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Q92090

- CP2K1_ONCMY

UniProt

Q92090 - CP2K1_ONCMY

Protein

Cytochrome P450 2K1

Gene

cyp2k1

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2K1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIK1
    Cytochrome P450 LMC2
    Gene namesi
    Name:cyp2k1
    OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
    Taxonomic identifieri8022 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Cytochrome P450 2K1PRO_0000051773Add
    BLAST

    Expressioni

    Inductioni

    Constitutively expressed.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92090.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92090-1 [UniParc]FASTAAdd to Basket

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    MSLIEDILQT SSTVTLLGTV LFLLVLYLRS SGSSSEEQGK EPPGPRPLPL    50
    LGNMLQLDLK KPYCTLCELS KKYGSIFTVH FGPKKVVVLA GYKTVKQALV 100
    NQAEDFGDRD ITPVFYDFNQ GHGILFANGD SWKEMRRFAL TNLRDFGMGK 150
    KGSEEKILEE IPYLIEVFEK HEGKAFDTTQ SVLYAVSNII SAIVYGSRFE 200
    YTDPLFTGMA DRAKESIHLT GSASIQMYNM FPWLGPWINN LTRLKKNIAD 250
    MKMEVIELVR GLKETLNPHM CRGFVDSFLV RKQTLEESGH MDSFYHDDNL 300
    VFSVGNLFSA GTDTTGTTLR WGLLLMTKYP HIQDQVQEEI SRVIGSRQTL 350
    VEDRKNLPYT DAVIHETQRL ANIVPMSVPH TTSRDVTFQG YFIKKGTSVI 400
    PLLTSVLQDD SEWESPNTFN PSHFLDEQGG FVKRDAFMAF SAGRRVCLGE 450
    GLARMELFLF FTSLLQRFRF SPPPGVTEDD LDLTPLLGFT LNPSPHQLCA 500
    VSRV 504
    Length:504
    Mass (Da):56,792
    Last modified:November 1, 1996 - v1
    Checksum:i3EFAE8D78D5EB21F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 72DI → GL in allele CYP2K1v2.
    Natural varianti37 – 371E → G in allele CYP2K1v2.
    Natural varianti79 – 791V → F in allele CYP2K1v2.
    Natural varianti256 – 2561I → T in allele CYP2K1v2.
    Natural varianti261 – 2611G → S in allele CYP2K1v2.
    Natural varianti372 – 3721N → D in allele CYP2K1v2.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11528 mRNA. Translation: AAA52078.1.
    AF045052 mRNA. Translation: AAC28309.1.
    PIRiS45644.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11528 mRNA. Translation: AAA52078.1 .
    AF045052 mRNA. Translation: AAC28309.1 .
    PIRi S45644.

    3D structure databases

    ProteinModelPortali Q92090.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the major rainbow trout constitutive cytochrome P450 (CYP2K1): identification of a new cytochrome P450 gene subfamily and its expression in mature rainbow trout liver and trunk kidney."
      Buhler D.R., Yang Y.-H., Dreher T.W., Miranda C.L., Wang J.-L.
      Arch. Biochem. Biophys. 312:45-51(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Cloning and sequencing of new cytochromes P450 from liver of rainbow trout."
      Yang Y.-H., Buhler D.R.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2K1_ONCMY
    AccessioniPrimary (citable) accession number: Q92090
    Secondary accession number(s): O93304
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3