Q920A1 (CLTR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cysteinyl leukotriene receptor 2
Short name=CysLTR2

Gene names

Name:	Cysltr2
Synonyms:	Cyslt2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Widely expressed at low levels, with highest expression in the spleen, thymus and adrenal gland, and lower in the kidney, brain and peripheral blood leukocytes.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara positive regulation of angiogenesis Inferred from electronic annotation. Source: Compara positive regulation of cell death Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from direct assay Ref.1. Source: MGI plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteinyl leukotriene receptor activity Inferred from direct assay Ref.1PubMed 11854273. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Cysteinyl leukotriene receptor 2		PRO_0000069304
Regions
	Topological domain	1 – 26	26	Extracellular Potential
	Transmembrane	27 – 47	21	Helical; Name=1; Potential
	Topological domain	48 – 56	9	Cytoplasmic Potential
	Transmembrane	57 – 77	21	Helical; Name=2; Potential
	Topological domain	78 – 98	21	Extracellular Potential
	Transmembrane	99 – 119	21	Helical; Name=3; Potential
	Topological domain	120 – 138	19	Cytoplasmic Potential
	Transmembrane	139 – 159	21	Helical; Name=4; Potential
	Topological domain	160 – 187	28	Extracellular Potential
	Transmembrane	188 – 208	21	Helical; Name=5; Potential
	Topological domain	209 – 229	21	Cytoplasmic Potential
	Transmembrane	230 – 250	21	Helical; Name=6; Potential
	Topological domain	251 – 271	21	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Name=7; Potential
	Topological domain	293 – 309	17	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	14	1	N-linked (GlcNAc...) Potential
	Disulfide bond	95 ↔ 171		By similarity
Experimental info
	Sequence conflict	122	1	L → Q in AAK97354. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q920A1 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: BA8B055A00D1CBFE	FASTA	309	35,213
	10 20 30 40 50 60 MEVTGTPSSY SNRNCTIENF KKEFYPIIYL IIFFWGALGN GFSIYVFLQT CKKSTSVNVF 70 80 90 100 110 120 MLNLATSDFL FISTLPFRAD YYFRGSNWIF GDLACRVMSY SLYVNMYTSI YFLTVLSVVR 130 140 150 160 170 180 FLATVHPFRM FHVTSVRSAW ILCGIIWVFI MASSALLLVN GQEEKDNIIS CLELSPQKFK 190 200 210 220 230 240 SLLIMNHIAV AVGFLLPFLT LTVCYLLIIR ILLKAEIPES GPRAAHRKAL TTIVIAMITF 250 260 270 280 290 300 LLCFLPYHAL RTLHLVTWDK DSCGDVLHKA TVITLTMAAA NSCFNPFLYY FAGENFKARL RAIFSKVHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization." Hui Y., Yang G., Galczenski H., Figueroa D.J., Austin C.P., Copeland N.G., Gilbert D.J., Jenkins N.A., Funk C.D. J. Biol. Chem. 276:47489-47495(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF331658 mRNA. Translation: AAK97354.1. CH466535 Genomic DNA. Translation: EDL35864.1. CH466535 Genomic DNA. Translation: EDL35865.1. BC132414 mRNA. Translation: AAI32415.1. BC132418 mRNA. Translation: AAI32419.1.
IPI	IPI00120287.
RefSeq	NP_001155884.1. NM_001162412.1. NP_598481.2. NM_133720.3.
UniGene	Mm.158324.
3D structure databases
ProteinModelPortal	Q920A1.
SMR	Q920A1. Positions 24-301.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000040715.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q920A1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000044664; ENSMUSP00000040715; ENSMUSG00000033470. ENSMUST00000169168; ENSMUSP00000125958; ENSMUSG00000033470.
GeneID	70086.
KEGG	mmu:70086.
Organism-specific databases
CTD	57105.
MGI	MGI:1917336. Cysltr2.
Phylogenomic databases
eggNOG	NOG119185.
GeneTree	ENSGT00680000099512.
HOGENOM	HOG000236328.
HOVERGEN	HBG099611.
InParanoid	A2RT90.
KO	K04323.
OMA	HPFRLLH.
OrthoDB	EOG4PNXH8.
Gene expression databases
Bgee	Q920A1.
CleanEx	MM_CYSLTR2.
Genevestigator	Q920A1.
GermOnline	ENSMUSG00000033470. Mus musculus.
Family and domain databases
InterPro	IPR013311. CLT2_recept. IPR004071. Cyst_leuk_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01903. CYSLT2RECPTR. PR01533. CYSLTRECPTR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	330978.
SOURCE	Search...

Entry information

Entry name

CLTR2_MOUSE

Accession

Primary (citable) accession number: Q920A1
Secondary accession number(s): A2RT90

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program