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Q920A1

- CLTR2_MOUSE

UniProt

Q920A1 - CLTR2_MOUSE

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Protein

Cysteinyl leukotriene receptor 2

Gene

Cysltr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

GO - Molecular functioni

  1. cysteinyl leukotriene receptor activity Source: MGI

GO - Biological processi

  1. positive regulation of angiogenesis Source: Ensembl
  2. positive regulation of cell death Source: Ensembl
  3. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 2
Short name:
CysLTR2
Gene namesi
Name:Cysltr2
Synonyms:Cyslt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1917336. Cysltr2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Cysteinyl leukotriene receptor 2PRO_0000069304Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 171PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ920A1.

Expressioni

Tissue specificityi

Widely expressed at low levels, with highest expression in the spleen, thymus and adrenal gland, and lower in the kidney, brain and peripheral blood leukocytes.

Gene expression databases

BgeeiQ920A1.
CleanExiMM_CYSLTR2.
GenevestigatoriQ920A1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040715.

Structurei

3D structure databases

ProteinModelPortaliQ920A1.
SMRiQ920A1. Positions 24-301.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Topological domaini48 – 569CytoplasmicSequence Analysis
Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini160 – 18728ExtracellularSequence AnalysisAdd
BLAST
Topological domaini209 – 22921CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini251 – 27121ExtracellularSequence AnalysisAdd
BLAST
Topological domaini293 – 30917CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei230 – 25021Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119185.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ920A1.
KOiK04323.
OMAiHPFRLLH.
OrthoDBiEOG74FF1B.
TreeFamiTF350009.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q920A1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVTGTPSSY SNRNCTIENF KKEFYPIIYL IIFFWGALGN GFSIYVFLQT
60 70 80 90 100
CKKSTSVNVF MLNLATSDFL FISTLPFRAD YYFRGSNWIF GDLACRVMSY
110 120 130 140 150
SLYVNMYTSI YFLTVLSVVR FLATVHPFRM FHVTSVRSAW ILCGIIWVFI
160 170 180 190 200
MASSALLLVN GQEEKDNIIS CLELSPQKFK SLLIMNHIAV AVGFLLPFLT
210 220 230 240 250
LTVCYLLIIR ILLKAEIPES GPRAAHRKAL TTIVIAMITF LLCFLPYHAL
260 270 280 290 300
RTLHLVTWDK DSCGDVLHKA TVITLTMAAA NSCFNPFLYY FAGENFKARL

RAIFSKVHL
Length:309
Mass (Da):35,213
Last modified:July 27, 2011 - v2
Checksum:iBA8B055A00D1CBFE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221L → Q in AAK97354. (PubMed:11591709)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF331658 mRNA. Translation: AAK97354.1.
CH466535 Genomic DNA. Translation: EDL35864.1.
CH466535 Genomic DNA. Translation: EDL35865.1.
BC132414 mRNA. Translation: AAI32415.1.
BC132418 mRNA. Translation: AAI32419.1.
CCDSiCCDS27265.1.
RefSeqiNP_001155884.1. NM_001162412.1.
NP_598481.2. NM_133720.3.
UniGeneiMm.158324.

Genome annotation databases

EnsembliENSMUST00000044664; ENSMUSP00000040715; ENSMUSG00000033470.
ENSMUST00000169168; ENSMUSP00000125958; ENSMUSG00000033470.
GeneIDi70086.
KEGGimmu:70086.
UCSCiuc007upi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF331658 mRNA. Translation: AAK97354.1 .
CH466535 Genomic DNA. Translation: EDL35864.1 .
CH466535 Genomic DNA. Translation: EDL35865.1 .
BC132414 mRNA. Translation: AAI32415.1 .
BC132418 mRNA. Translation: AAI32419.1 .
CCDSi CCDS27265.1.
RefSeqi NP_001155884.1. NM_001162412.1.
NP_598481.2. NM_133720.3.
UniGenei Mm.158324.

3D structure databases

ProteinModelPortali Q920A1.
SMRi Q920A1. Positions 24-301.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000040715.

Chemistry

GuidetoPHARMACOLOGYi 270.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q920A1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044664 ; ENSMUSP00000040715 ; ENSMUSG00000033470 .
ENSMUST00000169168 ; ENSMUSP00000125958 ; ENSMUSG00000033470 .
GeneIDi 70086.
KEGGi mmu:70086.
UCSCi uc007upi.2. mouse.

Organism-specific databases

CTDi 57105.
MGIi MGI:1917336. Cysltr2.

Phylogenomic databases

eggNOGi NOG119185.
GeneTreei ENSGT00760000118784.
HOGENOMi HOG000236328.
HOVERGENi HBG099611.
InParanoidi Q920A1.
KOi K04323.
OMAi HPFRLLH.
OrthoDBi EOG74FF1B.
TreeFami TF350009.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 330978.
PROi Q920A1.
SOURCEi Search...

Gene expression databases

Bgeei Q920A1.
CleanExi MM_CYSLTR2.
Genevestigatori Q920A1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization."
    Hui Y., Yang G., Galczenski H., Figueroa D.J., Austin C.P., Copeland N.G., Gilbert D.J., Jenkins N.A., Funk C.D.
    J. Biol. Chem. 276:47489-47495(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCLTR2_MOUSE
AccessioniPrimary (citable) accession number: Q920A1
Secondary accession number(s): A2RT90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3