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Protein

Farnesyl pyrophosphate synthase

Gene

Fdps

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity).By similarity

Catalytic activityi

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Enzyme regulationi

Inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell (By similarity).By similarity

Pathwayi: farnesyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Geranylgeranyl pyrophosphate synthase (Ggps1), Farnesyl pyrophosphate synthase (Fdps)
This subpathway is part of the pathway farnesyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate, the pathway farnesyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Pathwayi: geranyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Geranylgeranyl pyrophosphate synthase (Ggps1), Farnesyl pyrophosphate synthase (Fdps)
This subpathway is part of the pathway geranyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate, the pathway geranyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57Isopentenyl diphosphateBy similarity1
Binding sitei60Isopentenyl diphosphateBy similarity1
Binding sitei96Isopentenyl diphosphateBy similarity1
Sitei98Important for determining product chain lengthBy similarity1
Sitei99Important for determining product chain lengthBy similarity1
Metal bindingi103Magnesium 1By similarity1
Metal bindingi103Magnesium 2By similarity1
Metal bindingi107Magnesium 1By similarity1
Metal bindingi107Magnesium 2By similarity1
Binding sitei112Dimethylallyl diphosphateBy similarity1
Binding sitei113Isopentenyl diphosphateBy similarity1
Binding sitei200Dimethylallyl diphosphateBy similarity1
Binding sitei201Dimethylallyl diphosphateBy similarity1
Binding sitei240Dimethylallyl diphosphateBy similarity1
Metal bindingi243Magnesium 3By similarity1
Binding sitei257Dimethylallyl diphosphateBy similarity1
Binding sitei266Dimethylallyl diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCholesterol biosynthesis, Cholesterol metabolism, Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-191273 Cholesterol biosynthesis
UniPathwayiUPA00259; UER00368
UPA00260; UER00369

Names & Taxonomyi

Protein namesi
Recommended name:
Farnesyl pyrophosphate synthase (EC:2.5.1.10)
Short name:
FPP synthase
Short name:
FPS
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Cholesterol-regulated 39 kDa protein
Short name:
CR 39
Dimethylallyltranstransferase (EC:2.5.1.1)
Farnesyl diphosphate synthase
Geranyltranstransferase
Gene namesi
Name:Fdps
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:104888 Fdps

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001239451 – 353Farnesyl pyrophosphate synthaseAdd BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ920E5
MaxQBiQ920E5
PaxDbiQ920E5
PRIDEiQ920E5
TopDownProteomicsiQ920E5

PTM databases

iPTMnetiQ920E5
PhosphoSitePlusiQ920E5
SwissPalmiQ920E5

Expressioni

Gene expression databases

BgeeiENSMUSG00000059743
CleanExiMM_FDPS
ExpressionAtlasiQ920E5 baseline and differential
GenevisibleiQ920E5 MM

Interactioni

Subunit structurei

Homodimer. Interacts with RSAD2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080531

Structurei

3D structure databases

ProteinModelPortaliQ920E5
SMRiQ920E5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

eggNOGiKOG0711 Eukaryota
COG0142 LUCA
GeneTreeiENSGT00900000141074
HOGENOMiHOG000160912
HOVERGENiHBG005741
InParanoidiQ920E5
KOiK00787
OMAiITAPEDH
OrthoDBiEOG091G0BPT
PhylomeDBiQ920E5
TreeFamiTF300897

Family and domain databases

Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR000092 Polyprenyl_synt
IPR033749 Polyprenyl_synt_CS
PfamiView protein in Pfam
PF00348 polyprenyl_synt, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
PROSITEiView protein in PROSITE
PS00723 POLYPRENYL_SYNTHASE_1, 1 hit
PS00444 POLYPRENYL_SYNTHASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q920E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGNQKLDAY NQEKQNFIQH FSQIVKVLTE KELGHPEIGD AIARLKEVLE
60 70 80 90 100
YNALGGKYNR GLTVVQAFQE LVEPKKQDAE SLQRALTVGW CVELLQAFFL
110 120 130 140 150
VSDDIMDSSL TRRGQICWYQ KPGIGLDAIN DALLLEASIY RLLKFYCREQ
160 170 180 190 200
PYYLNLLELF LQSSYQTEIG QTLDLMTAPQ GHVDLGRYTE KRYKSIVKYK
210 220 230 240 250
TAFYSFYLPI AAAMYMAGID GEKEHANALK ILMEMGEFFQ VQDDYLDLFG
260 270 280 290 300
DPSVTGKVGT DIQDNKCSWL VVQCLLRASP QQRQILEENY GQKDPEKVAR
310 320 330 340 350
VKALYEALDL QSAFFKYEED SYNRLKSLIE QCSAPLPPSI FMELANKIYK

RRK
Length:353
Mass (Da):40,582
Last modified:December 1, 2001 - v1
Checksum:i9A3D7034ACAB576A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309508 mRNA Translation: AAL09445.1
AK088601 mRNA Translation: BAC40446.1
BC048497 mRNA Translation: AAH48497.1
CCDSiCCDS17488.1
RefSeqiNP_001240680.1, NM_001253751.1
NP_608219.1, NM_134469.4
UniGeneiMm.335450
Mm.39472
Mm.490094

Genome annotation databases

EnsembliENSMUST00000081848; ENSMUSP00000080531; ENSMUSG00000059743
ENSMUST00000196709; ENSMUSP00000142770; ENSMUSG00000059743
GeneIDi110196
KEGGimmu:110196
UCSCiuc008pxo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFPPS_MOUSE
AccessioniPrimary (citable) accession number: Q920E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health