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Reviewed, UniProtKB/Swiss-Prot Q92087 (CP19A_ORYLA)

Last modified February 9, 2010. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cytochrome P450 19A1
    EC=1.14.14.1
Alternative name(s):
    CYPXIX
    Aromatase
    Estrogen synthase
    Cytochrome P-450AROM
Gene names
Name: cyp19a1
Synonyms: cyp19
OrganismOryzias latipes (Medaka fish) (Japanese ricefish)
Taxonomic identifier8090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaAcanthopterygiiPercomorphaAtherinomorphaBeloniformesAdrianichthyidaeOryziinaeOryzias

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens By similarity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentMembrane
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextrinsic to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionaromatase activity

Inferred from electronic annotation. Source: EC

electron carrier activity

Inferred from electronic annotation. Source: InterPro

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Cytochrome P450 19A1
PRO_0000051972

Sites

Metal binding4461Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92087-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 39EFE4C412D2382A

FASTA51858,941
        10         20         30         40         50         60 
MDLIPACDRT MSSSCLVAEL VSIAPNTTVG LPSGIPMATR SLILLVCLLL MVWSHSEKKT 

        70         80         90        100        110        120 
IPGPSFCLGL GPLMSYLRFI WTGIGTASNY YNNKYGDIVR VWINGEETLI LSRASAVHHV 

       130        140        150        160        170        180 
LKNRKYTSRF GSKQGLSCIG MNEKGIIFNN NVALWKKIRT YFTKALTGPN LQQTVEVCVT 

       190        200        210        220        230        240 
STQTHLDNLS SLSYVDVLGF LRCTVVDISN RLFLGVPVDE KELLQKIHKY FDTWQTVLIK 

       250        260        270        280        290        300 
PDIYFKFSWI HQRHKTAAQE LQDAIESLVE RKRKEMEQAE KLDNINFTAE LIFAQGHGEL 

       310        320        330        340        350        360 
SAENVRQCVL EMVIAAPDTL SISLFFMLLL LKQNPHVELQ LLQEIDTIVG DSQLQNQDLQ 

       370        380        390        400        410        420 
KLQVLESFIN ECLRFHPVVD FTMRRALFDD IIDGHRVQKG TNIILNTGRM HRTEFFHKAN 

       430        440        450        460        470        480 
EFSLENFQKN TPRRYFQPFG SGPRACVGRH IAMVMMKSIL VTLLSQYSVC PHEGLTLDCL 

       490        500        510 
PQTNNLSQQP VEHHQEADHL SMTFLPRQRG IWESPSPF 

« Hide

References

[1]"Structure and promoter analysis of the cytochrome P-450 aromatase gene of the teleost fish, medaka (Oryzias latipes)."
Tanaka M., Fukada S., Matsuyama M., Nagahama Y.
J. Biochem. 117:719-725(1995) [PubMed: 7592531] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Orange-red.
Tissue: Ovarian follicle.
[2]"Isolation, characterization, and expression of cDNAs encoding the medaka (Oryzias latipes) ovarian follicle cytochrome P-450 aromatase."
Fukada S., Tanaka M., Matsuyama M., Kobayashi D., Nagahama Y.
Mol. Reprod. Dev. 45:285-290(1996) [PubMed: 8916038] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Ovarian follicle.
[3]"Construction of a linkage map of the Medaka (Oryzias latipes) and mapping of the Da mutant locus defective in dorsoventral patterning."
Ohtsuka M., Makino S., Yoda K., Wada H., Naruse K., Mitani H., Shima A., Ozato K., Kimura M., Inoko H.
Genome Res. 9:1277-1287(1999) [PubMed: 10613850] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 418-496.
Strain: Da and HNI.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D82968 mRNA. Translation: BAA11656.1.
D82969 Genomic DNA. Translation: BAA11657.1.
AB030454 Genomic DNA. Translation: BAA85121.1.
AB030455 Genomic DNA. Translation: BAA85122.1.

3D structure databases

SMRQ92087. Positions 62-508.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ92087.

Genome annotation databases

EnsemblENSORLT00000003689; ENSORLP00000003688; ENSORLG00000002949; Oryzias latipes. [Genome view]

Phylogenomic databases

eggNOGfiNOG06676.
HOVERGENQ92087.
InParanoidQ92087.

Enzyme and pathway databases

BRENDA1.14.14.1. 19130.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR017973. Cyt_P450_C.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP19A_ORYLA
AccessionPrimary (citable) accession number: Q92087
Secondary accession number(s): O13271, O13279, Q9PRF4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: February 9, 2010
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents