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Q920H4

- ACM5_MOUSE

UniProt

Q920H4 - ACM5_MOUSE

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Protein

Muscarinic acetylcholine receptor M5

Gene

Chrm5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity).By similarity

GO - Molecular functioni

  1. extracellular-glycine-gated chloride channel activity Source: MGI
  2. G-protein coupled acetylcholine receptor activity Source: Ensembl

GO - Biological processi

  1. chloride transmembrane transport Source: GOC
  2. chloride transport Source: GOC
  3. dopamine transport Source: MGI
  4. gastric acid secretion Source: InterPro
  5. regulation of phosphatidylinositol dephosphorylation Source: Ensembl
  6. transmission of nerve impulse Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M5
Gene namesi
Name:Chrm5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:109248. Chrm5.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of plasma membrane Source: InterPro
  3. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Muscarinic acetylcholine receptor M5PRO_0000069044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi103 ↔ 183PROSITE-ProRule annotation
Modified residuei501 – 5011PhosphothreonineSequence Analysis
Modified residuei505 – 5051PhosphothreonineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ920H4.

PTM databases

PhosphoSiteiQ920H4.

Expressioni

Gene expression databases

BgeeiQ920H4.
CleanExiMM_CHRM5.
GenevestigatoriQ920H4.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ920H4.
SMRiQ920H4. Positions 27-240, 439-507.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularBy similarityAdd
BLAST
Topological domaini54 – 6613CytoplasmicBy similarityAdd
BLAST
Topological domaini88 – 10417ExtracellularBy similarityAdd
BLAST
Topological domaini127 – 14620CytoplasmicBy similarityAdd
BLAST
Topological domaini170 – 19122ExtracellularBy similarityAdd
BLAST
Topological domaini215 – 443229CytoplasmicBy similarityAdd
BLAST
Topological domaini465 – 47814ExtracellularBy similarityAdd
BLAST
Topological domaini499 – 53234CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5324Helical; Name=1By similarityAdd
BLAST
Transmembranei67 – 8721Helical; Name=2By similarityAdd
BLAST
Transmembranei105 – 12622Helical; Name=3By similarityAdd
BLAST
Transmembranei147 – 16923Helical; Name=4By similarityAdd
BLAST
Transmembranei192 – 21423Helical; Name=5By similarityAdd
BLAST
Transmembranei444 – 46421Helical; Name=6By similarityAdd
BLAST
Transmembranei479 – 49820Helical; Name=7By similarityAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG250863.
GeneTreeiENSGT00760000119165.
HOGENOMiHOG000231484.
HOVERGENiHBG105720.
InParanoidiQ920H4.
KOiK04133.
OMAiYDTPKYF.
OrthoDBiEOG7V49Z7.
TreeFamiTF320495.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000502. Musac_Ach_M5_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PANTHERiPTHR24249:SF58. PTHR24249:SF58. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00542. MUSCRINICM5R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q920H4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGESYHNET TVNGTPVNHQ ALERHGLWEV ITIAAVTAVV SLMTIVGNVL
60 70 80 90 100
VMISFKVNSQ LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWVLGS
110 120 130 140 150
LACDLWLALD YVASNASVMN LLVISFDRYF SITRPLTYRA KRTPKRAGIM
160 170 180 190 200
IGLAWLVSFI LWAPAILCWQ YLVGKRTVPP DECQIQFLSE PTITFGTAIA
210 220 230 240 250
AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSDSVAEVK KRKPAHRTLL
260 270 280 290 300
RSFFSCPRPS LAQRVRNQAS WSSSRRSTST TGKPTQATDL SADWEKAEQV
310 320 330 340 350
TNCSSCPSSE DEAKATTDPV FQVVCKNEAK ESPGKEFNTQ ETKETFVSPR
360 370 380 390 400
TENNDYDTPK YFLSPGAAHR LKSQKCVAYK FRLVVKADGT QETNNGCRKV
410 420 430 440 450
KIMPCSFPVS KDPSTKGLDP HLSHQMTKRK RMVLVKERKA AQTLSAILLA
460 470 480 490 500
FIITWTPYNI MVLVSTFCDK CVPVTLWHLG YWLCYVNSTI NPICYALCNR
510 520 530
TFRKTFKLLL LCRWKKKKVE EKLYWQGNSK LP
Length:532
Mass (Da):60,253
Last modified:July 27, 2011 - v2
Checksum:i02AA5498F44C1DA6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti265 – 2651V → E in AAL26028. 1 PublicationCurated
Sequence conflicti265 – 2651V → E in AAI20616. (PubMed:15489334)Curated
Sequence conflicti325 – 3251C → Y in AAL26028. 1 PublicationCurated
Sequence conflicti325 – 3251C → Y in AAI20616. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF264051 Genomic DNA. Translation: AAL26028.1.
BC120615 mRNA. Translation: AAI20616.1.
AL731840 Genomic DNA. Translation: CAM25807.1.
CCDSiCCDS16556.1.
RefSeqiNP_991352.2. NM_205783.2.
XP_006499162.1. XM_006499099.1.
UniGeneiMm.297624.

Genome annotation databases

EnsembliENSMUST00000099589; ENSMUSP00000097185; ENSMUSG00000074939.
GeneIDi213788.
KEGGimmu:213788.
UCSCiuc008lpd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF264051 Genomic DNA. Translation: AAL26028.1 .
BC120615 mRNA. Translation: AAI20616.1 .
AL731840 Genomic DNA. Translation: CAM25807.1 .
CCDSi CCDS16556.1.
RefSeqi NP_991352.2. NM_205783.2.
XP_006499162.1. XM_006499099.1.
UniGenei Mm.297624.

3D structure databases

ProteinModelPortali Q920H4.
SMRi Q920H4. Positions 27-240, 439-507.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q920H4.
ChEMBLi CHEMBL2097162.
GuidetoPHARMACOLOGYi 17.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q920H4.

Proteomic databases

PRIDEi Q920H4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000099589 ; ENSMUSP00000097185 ; ENSMUSG00000074939 .
GeneIDi 213788.
KEGGi mmu:213788.
UCSCi uc008lpd.2. mouse.

Organism-specific databases

CTDi 1133.
MGIi MGI:109248. Chrm5.

Phylogenomic databases

eggNOGi NOG250863.
GeneTreei ENSGT00760000119165.
HOGENOMi HOG000231484.
HOVERGENi HBG105720.
InParanoidi Q920H4.
KOi K04133.
OMAi YDTPKYF.
OrthoDBi EOG7V49Z7.
TreeFami TF320495.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 374108.
PROi Q920H4.
SOURCEi Search...

Gene expression databases

Bgeei Q920H4.
CleanExi MM_CHRM5.
Genevestigatori Q920H4.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000502. Musac_Ach_M5_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view ]
PANTHERi PTHR24249:SF58. PTHR24249:SF58. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00542. MUSCRINICM5R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, sequence and functional expression of the mouse M1-M5 muscarinic acetylcholine receptor genes."
    Yamada M., Wess J.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiACM5_MOUSE
AccessioniPrimary (citable) accession number: Q920H4
Secondary accession number(s): A2AHU3, Q0VBI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3