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Protein

Integrin beta

Gene

ITGB3

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotationImported

Keywords - Biological processi

Cell adhesionUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-114608. Platelet degranulation.
R-GGA-1566948. Elastic fibre formation.
R-GGA-2129379. Molecules associated with elastic fibres.
R-GGA-216083. Integrin cell surface interactions.
R-GGA-3000170. Syndecan interactions.
R-GGA-3000178. ECM proteoglycans.
R-GGA-354192. Integrin alphaIIb beta3 signaling.
R-GGA-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-GGA-372708. p130Cas linkage to MAPK signaling for integrins.
R-GGA-4420097. VEGFA-VEGFR2 Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:ITGB3Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 27

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei711 – 73323HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 781761Integrin betaSequence analysisPRO_5007215480Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiQ92071. baseline.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000518.

Structurei

3D structure databases

SMRiQ92071. Positions 20-543, 703-779.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 453423INBInterPro annotationAdd
BLAST
Domaini626 – 71085Integrin_B_tailInterPro annotationAdd
BLAST
Domaini734 – 78047Integrin_b_cytInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation
Contains VWFA domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
KOiK06493.
OMAiGHGQCSC.
OrthoDBiEOG7T7GSB.
PhylomeDBiQ92071.
TreeFamiTF105392.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR027068. Integrin_beta-3.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR032695. Integrin_dom.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF25. PTHR10082:SF25. 1 hit.
PfamiPF07974. EGF_2. 2 hits.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELRVAFSI LVLCAAGSWG SNICATRGVT SCKQCLAVSP LCAWCSAEVV
60 70 80 90 100
AQSTPRCDLF ANLLQNGCGR DFIEFPRSSI TVLEERPLSD KGSGGSTTTQ
110 120 130 140 150
MSPQRIQLNL RPDDSQMFRV HVRQVEDYPV DIYYLMDLSN SMKDDLKNIQ
160 170 180 190 200
NLGTKLASEM RKLTSNLRIG FGAFVDKPIS PYMYISPPEA IKNPCYEIGE
210 220 230 240 250
KCLPMFGYKH VLTLTDEVMR FNEEVKKQSV SRNRDAPEGG FDAIIQATVC
260 270 280 290 300
DEKIGWRNDA SHLLVFTTDA KTHIALDGRL AGIVQPNDAQ CHIDKDNFYS
310 320 330 340 350
ASTTLDYPSL GLMTEKLSQK NINLIFAVTD TVVGLYQNYS ELIPGTTVGT
360 370 380 390 400
LSRDSSNVLQ LIVDAYGKIR SKVELEVRDL PEELSLSFNA TCLNDEVITG
410 420 430 440 450
LKSCMGLKIG DTVSFSIEAK VRGCPQERQK SFTIKPVGFK DSLTVVVNFD
460 470 480 490 500
CNCSCESQAE ANSSFCSKGN GSLECGVCRC NPGRLGSHCE CSEEEYNPSE
510 520 530 540 550
QDNCSPQPGQ PLCSQRGECI CGQCVCHGSD FGKVTGKYCE CDDFSCVRFK
560 570 580 590 600
GQMCSGHGQC SCGDCLCDSD WTGDYCNCTT RTDTCMSSNG LVCSGHGICV
610 620 630 640 650
CGKCDCIQPG SYGNTCEKCP TCSDACTIKK ECVECKKYER GTLVEQQSCG
660 670 680 690 700
RVCRDEIETV QELGDRGKDA VNCTYKDEND CVVRFQYYED SSGKSILYVI
710 720 730 740 750
EEPECPKGPD ILVVLLSVMG AILLIGLAAL LIWKLLITIH DRREFARFEE
760 770 780
EKARAKWDTG NNPLYKEATS TFTNITYRGN M
Length:781
Mass (Da):86,116
Last modified:November 1, 1996 - v1
Checksum:i7E991E605DF0CDBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03008614 Genomic DNA. No translation available.
X72378 mRNA. Translation: CAA51069.1.
PIRiS43534.
RefSeqiNP_989646.1. NM_204315.1.
UniGeneiGga.1039.

Genome annotation databases

EnsembliENSGALT00000000519; ENSGALP00000000518; ENSGALG00000000379.
GeneIDi374209.
KEGGigga:374209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03008614 Genomic DNA. No translation available.
X72378 mRNA. Translation: CAA51069.1.
PIRiS43534.
RefSeqiNP_989646.1. NM_204315.1.
UniGeneiGga.1039.

3D structure databases

SMRiQ92071. Positions 20-543, 703-779.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000000519; ENSGALP00000000518; ENSGALG00000000379.
GeneIDi374209.
KEGGigga:374209.

Organism-specific databases

CTDi374209.

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
KOiK06493.
OMAiGHGQCSC.
OrthoDBiEOG7T7GSB.
PhylomeDBiQ92071.
TreeFamiTF105392.

Enzyme and pathway databases

ReactomeiR-GGA-114608. Platelet degranulation.
R-GGA-1566948. Elastic fibre formation.
R-GGA-2129379. Molecules associated with elastic fibres.
R-GGA-216083. Integrin cell surface interactions.
R-GGA-3000170. Syndecan interactions.
R-GGA-3000178. ECM proteoglycans.
R-GGA-354192. Integrin alphaIIb beta3 signaling.
R-GGA-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-GGA-372708. p130Cas linkage to MAPK signaling for integrins.
R-GGA-4420097. VEGFA-VEGFR2 Pathway.

Gene expression databases

ExpressionAtlasiQ92071. baseline.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR027068. Integrin_beta-3.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR032695. Integrin_dom.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF25. PTHR10082:SF25. 1 hit.
PfamiPF07974. EGF_2. 2 hits.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cao X.
    Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: White leghornImported.
  2. "1,25-Dihydroxyvitamin D3 transcriptionally activates the beta 3-integrin subunit gene in avian osteoclast precursors."
    Mimura H., Cao X., Ross F.P., Chiba M., Teitelbaum S.L.
    Endocrinology 134:1061-1066(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: White leghornImported.
  3. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiQ92071_CHICK
AccessioniPrimary (citable) accession number: Q92071
Secondary accession number(s): F1NS08, Q90829
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.