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Q920E3

- KCNH5_MOUSE

UniProt

Q920E3 - KCNH5_MOUSE

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Protein
Potassium voltage-gated channel subfamily H member 5
Gene
Kcnh5, Eag2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current By similarity. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi550 – 668119cNMP
Add
BLAST

GO - Molecular functioni

  1. phosphorelay sensor kinase activity Source: InterPro
  2. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. potassium ion transmembrane transport Source: RefGenome
  2. regulation of G2/M transition of mitotic cell cycle Source: MGI
  3. regulation of membrane potential Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Calmodulin-binding, Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 5
Alternative name(s):
Ether-a-go-go potassium channel 2
Short name:
Eag2
Voltage-gated potassium channel subunit Kv10.2
Gene namesi
Name:Kcnh5
Synonyms:Eag2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:3584508. Kcnh5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 217217Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei218 – 23821Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Topological domaini239 – 2435Extracellular Reviewed prediction
Transmembranei244 – 26421Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini265 – 29127Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei292 – 31221Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Topological domaini313 – 3197Extracellular Reviewed prediction
Transmembranei320 – 34021Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini341 – 3466Cytoplasmic Reviewed prediction
Transmembranei347 – 36721Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Topological domaini368 – 41952Extracellular Reviewed prediction
Add
BLAST
Intramembranei420 – 44021Pore-forming; Name=Segment H5; Reviewed prediction
Add
BLAST
Topological domaini441 – 4466Extracellular Reviewed prediction
Transmembranei447 – 46721Helical; Name=Segment S6; Reviewed prediction
Add
BLAST
Topological domaini468 – 988521Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. integral component of plasma membrane Source: RefGenome
  3. intracellular Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 988988Potassium voltage-gated channel subfamily H member 5
PRO_0000054011Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi403 – 4031N-linked (GlcNAc...) Reviewed prediction
Cross-linki785 – 785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiQ920E3.

PTM databases

PhosphoSiteiQ920E3.

Expressioni

Gene expression databases

BgeeiQ920E3.
GenevestigatoriQ920E3.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ920E3.
SMRiQ920E3. Positions 26-135, 418-472, 478-689.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8673PAS
Add
BLAST
Domaini91 – 14353PAC
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni704 – 71512Calmodulin-binding Reviewed prediction
Add
BLAST
Regioni909 – 94840CAD (involved in subunit assembly) By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi432 – 4376Selectivity filter By similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2202.
GeneTreeiENSGT00680000099663.
HOGENOMiHOG000230794.
HOVERGENiHBG101348.
InParanoidiQ920E3.
KOiK04908.
OMAiGSTQSDP.
OrthoDBiEOG7QG43V.
TreeFamiTF313130.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003949. K_chnl_volt-dep_EAG.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01464. EAGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q920E3-1 [UniParc]FASTAAdd to Basket

