-acetyllysine By similarity | ||||||
Sequences
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References
| [1] | "Complex II from rat mitochondria." Tomitsuka E., Kita K. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | Lubec G., Afjehi-Sadat L. Submitted (NOV-2006) to UniProtKB Cited for: PROTEIN SEQUENCE OF 39-67; 225-238; 354-371 AND 444-457, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Spinal cord. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB072907 mRNA. Translation: BAB69818.1. |
| IPI | IPI00200659. |
| RefSeq | NP_569112.1. |
| UniGene | Rn.101725 |
3D structure databases | |
| SMR | Q920L2. Positions 44-656. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q920L2. |
PTM databases | |
| PhosphoSite | Q920L2. |
Proteomic databases | |
| PRIDE | Q920L2. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000018336; ENSRNOP00000018336; ENSRNOG00000013331; Rattus norvegicus. [Genome view] |
| GeneID | 157074. |
| KEGG | rno:157074. |
| NMPDR | fig|10116.3.peg.337. |
| UCSC | NM_130428. rat. |
Organism-specific databases | |
| CTD | 157074. |
| RGD | 621557. Sdha. |
Phylogenomic databases | |
| HOVERGEN | Q920L2. |
| PhylomeDB | Q920L2. |
Enzyme and pathway databases | |
| BRENDA | 1.3.5.1. 248. |
Gene expression databases | |
| ArrayExpress | Q920L2. |
| Genevestigator | Q920L2. |
| GermOnline | ENSRNOG00000013331. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR003953. FAD_bind2_N. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR003952. FRD_SDH_FAD_BS. IPR015939. Fum_Rdtase/Succ_DH_flav-like_C. IPR004112. Fum_Rdtase/Succ_DH_flav_C. IPR011281. Succ_DH_flav_su_fwd. IPR014006. Succ_Dhase_frdA_Gneg. [Graphical view] |
| Pfam | PF00890. FAD_binding_2. 1 hit. PF02910. Succ_DH_flav_C. 1 hit. [Graphical view] |
| PRINTS | PR00368. FADPNR. |
| TIGRFAMs | TIGR01816. sdhA_forward. 1 hit. TIGR01812. sdhA_frdA_Gneg. 1 hit. |
| PROSITE | PS00504. FRD_SDH_FAD_BINDING. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 620967. |
Entry information
| Entry name | DHSA_RAT | ||||||||
| Accession | Primary (citable) accession number: Q920L2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


