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Protein

Cysteinyl leukotriene receptor 2

Gene

Cysltr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

GO - Molecular functioni

  • cysteinyl leukotriene receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_297243. Leukotriene receptors.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 2
Short name:
CysLTR2
Gene namesi
Name:Cysltr2
Synonyms:Cyslt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1917336. Cysltr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 569CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 18728ExtracellularSequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini209 – 22921CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei230 – 25021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini251 – 27121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 30917CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Cysteinyl leukotriene receptor 2PRO_0000069304Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 171PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ920A1.
PRIDEiQ920A1.

Expressioni

Tissue specificityi

Widely expressed at low levels, with highest expression in the spleen, thymus and adrenal gland, and lower in the kidney, brain and peripheral blood leukocytes.

Gene expression databases

BgeeiQ920A1.
CleanExiMM_CYSLTR2.
GenevisibleiQ920A1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040715.

Structurei

3D structure databases

ProteinModelPortaliQ920A1.
SMRiQ920A1. Positions 24-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119185.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ920A1.
KOiK04323.
OMAiIRSAWIL.
OrthoDBiEOG74FF1B.
TreeFamiTF350009.

Family and domain databases

InterProiIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q920A1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVTGTPSSY SNRNCTIENF KKEFYPIIYL IIFFWGALGN GFSIYVFLQT
60 70 80 90 100
CKKSTSVNVF MLNLATSDFL FISTLPFRAD YYFRGSNWIF GDLACRVMSY
110 120 130 140 150
SLYVNMYTSI YFLTVLSVVR FLATVHPFRM FHVTSVRSAW ILCGIIWVFI
160 170 180 190 200
MASSALLLVN GQEEKDNIIS CLELSPQKFK SLLIMNHIAV AVGFLLPFLT
210 220 230 240 250
LTVCYLLIIR ILLKAEIPES GPRAAHRKAL TTIVIAMITF LLCFLPYHAL
260 270 280 290 300
RTLHLVTWDK DSCGDVLHKA TVITLTMAAA NSCFNPFLYY FAGENFKARL

RAIFSKVHL
Length:309
Mass (Da):35,213
Last modified:July 27, 2011 - v2
Checksum:iBA8B055A00D1CBFE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221L → Q in AAK97354 (PubMed:11591709).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331658 mRNA. Translation: AAK97354.1.
CH466535 Genomic DNA. Translation: EDL35864.1.
CH466535 Genomic DNA. Translation: EDL35865.1.
BC132414 mRNA. Translation: AAI32415.1.
BC132418 mRNA. Translation: AAI32419.1.
CCDSiCCDS27265.1.
RefSeqiNP_001155884.1. NM_001162412.1.
NP_598481.2. NM_133720.3.
XP_011243480.1. XM_011245178.1.
UniGeneiMm.158324.

Genome annotation databases

EnsembliENSMUST00000044664; ENSMUSP00000040715; ENSMUSG00000033470.
ENSMUST00000169168; ENSMUSP00000125958; ENSMUSG00000033470.
GeneIDi70086.
KEGGimmu:70086.
UCSCiuc007upi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331658 mRNA. Translation: AAK97354.1.
CH466535 Genomic DNA. Translation: EDL35864.1.
CH466535 Genomic DNA. Translation: EDL35865.1.
BC132414 mRNA. Translation: AAI32415.1.
BC132418 mRNA. Translation: AAI32419.1.
CCDSiCCDS27265.1.
RefSeqiNP_001155884.1. NM_001162412.1.
NP_598481.2. NM_133720.3.
XP_011243480.1. XM_011245178.1.
UniGeneiMm.158324.

3D structure databases

ProteinModelPortaliQ920A1.
SMRiQ920A1. Positions 24-301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040715.

Chemistry

GuidetoPHARMACOLOGYi270.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

MaxQBiQ920A1.
PRIDEiQ920A1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044664; ENSMUSP00000040715; ENSMUSG00000033470.
ENSMUST00000169168; ENSMUSP00000125958; ENSMUSG00000033470.
GeneIDi70086.
KEGGimmu:70086.
UCSCiuc007upi.2. mouse.

Organism-specific databases

CTDi57105.
MGIiMGI:1917336. Cysltr2.

Phylogenomic databases

eggNOGiNOG119185.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ920A1.
KOiK04323.
OMAiIRSAWIL.
OrthoDBiEOG74FF1B.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiREACT_297243. Leukotriene receptors.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi330978.
PROiQ920A1.
SOURCEiSearch...

Gene expression databases

BgeeiQ920A1.
CleanExiMM_CYSLTR2.
GenevisibleiQ920A1. MM.

Family and domain databases

InterProiIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization."
    Hui Y., Yang G., Galczenski H., Figueroa D.J., Austin C.P., Copeland N.G., Gilbert D.J., Jenkins N.A., Funk C.D.
    J. Biol. Chem. 276:47489-47495(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCLTR2_MOUSE
AccessioniPrimary (citable) accession number: Q920A1
Secondary accession number(s): A2RT90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.