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Q92058 (PPBT_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alkaline phosphatase, tissue-nonspecific isozyme

Short name=AP-TNAP
Short name=TNSALP
EC=3.1.3.1
Gene names
Name:ALPL
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactor

Binds 1 magnesium ion By similarity.

Binds 2 zinc ions By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor By similarity.

Sequence similarities

Belongs to the alkaline phosphatase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 498482Alkaline phosphatase, tissue-nonspecific isozyme
PRO_0000024029
Propeptide499 – 51921Removed in mature form Potential
PRO_0000024030

Sites

Active site1091Phosphoserine intermediate By similarity
Metal binding591Magnesium By similarity
Metal binding591Zinc 1 By similarity
Metal binding1091Zinc 1 By similarity
Metal binding1721Magnesium By similarity
Metal binding3311Magnesium By similarity
Metal binding3361Zinc 2 By similarity
Metal binding3401Zinc 2; via tele nitrogen By similarity
Metal binding3771Zinc 1 By similarity
Metal binding3781Zinc 1; via tele nitrogen By similarity
Metal binding4531Zinc 2; via tele nitrogen By similarity

Amino acid modifications

Lipidation4981GPI-anchor amidated serine Potential
Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation4291N-linked (GlcNAc...) Potential
Disulfide bond138 ↔ 200 By similarity
Disulfide bond488 ↔ 496 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92058 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7934C0EEC3B17B89

FASTA51956,760
        10         20         30         40         50         60 
MKAFLLTLLA QLCSASLVPE REKDPEYWRQ QAQETLRDAL RLQHLNQNVA KNLILFLGDG 

        70         80         90        100        110        120 
MGVSTVTAAR ILKGQLQHRK GEESLLEMDK FPYVALAKTY NTNAQVPDSA GTATAYLCGV 

       130        140        150        160        170        180 
KANEGTVGVS AGVTRDRCNT TKGQEVTSIL RWAKDEGKAV GIVTTTRVTH ATPSAAYAHS 

       190        200        210        220        230        240 
ANRDWYSDGE MPLDALEGGC KDIARQLVDN IPDIEVILGG GRKYMFPKNT SDVEYPQEER 

       250        260        270        280        290        300 
HRGTRLDGKD LVQAWHDTKP AGKVAKYVWH RRELLALNVS RVDFLLGLFE PGDMVYELDR 

       310        320        330        340        350        360 
NNETDPSLSE MVAVAIRMLQ KNPRGFFLLV EGGRIDHGHH EGKAKQALHE AVELDRAVGL 

       370        380        390        400        410        420 
AGRLTSPRDT LSVVTADHSH VFTFGGYTPR GNPIFGLAPM QSDVDRKPFT SILYGNGPGY 

       430        440        450        460        470        480 
KIVGGERENV SAVDFAHANY QAQAAVPLRQ ETHGGEDVAV FARGPMAHLL HGVDEQNYIP 

       490        500        510 
HAMAYAACIG PNRAHCSSAA RPAATATLLP VLLLLLLLC 

« Hide

References

[1]"Tissue-nonspecific alkaline phosphatase participates in the establishment and growth of feather germs in embryonic chick skin cultures."
Crawford K., Weissig H., Binette F., Millan J.L., Goetinck P.F.
Dev. Dyn. 204:48-56(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19108 mRNA. Translation: AAA92562.1.
RefSeqNP_990691.1. NM_205360.1.
UniGeneGga.760.

3D structure databases

ProteinModelPortalQ92058.
SMRQ92058. Positions 17-498.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000038334.

Proteomic databases

PaxDbQ92058.
PRIDEQ92058.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396317.
KEGGgga:396317.

Organism-specific databases

CTD249.

Phylogenomic databases

eggNOGCOG1785.
HOGENOMHOG000099118.
HOVERGENHBG007345.
InParanoidQ92058.
KOK01077.
PhylomeDBQ92058.

Family and domain databases

Gene3D3.40.720.10. 1 hit.
InterProIPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
[Graphical view]
PfamPF00245. Alk_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00113. ALKPHPHTASE.
SMARTSM00098. alkPPc. 1 hit.
[Graphical view]
SUPFAMSSF53649. SSF53649. 1 hit.
PROSITEPS00123. ALKALINE_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816365.

Entry information

Entry namePPBT_CHICK
AccessionPrimary (citable) accession number: Q92058
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families