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Q92072

- DNMT1_CHICK

UniProt

Q92072 - DNMT1_CHICK

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Protein

DNA (cytosine-5)-methyltransferase 1

Gene

DNMT1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development (By similarity). Mediates transcriptional repression by direct binding to HDAC2 (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi263 – 2631ZincBy similarity
Metal bindingi266 – 2661ZincBy similarity
Metal bindingi329 – 3291ZincBy similarity
Sitei420 – 4201Important for activityBy similarity
Active sitei1141 – 11411PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri558 – 60447CXXC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  3. DNA binding Source: UniProtKB-KW
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Protein family/group databases

REBASEi3020. M.GgaDnmt1.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferase 1 (EC:2.1.1.37)
Short name:
Dnmt1
Alternative name(s):
DNA methyltransferase GgaI
Short name:
DNA MTase GgaI
Short name:
M.GgaI
MCMT
Gene namesi
Name:DNMT1
Synonyms:AIM, DNMT
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi190 – 1901V → H: No loss of interaction with PCNA. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15371537DNA (cytosine-5)-methyltransferase 1PRO_0000088037Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei420 – 4201PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ92072.

Expressioni

Tissue specificityi

Testis and lung.

Interactioni

Subunit structurei

Interacts with PCNA.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ92072.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 9890DMAP-interactionAdd
BLAST
Domaini667 – 791125BAH 1PROSITE-ProRule annotationAdd
BLAST
Domaini883 – 1011129BAH 2PROSITE-ProRule annotationAdd
BLAST
Repeati1020 – 102121
Repeati1022 – 102322
Repeati1024 – 102523
Repeati1026 – 102724
Repeati1028 – 102925
Repeati1030 – 103126
Repeati1032 – 103327
Repeati1034 – 103528; approximate
Domaini1054 – 1513460SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni182 – 19413Interacts with PCNAAdd
BLAST
Regioni1020 – 1035168 X 2 AA tandem repeats of K-GAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi129 – 14921Poly-SerAdd
BLAST
Compositional biasi217 – 22711Poly-GluAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 2 BAH domains.PROSITE-ProRule annotation
Contains 1 CXXC-type zinc finger.PROSITE-ProRule annotation
Contains 1 DMAP-interaction domain.Curated
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri558 – 60447CXXC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG051384.
InParanoidiQ92072.
KOiK00558.
PhylomeDBiQ92072.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNA_C5-MeTrfase_1_euk.
IPR029063. SAM-dependent_MTases-like.
IPR002857. Znf_CXXC.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF01426. BAH. 2 hits.
PF06464. DMAP_binding. 1 hit.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92072-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPARSAPPPP ALPPALRRRL RDLERDEDSL SEKETLQEKL RLTRGFLRAE
60 70 80 90 100
VQRRLSALDA DVRCRELSEE RYLAKVKALL RRELAAENGD AAKLFSRASN
110 120 130 140 150
GCAGNGEEEW ERGGRGEDGA MEVEEAAASS SSSSSSSSSS SSSSSSSSSL
160 170 180 190 200
LPAPRARKAR RSRSNGESKK SPASSRVTRS SGRQPTILSV FSKGSTKRKS
210 220 230 240 250
EEVNGAVKPE VSAEKDEEEE EELEEKEQDE KRIKIETKEG SEIKDEITQV
260 270 280 290 300
KTSTPAKTTP PKCVDCRQYL DDPDLKFFQG DPDDALEEPE MLTDERLSIF
310 320 330 340 350
DANEDGFESY EDLPQHKVTS FSVYDKRGHL CPFDTGLIER NIELYFSGAV
360 370 380 390 400
KPIYDDNPCL DGGVRAKKLG PINAWWITGF DGGEKALIGF TTAFADYILM
410 420 430 440 450
EPSEEYAPIF ALMQEKIYMS KIVVEFLQNN RDVSYEDLLN KIETTVPPVG
460 470 480 490 500
LNFNRFTEDS LLRHAQFVVE QVESYDEAGD SDEPPVLITP CMRDLIKLAG
510 520 530 540 550
VTLGKRRAVR RQAIRHPTRI DKDKGPTKAT TTKLVYLIFD TFFSEQIEKD
560 570 580 590 600
EREDDKENAM KRRRCGVCEV CQQPECGKCK ACQNMVKFGG SGRSKQACLQ
610 620 630 640 650
RRCPNLAVRE ADEDEEVDDN IPEMPSPKKM LQGRKKKQNK SRISWVGEPI
660 670 680 690 700
KSDGKKDFYQ RVCIDSETLE VGDCVSVSPD DPTKPLYLAR VTAMWEDSSG
710 720 730 740 750
QMFHAHWFCP GSDTVLGATS DPLELFLVDE CEDMQLSYIH GKVNVIYKPP
760 770 780 790 800
SENWAMEGGL DMEIKMVEDD GRTYFYQMWY DQEYARFETP PRAQPMEDNK
810 820 830 840 850
YKFCLSCARL DEVRHKEIPK VAEPLDEGDG KMFYAMATKN GVQYRVGDSV
860 870 880 890 900
YLLPEAFSFS MKPASPAKRP KKEAVDEDLY PEHYRKYSEY IKGSNLDAPD
910 920 930 940 950
PYRVGRIKEI FCHIRTNGKP NEADIKLRIW KFYRPENTHK SMKATYHADI
960 970 980 990 1000
NLLYWSDEET TVDFCAVQGR CTVVYGEDLT ESIQDYSAGG LDRFYFLEAY
1010 1020 1030 1040 1050
NAKTKSFEDP PNHARSSGNK GKGKGKGKGK GKGKSSTTCE QSEPEPTELK
1060 1070 1080 1090 1100
LPKLRTLDVF SGCGGLSEGF HQAGVSETLW AIEMWEPAAQ AFRLNNPGTT
1110 1120 1130 1140 1150
VFTEDCNVLL KLVMSGEKTN SLGQKLPQKG DVEMLCGGPP CQGFSGMNRF
1160 1170 1180 1190 1200
NSRTYSKFKN SLVVSFLSYC DYYRPRFFLL ENVRNFVSFK RSMVLKLTLR
1210 1220 1230 1240 1250
CLVRMGYQCT FGVLQAGQYG VAQTRRRAIV LAAAPGEKLP MFPEPLHVFA
1260 1270 1280 1290 1300
PRACQLSVVV DDKKFVSNIT RTYSGPFRTI TVRDTMSDLP EIRNGASALE
1310 1320 1330 1340 1350
ISYNGEPQSW FQRQIRGSQY QPILRDHICK DMSALVAARM RHIPLAPGSD
1360 1370 1380 1390 1400
WRDLPNIEVR LSDGTSTRKL RYTHHEKKNG RSSSGALRGV CSCAEGKPCD
1410 1420 1430 1440 1450
PADRQFNTLI PWCLPHTGNR HNHWAGLYGR LEWDGFFSTT VTNPEPMGKQ
1460 1470 1480 1490 1500
GRVLHPEQHR VVSVRECARS QGFPDTYRLF GNILDKHRQV GNAVPPPLAK
1510 1520 1530
AIGLEIRACV GARMREESGA AVAPPAPEKM EMTAAAD
Length:1,537
Mass (Da):172,907
Last modified:November 1, 1996 - v1
Checksum:iFB7E0B2CD10EA17E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D43920 mRNA. Translation: BAA07867.1.
PIRiJC4172.
RefSeqiNP_996835.1. NM_206952.1.
UniGeneiGga.1206.

Genome annotation databases

GeneIDi396011.
KEGGigga:396011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D43920 mRNA. Translation: BAA07867.1 .
PIRi JC4172.
RefSeqi NP_996835.1. NM_206952.1.
UniGenei Gga.1206.

3D structure databases

ProteinModelPortali Q92072.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 3020. M.GgaDnmt1.

Proteomic databases

PRIDEi Q92072.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396011.
KEGGi gga:396011.

Organism-specific databases

CTDi 1786.

Phylogenomic databases

HOVERGENi HBG051384.
InParanoidi Q92072.
KOi K00558.
PhylomeDBi Q92072.

Miscellaneous databases

NextBioi 20816074.
PROi Q92072.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNA_C5-MeTrfase_1_euk.
IPR029063. SAM-dependent_MTases-like.
IPR002857. Znf_CXXC.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF01426. BAH. 2 hits.
PF06464. DMAP_binding. 1 hit.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view ]
PIRSFi PIRSF037404. DNMT1. 1 hit.
PRINTSi PR00105. C5METTRFRASE.
SMARTi SM00439. BAH. 2 hits.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and expression of a chicken DNA methyltransferase cDNA."
    Tajima S., Tsuda H., Wakabayashi N., Asaso A., Mizuno S., Nishimori K.
    J. Biochem. 117:1050-1057(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1."
    Chuang L.S.-H., Ian H.-I., Koh T.-W., Ng H.-H., Xu G., Li B.F.L.
    Science 277:1996-2000(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PCNA, MUTAGENESIS OF VAL-190.

Entry informationi

Entry nameiDNMT1_CHICK
AccessioniPrimary (citable) accession number: Q92072
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3