Reviewed, UniProtKB/Swiss-Prot Q92095 (CP1A1_OPSTA)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 1A1
    EC=1.14.14.1
Alternative name(s):
    CYPIA1

Gene names

Name:

cyp1a1

Organism

Opsanus tau (Oyster toadfish)

Taxonomic identifier

8068 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Paracanthopterygii › Batrachoididae › Opsanus

Protein attributes

Sequence length	521 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 521	521	Cytochrome P450 1A1		PRO_0000051643
Sites
	Metal binding	463	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92095-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4F73866C793FD3F3	FASTA	521	59,247
	10 20 30 40 50 60 MALIILPFIG SLSVSESLVA LITICVVYLI LTYSHTKIPA GLQRLPGPKP LPIIGNVLEI 70 80 90 100 110 120 GRKPYQTLTA LSKRYGPVFQ IQIGMRPVVV LSGSETVRQA LIKQGEDFSG RPDLYTFQFI 130 140 150 160 170 180 SDGKSLAFST DKVGVWRARR KLAYSALRSF SSLESTNQEY SCMLEEHICK EGEYLVKQLN 190 200 210 220 230 240 TSMKANGSFD PFRNIVVSVA NVICGMCFGR RYDHYDQELV SLVNLSEEFG QVVGTGNLAD 250 260 270 280 290 300 FIPVLRFLPS TAMKKFLSIN DRFDKFVKKI VSEHYATYNK DNIRDITDSL IDHCEDRKLD 310 320 330 340 350 360 ENCNVQVSDE KIVGIVNDLF GAGFDTVSTG LSWSVMYLVA YPEIQERLYQ EIKDSVGTER 370 380 390 400 410 420 MPLLSDRPSL PFLDAFILEI FRHSSFLPFT IPHCTTKNTS LNGYFIPKDT CVFINQWQIN 430 440 450 460 470 480 HDPELWKDPF SFNPERFLSA DGTELNRLEG EKVMLFGLGK RRCIGEVIAR NEVFLFLAII 490 500 510 520 IQRLQFHMLP GEPLDMTPEY GLTMKHKRCQ LRATMREKNE Q

References

[1]

"Identification of cytochrome P-450 1A (CYP1A) genes from two teleost fish, toadfish (Opsanus tau) and scup (Stenotomus chrysops), and phylogenetic analysis of CYP1A genes." Morrison H.G., Oleksiak M.F., Cornell N.W., Sogin M.L., Stegeman J.J. Biochem. J. 308:97-104(1995) [PubMed: 7755595] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U14161 mRNA. Translation: AAA74968.1.
PIR	S55317.
3D structure databases
SMR	Q92095. Positions 38-515.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q92095.
Enzyme and pathway databases
BRENDA	1.14.14.1. 289317.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008066. Cyt_P450_E_grp-I_CYP1. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit. PTHR19383:SF63. Cyt_P450_E_grp-I_CYP1. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01683. EP450ICYP1A. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP1A1_OPSTA

Accession

Primary (citable) accession number: Q92095

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 19, 2010
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)