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Protein

Chordin-like protein 1

Gene

Chrdl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation (By similarity). Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the inducing activity of BMP2. Plays a role during anterior segment eye development (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Osteogenesis

Enzyme and pathway databases

ReactomeiR-MMU-201451. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Chordin-like protein 1
Alternative name(s):
Neuralin-1
Neurogenesin-1
Ventroptin
Gene namesi
Name:Chrdl1
Synonyms:Ng1, Nrln1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1933172. Chrdl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000536923 – 447Chordin-like protein 1Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Glycosylationi286N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

May be glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ920C1.
PRIDEiQ920C1.

PTM databases

PhosphoSitePlusiQ920C1.

Expressioni

Tissue specificityi

Expressed in heart, brain, lung, liver, kidney and testis.

Developmental stagei

Expression starts in the neural plate at mid-gastrulation. Later on its expression becomes restricted to discrete regions of the central nervous system and to derivatives of the neural crest cells. Expressed as well in the primordial cells of the skeleton in mice embryos at 13.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000031283.
CleanExiMM_CHRDL1.
ExpressionAtlasiQ920C1. baseline and differential.
GenevisibleiQ920C1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056193.

Structurei

3D structure databases

ProteinModelPortaliQ920C1.
SMRiQ920C1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 95VWFC 1PROSITE-ProRule annotationAdd BLAST66
Domaini108 – 174VWFC 2PROSITE-ProRule annotationAdd BLAST67
Domaini253 – 318VWFC 3PROSITE-ProRule annotationAdd BLAST66

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi174 – 176Cell attachment siteSequence analysis3

Sequence similaritiesi

Contains 3 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IF8R. Eukaryota.
ENOG410YI5E. LUCA.
GeneTreeiENSGT00730000110792.
HOGENOMiHOG000049211.
HOVERGENiHBG051113.
InParanoidiQ920C1.
OMAiFDNKGYF.
OrthoDBiEOG091G0WK8.
PhylomeDBiQ920C1.

Family and domain databases

InterProiIPR030114. Chordin-like_1.
IPR001007. VWF_dom.
[Graphical view]
PANTHERiPTHR11339:SF230. PTHR11339:SF230. 2 hits.
PfamiPF00093. VWC. 3 hits.
[Graphical view]
SMARTiSM00214. VWC. 3 hits.
[Graphical view]
PROSITEiPS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q920C1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGMKYIISL FFIFVFLEGS KTEQVKHSDT YCVFQDKKYR VGEKWHPYLE
60 70 80 90 100
PYGLVYCVNC ICSENGNVLC SRVRCPSLHC LSPVHIPHLC CPRCPDSLPP
110 120 130 140 150
VNNKVTSKSC EYNGTTYQHG ELFIAEGLFQ NRQPNQCSQC SCSEGNVYCG
160 170 180 190 200
LKTCPKLTCA FPVSVPDSCC RVCRGDAELS WEHADGDIFR QPANREARHS
210 220 230 240 250
YLRSPYDPPP NRQAGGLPRF PGSRSHRGAV IDSQQASGTI VQIVINNKHK
260 270 280 290 300
HGQVCVSNGK TYSHGESWHP NLRAFGIVEC VLCTCNVTKQ ECKKIHCPNR
310 320 330 340 350
YPCKYPQKID GKCCKVCPEE PPSQNFDSKG SFCGEETMPV YESVFMEDGE
360 370 380 390 400
TTRKVALETE RPPQVEVHVW TIQKGILQHF HIEKISKRMF GELHHFKLVT
410 420 430 440
RTTLNQWKLF TEGEAQLSQM CSSQVCRTEL EDLVQVLYLG RPEKDHC
Length:447
Mass (Da):50,732
Last modified:December 1, 2001 - v1
Checksum:i94C999025A97545D
GO
Isoform Beta (identifier: Q920C1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     319-333: EEPPSQNFDSKGSFC → GKKAKGALAGGPAFG
     334-447: Missing.

