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Protein

Retinoid-inducible serine carboxypeptidase

Gene

Scpep1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in vascular wall and kidney homeostasis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei167PROSITE-ProRule annotation1
Active sitei371PROSITE-ProRule annotation1
Active sitei431PROSITE-ProRule annotation1

GO - Molecular functioni

  • serine-type carboxypeptidase activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERiratno-RISC. Carboxypeptidase_S10.
MEROPSiS10.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoid-inducible serine carboxypeptidase (EC:3.4.16.-)
Alternative name(s):
Serine carboxypeptidase 1
Gene namesi
Name:Scpep1
Synonyms:Risc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620067. Scpep1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • extracellular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000428629 – 452Retinoid-inducible serine carboxypeptidaseAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi126N-linked (GlcNAc...)Sequence analysis1
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi362N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ920A6.
PRIDEiQ920A6.

PTM databases

iPTMnetiQ920A6.
PhosphoSitePlusiQ920A6.

Expressioni

Tissue specificityi

Highly expressed in aorta, bladder, and kidney with much lower levels in all other tissues analyzed. Expression in kidney is restricted to proximal convoluted tubules.

Inductioni

By retinoic acid.

Gene expression databases

BgeeiENSRNOG00000002358.
GenevisibleiQ920A6. RN.

Interactioni

Protein-protein interaction databases

IntActiQ920A6. 1 interactor.
MINTiMINT-4576233.
STRINGi10116.ENSRNOP00000003219.

Structurei

3D structure databases

ProteinModelPortaliQ920A6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1283. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00860000133853.
HOGENOMiHOG000242971.
HOVERGENiHBG002816.
InParanoidiQ920A6.
KOiK09646.
OMAiIILEQAN.
OrthoDBiEOG091G0FY2.
PhylomeDBiQ920A6.
TreeFamiTF313740.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q920A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSRRICLV RLWLLLLSFL LGFSAGSALN WREQEGKEVW DYVTVREDAR
60 70 80 90 100
MFWWLYYATN PCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPLDTRLKP
110 120 130 140 150
RNTTWLQWAS LLFVDNPVGT GFSYVNTTDA YAKDLDTVAS DMMVLLKSFF
160 170 180 190 200
DCHKEFQTVP FYIFSESYGG KMAAGISLEL HKAIQQGTIK CNFSGVALGD
210 220 230 240 250
SWISPVDSVL SWGPYLYSVS LLDNKGLAEV SDIAEQVLNA VNKGFYKEAT
260 270 280 290 300
QLWGKAEMII EKNTDGVNFY NILTKSTPDT SMESSLEFFR SPLVRLCQRH
310 320 330 340 350
VRHLQGDALS QLMNGPIKKK LKIIPDDVSW GAQSSSVFIS MEEDFMKPVI
360 370 380 390 400
DIVDTLLELG VNVTVYNGQL DLIVDTIGQE SWVQKLKWPQ LSRFNQLKWK
410 420 430 440 450
ALYTNPKSSE TSAFVKSYEN LAFYWILKAG HMVPADQGDM ALKMMRLVTQ

QE
Length:452
Mass (Da):51,175
Last modified:December 1, 2001 - v1
Checksum:i9195A0E773E7853B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF330051 mRNA. Translation: AAK84661.1.
RefSeqiNP_596874.1. NM_133383.1.
UniGeneiRn.2108.

Genome annotation databases

EnsembliENSRNOT00000003219; ENSRNOP00000003219; ENSRNOG00000002358.
GeneIDi114861.
KEGGirno:114861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF330051 mRNA. Translation: AAK84661.1.
RefSeqiNP_596874.1. NM_133383.1.
UniGeneiRn.2108.

3D structure databases

ProteinModelPortaliQ920A6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ920A6. 1 interactor.
MINTiMINT-4576233.
STRINGi10116.ENSRNOP00000003219.

Protein family/group databases

ESTHERiratno-RISC. Carboxypeptidase_S10.
MEROPSiS10.013.

PTM databases

iPTMnetiQ920A6.
PhosphoSitePlusiQ920A6.

Proteomic databases

PaxDbiQ920A6.
PRIDEiQ920A6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003219; ENSRNOP00000003219; ENSRNOG00000002358.
GeneIDi114861.
KEGGirno:114861.

Organism-specific databases

CTDi59342.
RGDi620067. Scpep1.

Phylogenomic databases

eggNOGiKOG1283. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00860000133853.
HOGENOMiHOG000242971.
HOVERGENiHBG002816.
InParanoidiQ920A6.
KOiK09646.
OMAiIILEQAN.
OrthoDBiEOG091G0FY2.
PhylomeDBiQ920A6.
TreeFamiTF313740.

Miscellaneous databases

PROiQ920A6.

Gene expression databases

BgeeiENSRNOG00000002358.
GenevisibleiQ920A6. RN.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRISC_RAT
AccessioniPrimary (citable) accession number: Q920A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.