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Protein

KH domain-containing, RNA-binding, signal transduction-associated protein 2

Gene

Khdrbs2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis (By similarity). Binds both poly(A) and poly(U) homopolymers (By similarity). Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-8849468 PTK6 Regulates Proteins Involved in RNA Processing

Names & Taxonomyi

Protein namesi
Recommended name:
KH domain-containing, RNA-binding, signal transduction-associated protein 2
Alternative name(s):
Sam68-like mammalian protein 1
Short name:
SLM-1
Short name:
rSLM-1
Gene namesi
Name:Khdrbs2
Synonyms:Slm1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi621738 Khdrbs2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003089551 – 349KH domain-containing, RNA-binding, signal transduction-associated protein 2Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230Omega-N-methylarginineBy similarity1
Modified residuei240Omega-N-methylarginineBy similarity1

Post-translational modificationi

Methylated.By similarity
Phosphorylated on tyrosine residues by FYN. Tyrosine phosphorylated by PTK6 and SRC (By similarity). Tyrosine phosphorylated by SRC during mitosis (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ920F3
PRIDEiQ920F3

PTM databases

CarbonylDBiQ920F3
iPTMnetiQ920F3
PhosphoSitePlusiQ920F3

Expressioni

Tissue specificityi

Expressed in the cortex, cerebellum, striatum, midbrain, brainstem and thalamus of the brain (at protein level). Expressed in neurons (at protein level). Expressed in brain and testis. Expressed in the dentate gyrus of the hippocampus.1 Publication

Gene expression databases

BgeeiENSRNOG00000012284
GenevisibleiQ920F3 RN

Interactioni

Subunit structurei

Self-associates to form homooligomers. Interacts with SAFB, SFRS9 and YTHDC1. Found in a complex with KHDRBS1, KHDRBS2 and KHDRBS3. Interacts with RBMX (By similarity). Interacts with the SH3 domains of FYN and PLCG1 (By similarity). Interacts with the SH2 domains of FYN, GRAP2, PLCG1 and RASA1 (By similarity). Interacts with RBMX.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016579

Structurei

3D structure databases

ProteinModelPortaliQ920F3
SMRiQ920F3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 135KHPROSITE-ProRule annotationAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 264Pro-richAdd BLAST54

Sequence similaritiesi

Belongs to the KHDRBS family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG1588 Eukaryota
COG5176 LUCA
GeneTreeiENSGT00550000074434
HOGENOMiHOG000230771
HOVERGENiHBG079164
InParanoidiQ920F3
KOiK17843
OMAiEAYDNSY
OrthoDBiEOG091G0EED
PhylomeDBiQ920F3
TreeFamiTF314878

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR032571 Qua1_dom
IPR032335 Sam68-YY
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF16274 Qua1, 1 hit
PF16568 Sam68-YY, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SUPFAMiSSF54791 SSF54791, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q920F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEEKYLPEL MAEKDSLDPS FVHASRLLAE EIEKFQGSDG RKEDEEKKYL
60 70 80 90 100
DVISNKNIKL SERVLIPVKQ YPKFNFVGKL LGPRGNSLKR LQEETGAKMS
110 120 130 140 150
ILGKGSMRDK AKEEELRKSG EAKYAHLSDE LHVLIEVFAP PGEAYSRMSH
160 170 180 190 200
ALEEIKKFLV PDYNDEIRQE QLRELSYLNG SEESGRGRGI RGRGIRITPT
210 220 230 240 250
APSRGRGGAV PPPPPPGRGV LTPRGTTVTR GALPVPPVAR GVPTPRARGT
260 270 280 290 300
AAVPGYRAPP PPAPEAYEEY GYDDGYGGEY DDQTYEAYDN SYVTPTQSVP
310 320 330 340
EYYDYGHGVN EDAYDSYAPE EWTTTRSSLK APPPRSARGG YREHPYGRY
Length:349
Mass (Da):38,854
Last modified:December 1, 2001 - v1
Checksum:iB8566F0211C1D942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305618 mRNA Translation: AAL09360.1
RefSeqiNP_579852.1, NM_133318.1
UniGeneiRn.154423

Genome annotation databases

EnsembliENSRNOT00000016578; ENSRNOP00000016579; ENSRNOG00000012284
GeneIDi170843
KEGGirno:170843
UCSCiRGD:621738 rat

Similar proteinsi

Entry informationi

Entry nameiKHDR2_RAT
AccessioniPrimary (citable) accession number: Q920F3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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