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Q92090 (CP2K1_ONCMY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2K1

EC=1.14.14.1
Alternative name(s):
CYPIIK1
Cytochrome P450 LMC2
Gene names
Name:cyp2k1
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifier8022 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.

Induction

Constitutively expressed.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   Coding sequence diversityPolymorphism
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Cytochrome P450 2K1
PRO_0000051773

Sites

Metal binding4471Iron (heme axial ligand) By similarity

Natural variations

Natural variant6 – 72DI → GL in allele CYP2K1v2.
Natural variant371E → G in allele CYP2K1v2.
Natural variant791V → F in allele CYP2K1v2.
Natural variant2561I → T in allele CYP2K1v2.
Natural variant2611G → S in allele CYP2K1v2.
Natural variant3721N → D in allele CYP2K1v2.

Sequences

Sequence LengthMass (Da)Tools
Q92090 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 3EFAE8D78D5EB21F

FASTA50456,792
        10         20         30         40         50         60 
MSLIEDILQT SSTVTLLGTV LFLLVLYLRS SGSSSEEQGK EPPGPRPLPL LGNMLQLDLK 

        70         80         90        100        110        120 
KPYCTLCELS KKYGSIFTVH FGPKKVVVLA GYKTVKQALV NQAEDFGDRD ITPVFYDFNQ 

       130        140        150        160        170        180 
GHGILFANGD SWKEMRRFAL TNLRDFGMGK KGSEEKILEE IPYLIEVFEK HEGKAFDTTQ 

       190        200        210        220        230        240 
SVLYAVSNII SAIVYGSRFE YTDPLFTGMA DRAKESIHLT GSASIQMYNM FPWLGPWINN 

       250        260        270        280        290        300 
LTRLKKNIAD MKMEVIELVR GLKETLNPHM CRGFVDSFLV RKQTLEESGH MDSFYHDDNL 

       310        320        330        340        350        360 
VFSVGNLFSA GTDTTGTTLR WGLLLMTKYP HIQDQVQEEI SRVIGSRQTL VEDRKNLPYT 

       370        380        390        400        410        420 
DAVIHETQRL ANIVPMSVPH TTSRDVTFQG YFIKKGTSVI PLLTSVLQDD SEWESPNTFN 

       430        440        450        460        470        480 
PSHFLDEQGG FVKRDAFMAF SAGRRVCLGE GLARMELFLF FTSLLQRFRF SPPPGVTEDD 

       490        500 
LDLTPLLGFT LNPSPHQLCA VSRV 

« Hide

References

[1]"Cloning and sequencing of the major rainbow trout constitutive cytochrome P450 (CYP2K1): identification of a new cytochrome P450 gene subfamily and its expression in mature rainbow trout liver and trunk kidney."
Buhler D.R., Yang Y.-H., Dreher T.W., Miranda C.L., Wang J.-L.
Arch. Biochem. Biophys. 312:45-51(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Cloning and sequencing of new cytochromes P450 from liver of rainbow trout."
Yang Y.-H., Buhler D.R.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L11528 mRNA. Translation: AAA52078.1.
AF045052 mRNA. Translation: AAC28309.1.
PIRS45644.

3D structure databases

ProteinModelPortalQ92090.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2K1_ONCMY
AccessionPrimary (citable) accession number: Q92090
Secondary accession number(s): O93304
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families