Chrm5

Functionⁱ

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity).By similarity

GO - Molecular functionⁱ

extracellular-glycine-gated chloride channel activity
Source: MGI
Traceable author statementⁱ
- 11756520
G-protein coupled acetylcholine receptor activity Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway Source: GO_Central
dopamine transport
Source: MGI
Inferred from direct assayⁱ
- 11756520
gastric acid secretion Source: InterPro
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway Source: GO_Central
regulation of phosphatidylinositol dephosphorylation Source: Ensembl
synaptic transmission, cholinergic Source: GO_Central
transmission of nerve impulse
Source: MGI
Inferred from direct assayⁱ
- 11756520

Complete GO annotation...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390648. Muscarinic acetylcholine receptors. R-MMU-416476. G alpha (q) signalling events.

Reactomeⁱ

R-MMU-390648. Muscarinic acetylcholine receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Muscarinic acetylcholine receptor M5
Gene namesⁱ	Name:Chrm5
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:109248. Chrm5.

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 29	ExtracellularBy similarityAdd BLAST	29
Transmembraneⁱ	30 – 53	Helical; Name=1By similarityAdd BLAST	24
Topological domainⁱ	54 – 66	CytoplasmicBy similarityAdd BLAST	13
Transmembraneⁱ	67 – 87	Helical; Name=2By similarityAdd BLAST	21
Topological domainⁱ	88 – 104	ExtracellularBy similarityAdd BLAST	17
Transmembraneⁱ	105 – 126	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	127 – 146	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	147 – 169	Helical; Name=4By similarityAdd BLAST	23
Topological domainⁱ	170 – 191	ExtracellularBy similarityAdd BLAST	22
Transmembraneⁱ	192 – 214	Helical; Name=5By similarityAdd BLAST	23
Topological domainⁱ	215 – 443	CytoplasmicBy similarityAdd BLAST	229
Transmembraneⁱ	444 – 464	Helical; Name=6By similarityAdd BLAST	21
Topological domainⁱ	465 – 478	ExtracellularBy similarityAdd BLAST	14
Transmembraneⁱ	479 – 498	Helical; Name=7By similarityAdd BLAST	20
Topological domainⁱ	499 – 532	CytoplasmicBy similarityAdd BLAST	34

GO - Cellular componentⁱ

cell junction Source: UniProtKB-KW
integral component of plasma membrane Source: InterPro
postsynaptic membrane Source: UniProtKB-SubCell
synapse Source: GO_Central

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2097162.

ChEMBLⁱ

CHEMBL2097162.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069044	1 – 532	Muscarinic acetylcholine receptor M5Add BLAST		532

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	8	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	103 ↔ 183	PROSITE-ProRule annotation
Modified residueⁱ	501	PhosphothreonineSequence analysis	1
Modified residueⁱ	505	PhosphothreonineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q920H4.
PRIDEⁱ	Q920H4.

PTM databases

iPTMnetⁱ	Q920H4.
PhosphoSitePlusⁱ	Q920H4.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000074939.
CleanExⁱ	MM_CHRM5.

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q920H4. 1 interactor.
STRINGⁱ	10090.ENSMUSP00000097185.

Chemistry databases

BindingDBⁱ

Q920H4.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q920H4.
SMRⁱ	Q920H4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4220. Eukaryota. ENOG410YCQR. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00780000121874.
HOGENOMⁱ	HOG000231484.
HOVERGENⁱ	HBG105720.
InParanoidⁱ	Q920H4.
KEGG Orthology (KO) More...KOⁱ	K04133.
OMAⁱ	KCVAYKF.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI.
TreeFamⁱ	TF320495.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000502. Musac_Ach_M5_rcpt. IPR000995. Musac_Ach_rcpt.
PANTHERⁱ	PTHR24249:SF369. PTHR24249:SF369. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00243. MUSCARINICR. PR00542. MUSCRINICM5R.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q920H4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEGESYHNET TVNGTPVNHQ ALERHGLWEV ITIAAVTAVV SLMTIVGNVL 
        60         70         80         90        100
VMISFKVNSQ LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWVLGS 
       110        120        130        140        150
LACDLWLALD YVASNASVMN LLVISFDRYF SITRPLTYRA KRTPKRAGIM 
       160        170        180        190        200
IGLAWLVSFI LWAPAILCWQ YLVGKRTVPP DECQIQFLSE PTITFGTAIA 
       210        220        230        240        250
AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSDSVAEVK KRKPAHRTLL 
       260        270        280        290        300
RSFFSCPRPS LAQRVRNQAS WSSSRRSTST TGKPTQATDL SADWEKAEQV 
       310        320        330        340        350
TNCSSCPSSE DEAKATTDPV FQVVCKNEAK ESPGKEFNTQ ETKETFVSPR 
       360        370        380        390        400
TENNDYDTPK YFLSPGAAHR LKSQKCVAYK FRLVVKADGT QETNNGCRKV 
       410        420        430        440        450
KIMPCSFPVS KDPSTKGLDP HLSHQMTKRK RMVLVKERKA AQTLSAILLA 
       460        470        480        490        500
FIITWTPYNI MVLVSTFCDK CVPVTLWHLG YWLCYVNSTI NPICYALCNR 
       510        520        530 
TFRKTFKLLL LCRWKKKKVE EKLYWQGNSK LP

