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Q92081 (ACES_MYXGL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetylcholinesterase

Short name=AChE
EC=3.1.1.7
Gene names
Name:ache
Synonyms:ace1
OrganismMyxine glutinosa (Atlantic hagfish)
Taxonomic identifier7769 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperotretiMyxiniformesMyxinidaeMyxininaeMyxine

Protein attributes

Sequence length338 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

Catalytic activity

Acetylcholine + H2O = choline + acetate.

Subcellular location

Cell junctionsynapse. Secreted. Cell membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the type-B carboxylesterase/lipase family.

Ontologies

Keywords
   Biological processNeurotransmitter degradation
   Cellular componentCell junction
Cell membrane
Membrane
Secreted
Synapse
   Molecular functionHydrolase
Serine esterase
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological_processneurotransmitter catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

synapse

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionacetylcholinesterase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›338›338Acetylcholinesterase
PRO_0000070279

Sites

Active site991Acyl-ester intermediate By similarity
Active site2261Charge relay system By similarity

Amino acid modifications

Glycosylation81N-linked (GlcNAc...) Potential
Disulfide bond153 ↔ 164 By similarity

Experimental info

Non-terminal residue11
Non-terminal residue3381

Sequences

Sequence LengthMass (Da)Tools
Q92081 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: ADDCEA493D582BA2

FASTA33837,300
        10         20         30         40         50         60 
VPSPRPQNAT VMVWIFGGGF AYGTSSLNVY DGRYLAQAEG AIVVSMNYRV GALGFLSLPG 

        70         80         90        100        110        120 
SPVPGNAGLF DQQLALRWVH GNIHRFGGNP QSVTLFGESA GSASVAPHLL SRHSQQFFQR 

       130        140        150        160        170        180 
AILQSGTLNA PWATVEDTEA RRRAEALAQA LGCPTDDDNE LLNCLYARPP QEIVSKEGDV 

       190        200        210        220        230        240 
VIEPSIFRFP FVPVVDGHFI IDSPIVLLQQ GIFKKTDLLL GVNRNEGSFF LIYGAPGFSK 

       250        260        270        280        290        300 
DHESLISRED FLENIPMIVP QGNEVSVDAI VLQYTDWLAQ NDALKNRDAI EDIVGDYNVI 

       310        320        330 
CPVVEMATRY AEFGNNVYFY FFNQRASNLP WPQWMGVI 

« Hide

References

[1]"Biochemical and molecular characterization of acetylcholinesterase from the hagfish Myxine glutinosa."
Sanders M., Mathews B., Sutherland D., Soong W., Giles H., Pezzementi L.
Comp. Biochem. Physiol. 115B:97-110(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U55003 Genomic DNA. Translation: AAB17025.1.

3D structure databases

ProteinModelPortalQ92081.
SMRQ92081. Positions 1-337.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.979.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG008839.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR000997. Cholinesterase.
[Graphical view]
PfamPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSPR00878. CHOLNESTRASE.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00122. CARBOXYLESTERASE_B_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACES_MYXGL
AccessionPrimary (citable) accession number: Q92081
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families