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Protein

Opticin

Gene

Optc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds collagen fibrils.By similarity

GO - Biological processi

  • negative regulation of angiogenesis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Opticin
Alternative name(s):
Oculoglycan
Gene namesi
Name:Optc
Synonyms:Opt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2151113. Optc.

Subcellular locationi

GO - Cellular componenti

  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 328309OpticinPRO_0000032766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis
Modified residuei69 – 691SulfotyrosineSequence analysis
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis
Disulfide bondi285 ↔ 318By similarity
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

O-glycosylated.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

MaxQBiQ920A0.
PaxDbiQ920A0.
PRIDEiQ920A0.

PTM databases

PhosphoSiteiQ920A0.

Expressioni

Tissue specificityi

Present in the presumptive ciliary body during development and in the nonpigmented ciliary epithelium of the adult eye.

Gene expression databases

BgeeiENSMUSG00000010311.
CleanExiMM_OPTC.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120568.

Structurei

3D structure databases

ProteinModelPortaliQ920A0.
SMRiQ920A0. Positions 7-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 14938LRRNTAdd
BLAST
Repeati150 – 17122LRR 1Add
BLAST
Repeati174 – 19522LRR 2Add
BLAST
Repeati198 – 21922LRR 3Add
BLAST
Repeati244 – 26522LRR 4Add
BLAST
Repeati266 – 28621LRR 5Add
BLAST
Repeati296 – 31621LRR 6Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi79 – 11032Ser/Thr-richAdd
BLAST
Compositional biasi124 – 13613Cys-richAdd
BLAST

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000273909.
HOVERGENiHBG006850.
InParanoidiQ920A0.
KOiK08128.
PhylomeDBiQ920A0.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q920A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLAFLSLL SLVLQKAETA SLLGEREREE QSPEEGDTYA SLYVGNHTLS
60 70 80 90 100
IEDYNEVIDL SNYEELADYG DQIPEAKISN LTLPTRTSPT STVAQKTLSP
110 120 130 140 150
NLTMAVPTTT GLLNSQSSHG LPTCLVCVCL GSSVYCDDAD LENIPPLPQM
160 170 180 190 200
TTYLYARFNH ISHIQAGDFK GLTKLRRIDL SGNSISSIHN DALRLLPALQ
210 220 230 240 250
DLILPENQLA ALPVLPSGIE FLDVRLNRLQ SSGIQPEAFV ALKKLQFLYL
260 270 280 290 300
ANNMLDSIPG PLPLSLRSLH LQNNMIETME SDTFCDTGEH RHERRQLEDI
310 320
RLDGNPINLS LFPEAYFCLP RLPVGHFT
Length:328
Mass (Da):36,422
Last modified:July 27, 2011 - v2
Checksum:i3DF84F66FFC66DF3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1681D → Y in AAL12836 (PubMed:11527931).Curated
Sequence conflicti168 – 1681D → Y in AAL12835 (PubMed:11527931).Curated
Sequence conflicti285 – 2873CDT → SLS in AAL12836 (PubMed:11527931).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333980 mRNA. Translation: AAL12835.1.
AF333981 Genomic DNA. Translation: AAL12836.1.
AY077682 mRNA. Translation: AAL78287.1.
RefSeqiNP_473417.2. NM_054076.3.
UniGeneiMm.59985.

Genome annotation databases

GeneIDi269120.
KEGGimmu:269120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333980 mRNA. Translation: AAL12835.1.
AF333981 Genomic DNA. Translation: AAL12836.1.
AY077682 mRNA. Translation: AAL78287.1.
RefSeqiNP_473417.2. NM_054076.3.
UniGeneiMm.59985.

3D structure databases

ProteinModelPortaliQ920A0.
SMRiQ920A0. Positions 7-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120568.

PTM databases

PhosphoSiteiQ920A0.

Proteomic databases

MaxQBiQ920A0.
PaxDbiQ920A0.
PRIDEiQ920A0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi269120.
KEGGimmu:269120.

Organism-specific databases

CTDi26254.
MGIiMGI:2151113. Optc.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000273909.
HOVERGENiHBG006850.
InParanoidiQ920A0.
KOiK08128.
PhylomeDBiQ920A0.

Miscellaneous databases

PROiQ920A0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010311.
CleanExiMM_OPTC.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPT_MOUSE
AccessioniPrimary (citable) accession number: Q920A0
Secondary accession number(s): Q8K3K2, Q91ZZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.