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Protein

Integrin beta

Gene

integrin beta 2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotationImported
Biological processCell adhesionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:integrin beta 2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei703 – 728HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500431959525 – 772Integrin betaSequence analysisAdd BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 449UniRule annotation
Disulfide bondi35 ↔ 45UniRule annotation
Disulfide bondi38 ↔ 75UniRule annotation
Disulfide bondi48 ↔ 64UniRule annotation
Disulfide bondi194 ↔ 201UniRule annotation
Disulfide bondi248 ↔ 288UniRule annotation
Disulfide bondi422 ↔ 664UniRule annotation
Disulfide bondi447 ↔ 451UniRule annotation
Disulfide bondi468 ↔ 507UniRule annotation
Disulfide bondi473 ↔ 482UniRule annotation
Disulfide bondi484 ↔ 498UniRule annotation
Disulfide bondi513 ↔ 518UniRule annotation
Disulfide bondi515 ↔ 550UniRule annotation
Disulfide bondi520 ↔ 535UniRule annotation
Disulfide bondi537 ↔ 542UniRule annotation
Disulfide bondi558 ↔ 563UniRule annotation
Disulfide bondi560 ↔ 591UniRule annotation
Disulfide bondi565 ↔ 574UniRule annotation
Disulfide bondi597 ↔ 602UniRule annotation
Disulfide bondi599 ↔ 644UniRule annotation
Disulfide bondi604 ↔ 613UniRule annotation
Disulfide bondi616 ↔ 619UniRule annotation
Disulfide bondi623 ↔ 632UniRule annotation
Disulfide bondi629 ↔ 697UniRule annotation
Disulfide bondi648 ↔ 672UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PaxDbiQ92070.
PRIDEiQ92070.

Structurei

3D structure databases

ProteinModelPortaliQ92070.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 76PSIInterPro annotationAdd BLAST51
Domaini34 – 449INBInterPro annotationAdd BLAST416
Domaini623 – 702Integrin_B_tailInterPro annotationAdd BLAST80
Domaini726 – 772Integrin_b_cytInterPro annotationAdd BLAST47

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
KOiK06464.
PhylomeDBiQ92070.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
InterProiView protein in InterPro
IPR033760. Integrin_beta_N.
IPR015812. Integrin_bsu.
IPR015439. Integrin_bsu-2.
IPR014836. Integrin_bsu_cyt_dom.
IPR012896. Integrin_bsu_tail.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom.
IPR016201. PSI.
IPR002035. VWF_A.
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF47. PTHR10082:SF47. 1 hit.
PfamiView protein in Pfam
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiView protein in SMART
SM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRDCCLWLP AMTWVLLLLT TAFAAECPKI KVGTCKNCIQ SGPGCAWCKK
60 70 80 90 100
LSFTKAGEPD SNRCDTIEQL QQRGCPENEI EFPVNEIKRT QDSAFSNKIQ
110 120 130 140 150
LTPQEVHLKL RIREPAEFDV KFRRATGYPI DIYYLMDLSY SMLDDLENVK
160 170 180 190 200
KLGGQLLRAL ESTTPSRRIG FGSFVDKTVL PFVNTHPEKL KNPCPNKDSN
210 220 230 240 250
CQPPFAFKHI LSLTDNAEKF ESEVGKQFIS GNLDAPEGLD AMMQAAVCGD
260 270 280 290 300
LIGWRNVTRL LVYATDDGFH FAGDGKLGGI LTPNDGQCHL EDNMYKKSNE
310 320 330 340 350
FDYPSVGQLV QKLAENNIQP IFAVTSKMVD VYKKLSDMIP KSAVGELNED
360 370 380 390 400
SSNIIELIQV AYNNLSSRII LDHSTLPDVL DVKYDSICNN NTGAKNEARG
410 420 430 440 450
QCDNVKINDE VTFKVKVTAN ECIKSQSFTI RPLGFTDTLT VHLDSICDCD
460 470 480 490 500
CREQPDPTAC SGNGKVVCGI CSCNLSYTGK NCECDTKGKT SKELEGSCRK
510 520 530 540 550
DNSSVICSGL GDCVCGQCVC HTSDVPGKEI YGTFCDCDNM NCEFHNGSLC
560 570 580 590 600
GGEERGRCDC GECKCTPKYE GSACQCKKST DGCRNSRQNE CSLRGSCPCN
610 620 630 640 650
RCQCRGGYQP PFCEECPGCP SPCGRHISCV ECKSFNSGPL AKNCSVACTS
660 670 680 690 700
IQLADEPRAG SRQCKEKDSE NCWISFYMAQ DDGEEMYTVT VDPKKECPEP
710 720 730 740 750
PNIALIVGST IAGVALIGLL LLLTWRLLTE IFDRREYRRF EKEKSKAKWN
760 770
EADNPLFKSA TTTVMNPRFD GQ
Length:772
Mass (Da):85,369
Last modified:November 1, 1996 - v1
Checksum:iFAC0ED30E4287D27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71786 mRNA. Translation: CAA50671.1.
PIRiI50660. S32659.
RefSeqiNP_990582.1. NM_205251.1.
UniGeneiGga.4507.

Genome annotation databases

GeneIDi396181.
KEGGigga:396181.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ92070_CHICK
AccessioniPrimary (citable) accession number: Q92070
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)