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Protein

Src kinase-associated phosphoprotein 2

Gene

Skap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

B-cell activation

Enzyme and pathway databases

ReactomeiR-RNO-391160. Signal regulatory protein (SIRP) family interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Src kinase-associated phosphoprotein 2
Alternative name(s):
SKAP55 homolog
Short name:
SKAP-55HOM
Short name:
SKAP-HOM
Short name:
SKAP55-HOM
Src family-associated phosphoprotein 2
Src kinase-associated phosphoprotein 55-related protein
Gene namesi
Name:Skap2
Synonyms:Scap2, Skap55r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620159. Skap2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Src kinase-associated phosphoprotein 2PRO_0000270182Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61PhosphoserineCombined sources
Modified residuei9 – 91PhosphoserineCombined sources
Modified residuei75 – 751PhosphotyrosineBy similarity
Modified residuei87 – 871PhosphoserineCombined sources
Modified residuei90 – 901PhosphoserineCombined sources
Modified residuei151 – 1511PhosphotyrosineBy similarity
Modified residuei197 – 1971PhosphotyrosineBy similarity
Modified residuei223 – 2231PhosphoserineCombined sources
Modified residuei260 – 2601PhosphotyrosineBy similarity
Modified residuei272 – 2721PhosphoserineCombined sources
Modified residuei282 – 2821PhosphoserineCombined sources
Modified residuei285 – 2851PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ920G0.
PRIDEiQ920G0.

PTM databases

iPTMnetiQ920G0.

Expressioni

Gene expression databases

GenevisibleiQ920G0. RN.

Interactioni

Subunit structurei

Interacts with FYB, which is required for SKAP2 protein stability. Interacts with PTPNS1. Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3. Interacts with LAT, GRB2, PTK2B, and PRAM1. May interact with actin. May interact with FYN, HCK and LYN. Interacts with FASLG (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016608.

Structurei

3D structure databases

ProteinModelPortaliQ920G0.
SMRiQ920G0. Positions 14-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 219104PHPROSITE-ProRule annotationAdd
BLAST
Domaini296 – 35762SH3PROSITE-ProRule annotationAdd
BLAST

Domaini

The SH3 domain interacts with FYB and PTK2B.By similarity

Sequence similaritiesi

Belongs to the SKAP family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiENOG410IH8Q. Eukaryota.
ENOG410ZVZV. LUCA.
GeneTreeiENSGT00390000017856.
HOGENOMiHOG000231109.
HOVERGENiHBG052827.
InParanoidiQ920G0.
OMAiCFEICAP.
OrthoDBiEOG7K6PVB.
PhylomeDBiQ920G0.
TreeFamiTF331055.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00233. PH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q920G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNPGSTSSP GSIPEEIRNL LADVETFVAD TLKGENLSKK AKEKRDSLIK
60 70 80 90 100
KIKDVKSVYP QEFQDKGDAE EGDEYDDPFA GPPDTISLAS ERYDKDDDGP
110 120 130 140 150
SDGNQFPPIA AQDLSFVIKA GYLEKRRKDH SFLGFEWQKR WCALSKTVFY
160 170 180 190 200
YYGSDKDKQQ KGEFAIEGYD VRMNNTLRKD AKKDCCFEIC APDKRIYQFT
210 220 230 240 250
AASPKDAEEW VQQLKFILQD MGSDVIPEDE DEKGDLYDDV DHPVPVSSPQ
260 270 280 290 300
RSQPIDDEIY EELPEEEEDT ASVKMDEQGK GSRDSVQHPS GDKSTDYANF
310 320 330 340 350
YQGLWDCTGS LSDELSFKRG DVIYILSKEY NRYGWWVGEM QGAIGLVPKA

YLMEMYDI
Length:358
Mass (Da):40,717
Last modified:December 1, 2001 - v1
Checksum:iB2E5374860C9D9EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302132 mRNA. Translation: AAK97262.1.
BC070949 mRNA. Translation: AAH70949.1.
RefSeqiNP_569097.1. NM_130413.1.
XP_006236539.1. XM_006236477.2.
XP_006236540.1. XM_006236478.2.
UniGeneiRn.162747.

Genome annotation databases

EnsembliENSRNOT00000016608; ENSRNOP00000016608; ENSRNOG00000012228.
GeneIDi155183.
KEGGirno:155183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302132 mRNA. Translation: AAK97262.1.
BC070949 mRNA. Translation: AAH70949.1.
RefSeqiNP_569097.1. NM_130413.1.
XP_006236539.1. XM_006236477.2.
XP_006236540.1. XM_006236478.2.
UniGeneiRn.162747.

3D structure databases

ProteinModelPortaliQ920G0.
SMRiQ920G0. Positions 14-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016608.

PTM databases

iPTMnetiQ920G0.

Proteomic databases

PaxDbiQ920G0.
PRIDEiQ920G0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016608; ENSRNOP00000016608; ENSRNOG00000012228.
GeneIDi155183.
KEGGirno:155183.

Organism-specific databases

CTDi8935.
RGDi620159. Skap2.

Phylogenomic databases

eggNOGiENOG410IH8Q. Eukaryota.
ENOG410ZVZV. LUCA.
GeneTreeiENSGT00390000017856.
HOGENOMiHOG000231109.
HOVERGENiHBG052827.
InParanoidiQ920G0.
OMAiCFEICAP.
OrthoDBiEOG7K6PVB.
PhylomeDBiQ920G0.
TreeFamiTF331055.

Enzyme and pathway databases

ReactomeiR-RNO-391160. Signal regulatory protein (SIRP) family interactions.

Miscellaneous databases

PROiQ920G0.

Gene expression databases

GenevisibleiQ920G0. RN.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00233. PH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Src kinase-associated phosphoprotein homolog (SKAP55-HOM) in signaling from the high affinity IgE receptor aggregation."
    Sada K., Hong S., Siraganian R.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; SER-9; SER-87; SER-90; SER-223; SER-272; SER-282 AND SER-285, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSKAP2_RAT
AccessioniPrimary (citable) accession number: Q920G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.