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Protein

Thioredoxin-like protein 1

Gene

Txnl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Active thioredoxin with a redox potential of about -250 mV.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 1
Alternative name(s):
Thioredoxin-related protein
Gene namesi
Name:Txnl1
Synonyms:Trp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi621717. Txnl1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: At least 85% of the cellular TXNL1 is proteasome-associated.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001200182 – 289Thioredoxin-like protein 1Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 37Redox-activeBy similarity
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ920J4.
PRIDEiQ920J4.

PTM databases

iPTMnetiQ920J4.
PhosphoSitePlusiQ920J4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018818.
ExpressionAtlasiQ920J4. baseline and differential.
GenevisibleiQ920J4. RN.

Interactioni

Subunit structurei

Component of the 19S regulatory cap of the 26S proteasome. Interacts with PSMD14/RPN11. Interacts with, and reduces EEF1A1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi250856. 1 interactor.
IntActiQ920J4. 2 interactors.
MINTiMINT-4611005.
STRINGi10116.ENSRNOP00000025510.

Structurei

3D structure databases

ProteinModelPortaliQ920J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 109ThioredoxinAdd BLAST108
Domaini115 – 285PITHPROSITE-ProRule annotationAdd BLAST171

Sequence similaritiesi

Contains 1 PITH domain.PROSITE-ProRule annotation
Contains 1 thioredoxin domain.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0908. Eukaryota.
ENOG410YQ2G. LUCA.
GeneTreeiENSGT00530000063008.
HOGENOMiHOG000189802.
HOVERGENiHBG055982.
InParanoidiQ920J4.

Family and domain databases

Gene3Di2.60.120.470. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR010400. PITH_dom.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF06201. PITH. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS51532. PITH. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q920J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGVKPVGSD PDFQPELSGA GSRLAVVKFT MRGCGPCLRI APAFSSMSNK
60 70 80 90 100
YPQAVFLEVD VHQCQGTAAT NNISATPTFL FFRNKVRIDQ YQGADAVGLE
110 120 130 140 150
EKIKQHLEND PGSNEDTDIP KGYMDLMPFI NKAGCECLNE SDEHGFDNCL
160 170 180 190 200
RKDLSFLESD CDEQLLITVA FNQPVKLYSM KFQGPDNGQG PKYVKIFINL
210 220 230 240 250
PRSMDFEEAE RSEPTQALEL TEDDIKEDGI VPLRYVKFQN VNSVTLFVQS
260 270 280
NQGEEETTRI SYFTFIGTPV QATNMNDFKR VVGKKGESH
Length:289
Mass (Da):32,249
Last modified:January 23, 2007 - v3
Checksum:i208973DC16B61E01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140358 mRNA. Translation: AAK98516.1.
BC098908 mRNA. Translation: AAH98908.1.
RefSeqiNP_543163.1. NM_080887.2.
UniGeneiRn.40430.

Genome annotation databases

EnsembliENSRNOT00000025510; ENSRNOP00000025510; ENSRNOG00000018818.
GeneIDi140922.
KEGGirno:140922.
UCSCiRGD:621717. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140358 mRNA. Translation: AAK98516.1.
BC098908 mRNA. Translation: AAH98908.1.
RefSeqiNP_543163.1. NM_080887.2.
UniGeneiRn.40430.

3D structure databases

ProteinModelPortaliQ920J4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250856. 1 interactor.
IntActiQ920J4. 2 interactors.
MINTiMINT-4611005.
STRINGi10116.ENSRNOP00000025510.

PTM databases

iPTMnetiQ920J4.
PhosphoSitePlusiQ920J4.

Proteomic databases

PaxDbiQ920J4.
PRIDEiQ920J4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025510; ENSRNOP00000025510; ENSRNOG00000018818.
GeneIDi140922.
KEGGirno:140922.
UCSCiRGD:621717. rat.

Organism-specific databases

CTDi9352.
RGDi621717. Txnl1.

Phylogenomic databases

eggNOGiKOG0908. Eukaryota.
ENOG410YQ2G. LUCA.
GeneTreeiENSGT00530000063008.
HOGENOMiHOG000189802.
HOVERGENiHBG055982.
InParanoidiQ920J4.

Miscellaneous databases

PROiQ920J4.

Gene expression databases

BgeeiENSRNOG00000018818.
ExpressionAtlasiQ920J4. baseline and differential.
GenevisibleiQ920J4. RN.

Family and domain databases

Gene3Di2.60.120.470. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR010400. PITH_dom.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF06201. PITH. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS51532. PITH. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTXNL1_RAT
AccessioniPrimary (citable) accession number: Q920J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.