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Q92072 (DNMT1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA (cytosine-5)-methyltransferase 1

Short name=Dnmt1
EC=2.1.1.37
Alternative name(s):
DNA methyltransferase GgaI
Short name=DNA MTase GgaI
Short name=M.GgaI
MCMT
Gene names
Name:DNMT1
Synonyms:AIM, DNMT
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length1537 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development By similarity. Mediates transcriptional repression by direct binding to HDAC2 By similarity.

Catalytic activity

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Subunit structure

Interacts with PCNA. Ref.2

Subcellular location

Nucleus By similarity.

Tissue specificity

Testis and lung.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

Contains 2 BAH domains.

Contains 1 CXXC-type zinc finger.

Contains 1 DMAP-interaction domain.

Contains 1 SAM-dependent MTase C5-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15371537DNA (cytosine-5)-methyltransferase 1
PRO_0000088037

Regions

Domain9 – 9890DMAP-interaction
Domain667 – 791125BAH 1
Domain883 – 1011129BAH 2
Repeat1020 – 102121
Repeat1022 – 102322
Repeat1024 – 102523
Repeat1026 – 102724
Repeat1028 – 102925
Repeat1030 – 103126
Repeat1032 – 103327
Repeat1034 – 103528; approximate
Domain1054 – 1513460SAM-dependent MTase C5-type
Zinc finger558 – 60447CXXC-type
Region182 – 19413Interacts with PCNA
Region1020 – 1035168 X 2 AA tandem repeats of K-G
Compositional bias129 – 14921Poly-Ser
Compositional bias217 – 22711Poly-Glu

Sites

Active site11411 By similarity
Metal binding2631Zinc By similarity
Metal binding2661Zinc By similarity
Metal binding3291Zinc By similarity
Site4201Important for activity By similarity

Amino acid modifications

Modified residue4201Phosphoserine By similarity

Experimental info

Mutagenesis1901V → H: No loss of interaction with PCNA. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q92072 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: FB7E0B2CD10EA17E

FASTA1,537172,907
        10         20         30         40         50         60 
MPARSAPPPP ALPPALRRRL RDLERDEDSL SEKETLQEKL RLTRGFLRAE VQRRLSALDA 

        70         80         90        100        110        120 
DVRCRELSEE RYLAKVKALL RRELAAENGD AAKLFSRASN GCAGNGEEEW ERGGRGEDGA 

       130        140        150        160        170        180 
MEVEEAAASS SSSSSSSSSS SSSSSSSSSL LPAPRARKAR RSRSNGESKK SPASSRVTRS 

       190        200        210        220        230        240 
SGRQPTILSV FSKGSTKRKS EEVNGAVKPE VSAEKDEEEE EELEEKEQDE KRIKIETKEG 

       250        260        270        280        290        300 
SEIKDEITQV KTSTPAKTTP PKCVDCRQYL DDPDLKFFQG DPDDALEEPE MLTDERLSIF 

       310        320        330        340        350        360 
DANEDGFESY EDLPQHKVTS FSVYDKRGHL CPFDTGLIER NIELYFSGAV KPIYDDNPCL 

       370        380        390        400        410        420 
DGGVRAKKLG PINAWWITGF DGGEKALIGF TTAFADYILM EPSEEYAPIF ALMQEKIYMS 

       430        440        450        460        470        480 
KIVVEFLQNN RDVSYEDLLN KIETTVPPVG LNFNRFTEDS LLRHAQFVVE QVESYDEAGD 

       490        500        510        520        530        540 
SDEPPVLITP CMRDLIKLAG VTLGKRRAVR RQAIRHPTRI DKDKGPTKAT TTKLVYLIFD 

       550        560        570        580        590        600 
TFFSEQIEKD EREDDKENAM KRRRCGVCEV CQQPECGKCK ACQNMVKFGG SGRSKQACLQ 

       610        620        630        640        650        660 
RRCPNLAVRE ADEDEEVDDN IPEMPSPKKM LQGRKKKQNK SRISWVGEPI KSDGKKDFYQ 

       670        680        690        700        710        720 
RVCIDSETLE VGDCVSVSPD DPTKPLYLAR VTAMWEDSSG QMFHAHWFCP GSDTVLGATS 

