Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetylcholinesterase

Gene

ache

Organism
Myxine glutinosa (Atlantic hagfish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

Catalytic activityi

Acetylcholine + H2O = choline + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei226 – 2261Charge relay systemBy similarity

GO - Molecular functioni

  1. acetylcholinesterase activity Source: UniProtKB-EC

GO - Biological processi

  1. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Keywords - Biological processi

Neurotransmitter degradation

Protein family/group databases

MEROPSiS09.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholinesterase (EC:3.1.1.7)
Short name:
AChE
Gene namesi
Name:ache
Synonyms:ace1
OrganismiMyxine glutinosa (Atlantic hagfish)
Taxonomic identifieri7769 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperotretiMyxiniformesMyxinidaeMyxininaeMyxine

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-SubCell
  3. plasma membrane Source: UniProtKB-SubCell
  4. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›338›338AcetylcholinesterasePRO_0000070279Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi153 ↔ 164By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ92081.
SMRiQ92081. Positions 1-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008839.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q92081-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
VPSPRPQNAT VMVWIFGGGF AYGTSSLNVY DGRYLAQAEG AIVVSMNYRV
60 70 80 90 100
GALGFLSLPG SPVPGNAGLF DQQLALRWVH GNIHRFGGNP QSVTLFGESA
110 120 130 140 150
GSASVAPHLL SRHSQQFFQR AILQSGTLNA PWATVEDTEA RRRAEALAQA
160 170 180 190 200
LGCPTDDDNE LLNCLYARPP QEIVSKEGDV VIEPSIFRFP FVPVVDGHFI
210 220 230 240 250
IDSPIVLLQQ GIFKKTDLLL GVNRNEGSFF LIYGAPGFSK DHESLISRED
260 270 280 290 300
FLENIPMIVP QGNEVSVDAI VLQYTDWLAQ NDALKNRDAI EDIVGDYNVI
310 320 330
CPVVEMATRY AEFGNNVYFY FFNQRASNLP WPQWMGVI
Length:338
Mass (Da):37,300
Last modified:November 1, 1996 - v1
Checksum:iADDCEA493D582BA2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei338 – 3381

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55003 Genomic DNA. Translation: AAB17025.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55003 Genomic DNA. Translation: AAB17025.1.

3D structure databases

ProteinModelPortaliQ92081.
SMRiQ92081. Positions 1-337.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS09.980.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG008839.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Biochemical and molecular characterization of acetylcholinesterase from the hagfish Myxine glutinosa."
    Sanders M., Mathews B., Sutherland D., Soong W., Giles H., Pezzementi L.
    Comp. Biochem. Physiol. 115B:97-110(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiACES_MYXGL
AccessioniPrimary (citable) accession number: Q92081
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.