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Q92087 (CP19A_ORYLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aromatase

EC=1.14.14.14
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene names
Name:cyp19a1
Synonyms:cyp19
OrganismOryzias latipes (Medaka fish) (Japanese ricefish) [Reference proteome]
Taxonomic identifier8090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens By similarity.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Aromatase
PRO_0000051972

Sites

Metal binding4461Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92087 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 39EFE4C412D2382A

FASTA51858,941
        10         20         30         40         50         60 
MDLIPACDRT MSSSCLVAEL VSIAPNTTVG LPSGIPMATR SLILLVCLLL MVWSHSEKKT 

        70         80         90        100        110        120 
IPGPSFCLGL GPLMSYLRFI WTGIGTASNY YNNKYGDIVR VWINGEETLI LSRASAVHHV 

       130        140        150        160        170        180 
LKNRKYTSRF GSKQGLSCIG MNEKGIIFNN NVALWKKIRT YFTKALTGPN LQQTVEVCVT 

       190        200        210        220        230        240 
STQTHLDNLS SLSYVDVLGF LRCTVVDISN RLFLGVPVDE KELLQKIHKY FDTWQTVLIK 

       250        260        270        280        290        300 
PDIYFKFSWI HQRHKTAAQE LQDAIESLVE RKRKEMEQAE KLDNINFTAE LIFAQGHGEL 

       310        320        330        340        350        360 
SAENVRQCVL EMVIAAPDTL SISLFFMLLL LKQNPHVELQ LLQEIDTIVG DSQLQNQDLQ 

       370        380        390        400        410        420 
KLQVLESFIN ECLRFHPVVD FTMRRALFDD IIDGHRVQKG TNIILNTGRM HRTEFFHKAN 

       430        440        450        460        470        480 
EFSLENFQKN TPRRYFQPFG SGPRACVGRH IAMVMMKSIL VTLLSQYSVC PHEGLTLDCL 

       490        500        510 
PQTNNLSQQP VEHHQEADHL SMTFLPRQRG IWESPSPF 

« Hide

References

[1]"Structure and promoter analysis of the cytochrome P-450 aromatase gene of the teleost fish, medaka (Oryzias latipes)."
Tanaka M., Fukada S., Matsuyama M., Nagahama Y.
J. Biochem. 117:719-725(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Orange-red.
Tissue: Ovarian follicle.
[2]"Isolation, characterization, and expression of cDNAs encoding the medaka (Oryzias latipes) ovarian follicle cytochrome P-450 aromatase."
Fukada S., Tanaka M., Matsuyama M., Kobayashi D., Nagahama Y.
Mol. Reprod. Dev. 45:285-290(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Ovarian follicle.
[3]"Construction of a linkage map of the Medaka (Oryzias latipes) and mapping of the Da mutant locus defective in dorsoventral patterning."
Ohtsuka M., Makino S., Yoda K., Wada H., Naruse K., Mitani H., Shima A., Ozato K., Kimura M., Inoko H.
Genome Res. 9:1277-1287(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 418-496.
Strain: Da and HNI.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D82968 mRNA. Translation: BAA11656.1.
D82969 Genomic DNA. Translation: BAA11657.1.
AB030454 Genomic DNA. Translation: BAA85121.1.
AB030455 Genomic DNA. Translation: BAA85122.1.
RefSeqNP_001265808.1. NM_001278879.1.
UniGeneOla.156.

3D structure databases

ProteinModelPortalQ92087.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101174651.
KEGGola:101174651.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000111912.
HOVERGENHBG050750.
InParanoidQ92087.
KOK07434.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP19A_ORYLA
AccessionPrimary (citable) accession number: Q92087
Secondary accession number(s): O13271, O13279, Q9PRF4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families