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Protein

Retinoid-inducible serine carboxypeptidase

Gene

Scpep1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in vascular wall and kidney homeostasis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei167PROSITE-ProRule annotation1
Active sitei371PROSITE-ProRule annotation1
Active sitei431PROSITE-ProRule annotation1

GO - Molecular functioni

  • serine-type carboxypeptidase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERiratno-RISC Carboxypeptidase_S10
MEROPSiS10.013

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoid-inducible serine carboxypeptidase (EC:3.4.16.-)
Alternative name(s):
Serine carboxypeptidase 1
Gene namesi
Name:Scpep1
Synonyms:Risc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620067 Scpep1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000428629 – 452Retinoid-inducible serine carboxypeptidaseAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ920A6
PRIDEiQ920A6

PTM databases

iPTMnetiQ920A6
PhosphoSitePlusiQ920A6

Expressioni

Tissue specificityi

Highly expressed in aorta, bladder, and kidney with much lower levels in all other tissues analyzed. Expression in kidney is restricted to proximal convoluted tubules.

Inductioni

By retinoic acid.

Gene expression databases

BgeeiENSRNOG00000002358
GenevisibleiQ920A6 RN

Interactioni

Protein-protein interaction databases

IntActiQ920A6, 1 interactor
STRINGi10116.ENSRNOP00000003219

Structurei

3D structure databases

ProteinModelPortaliQ920A6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1283 Eukaryota
COG2939 LUCA
GeneTreeiENSGT00880000137977
HOGENOMiHOG000242971
HOVERGENiHBG002816
InParanoidiQ920A6
KOiK09646
OMAiTVASDMM
OrthoDBiEOG091G0FY2
PhylomeDBiQ920A6
TreeFamiTF313740

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q920A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSRRICLV RLWLLLLSFL LGFSAGSALN WREQEGKEVW DYVTVREDAR
60 70 80 90 100
MFWWLYYATN PCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPLDTRLKP
110 120 130 140 150
RNTTWLQWAS LLFVDNPVGT GFSYVNTTDA YAKDLDTVAS DMMVLLKSFF
160 170 180 190 200
DCHKEFQTVP FYIFSESYGG KMAAGISLEL HKAIQQGTIK CNFSGVALGD
210 220 230 240 250
SWISPVDSVL SWGPYLYSVS LLDNKGLAEV SDIAEQVLNA VNKGFYKEAT
260 270 280 290 300
QLWGKAEMII EKNTDGVNFY NILTKSTPDT SMESSLEFFR SPLVRLCQRH
310 320 330 340 350
VRHLQGDALS QLMNGPIKKK LKIIPDDVSW GAQSSSVFIS MEEDFMKPVI
360 370 380 390 400
DIVDTLLELG VNVTVYNGQL DLIVDTIGQE SWVQKLKWPQ LSRFNQLKWK
410 420 430 440 450
ALYTNPKSSE TSAFVKSYEN LAFYWILKAG HMVPADQGDM ALKMMRLVTQ

QE
Length:452
Mass (Da):51,175
Last modified:December 1, 2001 - v1
Checksum:i9195A0E773E7853B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF330051 mRNA Translation: AAK84661.1
RefSeqiNP_596874.1, NM_133383.1
UniGeneiRn.2108

Genome annotation databases

EnsembliENSRNOT00000003219; ENSRNOP00000003219; ENSRNOG00000002358
GeneIDi114861
KEGGirno:114861

Similar proteinsi

Entry informationi

Entry nameiRISC_RAT
AccessioniPrimary (citable) accession number: Q920A6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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