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Q920C1 (CRDL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chordin-like protein 1
Alternative name(s):
Neuralin-1
Neurogenesin-1
Ventroptin
Gene names
Name:Chrdl1
Synonyms:Ng1, Nrln1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation By similarity. Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the inducing activity of BMP2. Plays a role during anterior segment eye development By similarity. Ref.3

Subcellular location

Secreted Potential.

Tissue specificity

Expressed in heart, brain, lung, liver, kidney and testis.

Developmental stage

Expression starts in the neural plate at mid-gastrulation. Later on its expression becomes restricted to discrete regions of the central nervous system and to derivatives of the neural crest cells. Expressed as well in the primordial cells of the skeleton in mice embryos at 13.5 dpc. Ref.3

Post-translational modification

May be glycosylated. Ref.3

Sequence similarities

Contains 3 VWFC domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Alpha (identifier: Q920C1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Beta (identifier: Q920C1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     319-333: EEPPSQNFDSKGSFC → GKKAKGALAGGPAFG
     334-447: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 447425Chordin-like protein 1
PRO_0000005369

Regions

Domain30 – 9566VWFC 1
Domain108 – 17467VWFC 2
Domain253 – 31866VWFC 3
Motif174 – 1763Cell attachment site Potential

Amino acid modifications

Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation2861N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence319 – 33315EEPPS…KGSFC → GKKAKGALAGGPAFG in isoform Beta.
VSP_001076
Alternative sequence334 – 447114Missing in isoform Beta.
VSP_001077

Experimental info

Sequence conflict2111N → S in AAG27460. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform Alpha [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 94C999025A97545D

FASTA44750,732
        10         20         30         40         50         60 
MDGMKYIISL FFIFVFLEGS KTEQVKHSDT YCVFQDKKYR VGEKWHPYLE PYGLVYCVNC 

        70         80         90        100        110        120 
ICSENGNVLC SRVRCPSLHC LSPVHIPHLC CPRCPDSLPP VNNKVTSKSC EYNGTTYQHG 

       130        140        150        160        170        180 
ELFIAEGLFQ NRQPNQCSQC SCSEGNVYCG LKTCPKLTCA FPVSVPDSCC RVCRGDAELS 

       190        200        210        220        230        240 
WEHADGDIFR QPANREARHS YLRSPYDPPP NRQAGGLPRF PGSRSHRGAV IDSQQASGTI 

       250        260        270        280        290        300 
VQIVINNKHK HGQVCVSNGK TYSHGESWHP NLRAFGIVEC VLCTCNVTKQ ECKKIHCPNR 

       310        320        330        340        350        360 
YPCKYPQKID GKCCKVCPEE PPSQNFDSKG SFCGEETMPV YESVFMEDGE TTRKVALETE 

       370        380        390        400        410        420 
RPPQVEVHVW TIQKGILQHF HIEKISKRMF GELHHFKLVT RTTLNQWKLF TEGEAQLSQM 

       430        440 
CSSQVCRTEL EDLVQVLYLG RPEKDHC 

« Hide

Isoform Beta [UniParc].

Checksum: B9D08DE5AC74E1D6
Show »

FASTA33337,034

References

[1]"Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina."
Sakuta H., Suzuki R., Takahashi H., Kato A., Shintani T., Iemura S., Yamamoto T.S., Ueno N., Noda M.
Science 293:111-115(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
Strain: C57BL/6J.
[2]"Neuralin-1 is a novel chordin-related molecule expressed in the mouse neural plate."
Coffinier C.C., Tran U., Larrain J., De Robertis E.M.
Mech. Dev. 100:119-122(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
[3]"Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells."
Chandra A., Itakura T., Yang Z., Tamakoshi T., Xue X., Wang B., Ueki T., Sato K., Uezato T., Miura N.
Biochem. Biophys. Res. Commun. 344:786-791(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, GLYCOSYLATION, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF321853 mRNA. Translation: AAK95586.1.
AF296451 mRNA. Translation: AAK71523.1.
AF305714 mRNA. Translation: AAG27460.1.
RefSeqNP_001107857.1. NM_001114385.1.
NP_112548.2. NM_031258.3.
UniGeneMm.157697.

3D structure databases

ProteinModelPortalQ920C1.
SMRQ920C1. Positions 29-99, 105-175, 251-323.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ920C1.

Proteomic databases

PRIDEQ920C1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000063029; ENSMUSP00000056193; ENSMUSG00000031283. [Q920C1-1]
ENSMUST00000074660; ENSMUSP00000074230; ENSMUSG00000031283. [Q920C1-2]
ENSMUST00000112878; ENSMUSP00000108499; ENSMUSG00000031283. [Q920C1-1]
ENSMUST00000166406; ENSMUSP00000130284; ENSMUSG00000031283. [Q920C1-2]
GeneID83453.
KEGGmmu:83453.
UCSCuc009ume.2. mouse. [Q920C1-1]

Organism-specific databases

CTD91851.
MGIMGI:1933172. Chrdl1.

Phylogenomic databases

eggNOGNOG147797.
GeneTreeENSGT00730000110792.
HOGENOMHOG000049211.
HOVERGENHBG051113.
InParanoidQ920C1.
OMACRGDGEL.
OrthoDBEOG7XH6S0.
PhylomeDBQ920C1.

Gene expression databases

ArrayExpressQ920C1.
BgeeQ920C1.
CleanExMM_CHRDL1.
GenevestigatorQ920C1.

Family and domain databases

InterProIPR001007. VWF_C.
[Graphical view]
PfamPF00093. VWC. 3 hits.
[Graphical view]
SMARTSM00214. VWC. 3 hits.
[Graphical view]
PROSITEPS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio350576.
PROQ920C1.
SOURCESearch...

Entry information

Entry nameCRDL1_MOUSE
AccessionPrimary (citable) accession number: Q920C1
Secondary accession number(s): Q924K0, Q9EPZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot