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Protein

Membrane-spanning 4-domains subfamily A member 3

Gene

Ms4a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP) (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 3
Alternative name(s):
Hematopoietic-specific transmembrane protein 4
Short name:
HTm4
Gene namesi
Name:Ms4a3
Synonyms:Htm4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2158468. Ms4a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei27 – 4721HelicalSequence AnalysisAdd
BLAST
Topological domaini48 – 5811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST
Topological domaini80 – 9718CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei98 – 11821HelicalSequence AnalysisAdd
BLAST
Topological domaini119 – 14830ExtracellularSequence AnalysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence AnalysisAdd
BLAST
Topological domaini170 – 21344CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: MGI
  • integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Membrane-spanning 4-domains subfamily A member 3PRO_0000158633Add
BLAST

Proteomic databases

PRIDEiQ920C4.

Expressioni

Tissue specificityi

Expressed at low levels only in specific immune tissues, such as, spleen, bone marrow and peripheral blood leukocytes.

Gene expression databases

BgeeiQ920C4.
ExpressionAtlasiQ920C4. baseline and differential.
GenevisibleiQ920C4. MM.

Interactioni

Subunit structurei

Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108608.

Structurei

3D structure databases

ProteinModelPortaliQ920C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 646Poly-Phe

Domaini

The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.By similarity

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46884.
GeneTreeiENSGT00730000111024.
HOGENOMiHOG000113657.
HOVERGENiHBG052512.
InParanoidiQ920C4.
OMAiCCNSREE.
OrthoDBiEOG7VHSZF.
PhylomeDBiQ920C4.
TreeFamiTF335157.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
IPR030419. MS4A3.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF46. PTHR23320:SF46. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q920C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPEETGGSV YQPLDESRHV QRGVLQALGA IQILNGILIL ALGIFLVCLQ
60 70 80 90 100
HVSHHFRHFF FFTFYTGYPL WGAVFFISSG SLTVAAGRNP TRMLMQNSFG
110 120 130 140 150
INIASTTIAF VGTVFLSVHL AFNTQAFKGC QSSPSPDVCI SLGSSSDGLV
160 170 180 190 200
SLMLILTLLE LSVTISISAM WCLGNVCGLR EAITSPPNSV ESGILPEGSD
210
SENLNTQPQA SEE
Length:213
Mass (Da):22,872
Last modified:December 1, 2001 - v1
Checksum:iA3C0A60F602C2BB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321128 mRNA. Translation: AAL16955.1.
AK036464 mRNA. Translation: BAC29440.1.
AF280401 mRNA. Translation: AAK37993.1.
CCDSiCCDS29605.1.
RefSeqiNP_573509.1. NM_133246.5.
UniGeneiMm.240438.

Genome annotation databases

EnsembliENSMUST00000112984; ENSMUSP00000108608; ENSMUSG00000024681.
ENSMUST00000186023; ENSMUSP00000140508; ENSMUSG00000024681.
GeneIDi170813.
KEGGimmu:170813.
UCSCiuc008gsp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321128 mRNA. Translation: AAL16955.1.
AK036464 mRNA. Translation: BAC29440.1.
AF280401 mRNA. Translation: AAK37993.1.
CCDSiCCDS29605.1.
RefSeqiNP_573509.1. NM_133246.5.
UniGeneiMm.240438.

3D structure databases

ProteinModelPortaliQ920C4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108608.

Proteomic databases

PRIDEiQ920C4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112984; ENSMUSP00000108608; ENSMUSG00000024681.
ENSMUST00000186023; ENSMUSP00000140508; ENSMUSG00000024681.
GeneIDi170813.
KEGGimmu:170813.
UCSCiuc008gsp.2. mouse.

Organism-specific databases

CTDi932.
MGIiMGI:2158468. Ms4a3.

Phylogenomic databases

eggNOGiNOG46884.
GeneTreeiENSGT00730000111024.
HOGENOMiHOG000113657.
HOVERGENiHBG052512.
InParanoidiQ920C4.
OMAiCCNSREE.
OrthoDBiEOG7VHSZF.
PhylomeDBiQ920C4.
TreeFamiTF335157.

Miscellaneous databases

NextBioi370473.
PROiQ920C4.
SOURCEiSearch...

Gene expression databases

BgeeiQ920C4.
ExpressionAtlasiQ920C4. baseline and differential.
GenevisibleiQ920C4. MM.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
IPR030419. MS4A3.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF46. PTHR23320:SF46. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a mouse homologue of the human haematopoietic cell-specific four-transmembrane gene HTm4."
    Hulett M.D., Pagler E., Hornby J.R.
    Immunol. Cell Biol. 79:345-349(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Spleen.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone.
  3. "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse."
    Liang Y., Tedder T.F.
    Genomics 72:119-127(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-124.
    Strain: C57BL/6.
    Tissue: Bone marrow.

Entry informationi

Entry nameiMS4A3_MOUSE
AccessioniPrimary (citable) accession number: Q920C4
Secondary accession number(s): Q99MX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.