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Q920D5 (CASPC_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Caspase-12
Short name=CASP-12
EC=3.4.22.-
Gene names
Name:Casp12
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the activation cascade of caspases responsible for apoptosis execution By similarity.

Subunit structure

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by two subunits Potential. May interact with TRAF2 By similarity.

Sequence similarities

Belongs to the peptidase C14A family.

Contains 1 CARD domain.

Ontologies

Keywords
   Biological processApoptosis
   Molecular functionHydrolase
Protease
Thiol protease
   PTMZymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaging

Inferred from expression pattern PubMed 16139996. Source: RGD

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 17083921. Source: RGD

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from mutant phenotype PubMed 17083921. Source: RGD

protein autoprocessing

Inferred from direct assay PubMed 18332441. Source: RGD

proteolysis

Inferred from direct assay PubMed 18316105. Source: RGD

response to anoxia

Inferred from expression pattern PubMed 17083921. Source: RGD

response to cold

Inferred from expression pattern PubMed 18456407. Source: RGD

response to drug

Inferred from expression pattern PubMed 16236330. Source: RGD

response to endoplasmic reticulum stress

Inferred from expression pattern PubMed 16979584. Source: RGD

response to ethanol

Inferred from expression pattern PubMed 17433554. Source: RGD

response to iron(III) ion

Inferred from expression pattern PubMed 19594550. Source: RGD

response to nicotine

Inferred from expression pattern PubMed 18477628. Source: RGD

   Cellular_componentcytosol

Inferred from direct assay PubMed 18316105. Source: RGD

endoplasmic reticulum

Traceable author statement PubMed 12598725. Source: RGD

nucleus

Inferred from direct assay PubMed 18316105. Source: RGD

   Molecular_functioncysteine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

cysteine-type peptidase activity

Inferred from direct assay PubMed 18316105. Source: RGD

endopeptidase activity

Inferred from direct assay PubMed 18332441. Source: RGD

protease binding

Inferred from direct assay PubMed 18332441. Source: RGD

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

DDX58O957864EBI-1374296,EBI-995350From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – ? PotentialPRO_0000317444
Chain? – 420Caspase-12PRO_0000317445

Regions

Domain1 – 9292CARD

Sites

Active site2511 By similarity
Active site2991 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q920D5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: E00809BBC61461AC

FASTA42047,837
        10         20         30         40         50         60 
MAAKRTHERD PIYKIKGLAK DMLDGVFDDL MDKNVLNGDE LLKIGEGASL ILSKAENLVE 

        70         80         90        100        110        120 
SFFEKTEMAG KIFAGHIANS DKQLSLQFPS DDEEDELQKM FTPSSASESR GKVEDEEMEV 

       130        140        150        160        170        180 
NVGVAHASHL MLTVPQGIQS TEVQDSLKLC SRDWFCTMKT ERAEEIYPVM EKEGRTRLAL 

       190        200        210        220        230        240 
IICNKKFDYL FDRDDAETDI LNMKELLQNL GYSVVIKENL TAQEMETELM KFAGRPEHQS 

       250        260        270        280        290        300 
SDSTFLVFMS HGILEGICGV KHRNKKPDVL HDDTIFTIFN NSNCPSLRNK PKILIMQACR 

       310        320        330        340        350        360 
GRHTGTIWVS TSKGIATADT DEECVLSHRW NNSITKAHVE TDFIAFKSST PHNISWKVGK 

       370        380        390        400        410        420 
SGSLFISKLI DCFKKYCWCY HLEEIFRKVQ YSFEVPGELT QMPTIERVSM TRYFYLFPGN

« Hide

References

[1]"Cloning of rat caspase-12 mRNA."
Loisel T.P., Vaillancourt J., Roy S., Nicholson D.W.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF317633 mRNA. Translation: AAL26897.1.
IPIIPI00200423.
RefSeqNP_569106.1. NM_130422.1.
UniGeneRn.81078.

3D structure databases

HSSPHSSP built from PDB template 1SC4 based on UniProtKB P29466.
ProteinModelPortalQ920D5.
SMRQ920D5. Positions 165-308.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29839N.
IntActQ920D5. 2 interactions.
STRING10116.ENSRNOP00000010244.

Protein family/group databases

MEROPSC14.013.

Proteomic databases

PaxDbQ920D5.
PRIDEQ920D5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID156117.
KEGGrno:156117.
UCSCRGD:621758. rat.

Organism-specific databases

CTD100506742.
RGD621758. Casp12.

Phylogenomic databases

eggNOGNOG257064.
HOGENOMHOG000234399.
HOVERGENHBG076981.
KOK04741.
OrthoDBEOG4BP1C0.

Gene expression databases

ArrayExpressQ920D5.
GenevestigatorQ920D5.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
InterProIPR001315. CARD.
IPR017350. Caspase_IL-1_beta.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_cat.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR002398. Pept_C14_p45.
IPR015917. Pept_C14_p45_core.
[Graphical view]
PANTHERPTHR10454. PTHR10454. 1 hit.
PfamPF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFPIRSF038001. Caspase_ICE. 1 hit.
PRINTSPR00376. IL1BCENZYME.
SMARTSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMSSF47986. DEATH_like. 1 hit.
PROSITEPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio620935.

Entry information

Entry nameCASPC_RAT
AccessionPrimary (citable) accession number: Q920D5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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