Length:532

Mass (Da):60,253

Last modified:July 27, 2011 - v2

Checksum:ⁱ02AA5498F44C1DA6

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	265	V → E in AAL26028 (Ref. 1) Curated	1
Sequence conflictⁱ	265	V → E in AAI20616 (PubMed:15489334).Curated	1
Sequence conflictⁱ	325	C → Y in AAL26028 (Ref. 1) Curated	1
Sequence conflictⁱ	325	C → Y in AAI20616 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF264051 Genomic DNA. Translation: AAL26028.1. BC120615 mRNA. Translation: AAI20616.1. AL731840 Genomic DNA. Translation: CAM25807.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16556.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_991352.2. NM_205783.2. XP_006499162.1. XM_006499099.3.
UniGeneⁱ	Mm.297624.

Genome annotation databases

Ensemblⁱ	ENSMUST00000099589; ENSMUSP00000097185; ENSMUSG00000074939.
GeneIDⁱ	213788.
KEGGⁱ	mmu:213788.
UCSC genome browser More...UCSCⁱ	uc008lpd.2. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF264051 Genomic DNA. Translation: AAL26028.1. BC120615 mRNA. Translation: AAI20616.1. AL731840 Genomic DNA. Translation: CAM25807.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16556.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_991352.2. NM_205783.2. XP_006499162.1. XM_006499099.3.
UniGeneⁱ	Mm.297624.

3D structure databases

ProteinModelPortalⁱ	Q920H4.
SMRⁱ	Q920H4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q920H4. 1 interactor.
STRINGⁱ	10090.ENSMUSP00000097185.

Chemistry databases

BindingDBⁱ	Q920H4.
ChEMBLⁱ	CHEMBL2097162.

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q920H4.
PhosphoSitePlusⁱ	Q920H4.

Proteomic databases

PaxDbⁱ	Q920H4.
PRIDEⁱ	Q920H4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000099589; ENSMUSP00000097185; ENSMUSG00000074939.
GeneIDⁱ	213788.
KEGGⁱ	mmu:213788.
UCSC genome browser More...UCSCⁱ	uc008lpd.2. mouse.

Organism-specific databases

CTDⁱ	1133.
MGIⁱ	MGI:109248. Chrm5.

Phylogenomic databases

eggNOGⁱ	KOG4220. Eukaryota. ENOG410YCQR. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00780000121874.
HOGENOMⁱ	HOG000231484.
HOVERGENⁱ	HBG105720.
InParanoidⁱ	Q920H4.
KEGG Orthology (KO) More...KOⁱ	K04133.
OMAⁱ	KCVAYKF.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI.
TreeFamⁱ	TF320495.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390648. Muscarinic acetylcholine receptors. R-MMU-416476. G alpha (q) signalling events.

Reactomeⁱ

R-MMU-390648. Muscarinic acetylcholine receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q920H4.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000074939.
CleanExⁱ	MM_CHRM5.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000502. Musac_Ach_M5_rcpt. IPR000995. Musac_Ach_rcpt.
PANTHERⁱ	PTHR24249:SF369. PTHR24249:SF369. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00243. MUSCARINICR. PR00542. MUSCRINICM5R.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACM5_MOUSE
Accessionⁱ	Q920H4Primary (citable) accession number: Q920H4 Secondary accession number(s): A2AHU3, Q0VBI9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	July 27, 2011
	Last modified:	June 7, 2017
	This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q920H4 (ACM5_MOUSE)

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Muscarinic acetylcholine receptor M5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