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Q92072

- DNMT1_CHICK

UniProt

Q92072 - DNMT1_CHICK

Protein

DNA (cytosine-5)-methyltransferase 1

Gene

DNMT1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development By similarity. Mediates transcriptional repression by direct binding to HDAC2 By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi263 – 2631ZincBy similarity
    Metal bindingi266 – 2661ZincBy similarity
    Metal bindingi329 – 3291ZincBy similarity
    Sitei420 – 4201Important for activityBy similarity
    Active sitei1141 – 11411PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri558 – 60447CXXC-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
    3. DNA binding Source: UniProtKB-KW
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

    Protein family/group databases

    REBASEi3020. M.GgaDnmt1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA (cytosine-5)-methyltransferase 1 (EC:2.1.1.37)
    Short name:
    Dnmt1
    Alternative name(s):
    DNA methyltransferase GgaI
    Short name:
    DNA MTase GgaI
    Short name:
    M.GgaI
    MCMT
    Gene namesi
    Name:DNMT1
    Synonyms:AIM, DNMT
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi190 – 1901V → H: No loss of interaction with PCNA. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15371537DNA (cytosine-5)-methyltransferase 1PRO_0000088037Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei420 – 4201PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ92072.

    Expressioni

    Tissue specificityi

    Testis and lung.

    Interactioni

    Subunit structurei

    Interacts with PCNA.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ92072.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 9890DMAP-interactionAdd
    BLAST
    Domaini667 – 791125BAH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini883 – 1011129BAH 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati1020 – 102121
    Repeati1022 – 102322
    Repeati1024 – 102523
    Repeati1026 – 102724
    Repeati1028 – 102925
    Repeati1030 – 103126
    Repeati1032 – 103327
    Repeati1034 – 103528; approximate
    Domaini1054 – 1513460SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni182 – 19413Interacts with PCNAAdd
    BLAST
    Regioni1020 – 1035168 X 2 AA tandem repeats of K-GAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi129 – 14921Poly-SerAdd
    BLAST
    Compositional biasi217 – 22711Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 2 BAH domains.PROSITE-ProRule annotation
    Contains 1 CXXC-type zinc finger.PROSITE-ProRule annotation
    Contains 1 DMAP-interaction domain.Curated
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri558 – 60447CXXC-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    HOVERGENiHBG051384.
    KOiK00558.
    PhylomeDBiQ92072.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR001025. BAH_dom.
    IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR022702. Cytosine_MeTrfase1_RFD.
    IPR010506. DMAP1-bd.
    IPR017198. DNA_C5-MeTrfase_1_euk.
    IPR029063. SAM-dependent_MTases-like.
    IPR002857. Znf_CXXC.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF01426. BAH. 2 hits.
    PF06464. DMAP_binding. 1 hit.
    PF00145. DNA_methylase. 1 hit.
    PF12047. DNMT1-RFD. 1 hit.
    PF02008. zf-CXXC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037404. DNMT1. 1 hit.
    PRINTSiPR00105. C5METTRFRASE.
    SMARTiSM00439. BAH. 2 hits.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51038. BAH. 2 hits.
    PS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    PS51058. ZF_CXXC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92072-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPARSAPPPP ALPPALRRRL RDLERDEDSL SEKETLQEKL RLTRGFLRAE     50
    VQRRLSALDA DVRCRELSEE RYLAKVKALL RRELAAENGD AAKLFSRASN 100
    GCAGNGEEEW ERGGRGEDGA MEVEEAAASS SSSSSSSSSS SSSSSSSSSL 150
    LPAPRARKAR RSRSNGESKK SPASSRVTRS SGRQPTILSV FSKGSTKRKS 200
    EEVNGAVKPE VSAEKDEEEE EELEEKEQDE KRIKIETKEG SEIKDEITQV 250
    KTSTPAKTTP PKCVDCRQYL DDPDLKFFQG DPDDALEEPE MLTDERLSIF 300
    DANEDGFESY EDLPQHKVTS FSVYDKRGHL CPFDTGLIER NIELYFSGAV 350
    KPIYDDNPCL DGGVRAKKLG PINAWWITGF DGGEKALIGF TTAFADYILM 400
    EPSEEYAPIF ALMQEKIYMS KIVVEFLQNN RDVSYEDLLN KIETTVPPVG 450
    LNFNRFTEDS LLRHAQFVVE QVESYDEAGD SDEPPVLITP CMRDLIKLAG 500
    VTLGKRRAVR RQAIRHPTRI DKDKGPTKAT TTKLVYLIFD TFFSEQIEKD 550
    EREDDKENAM KRRRCGVCEV CQQPECGKCK ACQNMVKFGG SGRSKQACLQ 600
    RRCPNLAVRE ADEDEEVDDN IPEMPSPKKM LQGRKKKQNK SRISWVGEPI 650
    KSDGKKDFYQ RVCIDSETLE VGDCVSVSPD DPTKPLYLAR VTAMWEDSSG 700
    QMFHAHWFCP GSDTVLGATS DPLELFLVDE CEDMQLSYIH GKVNVIYKPP 750
    SENWAMEGGL DMEIKMVEDD GRTYFYQMWY DQEYARFETP PRAQPMEDNK 800
    YKFCLSCARL DEVRHKEIPK VAEPLDEGDG KMFYAMATKN GVQYRVGDSV 850
    YLLPEAFSFS MKPASPAKRP KKEAVDEDLY PEHYRKYSEY IKGSNLDAPD 900
    PYRVGRIKEI FCHIRTNGKP NEADIKLRIW KFYRPENTHK SMKATYHADI 950
    NLLYWSDEET TVDFCAVQGR CTVVYGEDLT ESIQDYSAGG LDRFYFLEAY 1000
    NAKTKSFEDP PNHARSSGNK GKGKGKGKGK GKGKSSTTCE QSEPEPTELK 1050
    LPKLRTLDVF SGCGGLSEGF HQAGVSETLW AIEMWEPAAQ AFRLNNPGTT 1100
    VFTEDCNVLL KLVMSGEKTN SLGQKLPQKG DVEMLCGGPP CQGFSGMNRF 1150
    NSRTYSKFKN SLVVSFLSYC DYYRPRFFLL ENVRNFVSFK RSMVLKLTLR 1200
    CLVRMGYQCT FGVLQAGQYG VAQTRRRAIV LAAAPGEKLP MFPEPLHVFA 1250
    PRACQLSVVV DDKKFVSNIT RTYSGPFRTI TVRDTMSDLP EIRNGASALE 1300
    ISYNGEPQSW FQRQIRGSQY QPILRDHICK DMSALVAARM RHIPLAPGSD 1350
    WRDLPNIEVR LSDGTSTRKL RYTHHEKKNG RSSSGALRGV CSCAEGKPCD 1400
    PADRQFNTLI PWCLPHTGNR HNHWAGLYGR LEWDGFFSTT VTNPEPMGKQ 1450
    GRVLHPEQHR VVSVRECARS QGFPDTYRLF GNILDKHRQV GNAVPPPLAK 1500
    AIGLEIRACV GARMREESGA AVAPPAPEKM EMTAAAD 1537
    Length:1,537
    Mass (Da):172,907
    Last modified:November 1, 1996 - v1
    Checksum:iFB7E0B2CD10EA17E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D43920 mRNA. Translation: BAA07867.1.
    PIRiJC4172.
    RefSeqiNP_996835.1. NM_206952.1.
    UniGeneiGga.1206.

