Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q920C4

- MS4A3_MOUSE

UniProt

Q920C4 - MS4A3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Membrane-spanning 4-domains subfamily A member 3

Gene

Ms4a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP) (By similarity).By similarity

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 3
Alternative name(s):
Hematopoietic-specific transmembrane protein 4
Short name:
HTm4
Gene namesi
Name:Ms4a3
Synonyms:Htm4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:2158468. Ms4a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei27 – 4721HelicalSequence AnalysisAdd
BLAST
Topological domaini48 – 5811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST
Topological domaini80 – 9718CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei98 – 11821HelicalSequence AnalysisAdd
BLAST
Topological domaini119 – 14830ExtracellularSequence AnalysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence AnalysisAdd
BLAST
Topological domaini170 – 21344CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Membrane-spanning 4-domains subfamily A member 3PRO_0000158633Add
BLAST

Proteomic databases

PRIDEiQ920C4.

Expressioni

Tissue specificityi

Expressed at low levels only in specific immune tissues, such as, spleen, bone marrow and peripheral blood leukocytes.

Gene expression databases

BgeeiQ920C4.
ExpressionAtlasiQ920C4. baseline and differential.
GenevestigatoriQ920C4.

Interactioni

Subunit structurei

Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ920C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 646Poly-Phe

Domaini

The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.By similarity

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46884.
GeneTreeiENSGT00730000111024.
HOGENOMiHOG000113657.
HOVERGENiHBG052512.
InParanoidiQ920C4.
OMAiSTVAMWC.
OrthoDBiEOG7VHSZF.
PhylomeDBiQ920C4.
TreeFamiTF335157.

Family and domain databases

InterProiIPR007237. CD20-like.
[Graphical view]
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q920C4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPEETGGSV YQPLDESRHV QRGVLQALGA IQILNGILIL ALGIFLVCLQ
60 70 80 90 100
HVSHHFRHFF FFTFYTGYPL WGAVFFISSG SLTVAAGRNP TRMLMQNSFG
110 120 130 140 150
INIASTTIAF VGTVFLSVHL AFNTQAFKGC QSSPSPDVCI SLGSSSDGLV
160 170 180 190 200
SLMLILTLLE LSVTISISAM WCLGNVCGLR EAITSPPNSV ESGILPEGSD
210
SENLNTQPQA SEE
Length:213
Mass (Da):22,872
Last modified:December 1, 2001 - v1
Checksum:iA3C0A60F602C2BB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321128 mRNA. Translation: AAL16955.1.
AK036464 mRNA. Translation: BAC29440.1.
AF280401 mRNA. Translation: AAK37993.1.
CCDSiCCDS29605.1.
RefSeqiNP_573509.1. NM_133246.5.
UniGeneiMm.240438.

Genome annotation databases

EnsembliENSMUST00000112984; ENSMUSP00000108608; ENSMUSG00000024681.
ENSMUST00000186023; ENSMUSP00000140508; ENSMUSG00000024681.
GeneIDi170813.
KEGGimmu:170813.
UCSCiuc008gsp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321128 mRNA. Translation: AAL16955.1 .
AK036464 mRNA. Translation: BAC29440.1 .
AF280401 mRNA. Translation: AAK37993.1 .
CCDSi CCDS29605.1.
RefSeqi NP_573509.1. NM_133246.5.
UniGenei Mm.240438.

3D structure databases

ProteinModelPortali Q920C4.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q920C4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000112984 ; ENSMUSP00000108608 ; ENSMUSG00000024681 .
ENSMUST00000186023 ; ENSMUSP00000140508 ; ENSMUSG00000024681 .
GeneIDi 170813.
KEGGi mmu:170813.
UCSCi uc008gsp.1. mouse.

Organism-specific databases

CTDi 932.
MGIi MGI:2158468. Ms4a3.

Phylogenomic databases

eggNOGi NOG46884.
GeneTreei ENSGT00730000111024.
HOGENOMi HOG000113657.
HOVERGENi HBG052512.
InParanoidi Q920C4.
OMAi STVAMWC.
OrthoDBi EOG7VHSZF.
PhylomeDBi Q920C4.
TreeFami TF335157.

Miscellaneous databases

NextBioi 370473.
PROi Q920C4.
SOURCEi Search...

Gene expression databases

Bgeei Q920C4.
ExpressionAtlasi Q920C4. baseline and differential.
Genevestigatori Q920C4.

Family and domain databases

InterProi IPR007237. CD20-like.
[Graphical view ]
Pfami PF04103. CD20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a mouse homologue of the human haematopoietic cell-specific four-transmembrane gene HTm4."
    Hulett M.D., Pagler E., Hornby J.R.
    Immunol. Cell Biol. 79:345-349(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Spleen.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone.
  3. "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse."
    Liang Y., Tedder T.F.
    Genomics 72:119-127(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-124.
    Strain: C57BL/6.
    Tissue: Bone marrow.

Entry informationi

Entry nameiMS4A3_MOUSE
AccessioniPrimary (citable) accession number: Q920C4
Secondary accession number(s): Q99MX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3