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Protein

Proteinase-activated receptor 3

Gene

F2rl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
  • thrombin receptor activity Source: InterPro

GO - Biological processi

  • blood coagulation Source: UniProtKB-KW
  • response to wounding Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Blood coagulation, Hemostasis

Names & Taxonomyi

Protein namesi
Recommended name:
Proteinase-activated receptor 3
Short name:
PAR-3
Alternative name(s):
Coagulation factor II receptor-like 2
Thrombin receptor-like 2
Gene namesi
Name:F2rl2
Synonyms:Par3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620871. F2rl2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini38 – 9356ExtracellularSequence analysisAdd
BLAST
Transmembranei94 – 11421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini115 – 1239CytoplasmicSequence analysis
Transmembranei124 – 14421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini145 – 16622ExtracellularSequence analysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini188 – 20821CytoplasmicSequence analysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini230 – 25728ExtracellularSequence analysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini279 – 30022CytoplasmicSequence analysisAdd
BLAST
Transmembranei301 – 32121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini322 – 33817ExtracellularSequence analysisAdd
BLAST
Transmembranei339 – 35921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini360 – 3689CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 3716Removed for receptor activationBy similarityPRO_0000012760Add
BLAST
Chaini38 – 368331Proteinase-activated receptor 3PRO_0000012761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence analysis
Disulfide bondi164 ↔ 243PROSITE-ProRule annotation

Post-translational modificationi

A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei37 – 382Cleavage; by thrombinBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ920E1.
PRIDEiQ920E1.

PTM databases

PhosphoSiteiQ920E1.

Interactioni

Subunit structurei

Interacts with INSC/inscuteable and GPSM2.By similarity

Protein-protein interaction databases

IntActiQ920E1. 1 interaction.
MINTiMINT-4953365.
STRINGi10116.ENSRNOP00000024292.

Structurei

3D structure databases

ProteinModelPortaliQ920E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJUX. Eukaryota.
ENOG4111GWA. LUCA.
HOGENOMiHOG000116291.
HOVERGENiHBG105658.
InParanoidiQ920E1.
KOiK04235.
PhylomeDBiQ920E1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003943. Prot_act_rcpt_3.
IPR003912. Protea_act_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01428. PROTEASEAR.
PR01429. PROTEASEAR3.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q920E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMKVLILVG VRLLFLPTTV CQSGMKHVSD NSALTAESFN GNEHSFEEFP
60 70 80 90 100
LSDIEGWTGA TTTIKAKCPE ESITTLHVNN ATMGYLRSSL STKVIPAIYI
110 120 130 140 150
LVFVIGVPAN IVTLWKLSSR TKSICLVIFH TNLAIADLLF CVTLPFKIAY
160 170 180 190 200
HLNGNDWVFG EVMCRVTTVA FYGNMYCAIL ILTCMGINRY LATVHPFTYR
210 220 230 240 250
KLPKRNFTLL MCGVVWVMVV LYMLPLAILK QEYHLVQPGI TTCHDVHDTC
260 270 280 290 300
ESPLPFQFYY FVSLAFFGFL IPFVVSVFCY TTLIHKLNAQ DRKWLRYIKA
310 320 330 340 350
VLLILVIFTI CFAPTNIILI IHHANYYYSN TDSLYFMYLI ALCLGSLNSC
360
LDPFLYFIMS KIVDQLTS
Length:368
Mass (Da):41,796
Last modified:December 1, 2001 - v1
Checksum:iCE0E94EDA3B80EF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF310076 mRNA. Translation: AAL26789.1.
RefSeqiNP_445765.1. NM_053313.1.
UniGeneiRn.206020.

Genome annotation databases

GeneIDi29636.
KEGGirno:29636.
UCSCiRGD:620871. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF310076 mRNA. Translation: AAL26789.1.
RefSeqiNP_445765.1. NM_053313.1.
UniGeneiRn.206020.

3D structure databases

ProteinModelPortaliQ920E1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ920E1. 1 interaction.
MINTiMINT-4953365.
STRINGi10116.ENSRNOP00000024292.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ920E1.

Proteomic databases

PaxDbiQ920E1.
PRIDEiQ920E1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29636.
KEGGirno:29636.
UCSCiRGD:620871. rat.

Organism-specific databases

CTDi2151.
RGDi620871. F2rl2.

Phylogenomic databases

eggNOGiENOG410IJUX. Eukaryota.
ENOG4111GWA. LUCA.
HOGENOMiHOG000116291.
HOVERGENiHBG105658.
InParanoidiQ920E1.
KOiK04235.
PhylomeDBiQ920E1.

Miscellaneous databases

PROiQ920E1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003943. Prot_act_rcpt_3.
IPR003912. Protea_act_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01428. PROTEASEAR.
PR01429. PROTEASEAR3.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAR3_RAT
AccessioniPrimary (citable) accession number: Q920E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.