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Q92087

- CP19A_ORYLA

UniProt

Q92087 - CP19A_ORYLA

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Protein

Aromatase

Gene

cyp19a1

Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.By similarity

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:cyp19a1
Synonyms:cyp19
OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
ProteomesiUP000001038: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518AromatasePRO_0000051972Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92087.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiQ92087.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92087-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLIPACDRT MSSSCLVAEL VSIAPNTTVG LPSGIPMATR SLILLVCLLL
60 70 80 90 100
MVWSHSEKKT IPGPSFCLGL GPLMSYLRFI WTGIGTASNY YNNKYGDIVR
110 120 130 140 150
VWINGEETLI LSRASAVHHV LKNRKYTSRF GSKQGLSCIG MNEKGIIFNN
160 170 180 190 200
NVALWKKIRT YFTKALTGPN LQQTVEVCVT STQTHLDNLS SLSYVDVLGF
210 220 230 240 250
LRCTVVDISN RLFLGVPVDE KELLQKIHKY FDTWQTVLIK PDIYFKFSWI
260 270 280 290 300
HQRHKTAAQE LQDAIESLVE RKRKEMEQAE KLDNINFTAE LIFAQGHGEL
310 320 330 340 350
SAENVRQCVL EMVIAAPDTL SISLFFMLLL LKQNPHVELQ LLQEIDTIVG
360 370 380 390 400
DSQLQNQDLQ KLQVLESFIN ECLRFHPVVD FTMRRALFDD IIDGHRVQKG
410 420 430 440 450
TNIILNTGRM HRTEFFHKAN EFSLENFQKN TPRRYFQPFG SGPRACVGRH
460 470 480 490 500
IAMVMMKSIL VTLLSQYSVC PHEGLTLDCL PQTNNLSQQP VEHHQEADHL
510
SMTFLPRQRG IWESPSPF
Length:518
Mass (Da):58,941
Last modified:November 1, 1996 - v1
Checksum:i39EFE4C412D2382A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D82968 mRNA. Translation: BAA11656.1.
D82969 Genomic DNA. Translation: BAA11657.1.
AB030454 Genomic DNA. Translation: BAA85121.1.
AB030455 Genomic DNA. Translation: BAA85122.1.
RefSeqiNP_001265808.1. NM_001278879.1.
UniGeneiOla.156.

Genome annotation databases

GeneIDi101174651.
KEGGiola:101174651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D82968 mRNA. Translation: BAA11656.1 .
D82969 Genomic DNA. Translation: BAA11657.1 .
AB030454 Genomic DNA. Translation: BAA85121.1 .
AB030455 Genomic DNA. Translation: BAA85122.1 .
RefSeqi NP_001265808.1. NM_001278879.1.
UniGenei Ola.156.

3D structure databases

ProteinModelPortali Q92087.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101174651.
KEGGi ola:101174651.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000111912.
HOVERGENi HBG050750.
InParanoidi Q92087.
KOi K07434.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and promoter analysis of the cytochrome P-450 aromatase gene of the teleost fish, medaka (Oryzias latipes)."
    Tanaka M., Fukada S., Matsuyama M., Nagahama Y.
    J. Biochem. 117:719-725(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Orange-red.
    Tissue: Ovarian follicle.
  2. "Isolation, characterization, and expression of cDNAs encoding the medaka (Oryzias latipes) ovarian follicle cytochrome P-450 aromatase."
    Fukada S., Tanaka M., Matsuyama M., Kobayashi D., Nagahama Y.
    Mol. Reprod. Dev. 45:285-290(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Ovarian follicle.
  3. "Construction of a linkage map of the Medaka (Oryzias latipes) and mapping of the Da mutant locus defective in dorsoventral patterning."
    Ohtsuka M., Makino S., Yoda K., Wada H., Naruse K., Mitani H., Shima A., Ozato K., Kimura M., Inoko H.
    Genome Res. 9:1277-1287(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 418-496.
    Strain: Da and HNI.

Entry informationi

Entry nameiCP19A_ORYLA
AccessioniPrimary (citable) accession number: Q92087
Secondary accession number(s): O13271, O13279, Q9PRF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3