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Q920H4 (ACM5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Muscarinic acetylcholine receptor M5
Gene names
Name:Chrm5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 532532Muscarinic acetylcholine receptor M5
PRO_0000069044

Regions

Topological domain1 – 2929Extracellular By similarity
Transmembrane30 – 5324Helical; Name=1; By similarity
Topological domain54 – 6613Cytoplasmic By similarity
Transmembrane67 – 8721Helical; Name=2; By similarity
Topological domain88 – 10417Extracellular By similarity
Transmembrane105 – 12622Helical; Name=3; By similarity
Topological domain127 – 14620Cytoplasmic By similarity
Transmembrane147 – 16923Helical; Name=4; By similarity
Topological domain170 – 19122Extracellular By similarity
Transmembrane192 – 21423Helical; Name=5; By similarity
Topological domain215 – 443229Cytoplasmic By similarity
Transmembrane444 – 46421Helical; Name=6; By similarity
Topological domain465 – 47814Extracellular By similarity
Transmembrane479 – 49820Helical; Name=7; By similarity
Topological domain499 – 53234Cytoplasmic By similarity

Amino acid modifications

Modified residue5011Phosphothreonine Potential
Modified residue5051Phosphothreonine Potential
Glycosylation81N-linked (GlcNAc...) Potential
Disulfide bond103 ↔ 183 By similarity

Experimental info

Sequence conflict2651V → E in AAL26028. Ref.1
Sequence conflict2651V → E in AAI20616. Ref.3
Sequence conflict3251C → Y in AAL26028. Ref.1
Sequence conflict3251C → Y in AAI20616. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q920H4 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 02AA5498F44C1DA6

FASTA53260,253
        10         20         30         40         50         60 
MEGESYHNET TVNGTPVNHQ ALERHGLWEV ITIAAVTAVV SLMTIVGNVL VMISFKVNSQ 

        70         80         90        100        110        120 
LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWVLGS LACDLWLALD YVASNASVMN 

       130        140        150        160        170        180 
LLVISFDRYF SITRPLTYRA KRTPKRAGIM IGLAWLVSFI LWAPAILCWQ YLVGKRTVPP 

       190        200        210        220        230        240 
DECQIQFLSE PTITFGTAIA AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSDSVAEVK 

       250        260        270        280        290        300 
KRKPAHRTLL RSFFSCPRPS LAQRVRNQAS WSSSRRSTST TGKPTQATDL SADWEKAEQV 

       310        320        330        340        350        360 
TNCSSCPSSE DEAKATTDPV FQVVCKNEAK ESPGKEFNTQ ETKETFVSPR TENNDYDTPK 

       370        380        390        400        410        420 
YFLSPGAAHR LKSQKCVAYK FRLVVKADGT QETNNGCRKV KIMPCSFPVS KDPSTKGLDP 

       430        440        450        460        470        480 
HLSHQMTKRK RMVLVKERKA AQTLSAILLA FIITWTPYNI MVLVSTFCDK CVPVTLWHLG 

       490        500        510        520        530 
YWLCYVNSTI NPICYALCNR TFRKTFKLLL LCRWKKKKVE EKLYWQGNSK LP 

« Hide

References

« Hide 'large scale' references
[1]"Isolation, sequence and functional expression of the mouse M1-M5 muscarinic acetylcholine receptor genes."
Yamada M., Wess J.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF264051 Genomic DNA. Translation: AAL26028.1.
BC120615 mRNA. Translation: AAI20616.1.
AL731840 Genomic DNA. Translation: CAM25807.1.
CCDSCCDS16556.1.
RefSeqNP_991352.2. NM_205783.2.
XP_006499162.1. XM_006499099.1.
UniGeneMm.297624.

3D structure databases

ProteinModelPortalQ920H4.
SMRQ920H4. Positions 27-240, 439-507.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ920H4.
ChEMBLCHEMBL2097162.
GuidetoPHARMACOLOGY17.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ920H4.

Proteomic databases

PRIDEQ920H4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000099589; ENSMUSP00000097185; ENSMUSG00000074939.
GeneID213788.
KEGGmmu:213788.
UCSCuc008lpd.2. mouse.

Organism-specific databases

CTD1133.
MGIMGI:109248. Chrm5.

Phylogenomic databases

eggNOGNOG250863.
GeneTreeENSGT00690000101881.
HOGENOMHOG000231484.
HOVERGENHBG105720.
InParanoidA2AHU3.
KOK04133.
OMAYDTPKYF.
OrthoDBEOG7V49Z7.
TreeFamTF320495.

Gene expression databases

BgeeQ920H4.
CleanExMM_CHRM5.
GenevestigatorQ920H4.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000502. Musac_Ach_M5_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PANTHERPTHR24249:SF58. PTHR24249:SF58. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00542. MUSCRINICM5R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio374108.
PROQ920H4.
SOURCESearch...

Entry information

Entry nameACM5_MOUSE
AccessionPrimary (citable) accession number: Q920H4
Secondary accession number(s): A2AHU3, Q0VBI9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries