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Protein

WD repeat-containing protein 7

Gene

Wdr7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 7
Alternative name(s):
TGF-beta resistance-associated protein TRAG
Gene namesi
Name:Wdr7
Synonyms:Kiaa0541, Trag
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1860197. Wdr7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14891489WD repeat-containing protein 7PRO_0000051354Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei935 – 9351PhosphoserineCombined sources
Modified residuei1455 – 14551PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ920I9.
MaxQBiQ920I9.
PaxDbiQ920I9.
PeptideAtlasiQ920I9.
PRIDEiQ920I9.

PTM databases

iPTMnetiQ920I9.
PhosphoSiteiQ920I9.
SwissPalmiQ920I9.

Expressioni

Gene expression databases

BgeeiQ920I9.
CleanExiMM_WDR7.
GenevisibleiQ920I9. MM.

Interactioni

Protein-protein interaction databases

BioGridi222341. 1 interaction.
IntActiQ920I9. 3 interactions.
MINTiMINT-4122315.
STRINGi10090.ENSMUSP00000072509.

Structurei

3D structure databases

ProteinModelPortaliQ920I9.
SMRiQ920I9. Positions 404-436, 456-594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati17 – 5640WD 1Add
BLAST
Repeati62 – 10443WD 2Add
BLAST
Repeati156 – 19944WD 3Add
BLAST
Repeati324 – 36643WD 4Add
BLAST
Repeati404 – 44340WD 5Add
BLAST
Repeati462 – 50746WD 6Add
BLAST
Repeati558 – 59740WD 7Add
BLAST
Repeati1350 – 138940WD 8Add
BLAST
Repeati1391 – 143141WD 9Add
BLAST

Sequence similaritiesi

Contains 9 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410ISJ1. Eukaryota.
ENOG410Y2AE. LUCA.
GeneTreeiENSGT00520000055590.
HOGENOMiHOG000001566.
HOVERGENiHBG067501.
InParanoidiQ920I9.
OMAiILKVWIV.
OrthoDBiEOG72VH5G.
TreeFamiTF313196.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q920I9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGNSLVLPI VLWGRKAPTH CISSILLTDD GGTIVTGCHD GQICLWDVSV
60 70 80 90 100
ELEVNPRALL FGHTASITCL SKACASGDKR YTVSASANGE MCLWDVNDGR
110 120 130 140 150
CIEFTKLACT HTGIQFYQFS VGNQQEGRLL CHGHYPEILV VDATSLEVLY
160 170 180 190 200
SLVSKISPDW ISSMSIIRSQ RTQEDTVVAL SVTGILKVWI VTSEMSGMQD
210 220 230 240 250
TEPIFEEESK PIYCQNCQSI SFCAFTQRSL LVVCSKYWRV FDAGDYSLLC
260 270 280 290 300
SGPSENGQTW TGGDFVSADK VIIWTENGQS YIYKLPASCL PASDSFRSDV
310 320 330 340 350
GKAVENLIPP VQHSLLDQKD KELVICPPVT RFFYGCKEYL HKLLIQGDSS
360 370 380 390 400
GRLNIWNIAD IAEKQEADEG LKMTTCISLQ EAFDKLKPCP AGIIDQLSVI
410 420 430 440 450
PNSNEPLKVT ASVYIPAHGR LVCGREDGSI IIVPATQTAI VQLLQGEHML
460 470 480 490 500
RRGWPPHRTL RGHRNKVTCL LYPHQVSARY DQRYLISGGV DFSVIIWDIF
510 520 530 540 550
SGEMKHIFCV HGGEITQLLV PPENCSARVQ HCICSVASDH SVGLLSLREK
560 570 580 590 600
KCIMLASRHL FPIQVIKWRP SDDYLVVGCT DGSVYVWQMD TGALDRCAMG
610 620 630 640 650
ITAVEILNAC DEAVPAAVDS LSHPAVNLKQ AMTRRSLAAL KNMAHHKLQT
660 670 680 690 700
LATNLLASEA SDKGNLPKYS HNSLMVQAIK TNLTDPDIHV LFFDVEALII
710 720 730 740 750
QLLTEEASRP NTALISPENL QKASGSSDKG GSFLTGKRAA VLFQQVKETI
760 770 780 790 800
KENIKEHLLD EEEDEEEARR QSREDSDPEY RASKSKPLTL LEYNLTMDTA
810 820 830 840 850
KLFMSCLHAW GLNEVLDEVC LDRLGMLKPH CTVSFGLLSR GGHMSLMLPG
860 870 880 890 900
YNQAAGKLLH AKAEVGRKLP AAEGVGKGTY TVSRAVTTQH LLSIISLANT
910 920 930 940 950
LMSMTNATFI GDHMKKGPTR PPRPGTPDLS KARDSPPPSS NIVQGQIKQA
960 970 980 990 1000
AAPVVSARSD ADHSGSDSAS PALPTCFLVN EGWSQLAAMH CVMLPDLLGL
1010 1020 1030 1040 1050
ERFRPPLLEM LARRWQDRCL EVREAAQALL LAELRRIEQA GRKETIDTWA
1060 1070 1080 1090 1100
PYLPQYMDHV ISPGVTAEAM QTMAAAPDAS GPEAKVQEEE HDLVDDDITA
1110 1120 1130 1140 1150
GCLSSVPQMK KISTSYEERR KQATAIVLLG VIGAEFGAEI EPPKLLTRPR
1160 1170 1180 1190 1200
SSSQIPEGFG LTSGGSNYSL ARHTCKALTY LLLQPPSPKL PPHSTIRRTA
1210 1220 1230 1240 1250
TDLIGRGFTV WEPYMDVSAV LMGLLELCAD AEKQLANITM GLPLSPAADS
1260 1270 1280 1290 1300
ARSARHALSL IATARPPAFI TTIAKEVHRH TALAANTQSQ QSIHTTTLAR
1310 1320 1330 1340 1350
AKGEILRVIE ILIEKMPTDV VDLLVEVMDI IMYCLEGSLV KKKGLQECFP
1360 1370 1380 1390 1400
AICRFYMVSY YERSHRIAVG ARHGSVALYD IRTGKCQTIH GHKGPITAVS
1410 1420 1430 1440 1450
FAPDGRYLAT YSNTDSHISF WQMNTSLLGS IGMLNSAPQL RCIKTYQVPP
1460 1470 1480
VQPASPGSHN ALKLARLIWT SNRNVILMAH DGKEHRFMV
Length:1,489
Mass (Da):163,450
Last modified:July 27, 2011 - v3
Checksum:i444A5509758C9E63
GO
Isoform 2 (identifier: Q920I9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     950-981: Missing.

