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Q920D5

- CASPC_RAT

UniProt

Q920D5 - CASPC_RAT

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Protein

Caspase-12

Gene

Casp12

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the activation cascade of caspases responsible for apoptosis execution.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei251 – 2511By similarity
Active sitei299 – 2991By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: RefGenome
  2. cysteine-type peptidase activity Source: RGD
  3. endopeptidase activity Source: RGD
  4. protease binding Source: RGD

GO - Biological processi

  1. aging Source: RGD
  2. apoptotic process Source: RGD
  3. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: RefGenome
  4. positive regulation of apoptotic process Source: RGD
  5. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  6. protein autoprocessing Source: RGD
  7. proteolysis Source: RGD
  8. response to anoxia Source: RGD
  9. response to cold Source: RGD
  10. response to drug Source: RGD
  11. response to endoplasmic reticulum stress Source: RGD
  12. response to ethanol Source: RGD
  13. response to inorganic substance Source: RGD
  14. response to iron(III) ion Source: RGD
  15. response to nicotine Source: RGD
  16. response to organonitrogen compound Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiC14.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-12 (EC:3.4.22.-)
Short name:
CASP-12
Gene namesi
Name:Casp12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621758. Casp12.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RGD
  2. endoplasmic reticulum Source: RGD
  3. intracellular membrane-bounded organelle Source: RGD
  4. nucleus Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 420Caspase-12PRO_0000317445
Propeptidei1 – ?Sequence AnalysisPRO_0000317444

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiQ920D5.
PRIDEiQ920D5.

Expressioni

Gene expression databases

GenevestigatoriQ920D5.

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by two subunits (Potential). May interact with TRAF2 (By similarity).By similarityCurated

Binary interactionsi

WithEntry#Exp.IntActNotes
DDX58O957864EBI-1374296,EBI-995350From a different organism.

Protein-protein interaction databases

DIPiDIP-29839N.
IntActiQ920D5. 2 interactions.
STRINGi10116.ENSRNOP00000010244.

Structurei

3D structure databases

ProteinModelPortaliQ920D5.
SMRiQ920D5. Positions 165-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9292CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated
Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG257064.
HOGENOMiHOG000234399.
HOVERGENiHBG076981.
InParanoidiQ920D5.
KOiK04741.
PhylomeDBiQ920D5.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q920D5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAKRTHERD PIYKIKGLAK DMLDGVFDDL MDKNVLNGDE LLKIGEGASL
60 70 80 90 100
ILSKAENLVE SFFEKTEMAG KIFAGHIANS DKQLSLQFPS DDEEDELQKM
110 120 130 140 150
FTPSSASESR GKVEDEEMEV NVGVAHASHL MLTVPQGIQS TEVQDSLKLC
160 170 180 190 200
SRDWFCTMKT ERAEEIYPVM EKEGRTRLAL IICNKKFDYL FDRDDAETDI
210 220 230 240 250
LNMKELLQNL GYSVVIKENL TAQEMETELM KFAGRPEHQS SDSTFLVFMS
260 270 280 290 300
HGILEGICGV KHRNKKPDVL HDDTIFTIFN NSNCPSLRNK PKILIMQACR
310 320 330 340 350
GRHTGTIWVS TSKGIATADT DEECVLSHRW NNSITKAHVE TDFIAFKSST
360 370 380 390 400
PHNISWKVGK SGSLFISKLI DCFKKYCWCY HLEEIFRKVQ YSFEVPGELT
410 420
QMPTIERVSM TRYFYLFPGN
Length:420
Mass (Da):47,837
Last modified:December 1, 2001 - v1
Checksum:iE00809BBC61461AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317633 mRNA. Translation: AAL26897.1.
RefSeqiNP_569106.1. NM_130422.1.
UniGeneiRn.81078.

Genome annotation databases

GeneIDi156117.
KEGGirno:156117.
UCSCiRGD:621758. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317633 mRNA. Translation: AAL26897.1 .
RefSeqi NP_569106.1. NM_130422.1.
UniGenei Rn.81078.

3D structure databases

ProteinModelPortali Q920D5.
SMRi Q920D5. Positions 165-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29839N.
IntActi Q920D5. 2 interactions.
STRINGi 10116.ENSRNOP00000010244.

Protein family/group databases

MEROPSi C14.013.

Proteomic databases

PaxDbi Q920D5.
PRIDEi Q920D5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 156117.
KEGGi rno:156117.
UCSCi RGD:621758. rat.

Organism-specific databases

CTDi 100506742.
RGDi 621758. Casp12.

Phylogenomic databases

eggNOGi NOG257064.
HOGENOMi HOG000234399.
HOVERGENi HBG076981.
InParanoidi Q920D5.
KOi K04741.
PhylomeDBi Q920D5.

Miscellaneous databases

NextBioi 620935.

Gene expression databases

Genevestigatori Q920D5.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProi IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
PRINTSi PR00376. IL1BCENZYME.
SMARTi SM00115. CASc. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of rat caspase-12 mRNA."
    Loisel T.P., Vaillancourt J., Roy S., Nicholson D.W.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCASPC_RAT
AccessioniPrimary (citable) accession number: Q920D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3