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Protein

Aromatase

Gene

cyp19a1

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.By similarity

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:cyp19a1
Synonyms:cyp19
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
Proteomesi
  • UP000001038 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519721 – 518AromataseAdd BLAST518

Interactioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000003688.

Structurei

3D structure databases

ProteinModelPortaliQ92087.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiQ92087.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92087-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLIPACDRT MSSSCLVAEL VSIAPNTTVG LPSGIPMATR SLILLVCLLL
60 70 80 90 100
MVWSHSEKKT IPGPSFCLGL GPLMSYLRFI WTGIGTASNY YNNKYGDIVR
110 120 130 140 150
VWINGEETLI LSRASAVHHV LKNRKYTSRF GSKQGLSCIG MNEKGIIFNN
160 170 180 190 200
NVALWKKIRT YFTKALTGPN LQQTVEVCVT STQTHLDNLS SLSYVDVLGF
210 220 230 240 250
LRCTVVDISN RLFLGVPVDE KELLQKIHKY FDTWQTVLIK PDIYFKFSWI
260 270 280 290 300
HQRHKTAAQE LQDAIESLVE RKRKEMEQAE KLDNINFTAE LIFAQGHGEL
310 320 330 340 350
SAENVRQCVL EMVIAAPDTL SISLFFMLLL LKQNPHVELQ LLQEIDTIVG
360 370 380 390 400
DSQLQNQDLQ KLQVLESFIN ECLRFHPVVD FTMRRALFDD IIDGHRVQKG
410 420 430 440 450
TNIILNTGRM HRTEFFHKAN EFSLENFQKN TPRRYFQPFG SGPRACVGRH
460 470 480 490 500
IAMVMMKSIL VTLLSQYSVC PHEGLTLDCL PQTNNLSQQP VEHHQEADHL
510
SMTFLPRQRG IWESPSPF
Length:518
Mass (Da):58,941
Last modified:November 1, 1996 - v1
Checksum:i39EFE4C412D2382A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82968 mRNA. Translation: BAA11656.1.
D82969 Genomic DNA. Translation: BAA11657.1.
AB030454 Genomic DNA. Translation: BAA85121.1.
AB030455 Genomic DNA. Translation: BAA85122.1.
RefSeqiNP_001265808.1. NM_001278879.1.
UniGeneiOla.156.

Genome annotation databases

GeneIDi101174651.
KEGGiola:101174651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82968 mRNA. Translation: BAA11656.1.
D82969 Genomic DNA. Translation: BAA11657.1.
AB030454 Genomic DNA. Translation: BAA85121.1.
AB030455 Genomic DNA. Translation: BAA85122.1.
RefSeqiNP_001265808.1. NM_001278879.1.
UniGeneiOla.156.

3D structure databases

ProteinModelPortaliQ92087.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8090.ENSORLP00000003688.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101174651.
KEGGiola:101174651.

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiQ92087.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP19A_ORYLA
AccessioniPrimary (citable) accession number: Q92087
Secondary accession number(s): O13271, O13279, Q9PRF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.