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Protein

Muscarinic acetylcholine receptor M5

Gene

Chrm5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390648 Muscarinic acetylcholine receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M5
Gene namesi
Name:Chrm5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:109248 Chrm5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularBy similarityAdd BLAST29
Transmembranei30 – 53Helical; Name=1By similarityAdd BLAST24
Topological domaini54 – 66CytoplasmicBy similarityAdd BLAST13
Transmembranei67 – 87Helical; Name=2By similarityAdd BLAST21
Topological domaini88 – 104ExtracellularBy similarityAdd BLAST17
Transmembranei105 – 126Helical; Name=3By similarityAdd BLAST22
Topological domaini127 – 146CytoplasmicBy similarityAdd BLAST20
Transmembranei147 – 169Helical; Name=4By similarityAdd BLAST23
Topological domaini170 – 191ExtracellularBy similarityAdd BLAST22
Transmembranei192 – 214Helical; Name=5By similarityAdd BLAST23
Topological domaini215 – 443CytoplasmicBy similarityAdd BLAST229
Transmembranei444 – 464Helical; Name=6By similarityAdd BLAST21
Topological domaini465 – 478ExtracellularBy similarityAdd BLAST14
Transmembranei479 – 498Helical; Name=7By similarityAdd BLAST20
Topological domaini499 – 532CytoplasmicBy similarityAdd BLAST34

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2097162

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690441 – 532Muscarinic acetylcholine receptor M5Add BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 183PROSITE-ProRule annotation
Modified residuei501PhosphothreonineSequence analysis1
Modified residuei505PhosphothreonineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ920H4
PRIDEiQ920H4

PTM databases

iPTMnetiQ920H4
PhosphoSitePlusiQ920H4

Expressioni

Gene expression databases

BgeeiENSMUSG00000074939
CleanExiMM_CHRM5

Interactioni

Protein-protein interaction databases

IntActiQ920H4 1 interactor.
STRINGi10090.ENSMUSP00000097185

Chemistry databases

BindingDBiQ920H4

Structurei

3D structure databases

ProteinModelPortaliQ920H4
SMRiQ920H4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4220 Eukaryota
ENOG410YCQR LUCA
GeneTreeiENSGT00780000121874
HOGENOMiHOG000231484
HOVERGENiHBG105720
InParanoidiQ920H4
KOiK04133
OMAiKLYWQGN
OrthoDBiEOG091G06VI
TreeFamiTF320495

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000502 Musac_Ach_M5_rcpt
IPR000995 Musac_Ach_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00243 MUSCARINICR
PR00542 MUSCRINICM5R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q920H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGESYHNET TVNGTPVNHQ ALERHGLWEV ITIAAVTAVV SLMTIVGNVL
60 70 80 90 100
VMISFKVNSQ LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWVLGS
110 120 130 140 150
LACDLWLALD YVASNASVMN LLVISFDRYF SITRPLTYRA KRTPKRAGIM
160 170 180 190 200
IGLAWLVSFI LWAPAILCWQ YLVGKRTVPP DECQIQFLSE PTITFGTAIA
210 220 230 240 250
AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSDSVAEVK KRKPAHRTLL
260 270 280 290 300
RSFFSCPRPS LAQRVRNQAS WSSSRRSTST TGKPTQATDL SADWEKAEQV
310 320 330 340 350
TNCSSCPSSE DEAKATTDPV FQVVCKNEAK ESPGKEFNTQ ETKETFVSPR
360 370 380 390 400
TENNDYDTPK YFLSPGAAHR LKSQKCVAYK FRLVVKADGT QETNNGCRKV
410 420 430 440 450
KIMPCSFPVS KDPSTKGLDP HLSHQMTKRK RMVLVKERKA AQTLSAILLA
460 470 480 490 500
FIITWTPYNI MVLVSTFCDK CVPVTLWHLG YWLCYVNSTI NPICYALCNR
510 520 530
TFRKTFKLLL LCRWKKKKVE EKLYWQGNSK LP
Length:532
Mass (Da):60,253
Last modified:July 27, 2011 - v2
Checksum:i02AA5498F44C1DA6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265V → E in AAL26028 (Ref. 1) Curated1
Sequence conflicti265V → E in AAI20616 (PubMed:15489334).Curated1
Sequence conflicti325C → Y in AAL26028 (Ref. 1) Curated1
Sequence conflicti325C → Y in AAI20616 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264051 Genomic DNA Translation: AAL26028.1
BC120615 mRNA Translation: AAI20616.1
AL731840 Genomic DNA Translation: CAM25807.1
CCDSiCCDS16556.1
RefSeqiNP_991352.2, NM_205783.2
XP_006499162.1, XM_006499099.3
UniGeneiMm.297624

Genome annotation databases

EnsembliENSMUST00000099589; ENSMUSP00000097185; ENSMUSG00000074939
GeneIDi213788
KEGGimmu:213788
UCSCiuc008lpd.2 mouse

Similar proteinsi

Entry informationi

Entry nameiACM5_MOUSE
AccessioniPrimary (citable) accession number: Q920H4
Secondary accession number(s): A2AHU3, Q0VBI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome