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Q920C1

- CRDL1_MOUSE

UniProt

Q920C1 - CRDL1_MOUSE

Protein

Chordin-like protein 1

Gene

Chrdl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation By similarity. Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the inducing activity of BMP2. Plays a role during anterior segment eye development By similarity.By similarity

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. compound eye development Source: UniProtKB
    3. eye development Source: UniProtKB
    4. negative regulation of BMP signaling pathway Source: MGI
    5. nervous system development Source: UniProtKB-KW
    6. ossification Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Osteogenesis

    Enzyme and pathway databases

    ReactomeiREACT_220505. Signaling by BMP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chordin-like protein 1
    Alternative name(s):
    Neuralin-1
    Neurogenesin-1
    Ventroptin
    Gene namesi
    Name:Chrdl1
    Synonyms:Ng1, Nrln1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1933172. Chrdl1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 447425Chordin-like protein 1PRO_0000005369Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    May be glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ920C1.

    PTM databases

    PhosphoSiteiQ920C1.

    Expressioni

    Tissue specificityi

    Expressed in heart, brain, lung, liver, kidney and testis.

    Developmental stagei

    Expression starts in the neural plate at mid-gastrulation. Later on its expression becomes restricted to discrete regions of the central nervous system and to derivatives of the neural crest cells. Expressed as well in the primordial cells of the skeleton in mice embryos at 13.5 dpc.1 Publication

    Gene expression databases

    ArrayExpressiQ920C1.
    BgeeiQ920C1.
    CleanExiMM_CHRDL1.
    GenevestigatoriQ920C1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ920C1.
    SMRiQ920C1. Positions 29-99, 105-175, 251-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 9566VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini108 – 17467VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini253 – 31866VWFC 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi174 – 1763Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Contains 3 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG147797.
    GeneTreeiENSGT00730000110792.
    HOGENOMiHOG000049211.
    HOVERGENiHBG051113.
    InParanoidiQ920C1.
    OMAiCPRCPED.
    OrthoDBiEOG7XH6S0.
    PhylomeDBiQ920C1.

    Family and domain databases

    InterProiIPR001007. VWF_C.
    [Graphical view]
    PfamiPF00093. VWC. 3 hits.
    [Graphical view]
    SMARTiSM00214. VWC. 3 hits.
    [Graphical view]
    PROSITEiPS01208. VWFC_1. 3 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Alpha (identifier: Q920C1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDGMKYIISL FFIFVFLEGS KTEQVKHSDT YCVFQDKKYR VGEKWHPYLE    50
    PYGLVYCVNC ICSENGNVLC SRVRCPSLHC LSPVHIPHLC CPRCPDSLPP 100
    VNNKVTSKSC EYNGTTYQHG ELFIAEGLFQ NRQPNQCSQC SCSEGNVYCG 150
    LKTCPKLTCA FPVSVPDSCC RVCRGDAELS WEHADGDIFR QPANREARHS 200
    YLRSPYDPPP NRQAGGLPRF PGSRSHRGAV IDSQQASGTI VQIVINNKHK 250
    HGQVCVSNGK TYSHGESWHP NLRAFGIVEC VLCTCNVTKQ ECKKIHCPNR 300
    YPCKYPQKID GKCCKVCPEE PPSQNFDSKG SFCGEETMPV YESVFMEDGE 350
    TTRKVALETE RPPQVEVHVW TIQKGILQHF HIEKISKRMF GELHHFKLVT 400
    RTTLNQWKLF TEGEAQLSQM CSSQVCRTEL EDLVQVLYLG RPEKDHC 447
    Length:447
    Mass (Da):50,732
    Last modified:December 1, 2001 - v1
    Checksum:i94C999025A97545D
    GO
    Isoform Beta (identifier: Q920C1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         319-333: EEPPSQNFDSKGSFC → GKKAKGALAGGPAFG
         334-447: Missing.

    Show »
    Length:333
    Mass (Da):37,034
    Checksum:iB9D08DE5AC74E1D6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti211 – 2111N → S in AAG27460. (PubMed:11118896)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei319 – 33315EEPPS…KGSFC → GKKAKGALAGGPAFG in isoform Beta. 2 PublicationsVSP_001076Add
    BLAST
    Alternative sequencei334 – 447114Missing in isoform Beta. 2 PublicationsVSP_001077Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321853 mRNA. Translation: AAK95586.1.
    AF296451 mRNA. Translation: AAK71523.1.
    AF305714 mRNA. Translation: AAG27460.1.
    CCDSiCCDS30453.1. [Q920C1-2]
    CCDS53208.1. [Q920C1-1]
    RefSeqiNP_001107857.1. NM_001114385.1. [Q920C1-1]
    NP_112548.2. NM_031258.3. [Q920C1-2]
    UniGeneiMm.157697.

    Genome annotation databases

    EnsembliENSMUST00000063029; ENSMUSP00000056193; ENSMUSG00000031283. [Q920C1-1]
    ENSMUST00000074660; ENSMUSP00000074230; ENSMUSG00000031283. [Q920C1-2]
    ENSMUST00000112878; ENSMUSP00000108499; ENSMUSG00000031283. [Q920C1-1]
    ENSMUST00000166406; ENSMUSP00000130284; ENSMUSG00000031283. [Q920C1-2]
    GeneIDi83453.
    KEGGimmu:83453.
    UCSCiuc009ume.2. mouse. [Q920C1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321853 mRNA. Translation: AAK95586.1 .
    AF296451 mRNA. Translation: AAK71523.1 .
    AF305714 mRNA. Translation: AAG27460.1 .
    CCDSi CCDS30453.1. [Q920C1-2 ]
    CCDS53208.1. [Q920C1-1 ]
    RefSeqi NP_001107857.1. NM_001114385.1. [Q920C1-1 ]
    NP_112548.2. NM_031258.3. [Q920C1-2 ]
    UniGenei Mm.157697.

    3D structure databases

    ProteinModelPortali Q920C1.
    SMRi Q920C1. Positions 29-99, 105-175, 251-323.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q920C1.

    Proteomic databases

    PRIDEi Q920C1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063029 ; ENSMUSP00000056193 ; ENSMUSG00000031283 . [Q920C1-1 ]
    ENSMUST00000074660 ; ENSMUSP00000074230 ; ENSMUSG00000031283 . [Q920C1-2 ]
    ENSMUST00000112878 ; ENSMUSP00000108499 ; ENSMUSG00000031283 . [Q920C1-1 ]
    ENSMUST00000166406 ; ENSMUSP00000130284 ; ENSMUSG00000031283 . [Q920C1-2 ]
    GeneIDi 83453.
    KEGGi mmu:83453.
    UCSCi uc009ume.2. mouse. [Q920C1-1 ]

    Organism-specific databases

    CTDi 91851.
    MGIi MGI:1933172. Chrdl1.

    Phylogenomic databases

    eggNOGi NOG147797.
    GeneTreei ENSGT00730000110792.
    HOGENOMi HOG000049211.
    HOVERGENi HBG051113.
    InParanoidi Q920C1.
    OMAi CPRCPED.
    OrthoDBi EOG7XH6S0.
    PhylomeDBi Q920C1.

    Enzyme and pathway databases

    Reactomei REACT_220505. Signaling by BMP.

    Miscellaneous databases

    NextBioi 350576.
    PROi Q920C1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q920C1.
    Bgeei Q920C1.
    CleanExi MM_CHRDL1.
    Genevestigatori Q920C1.

    Family and domain databases

    InterProi IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00093. VWC. 3 hits.
    [Graphical view ]
    SMARTi SM00214. VWC. 3 hits.
    [Graphical view ]
    PROSITEi PS01208. VWFC_1. 3 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina."
      Sakuta H., Suzuki R., Takahashi H., Kato A., Shintani T., Iemura S., Yamamoto T.S., Ueno N., Noda M.
      Science 293:111-115(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
      Strain: C57BL/6J.
    2. "Neuralin-1 is a novel chordin-related molecule expressed in the mouse neural plate."
      Coffinier C.C., Tran U., Larrain J., De Robertis E.M.
      Mech. Dev. 100:119-122(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
    3. "Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells."
      Chandra A., Itakura T., Yang Z., Tamakoshi T., Xue X., Wang B., Ueki T., Sato K., Uezato T., Miura N.
      Biochem. Biophys. Res. Commun. 344:786-791(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, GLYCOSYLATION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCRDL1_MOUSE
    AccessioniPrimary (citable) accession number: Q920C1
    Secondary accession number(s): Q924K0, Q9EPZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 17, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3