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Q920A1

- CLTR2_MOUSE

UniProt

Q920A1 - CLTR2_MOUSE

Protein

Cysteinyl leukotriene receptor 2

Gene

Cysltr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

    GO - Molecular functioni

    1. cysteinyl leukotriene receptor activity Source: MGI

    GO - Biological processi

    1. positive regulation of angiogenesis Source: Ensembl
    2. positive regulation of cell death Source: Ensembl
    3. positive regulation of ERK1 and ERK2 cascade Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteinyl leukotriene receptor 2
    Short name:
    CysLTR2
    Gene namesi
    Name:Cysltr2
    Synonyms:Cyslt2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1917336. Cysltr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: MGI
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Cysteinyl leukotriene receptor 2PRO_0000069304Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 171PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ920A1.

    Expressioni

    Tissue specificityi

    Widely expressed at low levels, with highest expression in the spleen, thymus and adrenal gland, and lower in the kidney, brain and peripheral blood leukocytes.

    Gene expression databases

    BgeeiQ920A1.
    CleanExiMM_CYSLTR2.
    GenevestigatoriQ920A1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000040715.

    Structurei

    3D structure databases

    ProteinModelPortaliQ920A1.
    SMRiQ920A1. Positions 24-301.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 569CytoplasmicSequence Analysis
    Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 18728ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 22921CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini251 – 27121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 30917CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG119185.
    GeneTreeiENSGT00750000117402.
    HOGENOMiHOG000236328.
    HOVERGENiHBG099611.
    InParanoidiA2RT90.
    KOiK04323.
    OMAiHPFRLLH.
    OrthoDBiEOG74FF1B.
    TreeFamiTF350009.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR013311. CLT2_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01903. CYSLT2RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q920A1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVTGTPSSY SNRNCTIENF KKEFYPIIYL IIFFWGALGN GFSIYVFLQT    50
    CKKSTSVNVF MLNLATSDFL FISTLPFRAD YYFRGSNWIF GDLACRVMSY 100
    SLYVNMYTSI YFLTVLSVVR FLATVHPFRM FHVTSVRSAW ILCGIIWVFI 150
    MASSALLLVN GQEEKDNIIS CLELSPQKFK SLLIMNHIAV AVGFLLPFLT 200
    LTVCYLLIIR ILLKAEIPES GPRAAHRKAL TTIVIAMITF LLCFLPYHAL 250
    RTLHLVTWDK DSCGDVLHKA TVITLTMAAA NSCFNPFLYY FAGENFKARL 300
    RAIFSKVHL 309
    Length:309
    Mass (Da):35,213
    Last modified:July 27, 2011 - v2
    Checksum:iBA8B055A00D1CBFE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti122 – 1221L → Q in AAK97354. (PubMed:11591709)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF331658 mRNA. Translation: AAK97354.1.
    CH466535 Genomic DNA. Translation: EDL35864.1.
    CH466535 Genomic DNA. Translation: EDL35865.1.
    BC132414 mRNA. Translation: AAI32415.1.
    BC132418 mRNA. Translation: AAI32419.1.
    CCDSiCCDS27265.1.
    RefSeqiNP_001155884.1. NM_001162412.1.
    NP_598481.2. NM_133720.3.
    UniGeneiMm.158324.

    Genome annotation databases

    EnsembliENSMUST00000044664; ENSMUSP00000040715; ENSMUSG00000033470.
    ENSMUST00000169168; ENSMUSP00000125958; ENSMUSG00000033470.
    GeneIDi70086.
    KEGGimmu:70086.
    UCSCiuc007upi.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF331658 mRNA. Translation: AAK97354.1 .
    CH466535 Genomic DNA. Translation: EDL35864.1 .
    CH466535 Genomic DNA. Translation: EDL35865.1 .
    BC132414 mRNA. Translation: AAI32415.1 .
    BC132418 mRNA. Translation: AAI32419.1 .
    CCDSi CCDS27265.1.
    RefSeqi NP_001155884.1. NM_001162412.1.
    NP_598481.2. NM_133720.3.
    UniGenei Mm.158324.

    3D structure databases

    ProteinModelPortali Q920A1.
    SMRi Q920A1. Positions 24-301.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000040715.

    Chemistry

    GuidetoPHARMACOLOGYi 270.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q920A1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044664 ; ENSMUSP00000040715 ; ENSMUSG00000033470 .
    ENSMUST00000169168 ; ENSMUSP00000125958 ; ENSMUSG00000033470 .
    GeneIDi 70086.
    KEGGi mmu:70086.
    UCSCi uc007upi.2. mouse.

    Organism-specific databases

    CTDi 57105.
    MGIi MGI:1917336. Cysltr2.

    Phylogenomic databases

    eggNOGi NOG119185.
    GeneTreei ENSGT00750000117402.
    HOGENOMi HOG000236328.
    HOVERGENi HBG099611.
    InParanoidi A2RT90.
    KOi K04323.
    OMAi HPFRLLH.
    OrthoDBi EOG74FF1B.
    TreeFami TF350009.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 330978.
    PROi Q920A1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q920A1.
    CleanExi MM_CYSLTR2.
    Genevestigatori Q920A1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR013311. CLT2_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01903. CYSLT2RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization."
      Hui Y., Yang G., Galczenski H., Figueroa D.J., Austin C.P., Copeland N.G., Gilbert D.J., Jenkins N.A., Funk C.D.
      J. Biol. Chem. 276:47489-47495(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiCLTR2_MOUSE
    AccessioniPrimary (citable) accession number: Q920A1
    Secondary accession number(s): A2RT90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3