Show »
Length:1,457
Mass (Da):160,325
Checksum:iA7E15F7B333501C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161F → L in BAE32595 (PubMed:16141072).Curated
Sequence conflicti168 – 1681R → H in AAL03981 (Ref. 1) Curated
Sequence conflicti168 – 1681R → H in AAL03982 (Ref. 1) Curated
Sequence conflicti566 – 5661I → V in BAE32595 (PubMed:16141072).Curated
Sequence conflicti579 – 5791C → S in AAL03981 (Ref. 1) Curated
Sequence conflicti579 – 5791C → S in AAL03982 (Ref. 1) Curated
Sequence conflicti938 – 9381P → A in AAL03981 (Ref. 1) Curated
Sequence conflicti938 – 9381P → A in AAL03982 (Ref. 1) Curated
Sequence conflicti938 – 9381P → A in BAC65586 (PubMed:12693553).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei950 – 98132Missing in isoform 2. 3 PublicationsVSP_015275Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188123 mRNA. Translation: AAL03981.1.
AF188124 mRNA. Translation: AAL03982.1.
AK154451 mRNA. Translation: BAE32595.1.
CH466528 Genomic DNA. Translation: EDL09715.1.
BC125573 mRNA. Translation: AAI25574.1.
BC137785 mRNA. Translation: AAI37786.1.
AK122304 mRNA. Translation: BAC65586.1.
CCDSiCCDS50307.1. [Q920I9-1]
RefSeqiNP_001014981.1. NM_001014981.1. [Q920I9-1]
XP_006525540.1. XM_006525477.2. [Q920I9-2]
UniGeneiMm.30850.

Genome annotation databases

EnsembliENSMUST00000072726; ENSMUSP00000072509; ENSMUSG00000040560. [Q920I9-1]
GeneIDi104082.
KEGGimmu:104082.
UCSCiuc008fea.2. mouse. [Q920I9-1]
uc008feb.2. mouse. [Q920I9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188123 mRNA. Translation: AAL03981.1.
AF188124 mRNA. Translation: AAL03982.1.
AK154451 mRNA. Translation: BAE32595.1.
CH466528 Genomic DNA. Translation: EDL09715.1.
BC125573 mRNA. Translation: AAI25574.1.
BC137785 mRNA. Translation: AAI37786.1.
AK122304 mRNA. Translation: BAC65586.1.
CCDSiCCDS50307.1. [Q920I9-1]
RefSeqiNP_001014981.1. NM_001014981.1. [Q920I9-1]
XP_006525540.1. XM_006525477.2. [Q920I9-2]
UniGeneiMm.30850.

3D structure databases

ProteinModelPortaliQ920I9.
SMRiQ920I9. Positions 404-436, 456-594.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222341. 1 interaction.
IntActiQ920I9. 3 interactions.
MINTiMINT-4122315.
STRINGi10090.ENSMUSP00000072509.

PTM databases

iPTMnetiQ920I9.
PhosphoSiteiQ920I9.
SwissPalmiQ920I9.

Proteomic databases

EPDiQ920I9.
MaxQBiQ920I9.
PaxDbiQ920I9.
PeptideAtlasiQ920I9.
PRIDEiQ920I9.

Protocols and materials databases

DNASUi104082.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072726; ENSMUSP00000072509; ENSMUSG00000040560. [Q920I9-1]
GeneIDi104082.
KEGGimmu:104082.
UCSCiuc008fea.2. mouse. [Q920I9-1]
uc008feb.2. mouse. [Q920I9-2]

Organism-specific databases

CTDi23335.
MGIiMGI:1860197. Wdr7.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410ISJ1. Eukaryota.
ENOG410Y2AE. LUCA.
GeneTreeiENSGT00520000055590.
HOGENOMiHOG000001566.
HOVERGENiHBG067501.
InParanoidiQ920I9.
OMAiILKVWIV.
OrthoDBiEOG72VH5G.
TreeFamiTF313196.

Miscellaneous databases

PROiQ920I9.
SOURCEiSearch...

Gene expression databases

BgeeiQ920I9.
CleanExiMM_WDR7.
GenevisibleiQ920I9. MM.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TRAG: a novel gene associated with TGF-beta resistance."
    Sanders S., Thorgeirsson S.S.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: 129/SvJ.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: NOD.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 292-1489 (ISOFORM 2).
    Tissue: Brain.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-935 AND SER-1455, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiWDR7_MOUSE
AccessioniPrimary (citable) accession number: Q920I9
Secondary accession number(s): Q059Q1
, Q3U440, Q80TY3, Q920J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.