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Q92058

- PPBT_CHICK

UniProt

Q92058 - PPBT_CHICK

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Protein

Alkaline phosphatase, tissue-nonspecific isozyme

Gene

ALPL

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.PROSITE-ProRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarityNote: Binds 1 Mg(2+) ion.By similarity
  • Zn2+By similarityNote: Binds 2 Zn(2+) ions.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591MagnesiumBy similarity
Metal bindingi59 – 591Zinc 1By similarity
Active sitei109 – 1091Phosphoserine intermediatePROSITE-ProRule annotation
Metal bindingi109 – 1091Zinc 1By similarity
Metal bindingi172 – 1721MagnesiumBy similarity
Metal bindingi331 – 3311MagnesiumBy similarity
Metal bindingi336 – 3361Zinc 2By similarity
Metal bindingi340 – 3401Zinc 2; via tele nitrogenBy similarity
Metal bindingi377 – 3771Zinc 1By similarity
Metal bindingi378 – 3781Zinc 1; via tele nitrogenBy similarity
Metal bindingi453 – 4531Zinc 2; via tele nitrogenBy similarity

GO - Molecular functioni

  1. alkaline phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline phosphatase, tissue-nonspecific isozyme (EC:3.1.3.1)
Short name:
AP-TNAP
Short name:
TNSALP
Gene namesi
Name:ALPL
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 498482Alkaline phosphatase, tissue-nonspecific isozymePRO_0000024029Add
BLAST
Propeptidei499 – 51921Removed in mature formSequence AnalysisPRO_0000024030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi138 ↔ 200By similarity
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi488 ↔ 496By similarity
Lipidationi498 – 4981GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ92058.
PRIDEiQ92058.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038334.

Structurei

3D structure databases

ProteinModelPortaliQ92058.
SMRiQ92058. Positions 17-498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alkaline phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1785.
HOGENOMiHOG000099118.
HOVERGENiHBG007345.
InParanoidiQ92058.
KOiK01077.
PhylomeDBiQ92058.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
[Graphical view]
PfamiPF00245. Alk_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00113. ALKPHPHTASE.
SMARTiSM00098. alkPPc. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00123. ALKALINE_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92058-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAFLLTLLA QLCSASLVPE REKDPEYWRQ QAQETLRDAL RLQHLNQNVA
60 70 80 90 100
KNLILFLGDG MGVSTVTAAR ILKGQLQHRK GEESLLEMDK FPYVALAKTY
110 120 130 140 150
NTNAQVPDSA GTATAYLCGV KANEGTVGVS AGVTRDRCNT TKGQEVTSIL
160 170 180 190 200
RWAKDEGKAV GIVTTTRVTH ATPSAAYAHS ANRDWYSDGE MPLDALEGGC
210 220 230 240 250
KDIARQLVDN IPDIEVILGG GRKYMFPKNT SDVEYPQEER HRGTRLDGKD
260 270 280 290 300
LVQAWHDTKP AGKVAKYVWH RRELLALNVS RVDFLLGLFE PGDMVYELDR
310 320 330 340 350
NNETDPSLSE MVAVAIRMLQ KNPRGFFLLV EGGRIDHGHH EGKAKQALHE
360 370 380 390 400
AVELDRAVGL AGRLTSPRDT LSVVTADHSH VFTFGGYTPR GNPIFGLAPM
410 420 430 440 450
QSDVDRKPFT SILYGNGPGY KIVGGERENV SAVDFAHANY QAQAAVPLRQ
460 470 480 490 500
ETHGGEDVAV FARGPMAHLL HGVDEQNYIP HAMAYAACIG PNRAHCSSAA
510
RPAATATLLP VLLLLLLLC
Length:519
Mass (Da):56,760
Last modified:November 1, 1996 - v1
Checksum:i7934C0EEC3B17B89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19108 mRNA. Translation: AAA92562.1.
RefSeqiNP_990691.1. NM_205360.1.
UniGeneiGga.760.

Genome annotation databases

GeneIDi396317.
KEGGigga:396317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19108 mRNA. Translation: AAA92562.1 .
RefSeqi NP_990691.1. NM_205360.1.
UniGenei Gga.760.

3D structure databases

ProteinModelPortali Q92058.
SMRi Q92058. Positions 17-498.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000038334.

Proteomic databases

PaxDbi Q92058.
PRIDEi Q92058.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396317.
KEGGi gga:396317.

Organism-specific databases

CTDi 249.

Phylogenomic databases

eggNOGi COG1785.
HOGENOMi HOG000099118.
HOVERGENi HBG007345.
InParanoidi Q92058.
KOi K01077.
PhylomeDBi Q92058.

Miscellaneous databases

NextBioi 20816365.

Family and domain databases

Gene3Di 3.40.720.10. 1 hit.
InterProi IPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
[Graphical view ]
Pfami PF00245. Alk_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00113. ALKPHPHTASE.
SMARTi SM00098. alkPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF53649. SSF53649. 1 hit.
PROSITEi PS00123. ALKALINE_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Tissue-nonspecific alkaline phosphatase participates in the establishment and growth of feather germs in embryonic chick skin cultures."
    Crawford K., Weissig H., Binette F., Millan J.L., Goetinck P.F.
    Dev. Dyn. 204:48-56(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPPBT_CHICK
AccessioniPrimary (citable) accession number: Q92058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3