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Q92090

- CP2K1_ONCMY

UniProt

Q92090 - CP2K1_ONCMY

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Protein

Cytochrome P450 2K1

Gene
cyp2k1
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi447 – 4471Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2K1 (EC:1.14.14.1)
Alternative name(s):
CYPIIK1
Cytochrome P450 LMC2
Gene namesi
Name:cyp2k1
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 2K1PRO_0000051773Add
BLAST

Expressioni

Inductioni

Constitutively expressed.

Structurei

3D structure databases

ProteinModelPortaliQ92090.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92090-1 [UniParc]FASTAAdd to Basket

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MSLIEDILQT SSTVTLLGTV LFLLVLYLRS SGSSSEEQGK EPPGPRPLPL    50
LGNMLQLDLK KPYCTLCELS KKYGSIFTVH FGPKKVVVLA GYKTVKQALV 100
NQAEDFGDRD ITPVFYDFNQ GHGILFANGD SWKEMRRFAL TNLRDFGMGK 150
KGSEEKILEE IPYLIEVFEK HEGKAFDTTQ SVLYAVSNII SAIVYGSRFE 200
YTDPLFTGMA DRAKESIHLT GSASIQMYNM FPWLGPWINN LTRLKKNIAD 250
MKMEVIELVR GLKETLNPHM CRGFVDSFLV RKQTLEESGH MDSFYHDDNL 300
VFSVGNLFSA GTDTTGTTLR WGLLLMTKYP HIQDQVQEEI SRVIGSRQTL 350
VEDRKNLPYT DAVIHETQRL ANIVPMSVPH TTSRDVTFQG YFIKKGTSVI 400
PLLTSVLQDD SEWESPNTFN PSHFLDEQGG FVKRDAFMAF SAGRRVCLGE 450
GLARMELFLF FTSLLQRFRF SPPPGVTEDD LDLTPLLGFT LNPSPHQLCA 500
VSRV 504
Length:504
Mass (Da):56,792
Last modified:November 1, 1996 - v1
Checksum:i3EFAE8D78D5EB21F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 72DI → GL in allele CYP2K1v2.
Natural varianti37 – 371E → G in allele CYP2K1v2.
Natural varianti79 – 791V → F in allele CYP2K1v2.
Natural varianti256 – 2561I → T in allele CYP2K1v2.
Natural varianti261 – 2611G → S in allele CYP2K1v2.
Natural varianti372 – 3721N → D in allele CYP2K1v2.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11528 mRNA. Translation: AAA52078.1.
AF045052 mRNA. Translation: AAC28309.1.
PIRiS45644.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11528 mRNA. Translation: AAA52078.1 .
AF045052 mRNA. Translation: AAC28309.1 .
PIRi S45644.

3D structure databases

ProteinModelPortali Q92090.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG015789.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of the major rainbow trout constitutive cytochrome P450 (CYP2K1): identification of a new cytochrome P450 gene subfamily and its expression in mature rainbow trout liver and trunk kidney."
    Buhler D.R., Yang Y.-H., Dreher T.W., Miranda C.L., Wang J.-L.
    Arch. Biochem. Biophys. 312:45-51(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Cloning and sequencing of new cytochromes P450 from liver of rainbow trout."
    Yang Y.-H., Buhler D.R.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP2K1_ONCMY
AccessioniPrimary (citable) accession number: Q92090
Secondary accession number(s): O93304
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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