Reviewed, UniProtKB/Swiss-Prot Q92080 (NARE_CHICK)

Names and origin

Protein names

Recommended name:
    Erythroblast NAD(P)(+)--arginine ADP-ribosyltransferase
    EC=2.4.2.31
Alternative name(s):
    Mono(ADP-ribosyl)transferase

Gene names

Name:

MADPRT

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine. NADP+ + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine.
Sequence similarities	Belongs to the Arg-specific ADP-ribosyltransferase family.

Ontologies

Keywords
Domain	Signal
Ligand	NAD NADP
Molecular function	Glycosyltransferase Transferase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	protein amino acid ADP-ribosylation Inferred from electronic annotation. Source: InterPro
Molecular function	NAD(P)+-protein-arginine ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 300	278	Erythroblast NAD(P)(+)--arginine ADP-ribosyltransferase		PRO_0000019341
Sites
	Active site	231	1	By similarity
	Binding site	107	1	NAD By similarity
	Binding site	164	1	NAD By similarity
	Binding site	183	1	NAD By similarity
	Binding site	217	1	NAD By similarity
Amino acid modifications
	Disulfide bond	51 ↔ 260		By similarity
	Disulfide bond	159 ↔ 208		By similarity
Experimental info
	Sequence conflict	60	1	Q → E in CAA58649. Ref.1
	Sequence conflict	81	1	E → K in CAA58649. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q92080-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 1D33BE2850D18158	FASTA	300	34,008
	10 20 30 40 50 60 MEEPLLHAIL GLVLLLSTRT DASAARSKKG PIKEVVMDMA PHSFDDQYQG CIDLMEAELQ 70 80 90 100 110 120 ELNRTEFANE TFAEGWRSAT EEWQRRWGRV SSPMVLRQDQ AIAVLAYTME GELYRVFNNA 130 140 150 160 170 180 TLTAGRSRQH YLSSYPFKTL HFLLSRALHT LQESQTQPCH NVFRGVRGTR FTAQQGTVVR 190 200 210 220 230 240 FGQFTSSSLQ KKVAEFFGLD TFFSVETCYG VPIKDLSTFP GEDEVLIPPF EQFRVTNSTY 250 260 270 280 290 300 TAGRSFIQLR SQGKSSTYNC EFVKEKRCKE RPCAFSADKS SPLPRSPWPG WAPLAAPHSH

References

[1]	"Sequence of a chicken erythroblast mono(ADP-ribosyl)transferase-encoding gene and its upstream region." Davis T., Shall S. Gene 164:371-372(1995) [PubMed: 7590361] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Blood.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X83676 Genomic DNA. Translation: CAA58649.1. X82397 mRNA. Translation: CAA57793.1.
IPI	IPI00577622.
PIR	JC4367.
UniGene	Gga.32075
3D structure databases
SMR	Q92080. Positions 35-262.
ModBase	Search...
Genome annotation databases
Ensembl	ENSGALT00000001284; ENSGALP00000001282; ENSGALG00000000871; Gallus gallus. [Genome view] ENSGALT00000036385; ENSGALP00000035605; ENSGALG00000000871; Gallus gallus. [Genome view]
Phylogenomic databases
HOGENOM	HBG443999.
HOVERGEN	Q92080.
InParanoid	Q92080.
Enzyme and pathway databases
BRENDA	2.4.2.31. 4.
Family and domain databases
InterPro	IPR000768. ART. [Graphical view]
PANTHER	PTHR10339. ART. 1 hit.
Pfam	PF01129. ART. 1 hit. [Graphical view]
PRINTS	PR00970. RIBTRNSFRASE.
PROSITE	PS01291. ART. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NARE_CHICK

Accession

Primary (citable) accession number: Q92080
Secondary accession number(s): Q91050

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 19, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)