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Protein

Aromatase

Gene

cyp19a1

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.By similarity

Catalytic activityi

Testosterone + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = 17-beta-estradiol + formate + 4 H2O + 3 [oxidized NADPH--hemoprotein reductase].By similarity
Androst-4-ene-3,17-dione + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = estrone + formate + 4 H2O + 3 [oxidized NADPH--hemoprotein reductase].By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14By similarity)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:cyp19a1
Synonyms:cyp19
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
Proteomesi
  • UP000001038 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519721 – 518AromataseAdd BLAST518

Proteomic databases

PRIDEiQ92087

Interactioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000003688

Structurei

3D structure databases

ProteinModelPortaliQ92087
SMRiQ92087
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
HOGENOMiHOG000111912
HOVERGENiHBG050750
InParanoidiQ92087
KOiK07434

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q92087-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLIPACDRT MSSSCLVAEL VSIAPNTTVG LPSGIPMATR SLILLVCLLL
60 70 80 90 100
MVWSHSEKKT IPGPSFCLGL GPLMSYLRFI WTGIGTASNY YNNKYGDIVR
110 120 130 140 150
VWINGEETLI LSRASAVHHV LKNRKYTSRF GSKQGLSCIG MNEKGIIFNN
160 170 180 190 200
NVALWKKIRT YFTKALTGPN LQQTVEVCVT STQTHLDNLS SLSYVDVLGF
210 220 230 240 250
LRCTVVDISN RLFLGVPVDE KELLQKIHKY FDTWQTVLIK PDIYFKFSWI
260 270 280 290 300
HQRHKTAAQE LQDAIESLVE RKRKEMEQAE KLDNINFTAE LIFAQGHGEL
310 320 330 340 350
SAENVRQCVL EMVIAAPDTL SISLFFMLLL LKQNPHVELQ LLQEIDTIVG
360 370 380 390 400
DSQLQNQDLQ KLQVLESFIN ECLRFHPVVD FTMRRALFDD IIDGHRVQKG
410 420 430 440 450
TNIILNTGRM HRTEFFHKAN EFSLENFQKN TPRRYFQPFG SGPRACVGRH
460 470 480 490 500
IAMVMMKSIL VTLLSQYSVC PHEGLTLDCL PQTNNLSQQP VEHHQEADHL
510
SMTFLPRQRG IWESPSPF
Length:518
Mass (Da):58,941
Last modified:November 1, 1996 - v1
Checksum:i39EFE4C412D2382A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82968 mRNA Translation: BAA11656.1
D82969 Genomic DNA Translation: BAA11657.1
AB030454 Genomic DNA Translation: BAA85121.1
AB030455 Genomic DNA Translation: BAA85122.1
RefSeqiNP_001265808.1, NM_001278879.1
UniGeneiOla.156

Genome annotation databases

GeneIDi101174651
KEGGiola:101174651

Similar proteinsi

Entry informationi

Entry nameiCP19A_ORYLA
AccessioniPrimary (citable) accession number: Q92087
Secondary accession number(s): O13271, O13279, Q9PRF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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