       730        740        750        760        770        780 
DPLELFLVDE CEDMQLSYIH GKVNVIYKPP SENWAMEGGL DMEIKMVEDD GRTYFYQMWY 

       790        800        810        820        830        840 
DQEYARFETP PRAQPMEDNK YKFCLSCARL DEVRHKEIPK VAEPLDEGDG KMFYAMATKN 

       850        860        870        880        890        900 
GVQYRVGDSV YLLPEAFSFS MKPASPAKRP KKEAVDEDLY PEHYRKYSEY IKGSNLDAPD 

       910        920        930        940        950        960 
PYRVGRIKEI FCHIRTNGKP NEADIKLRIW KFYRPENTHK SMKATYHADI NLLYWSDEET 

       970        980        990       1000       1010       1020 
TVDFCAVQGR CTVVYGEDLT ESIQDYSAGG LDRFYFLEAY NAKTKSFEDP PNHARSSGNK 

      1030       1040       1050       1060       1070       1080 
GKGKGKGKGK GKGKSSTTCE QSEPEPTELK LPKLRTLDVF SGCGGLSEGF HQAGVSETLW 

      1090       1100       1110       1120       1130       1140 
AIEMWEPAAQ AFRLNNPGTT VFTEDCNVLL KLVMSGEKTN SLGQKLPQKG DVEMLCGGPP 

      1150       1160       1170       1180       1190       1200 
CQGFSGMNRF NSRTYSKFKN SLVVSFLSYC DYYRPRFFLL ENVRNFVSFK RSMVLKLTLR 

      1210       1220       1230       1240       1250       1260 
CLVRMGYQCT FGVLQAGQYG VAQTRRRAIV LAAAPGEKLP MFPEPLHVFA PRACQLSVVV 

      1270       1280       1290       1300       1310       1320 
DDKKFVSNIT RTYSGPFRTI TVRDTMSDLP EIRNGASALE ISYNGEPQSW FQRQIRGSQY 

      1330       1340       1350       1360       1370       1380 
QPILRDHICK DMSALVAARM RHIPLAPGSD WRDLPNIEVR LSDGTSTRKL RYTHHEKKNG 

      1390       1400       1410       1420       1430       1440 
RSSSGALRGV CSCAEGKPCD PADRQFNTLI PWCLPHTGNR HNHWAGLYGR LEWDGFFSTT 

      1450       1460       1470       1480       1490       1500 
VTNPEPMGKQ GRVLHPEQHR VVSVRECARS QGFPDTYRLF GNILDKHRQV GNAVPPPLAK 

      1510       1520       1530 
AIGLEIRACV GARMREESGA AVAPPAPEKM EMTAAAD 

« Hide

References

[1]"Isolation and expression of a chicken DNA methyltransferase cDNA."
Tajima S., Tsuda H., Wakabayashi N., Asaso A., Mizuno S., Nishimori K.
J. Biochem. 117:1050-1057(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1."
Chuang L.S.-H., Ian H.-I., Koh T.-W., Ng H.-H., Xu G., Li B.F.L.
Science 277:1996-2000(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PCNA, MUTAGENESIS OF VAL-190.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D43920 mRNA. Translation: BAA07867.1.
PIRJC4172.
RefSeqNP_996835.1. NM_206952.1.
UniGeneGga.1206.

3D structure databases

ProteinModelPortalQ92072.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

REBASE3020. M.GgaDnmt1.

Proteomic databases

PRIDEQ92072.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396011.
KEGGgga:396011.

Organism-specific databases

CTD1786.

Phylogenomic databases

HOVERGENHBG051384.
KOK00558.
PhylomeDBQ92072.

Family and domain databases

InterProIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNA_C5-MeTrfase_1_euk.
IPR002857. Znf_CXXC.
[Graphical view]
PANTHERPTHR10629. PTHR10629. 1 hit.
PfamPF01426. BAH. 2 hits.
PF06464. DMAP_binding. 1 hit.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFPIRSF037404. DNMT1. 1 hit.
PRINTSPR00105. C5METTRFRASE.
SMARTSM00439. BAH. 2 hits.
[Graphical view]
PROSITEPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816074.
PROQ92072.

Entry information

Entry nameDNMT1_CHICK
AccessionPrimary (citable) accession number: Q92072
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families