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Q92072

- DNMT1_CHICK

UniProt

Q92072 - DNMT1_CHICK

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Protein
DNA (cytosine-5)-methyltransferase 1
Gene
DNMT1, AIM, DNMT
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development By similarity. Mediates transcriptional repression by direct binding to HDAC2 By similarity.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi263 – 2631Zinc By similarity
Metal bindingi266 – 2661Zinc By similarity
Metal bindingi329 – 3291Zinc By similarity
Sitei420 – 4201Important for activity By similarity
Active sitei1141 – 11411 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri558 – 60447CXXC-type
Add
BLAST

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: UniProtKB-KW
  3. chromatin binding Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Protein family/group databases

REBASEi3020. M.GgaDnmt1.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferase 1 (EC:2.1.1.37)
Short name:
Dnmt1
Alternative name(s):
DNA methyltransferase GgaI
Short name:
DNA MTase GgaI
Short name:
M.GgaI
MCMT
Gene namesi
Name:DNMT1
Synonyms:AIM, DNMT
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi190 – 1901V → H: No loss of interaction with PCNA. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15371537DNA (cytosine-5)-methyltransferase 1
PRO_0000088037Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei420 – 4201Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ92072.

Expressioni

Tissue specificityi

Testis and lung.

Interactioni

Subunit structurei

Interacts with PCNA.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ92072.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 9890DMAP-interaction
Add
BLAST
Domaini667 – 791125BAH 1
Add
BLAST
Domaini883 – 1011129BAH 2
Add
BLAST
Repeati1020 – 102121
Repeati1022 – 102322
Repeati1024 – 102523
Repeati1026 – 102724
Repeati1028 – 102925
Repeati1030 – 103126
Repeati1032 – 103327
Repeati1034 – 103528; approximate
Domaini1054 – 1513460SAM-dependent MTase C5-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni182 – 19413Interacts with PCNA
Add
BLAST
Regioni1020 – 1035168 X 2 AA tandem repeats of K-G
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi129 – 14921Poly-Ser
Add
BLAST
Compositional biasi217 – 22711Poly-Glu
Add
BLAST

Sequence similaritiesi

Contains 2 BAH domains.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG051384.
KOiK00558.
PhylomeDBiQ92072.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNA_C5-MeTrfase_1_euk.
IPR029063. SAM-dependent_MTases-like.
IPR002857. Znf_CXXC.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF01426. BAH. 2 hits.
PF06464. DMAP_binding. 1 hit.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92072-1 [UniParc]FASTAAdd to Basket

