Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q920C4 (MS4A3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membrane-spanning 4-domains subfamily A member 3
Alternative name(s):
Hematopoietic-specific transmembrane protein 4
Short name=HTm4
Gene names
Name:Ms4a3
Synonyms:Htm4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP) By similarity.

Subunit structure

Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed at low levels only in specific immune tissues, such as, spleen, bone marrow and peripheral blood leukocytes.

Domain

The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity By similarity.

Sequence similarities

Belongs to the MS4A family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15704002. Source: MGI

integral component of membrane

Traceable author statement Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213Membrane-spanning 4-domains subfamily A member 3
PRO_0000158633

Regions

Topological domain1 – 2626Cytoplasmic Potential
Transmembrane27 – 4721Helical; Potential
Topological domain48 – 5811Extracellular Potential
Transmembrane59 – 7921Helical; Potential
Topological domain80 – 9718Cytoplasmic Potential
Transmembrane98 – 11821Helical; Potential
Topological domain119 – 14830Extracellular Potential
Transmembrane149 – 16921Helical; Potential
Topological domain170 – 21344Cytoplasmic Potential
Compositional bias59 – 646Poly-Phe

Sequences

Sequence LengthMass (Da)Tools
Q920C4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: A3C0A60F602C2BB0

FASTA21322,872
        10         20         30         40         50         60 
MKPEETGGSV YQPLDESRHV QRGVLQALGA IQILNGILIL ALGIFLVCLQ HVSHHFRHFF 

        70         80         90        100        110        120 
FFTFYTGYPL WGAVFFISSG SLTVAAGRNP TRMLMQNSFG INIASTTIAF VGTVFLSVHL 

       130        140        150        160        170        180 
AFNTQAFKGC QSSPSPDVCI SLGSSSDGLV SLMLILTLLE LSVTISISAM WCLGNVCGLR 

       190        200        210 
EAITSPPNSV ESGILPEGSD SENLNTQPQA SEE 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a mouse homologue of the human haematopoietic cell-specific four-transmembrane gene HTm4."
Hulett M.D., Pagler E., Hornby J.R.
Immunol. Cell Biol. 79:345-349(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Spleen.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone.
[3]"Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse."
Liang Y., Tedder T.F.
Genomics 72:119-127(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-124.
Strain: C57BL/6.
Tissue: Bone marrow.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF321128 mRNA. Translation: AAL16955.1.
AK036464 mRNA. Translation: BAC29440.1.
AF280401 mRNA. Translation: AAK37993.1.
RefSeqNP_573509.1. NM_133246.4.
XP_006526789.1. XM_006526726.1.
UniGeneMm.240438.

3D structure databases

ProteinModelPortalQ920C4.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ920C4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000112984; ENSMUSP00000108608; ENSMUSG00000024681.
GeneID170813.
KEGGmmu:170813.
UCSCuc008gsp.1. mouse.

Organism-specific databases

CTD932.
MGIMGI:2158468. Ms4a3.

Phylogenomic databases

eggNOGNOG46884.
GeneTreeENSGT00730000111024.
HOGENOMHOG000113657.
HOVERGENHBG052512.
InParanoidQ920C4.
OMACCNSREE.
OrthoDBEOG7VHSZF.
PhylomeDBQ920C4.
TreeFamTF335157.

Gene expression databases

ArrayExpressQ920C4.
BgeeQ920C4.
GenevestigatorQ920C4.

Family and domain databases

InterProIPR007237. CD20-like.
[Graphical view]
PfamPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio370473.
PROQ920C4.
SOURCESearch...

Entry information

Entry nameMS4A3_MOUSE
AccessionPrimary (citable) accession number: Q920C4
Secondary accession number(s): Q99MX6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot