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Q92095

- CP1A1_OPSTA

UniProt

Q92095 - CP1A1_OPSTA

Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Opsanus tau (Oyster toadfish) (Gadus tau)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei229 – 2291SubstrateBy similarity
    Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:cyp1a1
    OrganismiOpsanus tau (Oyster toadfish) (Gadus tau)
    Taxonomic identifieri8068 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataBatrachoidimorphariaBatrachoididaeOpsanus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Cytochrome P450 1A1PRO_0000051643Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ92095.
    SMRiQ92095. Positions 38-515.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92095-1 [UniParc]FASTAAdd to Basket

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    MALIILPFIG SLSVSESLVA LITICVVYLI LTYSHTKIPA GLQRLPGPKP    50
    LPIIGNVLEI GRKPYQTLTA LSKRYGPVFQ IQIGMRPVVV LSGSETVRQA 100
    LIKQGEDFSG RPDLYTFQFI SDGKSLAFST DKVGVWRARR KLAYSALRSF 150
    SSLESTNQEY SCMLEEHICK EGEYLVKQLN TSMKANGSFD PFRNIVVSVA 200
    NVICGMCFGR RYDHYDQELV SLVNLSEEFG QVVGTGNLAD FIPVLRFLPS 250
    TAMKKFLSIN DRFDKFVKKI VSEHYATYNK DNIRDITDSL IDHCEDRKLD 300
    ENCNVQVSDE KIVGIVNDLF GAGFDTVSTG LSWSVMYLVA YPEIQERLYQ 350
    EIKDSVGTER MPLLSDRPSL PFLDAFILEI FRHSSFLPFT IPHCTTKNTS 400
    LNGYFIPKDT CVFINQWQIN HDPELWKDPF SFNPERFLSA DGTELNRLEG 450
    EKVMLFGLGK RRCIGEVIAR NEVFLFLAII IQRLQFHMLP GEPLDMTPEY 500
    GLTMKHKRCQ LRATMREKNE Q 521
    Length:521
    Mass (Da):59,247
    Last modified:November 1, 1996 - v1
    Checksum:i4F73866C793FD3F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14161 mRNA. Translation: AAA74968.1.
    PIRiS55317.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14161 mRNA. Translation: AAA74968.1 .
    PIRi S55317.

    3D structure databases

    ProteinModelPortali Q92095.
    SMRi Q92095. Positions 38-515.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of cytochrome P-450 1A (CYP1A) genes from two teleost fish, toadfish (Opsanus tau) and scup (Stenotomus chrysops), and phylogenetic analysis of CYP1A genes."
      Morrison H.G., Oleksiak M.F., Cornell N.W., Sogin M.L., Stegeman J.J.
      Biochem. J. 308:97-104(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_OPSTA
    AccessioniPrimary (citable) accession number: Q92095
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3