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Protein

Acidic phospholipase A2 C

Gene
N/A
Organism
Naja sputatrix (Malayan spitting cobra) (Naja naja sputatrix)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.By similarity

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Calcium; via carbonyl oxygenBy similarity1
Metal bindingi56Calcium; via carbonyl oxygenBy similarity1
Metal bindingi58Calcium; via carbonyl oxygenBy similarity1
Active sitei74By similarity1
Metal bindingi75CalciumBy similarity1
Active sitei120By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Toxin
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic phospholipase A2 C (EC:3.1.1.4)
Short name:
svPLA2
Alternative name(s):
NAJPLA-2C
Short name:
APLA
Phosphatidylcholine 2-acylhydrolase
OrganismiNaja sputatrix (Malayan spitting cobra) (Naja naja sputatrix)
Taxonomic identifieri33626 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002293422 – 27By similarity6
ChainiPRO_000002293528 – 146Acidic phospholipase A2 CAdd BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 98By similarity
Disulfide bondi53 ↔ 145By similarity
Disulfide bondi55 ↔ 71By similarity
Disulfide bondi70 ↔ 126By similarity
Disulfide bondi77 ↔ 119By similarity
Disulfide bondi87 ↔ 112By similarity
Disulfide bondi105 ↔ 117By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ92086

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliQ92086
SMRiQ92086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG008137

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPAHLLILA AVCVSPLGAS SNRPMPLNLY QFKNMVQCTV PNRSWWDFAD
60 70 80 90 100
YGCYCGRGGS GTPVDDLDRC CQVHDNCYGE AEKISRCWPY FKTYSYECSQ
110 120 130 140
GTLTCKGGNN ACAAAVCDCD RLAAICFAGA PYNDNNYNID LKARCQ
Length:146
Mass (Da):16,082
Last modified:November 1, 1996 - v1
Checksum:i2B6FDAADC01FBBE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42006 mRNA Translation: AAA66029.1

Similar proteinsi

Entry informationi

Entry nameiPA2AC_NAJSP
AccessioniPrimary (citable) accession number: Q92086
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

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