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Q92087

- CP19A_ORYLA

UniProt

Q92087 - CP19A_ORYLA

Protein

Aromatase

Gene

cyp19a1

Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.By similarity

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIX
    Cytochrome P-450AROM
    Cytochrome P450 19A1
    Estrogen synthase
    Gene namesi
    Name:cyp19a1
    Synonyms:cyp19
    OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
    Taxonomic identifieri8090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
    ProteomesiUP000001038: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518AromatasePRO_0000051972Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ92087.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000111912.
    HOVERGENiHBG050750.
    InParanoidiQ92087.
    KOiK07434.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92087-1 [UniParc]FASTAAdd to Basket

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    MDLIPACDRT MSSSCLVAEL VSIAPNTTVG LPSGIPMATR SLILLVCLLL    50
    MVWSHSEKKT IPGPSFCLGL GPLMSYLRFI WTGIGTASNY YNNKYGDIVR 100
    VWINGEETLI LSRASAVHHV LKNRKYTSRF GSKQGLSCIG MNEKGIIFNN 150
    NVALWKKIRT YFTKALTGPN LQQTVEVCVT STQTHLDNLS SLSYVDVLGF 200
    LRCTVVDISN RLFLGVPVDE KELLQKIHKY FDTWQTVLIK PDIYFKFSWI 250
    HQRHKTAAQE LQDAIESLVE RKRKEMEQAE KLDNINFTAE LIFAQGHGEL 300
    SAENVRQCVL EMVIAAPDTL SISLFFMLLL LKQNPHVELQ LLQEIDTIVG 350
    DSQLQNQDLQ KLQVLESFIN ECLRFHPVVD FTMRRALFDD IIDGHRVQKG 400
    TNIILNTGRM HRTEFFHKAN EFSLENFQKN TPRRYFQPFG SGPRACVGRH 450
    IAMVMMKSIL VTLLSQYSVC PHEGLTLDCL PQTNNLSQQP VEHHQEADHL 500
    SMTFLPRQRG IWESPSPF 518
    Length:518
    Mass (Da):58,941
    Last modified:November 1, 1996 - v1
    Checksum:i39EFE4C412D2382A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D82968 mRNA. Translation: BAA11656.1.
    D82969 Genomic DNA. Translation: BAA11657.1.
    AB030454 Genomic DNA. Translation: BAA85121.1.
    AB030455 Genomic DNA. Translation: BAA85122.1.
    RefSeqiNP_001265808.1. NM_001278879.1.
    UniGeneiOla.156.

    Genome annotation databases

    GeneIDi101174651.
    KEGGiola:101174651.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D82968 mRNA. Translation: BAA11656.1 .
    D82969 Genomic DNA. Translation: BAA11657.1 .
    AB030454 Genomic DNA. Translation: BAA85121.1 .
    AB030455 Genomic DNA. Translation: BAA85122.1 .
    RefSeqi NP_001265808.1. NM_001278879.1.
    UniGenei Ola.156.

    3D structure databases

    ProteinModelPortali Q92087.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101174651.
    KEGGi ola:101174651.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000111912.
    HOVERGENi HBG050750.
    InParanoidi Q92087.
    KOi K07434.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and promoter analysis of the cytochrome P-450 aromatase gene of the teleost fish, medaka (Oryzias latipes)."
      Tanaka M., Fukada S., Matsuyama M., Nagahama Y.
      J. Biochem. 117:719-725(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Orange-red.
      Tissue: Ovarian follicle.
    2. "Isolation, characterization, and expression of cDNAs encoding the medaka (Oryzias latipes) ovarian follicle cytochrome P-450 aromatase."
      Fukada S., Tanaka M., Matsuyama M., Kobayashi D., Nagahama Y.
      Mol. Reprod. Dev. 45:285-290(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Ovarian follicle.
    3. "Construction of a linkage map of the Medaka (Oryzias latipes) and mapping of the Da mutant locus defective in dorsoventral patterning."
      Ohtsuka M., Makino S., Yoda K., Wada H., Naruse K., Mitani H., Shima A., Ozato K., Kimura M., Inoko H.
      Genome Res. 9:1277-1287(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 418-496.
      Strain: Da and HNI.

    Entry informationi

    Entry nameiCP19A_ORYLA
    AccessioniPrimary (citable) accession number: Q92087
    Secondary accession number(s): O13271, O13279, Q9PRF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3