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MPARSAPPPP ALPPALRRRL RDLERDEDSL SEKETLQEKL RLTRGFLRAE     50
VQRRLSALDA DVRCRELSEE RYLAKVKALL RRELAAENGD AAKLFSRASN 100
GCAGNGEEEW ERGGRGEDGA MEVEEAAASS SSSSSSSSSS SSSSSSSSSL 150
LPAPRARKAR RSRSNGESKK SPASSRVTRS SGRQPTILSV FSKGSTKRKS 200
EEVNGAVKPE VSAEKDEEEE EELEEKEQDE KRIKIETKEG SEIKDEITQV 250
KTSTPAKTTP PKCVDCRQYL DDPDLKFFQG DPDDALEEPE MLTDERLSIF 300
DANEDGFESY EDLPQHKVTS FSVYDKRGHL CPFDTGLIER NIELYFSGAV 350
KPIYDDNPCL DGGVRAKKLG PINAWWITGF DGGEKALIGF TTAFADYILM 400
EPSEEYAPIF ALMQEKIYMS KIVVEFLQNN RDVSYEDLLN KIETTVPPVG 450
LNFNRFTEDS LLRHAQFVVE QVESYDEAGD SDEPPVLITP CMRDLIKLAG 500
VTLGKRRAVR RQAIRHPTRI DKDKGPTKAT TTKLVYLIFD TFFSEQIEKD 550
EREDDKENAM KRRRCGVCEV CQQPECGKCK ACQNMVKFGG SGRSKQACLQ 600
RRCPNLAVRE ADEDEEVDDN IPEMPSPKKM LQGRKKKQNK SRISWVGEPI 650
KSDGKKDFYQ RVCIDSETLE VGDCVSVSPD DPTKPLYLAR VTAMWEDSSG 700
QMFHAHWFCP GSDTVLGATS DPLELFLVDE CEDMQLSYIH GKVNVIYKPP 750
SENWAMEGGL DMEIKMVEDD GRTYFYQMWY DQEYARFETP PRAQPMEDNK 800
YKFCLSCARL DEVRHKEIPK VAEPLDEGDG KMFYAMATKN GVQYRVGDSV 850
YLLPEAFSFS MKPASPAKRP KKEAVDEDLY PEHYRKYSEY IKGSNLDAPD 900
PYRVGRIKEI FCHIRTNGKP NEADIKLRIW KFYRPENTHK SMKATYHADI 950
NLLYWSDEET TVDFCAVQGR CTVVYGEDLT ESIQDYSAGG LDRFYFLEAY 1000
NAKTKSFEDP PNHARSSGNK GKGKGKGKGK GKGKSSTTCE QSEPEPTELK 1050
LPKLRTLDVF SGCGGLSEGF HQAGVSETLW AIEMWEPAAQ AFRLNNPGTT 1100
VFTEDCNVLL KLVMSGEKTN SLGQKLPQKG DVEMLCGGPP CQGFSGMNRF 1150
NSRTYSKFKN SLVVSFLSYC DYYRPRFFLL ENVRNFVSFK RSMVLKLTLR 1200
CLVRMGYQCT FGVLQAGQYG VAQTRRRAIV LAAAPGEKLP MFPEPLHVFA 1250
PRACQLSVVV DDKKFVSNIT RTYSGPFRTI TVRDTMSDLP EIRNGASALE 1300
ISYNGEPQSW FQRQIRGSQY QPILRDHICK DMSALVAARM RHIPLAPGSD 1350
WRDLPNIEVR LSDGTSTRKL RYTHHEKKNG RSSSGALRGV CSCAEGKPCD 1400
PADRQFNTLI PWCLPHTGNR HNHWAGLYGR LEWDGFFSTT VTNPEPMGKQ 1450
GRVLHPEQHR VVSVRECARS QGFPDTYRLF GNILDKHRQV GNAVPPPLAK 1500
AIGLEIRACV GARMREESGA AVAPPAPEKM EMTAAAD 1537
Length:1,537
Mass (Da):172,907
Last modified:November 1, 1996 - v1
Checksum:iFB7E0B2CD10EA17E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D43920 mRNA. Translation: BAA07867.1.
PIRiJC4172.
RefSeqiNP_996835.1. NM_206952.1.
UniGeneiGga.1206.

Genome annotation databases

GeneIDi396011.
KEGGigga:396011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D43920 mRNA. Translation: BAA07867.1 .
PIRi JC4172.
RefSeqi NP_996835.1. NM_206952.1.
UniGenei Gga.1206.

3D structure databases

ProteinModelPortali Q92072.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 3020. M.GgaDnmt1.

Proteomic databases

PRIDEi Q92072.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396011.
KEGGi gga:396011.

Organism-specific databases

CTDi 1786.

Phylogenomic databases

HOVERGENi HBG051384.
KOi K00558.
PhylomeDBi Q92072.

Miscellaneous databases

NextBioi 20816074.
PROi Q92072.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNA_C5-MeTrfase_1_euk.
IPR029063. SAM-dependent_MTases-like.
IPR002857. Znf_CXXC.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF01426. BAH. 2 hits.
PF06464. DMAP_binding. 1 hit.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view ]
PIRSFi PIRSF037404. DNMT1. 1 hit.
PRINTSi PR00105. C5METTRFRASE.
SMARTi SM00439. BAH. 2 hits.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and expression of a chicken DNA methyltransferase cDNA."
    Tajima S., Tsuda H., Wakabayashi N., Asaso A., Mizuno S., Nishimori K.
    J. Biochem. 117:1050-1057(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1."
    Chuang L.S.-H., Ian H.-I., Koh T.-W., Ng H.-H., Xu G., Li B.F.L.
    Science 277:1996-2000(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PCNA, MUTAGENESIS OF VAL-190.

Entry informationi

Entry nameiDNMT1_CHICK
AccessioniPrimary (citable) accession number: Q92072
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi