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Protein

Fc receptor-like A

Gene

Fcrla

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be implicated in B-cell differentiation and lymphomagenesis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like A
Alternative name(s):
Fc receptor homolog expressed in B-cells
Fc receptor-like and mucin-like protein 1
Fc receptor-like protein
Fc receptor-related protein X
Short name:
FcRX
Gene namesi
Name:Fcrla
Synonyms:Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138647. Fcrla.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Seems not to be secreted.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030By similarityAdd
BLAST
Chaini31 – 352322Fc receptor-like APRO_0000227936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi109 ↔ 153PROSITE-ProRule annotation
Disulfide bondi202 ↔ 250PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ920A9.
MaxQBiQ920A9.
PaxDbiQ920A9.
PRIDEiQ920A9.

Expressioni

Tissue specificityi

Highly expressed in spleen. Expressed in immature B-cell and B-cell lines.1 Publication

Gene expression databases

BgeeiQ920A9.
CleanExiMM_FCRL1.
MM_FCRLA.
ExpressionAtlasiQ920A9. baseline and differential.
GenevisibleiQ920A9. MM.

Interactioni

Subunit structurei

Monomer or homodimer; disulfide-linked.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Traf2P394295EBI-646587,EBI-520016

Protein-protein interaction databases

IntActiQ920A9. 1 interaction.
STRINGi10090.ENSMUSP00000036380.

Structurei

3D structure databases

ProteinModelPortaliQ920A9.
SMRiQ920A9. Positions 32-272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 16990Ig-like C2-type 1Add
BLAST
Domaini182 – 26079Ig-like C2-type 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi289 – 2946Poly-Pro

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IHSR. Eukaryota.
ENOG4111EGY. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000036934.
HOVERGENiHBG059243.
InParanoidiQ920A9.
OMAiTLSCQTK.
OrthoDBiEOG7H1JM6.
PhylomeDBiQ920A9.
TreeFamiTF335097.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q920A9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLSCTLTQW ALYVCPAVLL ATQMLLAASS ETLKCEGLVS TEQGSCQAAA
60 70 80 90 100
EEDEGDEDDG DMTQSSEAGF QFKGYTFSKP FHLSVSYDWL ILQGPATLIF
110 120 130 140 150
EGDTLVLHCR AWQDWPLTQV IFYREGSALG PPGPKSEFSI TMVQKSDGGH
160 170 180 190 200
YHCSGIFRSP GPGSREAASP VAITVQELFA APVLKALPSS EPQEGGSVTL
210 220 230 240 250
SCQTKLALQR SASRLLFSFY KDGRSLSVRG VSSELKIPKA SEEHSGSYWC
260 270 280 290 300
EAVTEDRQIS KQSPQLEIWV QALQKPTASE TPPTEALGPL PPPPASSAEQ
310 320 330 340 350
PRFSSPDPHL HHQMQLLLKQ IQDVRALLGH LVMELRDLSV YLKPGTTKVA

DK
Length:352
Mass (Da):38,348
Last modified:December 1, 2001 - v1
Checksum:i68836C3C2B6077B7
GO
Isoform 2 (identifier: Q920A9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-27: A → AA

Show »
Length:353
Mass (Da):38,420
Checksum:i6FAB4687B4E92B3C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191Missing in BAE42968 (PubMed:16141072).Curated
Sequence conflicti22 – 221T → I in BAE42968 (PubMed:16141072).Curated
Sequence conflicti30 – 301S → L in BAE42968 (PubMed:16141072).Curated
Sequence conflicti69 – 691G → D in BAE42968 (PubMed:16141072).Curated
Sequence conflicti108 – 1081H → Y in BAE42968 (PubMed:16141072).Curated
Sequence conflicti291 – 2933PPP → LPA in AAL58112 (PubMed:11891275).Curated
Sequence conflicti321 – 3211I → M in BAE42968 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei27 – 271A → AA in isoform 2. 4 PublicationsVSP_017610

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329487 mRNA. Translation: AAL23897.1.
AF426462 mRNA. Translation: AAL58112.1.
AF531424 mRNA. Translation: AAM97592.1.
AK041572 mRNA. Translation: BAC30990.1.
AK172370 mRNA. Translation: BAE42968.1.
BC064708 mRNA. Translation: AAH64708.1.
CCDSiCCDS48439.1. [Q920A9-1]
CCDS48440.1. [Q920A9-2]
RefSeqiNP_001153687.1. NM_001160215.1. [Q920A9-2]
NP_660123.1. NM_145141.2. [Q920A9-1]
UniGeneiMm.1850.

Genome annotation databases

EnsembliENSMUST00000046322; ENSMUSP00000036380; ENSMUSG00000038421. [Q920A9-2]
ENSMUST00000159171; ENSMUSP00000124853; ENSMUSG00000038421. [Q920A9-1]
GeneIDi98752.
KEGGimmu:98752.
UCSCiuc007dmq.2. mouse. [Q920A9-1]
uc007dmr.2. mouse. [Q920A9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329487 mRNA. Translation: AAL23897.1.
AF426462 mRNA. Translation: AAL58112.1.
AF531424 mRNA. Translation: AAM97592.1.
AK041572 mRNA. Translation: BAC30990.1.
AK172370 mRNA. Translation: BAE42968.1.
BC064708 mRNA. Translation: AAH64708.1.
CCDSiCCDS48439.1. [Q920A9-1]
CCDS48440.1. [Q920A9-2]
RefSeqiNP_001153687.1. NM_001160215.1. [Q920A9-2]
NP_660123.1. NM_145141.2. [Q920A9-1]
UniGeneiMm.1850.

3D structure databases

ProteinModelPortaliQ920A9.
SMRiQ920A9. Positions 32-272.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ920A9. 1 interaction.
STRINGi10090.ENSMUSP00000036380.

Proteomic databases

EPDiQ920A9.
MaxQBiQ920A9.
PaxDbiQ920A9.
PRIDEiQ920A9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046322; ENSMUSP00000036380; ENSMUSG00000038421. [Q920A9-2]
ENSMUST00000159171; ENSMUSP00000124853; ENSMUSG00000038421. [Q920A9-1]
GeneIDi98752.
KEGGimmu:98752.
UCSCiuc007dmq.2. mouse. [Q920A9-1]
uc007dmr.2. mouse. [Q920A9-2]

Organism-specific databases

CTDi84824.
MGIiMGI:2138647. Fcrla.

Phylogenomic databases

eggNOGiENOG410IHSR. Eukaryota.
ENOG4111EGY. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000036934.
HOVERGENiHBG059243.
InParanoidiQ920A9.
OMAiTLSCQTK.
OrthoDBiEOG7H1JM6.
PhylomeDBiQ920A9.
TreeFamiTF335097.

Miscellaneous databases

NextBioi353633.
PROiQ920A9.
SOURCEiSearch...

Gene expression databases

BgeeiQ920A9.
CleanExiMM_FCRL1.
MM_FCRLA.
ExpressionAtlasiQ920A9. baseline and differential.
GenevisibleiQ920A9. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features."
    Mechetina L.V., Najakshin A.M., Volkova O.Y., Guselnikov S.V., Faizulin R.Z., Alabyev B.Y., Chikaev N.A., Vinogradova M.S., Taranin A.V.
    Eur. J. Immunol. 32:87-96(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Spleen.
  2. "An unusual Fc receptor-related protein expressed in human centroblasts."
    Facchetti F., Cella M., Festa S., Fremont D.H., Colonna M.
    Proc. Natl. Acad. Sci. U.S.A. 99:3776-3781(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells."
    Davis R.S., Li H., Chen C.-C., Wang Y.-H., Cooper M.D., Burrows P.D.
    Int. Immunol. 14:1075-1083(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Strain: BALB/cJ.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: NOD.
    Tissue: Spleen.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Heart and Lung.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiFCRLA_MOUSE
AccessioniPrimary (citable) accession number: Q920A9
Secondary accession number(s): Q3T9Q2, Q8K3U9, Q8VHP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.