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Q92081

- ACES_MYXGL

UniProt

Q92081 - ACES_MYXGL

Protein

Acetylcholinesterase

Gene

ache

Organism
Myxine glutinosa (Atlantic hagfish)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

    Catalytic activityi

    Acetylcholine + H2O = choline + acetate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei99 – 991Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei226 – 2261Charge relay systemBy similarity

    GO - Molecular functioni

    1. acetylcholinesterase activity Source: UniProtKB-EC

    GO - Biological processi

    1. neurotransmitter catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Keywords - Biological processi

    Neurotransmitter degradation

    Protein family/group databases

    MEROPSiS09.979.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylcholinesterase (EC:3.1.1.7)
    Short name:
    AChE
    Gene namesi
    Name:ache
    Synonyms:ace1
    OrganismiMyxine glutinosa (Atlantic hagfish)
    Taxonomic identifieri7769 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperotretiMyxiniformesMyxinidaeMyxininaeMyxine

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. extracellular region Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB-SubCell
    4. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Secreted, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›338›338AcetylcholinesterasePRO_0000070279Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi153 ↔ 164By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ92081.
    SMRiQ92081. Positions 1-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG008839.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR000997. Cholinesterase.
    [Graphical view]
    PfamiPF00135. COesterase. 1 hit.
    [Graphical view]
    PRINTSiPR00878. CHOLNESTRASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q92081-1 [UniParc]FASTAAdd to Basket

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    VPSPRPQNAT VMVWIFGGGF AYGTSSLNVY DGRYLAQAEG AIVVSMNYRV    50
    GALGFLSLPG SPVPGNAGLF DQQLALRWVH GNIHRFGGNP QSVTLFGESA 100
    GSASVAPHLL SRHSQQFFQR AILQSGTLNA PWATVEDTEA RRRAEALAQA 150
    LGCPTDDDNE LLNCLYARPP QEIVSKEGDV VIEPSIFRFP FVPVVDGHFI 200
    IDSPIVLLQQ GIFKKTDLLL GVNRNEGSFF LIYGAPGFSK DHESLISRED 250
    FLENIPMIVP QGNEVSVDAI VLQYTDWLAQ NDALKNRDAI EDIVGDYNVI 300
    CPVVEMATRY AEFGNNVYFY FFNQRASNLP WPQWMGVI 338
    Length:338
    Mass (Da):37,300
    Last modified:November 1, 1996 - v1
    Checksum:iADDCEA493D582BA2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei338 – 3381

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55003 Genomic DNA. Translation: AAB17025.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55003 Genomic DNA. Translation: AAB17025.1 .

    3D structure databases

    ProteinModelPortali Q92081.
    SMRi Q92081. Positions 1-337.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.979.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG008839.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR000997. Cholinesterase.
    [Graphical view ]
    Pfami PF00135. COesterase. 1 hit.
    [Graphical view ]
    PRINTSi PR00878. CHOLNESTRASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Biochemical and molecular characterization of acetylcholinesterase from the hagfish Myxine glutinosa."
      Sanders M., Mathews B., Sutherland D., Soong W., Giles H., Pezzementi L.
      Comp. Biochem. Physiol. 115B:97-110(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiACES_MYXGL
    AccessioniPrimary (citable) accession number: Q92081
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3