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Q920C4

- MS4A3_MOUSE

UniProt

Q920C4 - MS4A3_MOUSE

Protein

Membrane-spanning 4-domains subfamily A member 3

Gene

Ms4a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP) By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 3
    Alternative name(s):
    Hematopoietic-specific transmembrane protein 4
    Short name:
    HTm4
    Gene namesi
    Name:Ms4a3
    Synonyms:Htm4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:2158468. Ms4a3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. integral component of membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213Membrane-spanning 4-domains subfamily A member 3PRO_0000158633Add
    BLAST

    Proteomic databases

    PRIDEiQ920C4.

    Expressioni

    Tissue specificityi

    Expressed at low levels only in specific immune tissues, such as, spleen, bone marrow and peripheral blood leukocytes.

    Gene expression databases

    ArrayExpressiQ920C4.
    BgeeiQ920C4.
    GenevestigatoriQ920C4.

    Interactioni

    Subunit structurei

    Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ920C4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini48 – 5811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini80 – 9718CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini119 – 14830ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini170 – 21344CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi59 – 646Poly-Phe

    Domaini

    The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.By similarity

    Sequence similaritiesi

    Belongs to the MS4A family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46884.
    GeneTreeiENSGT00730000111024.
    HOGENOMiHOG000113657.
    HOVERGENiHBG052512.
    InParanoidiQ920C4.
    OMAiSTVAMWC.
    OrthoDBiEOG7VHSZF.
    PhylomeDBiQ920C4.
    TreeFamiTF335157.

    Family and domain databases

    InterProiIPR007237. CD20-like.
    [Graphical view]
    PfamiPF04103. CD20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q920C4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPEETGGSV YQPLDESRHV QRGVLQALGA IQILNGILIL ALGIFLVCLQ    50
    HVSHHFRHFF FFTFYTGYPL WGAVFFISSG SLTVAAGRNP TRMLMQNSFG 100
    INIASTTIAF VGTVFLSVHL AFNTQAFKGC QSSPSPDVCI SLGSSSDGLV 150
    SLMLILTLLE LSVTISISAM WCLGNVCGLR EAITSPPNSV ESGILPEGSD 200
    SENLNTQPQA SEE 213
    Length:213
    Mass (Da):22,872
    Last modified:December 1, 2001 - v1
    Checksum:iA3C0A60F602C2BB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321128 mRNA. Translation: AAL16955.1.
    AK036464 mRNA. Translation: BAC29440.1.
    AF280401 mRNA. Translation: AAK37993.1.
    CCDSiCCDS29605.1.
    RefSeqiNP_573509.1. NM_133246.4.
    XP_006526789.1. XM_006526726.1.
    UniGeneiMm.240438.

    Genome annotation databases

    EnsembliENSMUST00000112984; ENSMUSP00000108608; ENSMUSG00000024681.
    GeneIDi170813.
    KEGGimmu:170813.
    UCSCiuc008gsp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321128 mRNA. Translation: AAL16955.1 .
    AK036464 mRNA. Translation: BAC29440.1 .
    AF280401 mRNA. Translation: AAK37993.1 .
    CCDSi CCDS29605.1.
    RefSeqi NP_573509.1. NM_133246.4.
    XP_006526789.1. XM_006526726.1.
    UniGenei Mm.240438.

    3D structure databases

    ProteinModelPortali Q920C4.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q920C4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000112984 ; ENSMUSP00000108608 ; ENSMUSG00000024681 .
    GeneIDi 170813.
    KEGGi mmu:170813.
    UCSCi uc008gsp.1. mouse.

    Organism-specific databases

    CTDi 932.
    MGIi MGI:2158468. Ms4a3.

    Phylogenomic databases

    eggNOGi NOG46884.
    GeneTreei ENSGT00730000111024.
    HOGENOMi HOG000113657.
    HOVERGENi HBG052512.
    InParanoidi Q920C4.
    OMAi STVAMWC.
    OrthoDBi EOG7VHSZF.
    PhylomeDBi Q920C4.
    TreeFami TF335157.

    Miscellaneous databases

    NextBioi 370473.
    PROi Q920C4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q920C4.
    Bgeei Q920C4.
    Genevestigatori Q920C4.

    Family and domain databases

    InterProi IPR007237. CD20-like.
    [Graphical view ]
    Pfami PF04103. CD20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a mouse homologue of the human haematopoietic cell-specific four-transmembrane gene HTm4."
      Hulett M.D., Pagler E., Hornby J.R.
      Immunol. Cell Biol. 79:345-349(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Spleen.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone.
    3. "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse."
      Liang Y., Tedder T.F.
      Genomics 72:119-127(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-124.
      Strain: C57BL/6.
      Tissue: Bone marrow.

    Entry informationi

    Entry nameiMS4A3_MOUSE
    AccessioniPrimary (citable) accession number: Q920C4
    Secondary accession number(s): Q99MX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3