Acetylcholinesterase - Myxine glutinosa (Atlantic hagfish)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Acetylcholinesterase
Short name=AChE
EC=3.1.1.7

Gene names

Name:	ache
Synonyms:	ace1

Organism

Myxine glutinosa (Atlantic hagfish)

Taxonomic identifier

7769 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Hyperotreti › Myxiniformes › Myxinidae › Myxininae › Myxine

Protein attributes

Sequence length	338 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
Catalytic activity	Acetylcholine + H₂O = choline + acetate.
Subcellular location	Cell junction › synapse. Secreted. Cell membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the type-B carboxylesterase/lipase family.

Ontologies

Keywords
Biological process	Neurotransmitter degradation
Cellular component	Cell junction Cell membrane Membrane Secreted Synapse
Molecular function	Hydrolase Serine esterase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological_process	neurotransmitter catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acetylcholinesterase activity Inferred from electronic annotation. Source: EC carboxylesterase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – ›338

›338

Acetylcholinesterase

PRO_0000070279

Sites

Active site

99

1

Acyl-ester intermediate By similarity

Active site

226

1

Charge relay system By similarity

Amino acid modifications

Glycosylation

8

1

N-linked (GlcNAc...) Potential

Disulfide bond

153 ↔ 164

By similarity

Experimental info

Non-terminal residue

1

Non-terminal residue

338

1

Sequences

Sequence

Length

Mass (Da)

Tools

Q92081 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: ADDCEA493D582BA2
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FASTA

338

37,300

        10         20         30         40         50         60 
VPSPRPQNAT VMVWIFGGGF AYGTSSLNVY DGRYLAQAEG AIVVSMNYRV GALGFLSLPG 

        70         80         90        100        110        120 
SPVPGNAGLF DQQLALRWVH GNIHRFGGNP QSVTLFGESA GSASVAPHLL SRHSQQFFQR 

       130        140        150        160        170        180 
AILQSGTLNA PWATVEDTEA RRRAEALAQA LGCPTDDDNE LLNCLYARPP QEIVSKEGDV 

       190        200        210        220        230        240 
VIEPSIFRFP FVPVVDGHFI IDSPIVLLQQ GIFKKTDLLL GVNRNEGSFF LIYGAPGFSK 

       250        260        270        280        290        300 
DHESLISRED FLENIPMIVP QGNEVSVDAI VLQYTDWLAQ NDALKNRDAI EDIVGDYNVI 

       310        320        330 
CPVVEMATRY AEFGNNVYFY FFNQRASNLP WPQWMGVI

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References

[1]

"Biochemical and molecular characterization of acetylcholinesterase from the hagfish Myxine glutinosa."
Sanders M., Mathews B., Sutherland D., Soong W., Giles H., Pezzementi L.
Comp. Biochem. Physiol. 115B:97-110(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U55003 Genomic DNA. Translation: AAB17025.1.
3D structure databases
ProteinModelPortal	Q92081.
SMR	Q92081. Positions 1-337.
ModBase	Search...
Protein family/group databases
MEROPS	S09.979.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG008839.
Family and domain databases
InterPro	IPR002018. CarbesteraseB. IPR019826. Carboxylesterase_B_AS. IPR000997. Cholinesterase. [Graphical view]
Pfam	PF00135. COesterase. 1 hit. [Graphical view]
PRINTS	PR00878. CHOLNESTRASE.
PROSITE	PS00122. CARBOXYLESTERASE_B_1. 1 hit. PS00941. CARBOXYLESTERASE_B_2. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACES_MYXGL

Accession

Primary (citable) accession number: Q92081

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families