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Protein

Integrin beta

Gene

ITGB3

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotationImported
Biological processCell adhesionUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-1566948 Elastic fibre formation
R-GGA-2129379 Molecules associated with elastic fibres
R-GGA-216083 Integrin cell surface interactions
R-GGA-3000170 Syndecan interactions
R-GGA-3000178 ECM proteoglycans
R-GGA-354192 Integrin alphaIIb beta3 signaling
R-GGA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-GGA-372708 p130Cas linkage to MAPK signaling for integrins
R-GGA-4420097 VEGFA-VEGFR2 Pathway
R-GGA-5674135 MAP2K and MAPK activation

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:ITGB3Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei711 – 733HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501431243821 – 781Integrin betaSequence analysisAdd BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 453UniRule annotation
Disulfide bondi32 ↔ 42UniRule annotation
Disulfide bondi35 ↔ 68UniRule annotation
Disulfide bondi45 ↔ 57UniRule annotation
Disulfide bondi195 ↔ 202UniRule annotation
Disulfide bondi250 ↔ 291UniRule annotation
Disulfide bondi392 ↔ 404UniRule annotation
Disulfide bondi424 ↔ 673UniRule annotation
Disulfide bondi451 ↔ 455UniRule annotation
Disulfide bondi466 ↔ 478UniRule annotation
Disulfide bondi475 ↔ 513UniRule annotation
Disulfide bondi480 ↔ 489UniRule annotation
Disulfide bondi491 ↔ 504UniRule annotation
Disulfide bondi519 ↔ 524UniRule annotation
Disulfide bondi521 ↔ 554UniRule annotation
Disulfide bondi526 ↔ 539UniRule annotation
Disulfide bondi541 ↔ 546UniRule annotation
Disulfide bondi560 ↔ 565UniRule annotation
Disulfide bondi562 ↔ 593UniRule annotation
Disulfide bondi567 ↔ 576UniRule annotation
Disulfide bondi578 ↔ 585UniRule annotation
Disulfide bondi599 ↔ 604UniRule annotation
Disulfide bondi601 ↔ 649UniRule annotation
Disulfide bondi606 ↔ 616UniRule annotation
Disulfide bondi626 ↔ 635UniRule annotation
Disulfide bondi632 ↔ 705UniRule annotation
Disulfide bondi653 ↔ 681UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000000379

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000518

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 453INBInterPro annotationAdd BLAST423
Domaini626 – 710Integrin_B_tailInterPro annotationAdd BLAST85
Domaini734 – 780Integrin_b_cytInterPro annotationAdd BLAST47

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064
HOGENOMiHOG000252936
HOVERGENiHBG006190
KOiK06493
OMAiCHSSDFG
OrthoDBiEOG091G029W
TreeFamiTF105392

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013111 EGF_extracell
IPR027068 Integrin_beta-3
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR014836 Integrin_bsu_cyt_dom
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF25 PTHR10082:SF25, 1 hit
PfamiView protein in Pfam
PF07974 EGF_2, 2 hits
PF08725 Integrin_b_cyt, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PIRSFiPIRSF002512 Integrin_B, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 1 hit
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00243 INTEGRIN_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q92071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELRVAFSI LVLCAAGSWG SNICATRGVT SCKQCLAVSP LCAWCSAEVV
60 70 80 90 100
AQSTPRCDLF ANLLQNGCGR DFIEFPRSSI TVLEERPLSD KGSGGSTTTQ
110 120 130 140 150
MSPQRIQLNL RPDDSQMFRV HVRQVEDYPV DIYYLMDLSN SMKDDLKNIQ
160 170 180 190 200
NLGTKLASEM RKLTSNLRIG FGAFVDKPIS PYMYISPPEA IKNPCYEIGE
210 220 230 240 250
KCLPMFGYKH VLTLTDEVMR FNEEVKKQSV SRNRDAPEGG FDAIIQATVC
260 270 280 290 300
DEKIGWRNDA SHLLVFTTDA KTHIALDGRL AGIVQPNDAQ CHIDKDNFYS
310 320 330 340 350
ASTTLDYPSL GLMTEKLSQK NINLIFAVTD TVVGLYQNYS ELIPGTTVGT
360 370 380 390 400
LSRDSSNVLQ LIVDAYGKIR SKVELEVRDL PEELSLSFNA TCLNDEVITG
410 420 430 440 450
LKSCMGLKIG DTVSFSIEAK VRGCPQERQK SFTIKPVGFK DSLTVVVNFD
460 470 480 490 500
CNCSCESQAE ANSSFCSKGN GSLECGVCRC NPGRLGSHCE CSEEEYNPSE
510 520 530 540 550
QDNCSPQPGQ PLCSQRGECI CGQCVCHGSD FGKVTGKYCE CDDFSCVRFK
560 570 580 590 600
GQMCSGHGQC SCGDCLCDSD WTGDYCNCTT RTDTCMSSNG LVCSGHGICV
610 620 630 640 650
CGKCDCIQPG SYGNTCEKCP TCSDACTIKK ECVECKKYER GTLVEQQSCG
660 670 680 690 700
RVCRDEIETV QELGDRGKDA VNCTYKDEND CVVRFQYYED SSGKSILYVI
710 720 730 740 750
EEPECPKGPD ILVVLLSVMG AILLIGLAAL LIWKLLITIH DRREFARFEE
760 770 780
EKARAKWDTG NNPLYKEATS TFTNITYRGN M
Length:781
Mass (Da):86,116
Last modified:November 1, 1996 - v1
Checksum:i7E991E605DF0CDBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000381 Genomic DNA No translation available.
X72378 mRNA Translation: CAA51069.1
PIRiS43534
RefSeqiNP_989646.1, NM_204315.1
UniGeneiGga.1039

Genome annotation databases

EnsembliENSGALT00000000519; ENSGALP00000000518; ENSGALG00000000379
GeneIDi374209
KEGGigga:374209

Similar proteinsi

Entry informationi

Entry nameiQ92071_CHICK
AccessioniPrimary (citable) accession number: Q92071
Secondary accession number(s): F1NS08, Q90829
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health