Reviewed,
UniProtKB/Swiss-Prot Q92058 (PPBT_CHICK)
Last modified
February 9, 2010.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Alkaline phosphatase, tissue-nonspecific isozyme Short name=AP-TNAP Short name=TNSALP EC=3.1.3.1 | ||
| Gene names |
| ||
| Organism | Gallus gallus (Chicken) | ||
| Taxonomic identifier | 9031 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 519 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | A phosphate monoester + H2O = an alcohol + phosphate. |
| Cofactor | Binds 1 magnesium ion By similarity. Binds 2 zinc ions By similarity. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Cell membrane; Lipid-anchor › GPI-anchor By similarity. |
| Sequence similarities | Belongs to the alkaline phosphatase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Signal |
| Ligand | Magnesium Metal-binding Zinc |
| Molecular function | Hydrolase |
| PTM | GPI-anchor Glycoprotein Lipoprotein Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | alkaline phosphatase activity Inferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 16 | 16 | Potential | ||||||
| Chain | 17 – 498 | 482 | Alkaline phosphatase, tissue-nonspecific isozyme | PRO_0000024029 | |||||
| Propeptide | 499 – 519 | 21 | Removed in mature form Potential | PRO_0000024030 | |||||
Sites | |||||||||
| Active site | 109 | 1 | Phosphoserine intermediate By similarity | ||||||
| Metal binding | 59 | 1 | Magnesium Potential | ||||||
| Metal binding | 59 | 1 | Zinc 2 Potential | ||||||
| Metal binding | 172 | 1 | Magnesium Potential | ||||||
| Metal binding | 331 | 1 | Magnesium Potential | ||||||
| Metal binding | 336 | 1 | Zinc 1 Potential | ||||||
| Metal binding | 340 | 1 | Zinc 1 Potential | ||||||
| Metal binding | 377 | 1 | Zinc 2 Potential | ||||||
| Metal binding | 378 | 1 | Zinc 2 Potential | ||||||
| Metal binding | 453 | 1 | Zinc 1 Potential | ||||||
Amino acid modifications | |||||||||
| Lipidation | 498 | 1 | GPI-anchor amidated serine Potential | ||||||
| Glycosylation | 139 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 229 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 278 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 302 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 429 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| [1] | "Tissue-nonspecific alkaline phosphatase participates in the establishment and growth of feather germs in embryonic chick skin cultures." Crawford K., Weissig H., Binette F., Millan J.L., Goetinck P.F. Dev. Dyn. 204:48-56(1995) [PubMed: 8563025] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U19108 mRNA. Translation: AAA92562.1. |
| IPI | IPI00590885. |
| UniGene | Gga.760 |
3D structure databases | |
| SMR | Q92058. Positions 17-498. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q92058. |
Proteomic databases | |
| PRIDE | Q92058. |
Genome annotation databases | |
| Ensembl | ENSGALT00000039123; ENSGALP00000038334; ENSGALG00000023542; Gallus gallus. [Genome view] |
Phylogenomic databases | |
| eggNOG | veNOG11760. |
| HOGENOM | HBG617166. |
| HOVERGEN | Q92058. |
| InParanoid | Q92058. |
| PhylomeDB | Q92058. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.1. 4. |
Family and domain databases | |
| InterPro | IPR017849. Alkaline_Pase-like_a/b/a. IPR001952. Alkaline_phosphatase. IPR018299. Alkaline_phosphatase_AS. IPR017850. Alkaline_phosphatase_core. [Graphical view] |
| Gene3D | G3DSA:3.40.720.10. Alk_phosphtse. 1 hit. |
| Pfam | PF00245. Alk_phosphatase. 1 hit. [Graphical view] |
| PRINTS | PR00113. ALKPHPHTASE. |
| SMART | SM00098. alkPPc. 1 hit. [Graphical view] |
| PROSITE | PS00123. ALKALINE_PHOSPHATASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PPBT_CHICK | ||||||||
| Accession | Primary (citable) accession number: Q92058 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

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