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Protein

Caspase-12

Gene

Casp12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the activation cascade of caspases responsible for apoptosis execution.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei251By similarity1
Active sitei299By similarity1

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: RGD
  • cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
  • cysteine-type peptidase activity Source: RGD
  • endopeptidase activity Source: RGD
  • protease binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • apoptotic process Source: RGD
  • cellular response to manganese ion Source: ParkinsonsUK-UCL
  • endoplasmic reticulum unfolded protein response Source: RGD
  • intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
  • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  • protein autoprocessing Source: RGD
  • proteolysis Source: RGD
  • response to anoxia Source: RGD
  • response to cold Source: RGD
  • response to drug Source: RGD
  • response to endoplasmic reticulum stress Source: RGD
  • response to ethanol Source: RGD
  • response to inorganic substance Source: RGD
  • response to iron(III) ion Source: RGD
  • response to nicotine Source: RGD
  • response to organonitrogen compound Source: RGD
  • self proteolysis Source: RGD

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis

Protein family/group databases

MEROPSiC14.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-12 (EC:3.4.22.-)
Short name:
CASP-12
Gene namesi
Name:Casp12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621758. Casp12.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000317445? – 420Caspase-12
PropeptideiPRO_00003174441 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein, Zymogen

Proteomic databases

PaxDbiQ920D5.
PRIDEiQ920D5.

PTM databases

iPTMnetiQ920D5.
PhosphoSitePlusiQ920D5.

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by two subunits (Potential). May interact with TRAF2 (By similarity).By similarityCurated

Binary interactionsi

WithEntry#Exp.IntActNotes
DDX58O957864EBI-1374296,EBI-995350From Homo sapiens.

GO - Molecular functioni

  • protease binding Source: RGD

Protein-protein interaction databases

DIPiDIP-29839N.
IntActiQ920D5. 5 interactors.
STRINGi10116.ENSRNOP00000010244.

Structurei

3D structure databases

ProteinModelPortaliQ920D5.
SMRiQ920D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92CARDPROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOGENOMiHOG000234399.
HOVERGENiHBG076981.
InParanoidiQ920D5.
KOiK04741.
PhylomeDBiQ920D5.

Family and domain databases

CDDicd00032. CASc. 1 hit.
InterProiView protein in InterPro
IPR001315. CARD.
IPR029030. Caspase-like_dom_sf.
IPR035713. Caspase_12.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom_sf.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
PANTHERiPTHR10454:SF134. PTHR10454:SF134. 1 hit.
PfamiView protein in Pfam
PF00619. CARD. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiView protein in SMART
SM00115. CASc. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiView protein in PROSITE
PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q920D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKRTHERD PIYKIKGLAK DMLDGVFDDL MDKNVLNGDE LLKIGEGASL
60 70 80 90 100
ILSKAENLVE SFFEKTEMAG KIFAGHIANS DKQLSLQFPS DDEEDELQKM
110 120 130 140 150
FTPSSASESR GKVEDEEMEV NVGVAHASHL MLTVPQGIQS TEVQDSLKLC
160 170 180 190 200
SRDWFCTMKT ERAEEIYPVM EKEGRTRLAL IICNKKFDYL FDRDDAETDI
210 220 230 240 250
LNMKELLQNL GYSVVIKENL TAQEMETELM KFAGRPEHQS SDSTFLVFMS
260 270 280 290 300
HGILEGICGV KHRNKKPDVL HDDTIFTIFN NSNCPSLRNK PKILIMQACR
310 320 330 340 350
GRHTGTIWVS TSKGIATADT DEECVLSHRW NNSITKAHVE TDFIAFKSST
360 370 380 390 400
PHNISWKVGK SGSLFISKLI DCFKKYCWCY HLEEIFRKVQ YSFEVPGELT
410 420
QMPTIERVSM TRYFYLFPGN
Length:420
Mass (Da):47,837
Last modified:December 1, 2001 - v1
Checksum:iE00809BBC61461AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317633 mRNA. Translation: AAL26897.1.
RefSeqiNP_569106.1. NM_130422.1.
UniGeneiRn.81078.

Genome annotation databases

GeneIDi156117.
KEGGirno:156117.
UCSCiRGD:621758. rat.

Similar proteinsi

Entry informationi

Entry nameiCASPC_RAT
AccessioniPrimary (citable) accession number: Q920D5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families