    Genome annotation databases

    GeneIDi396011.
    KEGGigga:396011.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D43920 mRNA. Translation: BAA07867.1 .
    PIRi JC4172.
    RefSeqi NP_996835.1. NM_206952.1.
    UniGenei Gga.1206.

    3D structure databases

    ProteinModelPortali Q92072.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 3020. M.GgaDnmt1.

    Proteomic databases

    PRIDEi Q92072.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396011.
    KEGGi gga:396011.

    Organism-specific databases

    CTDi 1786.

    Phylogenomic databases

    HOVERGENi HBG051384.
    KOi K00558.
    PhylomeDBi Q92072.

    Miscellaneous databases

    NextBioi 20816074.
    PROi Q92072.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR001025. BAH_dom.
    IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR022702. Cytosine_MeTrfase1_RFD.
    IPR010506. DMAP1-bd.
    IPR017198. DNA_C5-MeTrfase_1_euk.
    IPR029063. SAM-dependent_MTases-like.
    IPR002857. Znf_CXXC.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF01426. BAH. 2 hits.
    PF06464. DMAP_binding. 1 hit.
    PF00145. DNA_methylase. 1 hit.
    PF12047. DNMT1-RFD. 1 hit.
    PF02008. zf-CXXC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037404. DNMT1. 1 hit.
    PRINTSi PR00105. C5METTRFRASE.
    SMARTi SM00439. BAH. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51038. BAH. 2 hits.
    PS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    PS51058. ZF_CXXC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and expression of a chicken DNA methyltransferase cDNA."
      Tajima S., Tsuda H., Wakabayashi N., Asaso A., Mizuno S., Nishimori K.
      J. Biochem. 117:1050-1057(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1."
      Chuang L.S.-H., Ian H.-I., Koh T.-W., Ng H.-H., Xu G., Li B.F.L.
      Science 277:1996-2000(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PCNA, MUTAGENESIS OF VAL-190.

    Entry informationi

    Entry nameiDNMT1_CHICK
    AccessioniPrimary (citable) accession number: Q92072
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3