« Hide

MPGGKRGLVA PQNTFLENIV RRSSESSFLL GNAQIVDWPV VYSNDGFCKL    50
SGYHRADVMQ KSSTCSFMYG ELTDKKTIEK VRQTFDNYES NCFEVLLYKK 100
NRTPVWFYMQ IAPIRNEHEK VVLFLCTFKD ITLFKQPIED DSTKGWTKFA 150
RLTRALTNSR SVLQQLTPMN KTETVHKHSR LAEVLQLGSD ILPQYKQEAP 200
KTPPHIILHY CAFKTTWDWV ILILTFYTAI MVPYNVSFKT KQNNIAWLVL 250
DSVVDVIFLV DIVLNFHTTF VGPGGEVISD PKLIRMNYLK TWFVIDLLSC 300
LPYDIINAFE NVDEGISSLF SSLKVVRLLR LGRVARKLDH YLEYGAAVLV 350
LLVCVFGLVA HWLACIWYSI GDYEVIDEVT NTIQIDSWLY QLALSIGTPY 400
RYNTSAGIWE GGPSKDSLYV SSLYFTMTSL TTIGFGNIAP TTDVEKMFSV 450
AMMMVGSLLY ATIFGNVTTI FQQMYANTNR YHEMLNNVRD FLKLYQVPKG 500
LSERVMDYIV STWSMSKGID TEKVLSICPK DMRADICVHL NRKVFNEHPA 550
FRLASDGCLR ALAVEFQTIH CAPGDLIYHA GESVDALCFV VSGSLEVIQD 600
EEVVAILGKG DVFGDIFWKE TTLAHACANV RALTYCDLHI IKREALLKVL 650
DFYTAFANSF SRNLTLTCNL RKRIIFRKIS DVKKEEEERL RQKNEVTLSI 700
PVDHPVRKLF QKFKQQKELR IQGSAQSDPE RSQLQVESRP LQNGASITGT 750
SVVTVSQITP IQTSLAYVKT SESLKQNNRD AMELKPNGGA EPKCLKVNSP 800
IRMKNGNGKG WLRLKNNMGA QEEKKEDWNN VTKAESMGLL SEDPKGSDSE 850
NSVTKNPLRK TDSCDSGITK SDLRLDKAGE ARSPLEHSPS QADVKHSFYP 900
IPEQALQTTL QEVKHELKED IQLLSCRMTA LEKQVAEILK LLSEKSVPQT 950
SSPKPQIPLQ VPPQIPCQDI FSVSRPESPE SDKDEINF 988
Length:988
Mass (Da):111,810
Last modified:July 27, 2011 - v3
Checksum:i8CC29099AFC4755A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti552 – 5521R → Q in BAC27869. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK032438 mRNA. Translation: BAC27869.1.
AC110175 Genomic DNA. No translation available.
AC131762 Genomic DNA. No translation available.
CT010432 Genomic DNA. No translation available.
AF309565 mRNA. Translation: AAL09442.1.
CCDSiCCDS25980.1.
RefSeqiNP_766393.2. NM_172805.3.
UniGeneiMm.44465.

Genome annotation databases

EnsembliENSMUST00000042299; ENSMUSP00000046864; ENSMUSG00000034402.
GeneIDi238271.
KEGGimmu:238271.
UCSCiuc007nwz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK032438 mRNA. Translation: BAC27869.1 .
AC110175 Genomic DNA. No translation available.
AC131762 Genomic DNA. No translation available.
CT010432 Genomic DNA. No translation available.
AF309565 mRNA. Translation: AAL09442.1 .
CCDSi CCDS25980.1.
RefSeqi NP_766393.2. NM_172805.3.
UniGenei Mm.44465.

3D structure databases

ProteinModelPortali Q920E3.
SMRi Q920E3. Positions 26-135, 418-472, 478-689.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q920E3.

Proteomic databases

PRIDEi Q920E3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042299 ; ENSMUSP00000046864 ; ENSMUSG00000034402 .
GeneIDi 238271.
KEGGi mmu:238271.
UCSCi uc007nwz.2. mouse.

Organism-specific databases

CTDi 27133.
MGIi MGI:3584508. Kcnh5.

Phylogenomic databases

eggNOGi COG2202.
GeneTreei ENSGT00680000099663.
HOGENOMi HOG000230794.
HOVERGENi HBG101348.
InParanoidi Q920E3.
KOi K04908.
OMAi GSTQSDP.
OrthoDBi EOG7QG43V.
TreeFami TF313130.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 383713.
PROi Q920E3.
SOURCEi Search...

Gene expression databases

Bgeei Q920E3.
Genevestigatori Q920E3.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003949. K_chnl_volt-dep_EAG.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
PR01464. EAGCHANNEL.
SMARTi SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Olfactory bulb.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Cloning of the mouse eag2 potassium channel."
    Saganich M.J., Vega-Saenz de Miera E.C., Rudy B.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-203.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiKCNH5_MOUSE
AccessioniPrimary (citable) accession number: Q920E3
Secondary accession number(s): E9QPM0, Q8C035
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi