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Q920D5

- CASPC_RAT

UniProt

Q920D5 - CASPC_RAT

Protein

Caspase-12

Gene

Casp12

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Involved in the activation cascade of caspases responsible for apoptosis execution.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei251 – 2511By similarity
    Active sitei299 – 2991By similarity

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: RefGenome
    2. cysteine-type peptidase activity Source: RGD
    3. endopeptidase activity Source: RGD
    4. protease binding Source: RGD
    5. protein binding Source: IntAct

    GO - Biological processi

    1. aging Source: RGD
    2. apoptotic process Source: RGD
    3. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: RefGenome
    4. positive regulation of apoptotic process Source: RGD
    5. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
    6. protein autoprocessing Source: RGD
    7. proteolysis Source: RGD
    8. response to anoxia Source: RGD
    9. response to cold Source: RGD
    10. response to drug Source: RGD
    11. response to endoplasmic reticulum stress Source: RGD
    12. response to ethanol Source: RGD
    13. response to inorganic substance Source: RGD
    14. response to iron(III) ion Source: RGD
    15. response to nicotine Source: RGD
    16. response to organonitrogen compound Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiC14.013.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caspase-12 (EC:3.4.22.-)
    Short name:
    CASP-12
    Gene namesi
    Name:Casp12
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621758. Casp12.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. endoplasmic reticulum Source: RGD
    3. intracellular membrane-bounded organelle Source: RGD
    4. nucleus Source: RGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 420Caspase-12PRO_0000317445
    Propeptidei1 – ?Sequence AnalysisPRO_0000317444

    Keywords - PTMi

    Zymogen

    Proteomic databases

    PaxDbiQ920D5.
    PRIDEiQ920D5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ920D5.

    Interactioni

    Subunit structurei

    Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by two subunits Potential. May interact with TRAF2 By similarity.By similarityCurated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DDX58O957864EBI-1374296,EBI-995350From a different organism.

    Protein-protein interaction databases

    DIPiDIP-29839N.
    IntActiQ920D5. 2 interactions.
    STRINGi10116.ENSRNOP00000010244.

    Structurei

    3D structure databases

    ProteinModelPortaliQ920D5.
    SMRiQ920D5. Positions 165-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9292CARDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C14A family.Curated
    Contains 1 CARD domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG257064.
    HOGENOMiHOG000234399.
    HOVERGENiHBG076981.
    KOiK04741.
    PhylomeDBiQ920D5.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProiIPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
    PRINTSiPR00376. IL1BCENZYME.
    SMARTiSM00115. CASc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q920D5-1 [UniParc]FASTAAdd to Basket

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    MAAKRTHERD PIYKIKGLAK DMLDGVFDDL MDKNVLNGDE LLKIGEGASL    50
    ILSKAENLVE SFFEKTEMAG KIFAGHIANS DKQLSLQFPS DDEEDELQKM 100
    FTPSSASESR GKVEDEEMEV NVGVAHASHL MLTVPQGIQS TEVQDSLKLC 150
    SRDWFCTMKT ERAEEIYPVM EKEGRTRLAL IICNKKFDYL FDRDDAETDI 200
    LNMKELLQNL GYSVVIKENL TAQEMETELM KFAGRPEHQS SDSTFLVFMS 250
    HGILEGICGV KHRNKKPDVL HDDTIFTIFN NSNCPSLRNK PKILIMQACR 300
    GRHTGTIWVS TSKGIATADT DEECVLSHRW NNSITKAHVE TDFIAFKSST 350
    PHNISWKVGK SGSLFISKLI DCFKKYCWCY HLEEIFRKVQ YSFEVPGELT 400
    QMPTIERVSM TRYFYLFPGN 420
    Length:420
    Mass (Da):47,837
    Last modified:December 1, 2001 - v1
    Checksum:iE00809BBC61461AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF317633 mRNA. Translation: AAL26897.1.
    RefSeqiNP_569106.1. NM_130422.1.
    UniGeneiRn.81078.

    Genome annotation databases

    GeneIDi156117.
    KEGGirno:156117.
    UCSCiRGD:621758. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF317633 mRNA. Translation: AAL26897.1 .
    RefSeqi NP_569106.1. NM_130422.1.
    UniGenei Rn.81078.

    3D structure databases

    ProteinModelPortali Q920D5.
    SMRi Q920D5. Positions 165-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-29839N.
    IntActi Q920D5. 2 interactions.
    STRINGi 10116.ENSRNOP00000010244.

    Protein family/group databases

    MEROPSi C14.013.

    Proteomic databases

    PaxDbi Q920D5.
    PRIDEi Q920D5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 156117.
    KEGGi rno:156117.
    UCSCi RGD:621758. rat.

    Organism-specific databases

    CTDi 100506742.
    RGDi 621758. Casp12.

    Phylogenomic databases

    eggNOGi NOG257064.
    HOGENOMi HOG000234399.
    HOVERGENi HBG076981.
    KOi K04741.
    PhylomeDBi Q920D5.

    Miscellaneous databases

    NextBioi 620935.

    Gene expression databases

    Genevestigatori Q920D5.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProi IPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
    PRINTSi PR00376. IL1BCENZYME.
    SMARTi SM00115. CASc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of rat caspase-12 mRNA."
      Loisel T.P., Vaillancourt J., Roy S., Nicholson D.W.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCASPC_RAT
    AccessioniPrimary (citable) accession number: Q920D5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3