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Q92058

- PPBT_CHICK

UniProt

Q92058 - PPBT_CHICK

Protein

Alkaline phosphatase, tissue-nonspecific isozyme

Gene

ALPL

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.PROSITE-ProRule annotation

    Cofactori

    Binds 1 magnesium ion.By similarity
    Binds 2 zinc ions.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591MagnesiumBy similarity
    Metal bindingi59 – 591Zinc 1By similarity
    Active sitei109 – 1091Phosphoserine intermediatePROSITE-ProRule annotation
    Metal bindingi109 – 1091Zinc 1By similarity
    Metal bindingi172 – 1721MagnesiumBy similarity
    Metal bindingi331 – 3311MagnesiumBy similarity
    Metal bindingi336 – 3361Zinc 2By similarity
    Metal bindingi340 – 3401Zinc 2; via tele nitrogenBy similarity
    Metal bindingi377 – 3771Zinc 1By similarity
    Metal bindingi378 – 3781Zinc 1; via tele nitrogenBy similarity
    Metal bindingi453 – 4531Zinc 2; via tele nitrogenBy similarity

    GO - Molecular functioni

    1. alkaline phosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alkaline phosphatase, tissue-nonspecific isozyme (EC:3.1.3.1)
    Short name:
    AP-TNAP
    Short name:
    TNSALP
    Gene namesi
    Name:ALPL
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 498482Alkaline phosphatase, tissue-nonspecific isozymePRO_0000024029Add
    BLAST
    Propeptidei499 – 51921Removed in mature formSequence AnalysisPRO_0000024030Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi138 ↔ 200By similarity
    Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi488 ↔ 496By similarity
    Lipidationi498 – 4981GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ92058.
    PRIDEiQ92058.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000038334.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92058.
    SMRiQ92058. Positions 17-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alkaline phosphatase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1785.
    HOGENOMiHOG000099118.
    HOVERGENiHBG007345.
    InParanoidiQ92058.
    KOiK01077.
    PhylomeDBiQ92058.

    Family and domain databases

    Gene3Di3.40.720.10. 1 hit.
    InterProiIPR017849. Alkaline_Pase-like_a/b/a.
    IPR001952. Alkaline_phosphatase.
    IPR018299. Alkaline_phosphatase_AS.
    IPR017850. Alkaline_phosphatase_core.
    [Graphical view]
    PfamiPF00245. Alk_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00113. ALKPHPHTASE.
    SMARTiSM00098. alkPPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53649. SSF53649. 1 hit.
    PROSITEiPS00123. ALKALINE_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q92058-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAFLLTLLA QLCSASLVPE REKDPEYWRQ QAQETLRDAL RLQHLNQNVA    50
    KNLILFLGDG MGVSTVTAAR ILKGQLQHRK GEESLLEMDK FPYVALAKTY 100
    NTNAQVPDSA GTATAYLCGV KANEGTVGVS AGVTRDRCNT TKGQEVTSIL 150
    RWAKDEGKAV GIVTTTRVTH ATPSAAYAHS ANRDWYSDGE MPLDALEGGC 200
    KDIARQLVDN IPDIEVILGG GRKYMFPKNT SDVEYPQEER HRGTRLDGKD 250
    LVQAWHDTKP AGKVAKYVWH RRELLALNVS RVDFLLGLFE PGDMVYELDR 300
    NNETDPSLSE MVAVAIRMLQ KNPRGFFLLV EGGRIDHGHH EGKAKQALHE 350
    AVELDRAVGL AGRLTSPRDT LSVVTADHSH VFTFGGYTPR GNPIFGLAPM 400
    QSDVDRKPFT SILYGNGPGY KIVGGERENV SAVDFAHANY QAQAAVPLRQ 450
    ETHGGEDVAV FARGPMAHLL HGVDEQNYIP HAMAYAACIG PNRAHCSSAA 500
    RPAATATLLP VLLLLLLLC 519
    Length:519
    Mass (Da):56,760
    Last modified:November 1, 1996 - v1
    Checksum:i7934C0EEC3B17B89
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19108 mRNA. Translation: AAA92562.1.
    RefSeqiNP_990691.1. NM_205360.1.
    UniGeneiGga.760.

    Genome annotation databases

    GeneIDi396317.
    KEGGigga:396317.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19108 mRNA. Translation: AAA92562.1 .
    RefSeqi NP_990691.1. NM_205360.1.
    UniGenei Gga.760.

    3D structure databases

    ProteinModelPortali Q92058.
    SMRi Q92058. Positions 17-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000038334.

    Proteomic databases

    PaxDbi Q92058.
    PRIDEi Q92058.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396317.
    KEGGi gga:396317.

    Organism-specific databases

    CTDi 249.

    Phylogenomic databases

    eggNOGi COG1785.
    HOGENOMi HOG000099118.
    HOVERGENi HBG007345.
    InParanoidi Q92058.
    KOi K01077.
    PhylomeDBi Q92058.

    Miscellaneous databases

    NextBioi 20816365.

    Family and domain databases

    Gene3Di 3.40.720.10. 1 hit.
    InterProi IPR017849. Alkaline_Pase-like_a/b/a.
    IPR001952. Alkaline_phosphatase.
    IPR018299. Alkaline_phosphatase_AS.
    IPR017850. Alkaline_phosphatase_core.
    [Graphical view ]
    Pfami PF00245. Alk_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00113. ALKPHPHTASE.
    SMARTi SM00098. alkPPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53649. SSF53649. 1 hit.
    PROSITEi PS00123. ALKALINE_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tissue-nonspecific alkaline phosphatase participates in the establishment and growth of feather germs in embryonic chick skin cultures."
      Crawford K., Weissig H., Binette F., Millan J.L., Goetinck P.F.
      Dev. Dyn. 204:48-56(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPPBT_CHICK
    AccessioniPrimary (citable) accession number: Q92058
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3