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Protein

Brain and acute leukemia cytoplasmic protein

Gene

Baalc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Brain and acute leukemia cytoplasmic protein
Gene namesi
Name:Baalc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi628703. Baalc.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Membrane 1 Publication

  • Note: Postsynaptic lipid rafts.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2 – 21G → A: Abolishes myristoylation. 1 Publication
Mutagenesisi3 – 31C → A: Abolishes palmitoylation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 145144Brain and acute leukemia cytoplasmic proteinPRO_0000248208Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Lipidationi3 – 31S-palmitoyl cysteine1 Publication

Post-translational modificationi

Palmitoylation and myristoylation target the protein to the lipid rafts.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

PaxDbiQ920K5.
PRIDEiQ920K5.

Expressioni

Tissue specificityi

Brain. Expressed widely in the frontal part of the brain, especially in the neocortex, hippocampus and olfactory bulb and expression increases in parallel with synaptogenesis.2 Publications

Developmental stagei

First detected at 1 week after birth and increases significantly during 2 and 3 weeks after birth. Levels decrease at 6 weeks after birth.1 Publication

Gene expression databases

GenevisibleiQ920K5. RN.

Interactioni

Subunit structurei

Interacts with CAMK2A.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006411.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4 – 3633Interaction with CAMK2AAdd
BLAST

Phylogenomic databases

eggNOGiENOG410J2Z9. Eukaryota.
ENOG410Z0VT. LUCA.
GeneTreeiENSGT00390000013853.
HOGENOMiHOG000253947.
HOVERGENiHBG080887.
InParanoidiQ920K5.
OMAiSIQQMDR.
OrthoDBiEOG7D2FG6.
PhylomeDBiQ920K5.
TreeFamiTF330767.

Family and domain databases

InterProiIPR009728. BAALC.
[Graphical view]
PANTHERiPTHR14731. PTHR14731. 1 hit.
PfamiPF06989. BAALC_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q920K5-1) [UniParc]FASTAAdd to basket

Also known as: 1-6-8

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCGGSRADA IEPRYYESWT RETESTWLTY TDSDALPSAA ATDSGPEAGG
60 70 80 90 100
LHAGVLEDGP SSNGVLRPAA PGGIANPEKK MNCGTQCPNS QSLSSGPLTQ
110 120 130 140
KQNGLWTTEA KRDAKRMSAR EVAISVTENI RQMDRSKRVT KNCIN
Length:145
Mass (Da):15,475
Last modified:January 23, 2007 - v3
Checksum:iD5A27AD67456F341
GO
Isoform 2 (identifier: Q920K5-2) [UniParc]FASTAAdd to basket

Also known as: 1-8

The sequence of this isoform differs from the canonical sequence as follows:
     55-145: Missing.

Show »
Length:54
Mass (Da):5,667
Checksum:iFEE8C0EBFBCDB829
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei55 – 14591Missing in isoform 2. 1 PublicationVSP_020208Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF371321 mRNA. Translation: AAL50517.1.
AF371325 mRNA. Translation: AAL50521.1.
AB073318 mRNA. Translation: BAB70507.1.
RefSeqiNP_658907.1. NM_144762.2. [Q920K5-1]
UniGeneiRn.19969.

Genome annotation databases

EnsembliENSRNOT00000006411; ENSRNOP00000006411; ENSRNOG00000004697. [Q920K5-1]
GeneIDi140720.
KEGGirno:140720.
UCSCiRGD:628703. rat. [Q920K5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF371321 mRNA. Translation: AAL50517.1.
AF371325 mRNA. Translation: AAL50521.1.
AB073318 mRNA. Translation: BAB70507.1.
RefSeqiNP_658907.1. NM_144762.2. [Q920K5-1]
UniGeneiRn.19969.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006411.

Proteomic databases

PaxDbiQ920K5.
PRIDEiQ920K5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006411; ENSRNOP00000006411; ENSRNOG00000004697. [Q920K5-1]
GeneIDi140720.
KEGGirno:140720.
UCSCiRGD:628703. rat. [Q920K5-1]

Organism-specific databases

CTDi79870.
RGDi628703. Baalc.

Phylogenomic databases

eggNOGiENOG410J2Z9. Eukaryota.
ENOG410Z0VT. LUCA.
GeneTreeiENSGT00390000013853.
HOGENOMiHOG000253947.
HOVERGENiHBG080887.
InParanoidiQ920K5.
OMAiSIQQMDR.
OrthoDBiEOG7D2FG6.
PhylomeDBiQ920K5.
TreeFamiTF330767.

Miscellaneous databases

PROiQ920K5.

Gene expression databases

GenevisibleiQ920K5. RN.

Family and domain databases

InterProiIPR009728. BAALC.
[Graphical view]
PANTHERiPTHR14731. PTHR14731. 1 hit.
PfamiPF06989. BAALC_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia."
    Tanner S.M., Austin J.L., Leone G., Rush L.J., Plass C., Heinonen K., Mrozek K., Sill H., Knuutila S., Kolitz J.E., Archer K.J., Caligiuri M.A., Bloomfield C.D., de La Chapelle A.
    Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
  2. "BAALC 1-6-8 protein is targeted to postsynaptic lipid rafts by its N-terminal miristoylation and palmitoylation, and interacts with a, but not b, subunit of Ca2+/calmodulin-dependent protein kinase II."
    Wang X., Tian Q.-B., Okano A., Sakagami H., Moon I.S., Kondo H., Endo S., Suzuki T.
    J. Neurochem. 92:647-659(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CAMK2A, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MYRISTOYLATION AT GLY-2, PALMITOYLATION AT CYS-3, MUTAGENESIS OF GLY-2 AND CYS-3.

Entry informationi

Entry nameiBAALC_RAT
AccessioniPrimary (citable) accession number: Q920K5
Secondary accession number(s): Q790N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.