Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Germ cell-less protein-like 1

Gene

Gmcl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport.

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • regulation of transcription, DNA-templated Source: MGI
  • spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Germ cell-less protein-like 1
Short name:
mGcl-1
Alternative name(s):
DP-interacting protein
Short name:
DIP
Gene namesi
Name:Gmcl1
Synonyms:Gcl, Gcl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1345156. Gmcl1.

Subcellular locationi

GO - Cellular componenti

  • nuclear envelope Source: MGI
  • nuclear matrix Source: MGI
  • ubiquitin ligase complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000875211 – 524Germ cell-less protein-like 1Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphoserineCombined sources1
Modified residuei66PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ920G9.
PaxDbiQ920G9.
PRIDEiQ920G9.

PTM databases

iPTMnetiQ920G9.
PhosphoSitePlusiQ920G9.

Expressioni

Tissue specificityi

Ubiquitously expressed at low levels throughout development and in adult tissues.

Developmental stagei

Highest levels in pachytene and diplotene stage spermatocytes and primordial germ cells of the male and the female.

Gene expression databases

BgeeiENSMUSG00000001157.
CleanExiMM_GMCL1.
ExpressionAtlasiQ920G9. baseline and differential.
GenevisibleiQ920G9. MM.

Interactioni

Subunit structurei

Interacts with TMPO-Beta, TSG101 and TFDP2. Interacts with EMD (By similarity).By similarity

Protein-protein interaction databases

BioGridi204775. 5 interactors.
DIPiDIP-24259N.
STRINGi10090.ENSMUSP00000001185.

Structurei

3D structure databases

ProteinModelPortaliQ920G9.
SMRiQ920G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 176BTBPROSITE-ProRule annotationAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi47 – 53Nuclear localization signalSequence analysis7
Motifi83 – 89Nuclear localization signalSequence analysis7

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4682. Eukaryota.
ENOG410XPEJ. LUCA.
GeneTreeiENSGT00390000003212.
HOGENOMiHOG000232133.
HOVERGENiHBG051741.
InParanoidiQ920G9.
KOiK10485.
OMAiKWRWTGF.
OrthoDBiEOG091G07ZV.
PhylomeDBiQ920G9.
TreeFamiTF316048.

Family and domain databases

InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q920G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALSSRVLR PAGRTEQPEP TPGAGGAARR SDAGEDAGHS FCYCPGGRKR
60 70 80 90 100
KRSSGTFCYC HPDSETDDDE DEGDEQQRLL NTPRRKKLKS TSKYIYQTLF
110 120 130 140 150
LNGENSDIKI CALGEEWSLH KIYLCQSGYF SSMFSGSWKE SSMNIIELEI
160 170 180 190 200
PDQNIDIEAL QVAFGSLYRD DVLIKPSRVV AILAAACMLQ LDGLIQQCGE
210 220 230 240 250
TMKETISVRT VCGYYTSAGT YGLDSVKKKC LEWLLNNLMT HQSVELFKEL
260 270 280 290 300
SINVMKQLIG SSNLFVMQVE MDVYTALKKW MFLQLVPSWN GSLKQLLTET
310 320 330 340 350
DVWFSKWKKD FEGTTFLETE QGKPFAPVFR HLRLQYIISD LASARIIEQD
360 370 380 390 400
SLVPSEWLAA VYKQQWLAML RAEQDSEVGP QEINKEELEG NSMRCGRKLA
410 420 430 440 450
KDGEYCWRWT GFNFGFDLLV TYTNRYIIFK RNTLNQPCSG SVSLQPRRSI
460 470 480 490 500
AFRLRLASFD SSGKLICSRA TGYQILTLEK DQEQVVMNLD SRLLIFPLYI
510 520
CCNFLYISPE KRTESNRHPE NPGH
Length:524
Mass (Da):59,654
Last modified:May 24, 2004 - v2
Checksum:i3DCC974A758D14C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151P → L in AAK69515 (PubMed:11591818).Curated1
Sequence conflicti177S → N in AAK69515 (PubMed:11591818).Curated1
Sequence conflicti192D → N in AAK69515 (PubMed:11591818).Curated1
Sequence conflicti198C → W in AAK69515 (PubMed:11591818).Curated1
Sequence conflicti386E → G in BAB23499 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163665 mRNA. Translation: AAD52204.1.
AF186095 mRNA. Translation: AAF01415.1.
AF282322 mRNA. Translation: AAK69515.1.
AK004716 mRNA. Translation: BAB23499.1.
BC054767 mRNA. Translation: AAH54767.1.
CCDSiCCDS20316.1.
PIRiJC7090.
RefSeqiNP_035948.3. NM_011818.3.
UniGeneiMm.321452.

Genome annotation databases

EnsembliENSMUST00000001185; ENSMUSP00000001185; ENSMUSG00000001157.
GeneIDi23885.
KEGGimmu:23885.
UCSCiuc009csl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163665 mRNA. Translation: AAD52204.1.
AF186095 mRNA. Translation: AAF01415.1.
AF282322 mRNA. Translation: AAK69515.1.
AK004716 mRNA. Translation: BAB23499.1.
BC054767 mRNA. Translation: AAH54767.1.
CCDSiCCDS20316.1.
PIRiJC7090.
RefSeqiNP_035948.3. NM_011818.3.
UniGeneiMm.321452.

3D structure databases

ProteinModelPortaliQ920G9.
SMRiQ920G9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204775. 5 interactors.
DIPiDIP-24259N.
STRINGi10090.ENSMUSP00000001185.

PTM databases

iPTMnetiQ920G9.
PhosphoSitePlusiQ920G9.

Proteomic databases

EPDiQ920G9.
PaxDbiQ920G9.
PRIDEiQ920G9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001185; ENSMUSP00000001185; ENSMUSG00000001157.
GeneIDi23885.
KEGGimmu:23885.
UCSCiuc009csl.2. mouse.

Organism-specific databases

CTDi64395.
MGIiMGI:1345156. Gmcl1.

Phylogenomic databases

eggNOGiKOG4682. Eukaryota.
ENOG410XPEJ. LUCA.
GeneTreeiENSGT00390000003212.
HOGENOMiHOG000232133.
HOVERGENiHBG051741.
InParanoidiQ920G9.
KOiK10485.
OMAiKWRWTGF.
OrthoDBiEOG091G07ZV.
PhylomeDBiQ920G9.
TreeFamiTF316048.

Miscellaneous databases

PROiQ920G9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001157.
CleanExiMM_GMCL1.
ExpressionAtlasiQ920G9. baseline and differential.
GenevisibleiQ920G9. MM.

Family and domain databases

InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGMCL1_MOUSE
AccessioniPrimary (citable) accession number: Q920G9
Secondary accession number(s): Q9DBW5, Q9QUP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.