Show »
Length:333
Mass (Da):37,034
Checksum:iB9D08DE5AC74E1D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211N → S in AAG27460 (PubMed:11118896).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001076319 – 333EEPPS…KGSFC → GKKAKGALAGGPAFG in isoform Beta. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_001077334 – 447Missing in isoform Beta. 2 PublicationsAdd BLAST114

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321853 mRNA. Translation: AAK95586.1.
AF296451 mRNA. Translation: AAK71523.1.
AF305714 mRNA. Translation: AAG27460.1.
CCDSiCCDS30453.1. [Q920C1-2]
CCDS53208.1. [Q920C1-1]
RefSeqiNP_001107857.1. NM_001114385.1. [Q920C1-1]
NP_112548.2. NM_031258.3. [Q920C1-2]
UniGeneiMm.157697.

Genome annotation databases

EnsembliENSMUST00000063029; ENSMUSP00000056193; ENSMUSG00000031283. [Q920C1-1]
ENSMUST00000074660; ENSMUSP00000074230; ENSMUSG00000031283. [Q920C1-2]
ENSMUST00000112878; ENSMUSP00000108499; ENSMUSG00000031283. [Q920C1-1]
ENSMUST00000166406; ENSMUSP00000130284; ENSMUSG00000031283. [Q920C1-2]
GeneIDi83453.
KEGGimmu:83453.
UCSCiuc009ume.2. mouse. [Q920C1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321853 mRNA. Translation: AAK95586.1.
AF296451 mRNA. Translation: AAK71523.1.
AF305714 mRNA. Translation: AAG27460.1.
CCDSiCCDS30453.1. [Q920C1-2]
CCDS53208.1. [Q920C1-1]
RefSeqiNP_001107857.1. NM_001114385.1. [Q920C1-1]
NP_112548.2. NM_031258.3. [Q920C1-2]
UniGeneiMm.157697.

3D structure databases

ProteinModelPortaliQ920C1.
SMRiQ920C1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056193.

PTM databases

PhosphoSitePlusiQ920C1.

Proteomic databases

PaxDbiQ920C1.
PRIDEiQ920C1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063029; ENSMUSP00000056193; ENSMUSG00000031283. [Q920C1-1]
ENSMUST00000074660; ENSMUSP00000074230; ENSMUSG00000031283. [Q920C1-2]
ENSMUST00000112878; ENSMUSP00000108499; ENSMUSG00000031283. [Q920C1-1]
ENSMUST00000166406; ENSMUSP00000130284; ENSMUSG00000031283. [Q920C1-2]
GeneIDi83453.
KEGGimmu:83453.
UCSCiuc009ume.2. mouse. [Q920C1-1]

Organism-specific databases

CTDi91851.
MGIiMGI:1933172. Chrdl1.

Phylogenomic databases

eggNOGiENOG410IF8R. Eukaryota.
ENOG410YI5E. LUCA.
GeneTreeiENSGT00730000110792.
HOGENOMiHOG000049211.
HOVERGENiHBG051113.
InParanoidiQ920C1.
OMAiFDNKGYF.
OrthoDBiEOG091G0WK8.
PhylomeDBiQ920C1.

Enzyme and pathway databases

ReactomeiR-MMU-201451. Signaling by BMP.

Miscellaneous databases

PROiQ920C1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031283.
CleanExiMM_CHRDL1.
ExpressionAtlasiQ920C1. baseline and differential.
GenevisibleiQ920C1. MM.

Family and domain databases

InterProiIPR030114. Chordin-like_1.
IPR001007. VWF_dom.
[Graphical view]
PANTHERiPTHR11339:SF230. PTHR11339:SF230. 2 hits.
PfamiPF00093. VWC. 3 hits.
[Graphical view]
SMARTiSM00214. VWC. 3 hits.
[Graphical view]
PROSITEiPS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRDL1_MOUSE
AccessioniPrimary (citable) accession number: Q920C1
Secondary accession number(s): Q924K0, Q9EPZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.