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Protein

Mitoferrin-1

Gene

Slc25a37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe2+, is then probably delivered to ferrochelatase to catalyze Fe2+ incorporation into protoprophyrin IX to make heme.1 Publication

GO - Molecular functioni

  • ferrous iron transmembrane transporter activity Source: Reactome
  • iron ion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • iron ion homeostasis Source: UniProtKB-KW
  • mitochondrial iron ion transport Source: UniProtKB
  • small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

ReactomeiR-MMU-1362409. Mitochondrial iron-sulfur cluster biogenesis.

Protein family/group databases

TCDBi2.A.29.5.5. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitoferrin-1
Alternative name(s):
Mitochondrial iron transporter 1
Mitochondrial solute carrier protein
Solute carrier family 25 member 37
Gene namesi
Name:Slc25a37
Synonyms:Mfrn, Mscp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1914962. Slc25a37.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 64Helical; Name=1Sequence analysisAdd BLAST20
Transmembranei106 – 125Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei143 – 162Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei200 – 219Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei234 – 253Helical; Name=5Sequence analysisAdd BLAST20
Transmembranei301 – 320Helical; Name=6Sequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352521 – 338Mitoferrin-1Add BLAST338

Proteomic databases

PaxDbiQ920G8.
PRIDEiQ920G8.

PTM databases

PhosphoSitePlusiQ920G8.

Expressioni

Tissue specificityi

Highly expressed in hematopoietic organs, fetal liver, bone marrow and spleen.2 Publications

Developmental stagei

In the developing embryo, it is first detected at embryonic day 7.5 (E7.5) in the extraembryonic yolk sac, coincident with the appearance of blood islands. Later, restricted expression is seen in E14.5 fetal liver, the primary source of erythrocyte production in mid-gestation. Expression decreases in the spleen around 4-5 weeks of age, suggesting that it is decreased during splenic lymphocyte maturation.1 Publication

Gene expression databases

BgeeiENSMUSG00000034248.
CleanExiMM_SLC25A37.
ExpressionAtlasiQ920G8. baseline and differential.
GenevisibleiQ920G8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039990.

Structurei

3D structure databases

ProteinModelPortaliQ920G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 131Solcar 1Add BLAST89
Repeati141 – 225Solcar 2Add BLAST85
Repeati232 – 326Solcar 3Add BLAST95

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0760. Eukaryota.
ENOG410XNT2. LUCA.
GeneTreeiENSGT00550000074721.
HOGENOMiHOG000038810.
HOVERGENiHBG079464.
InParanoidiQ920G8.
KOiK15113.
OMAiPRRDYNP.
OrthoDBiEOG091G0PU8.
PhylomeDBiQ920G8.
TreeFamiTF314118.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q920G8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELRRGGVGN QAAGRRMDGD CRDGGCGSKD AGSEDYENLP TSASVSTHMT
60 70 80 90 100
AGAMAGILEH SIMYPVDSVK TRMQSLNPDP KARYTSIYGA LKRIMHTEGF
110 120 130 140 150
WRPLRGLNVM MMGAGPAHAM YFACYENMKR TLNDVFSHQG NSHLANGVAG
160 170 180 190 200
SMATLLHDAV MNPAEVVKQR LQMYNSQHQS AFSCIRTVWR TEGLGAFYRS
210 220 230 240 250
YTTQLTMNIP FQSIHFITYE FLQEQVNPRR DYNPQSHIIS GGLAGALAAA
260 270 280 290 300
ATTPLDVCKT LLNTQENMAL SLANVSGRLS GMANAFRTVY QLNGLAGYFK
310 320 330
GIQARVIYQM PSTAISWSVY EFFKYILTKR QLENRTLY
Length:338
Mass (Da):37,510
Last modified:December 1, 2001 - v1
Checksum:iBB35B1F70C56A3FE
GO
Isoform 2 (identifier: Q920G8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-182: VAGSMATLLHDAVMNPAEVVKQRLQMYNSQHQSAF → ILKAFVWSWEALLSGASSPGPSNLHPRQTENSRVT
     183-338: Missing.

Show »
Length:182
Mass (Da):19,838
Checksum:i18E2C5E801228693
GO
Isoform 3 (identifier: Q920G8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-112: TRMQSLNPDP...PLRGLNVMMM → GHCSASLNLK...AQLVVGTEVL
     113-338: Missing.

Note: No experimental confirmation available.
Show »
Length:112
Mass (Da):11,616
Checksum:iD001C82BEE13BBFB
GO
Isoform 4 (identifier: Q920G8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-81: TRMQSLNPDPK → MDYLSPEKRIY
     82-338: Missing.

Note: No experimental confirmation available.
Show »
Length:81
Mass (Da):8,673
Checksum:i658FB174AEEA27FB
GO
Isoform 5 (identifier: Q920G8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-108: TRMQSLNPDP...GFWRPLRGLN → GHCSASLNLK...SLPNAQDIGK
     109-338: Missing.

Note: No experimental confirmation available.
Show »
Length:108
Mass (Da):11,219
Checksum:iF5491966426FFD83
GO

Sequence cautioni

The sequence BAB29978 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC25649 differs from that shown. Reason: Frameshift at positions 141 and 196.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115G → R in BAC25649 (PubMed:16141072).Curated1
Sequence conflicti138H → P in BAC25649 (PubMed:16141072).Curated1
Sequence conflicti141N → T in BAC25649 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01840571 – 112TRMQS…NVMMM → GHCSASLNLKFINSARMVGP TASWMGLSSLPNAQLVVGTE VL in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_01840671 – 108TRMQS…LRGLN → GHCSASLNLKFINSARMVGP TASWMGLSSLPNAQDIGK in isoform 5. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_01840771 – 81TRMQSLNPDPK → MDYLSPEKRIY in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_01840882 – 338Missing in isoform 4. 1 PublicationAdd BLAST257
Alternative sequenceiVSP_018409109 – 338Missing in isoform 5. 1 PublicationAdd BLAST230
Alternative sequenceiVSP_018410113 – 338Missing in isoform 3. 1 PublicationAdd BLAST226
Alternative sequenceiVSP_018411148 – 182VAGSM…HQSAF → ILKAFVWSWEALLSGASSPG PSNLHPRQTENSRVT in isoform 2. 2 PublicationsAdd BLAST35
Alternative sequenceiVSP_018412183 – 338Missing in isoform 2. 2 PublicationsAdd BLAST156

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288621 mRNA. Translation: AAL23859.1.
AF361699 mRNA. Translation: AAL27990.1.
AK015790 mRNA. Translation: BAB29978.1. Different initiation.
AK019700 mRNA. Translation: BAB31839.2.
AK021203 mRNA. Translation: BAC25649.1. Frameshift.
AK050414 mRNA. Translation: BAC34243.1.
AK086749 mRNA. Translation: BAC39735.1.
CCDSiCCDS27238.1. [Q920G8-1]
RefSeqiNP_080607.2. NM_026331.3. [Q920G8-1]
UniGeneiMm.291443.
Mm.293635.
Mm.489765.

Genome annotation databases

EnsembliENSMUST00000037064; ENSMUSP00000039990; ENSMUSG00000034248. [Q920G8-1]
ENSMUST00000179116; ENSMUSP00000135940; ENSMUSG00000093954. [Q920G8-4]
ENSMUST00000183695; ENSMUSP00000138883; ENSMUSG00000093954. [Q920G8-3]
ENSMUST00000183840; ENSMUSP00000138845; ENSMUSG00000093954. [Q920G8-5]
ENSMUST00000184816; ENSMUSP00000138904; ENSMUSG00000093954. [Q920G8-3]
ENSMUST00000184914; ENSMUSP00000139104; ENSMUSG00000034248. [Q920G8-2]
GeneIDi67712.
KEGGimmu:67712.
UCSCiuc029sla.1. mouse. [Q920G8-1]
uc029sll.1. mouse. [Q920G8-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288621 mRNA. Translation: AAL23859.1.
AF361699 mRNA. Translation: AAL27990.1.
AK015790 mRNA. Translation: BAB29978.1. Different initiation.
AK019700 mRNA. Translation: BAB31839.2.
AK021203 mRNA. Translation: BAC25649.1. Frameshift.
AK050414 mRNA. Translation: BAC34243.1.
AK086749 mRNA. Translation: BAC39735.1.
CCDSiCCDS27238.1. [Q920G8-1]
RefSeqiNP_080607.2. NM_026331.3. [Q920G8-1]
UniGeneiMm.291443.
Mm.293635.
Mm.489765.

3D structure databases

ProteinModelPortaliQ920G8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039990.

Protein family/group databases

TCDBi2.A.29.5.5. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSitePlusiQ920G8.

Proteomic databases

PaxDbiQ920G8.
PRIDEiQ920G8.

Protocols and materials databases

DNASUi67712.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037064; ENSMUSP00000039990; ENSMUSG00000034248. [Q920G8-1]
ENSMUST00000179116; ENSMUSP00000135940; ENSMUSG00000093954. [Q920G8-4]
ENSMUST00000183695; ENSMUSP00000138883; ENSMUSG00000093954. [Q920G8-3]
ENSMUST00000183840; ENSMUSP00000138845; ENSMUSG00000093954. [Q920G8-5]
ENSMUST00000184816; ENSMUSP00000138904; ENSMUSG00000093954. [Q920G8-3]
ENSMUST00000184914; ENSMUSP00000139104; ENSMUSG00000034248. [Q920G8-2]
GeneIDi67712.
KEGGimmu:67712.
UCSCiuc029sla.1. mouse. [Q920G8-1]
uc029sll.1. mouse. [Q920G8-4]

Organism-specific databases

CTDi51312.
MGIiMGI:1914962. Slc25a37.

Phylogenomic databases

eggNOGiKOG0760. Eukaryota.
ENOG410XNT2. LUCA.
GeneTreeiENSGT00550000074721.
HOGENOMiHOG000038810.
HOVERGENiHBG079464.
InParanoidiQ920G8.
KOiK15113.
OMAiPRRDYNP.
OrthoDBiEOG091G0PU8.
PhylomeDBiQ920G8.
TreeFamiTF314118.

Enzyme and pathway databases

ReactomeiR-MMU-1362409. Mitochondrial iron-sulfur cluster biogenesis.

Miscellaneous databases

ChiTaRSiSlc25a37. mouse.
PROiQ920G8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034248.
CleanExiMM_SLC25A37.
ExpressionAtlasiQ920G8. baseline and differential.
GenevisibleiQ920G8. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMFRN1_MOUSE
AccessioniPrimary (citable) accession number: Q920G8
Secondary accession number(s): Q8C367
, Q8CEJ7, Q91ZY0, Q9D2G3, Q9D547
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.