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Protein

Acetylserotonin O-methyltransferase

Gene

ASMT

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).By similarity

Catalytic activityi

S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin.

Pathwayi: melatonin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes melatonin from serotonin.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetylserotonin O-methyltransferase (ASMT), Serotonin N-acetyltransferase (AANAT)
  2. no protein annotated in this organism
This subpathway is part of the pathway melatonin biosynthesis, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes melatonin from serotonin, the pathway melatonin biosynthesis and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei148S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei165S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei211S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei253S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei256Proton donor/acceptorBy similarity1
Binding sitei257SubstrateBy similarity1
Binding sitei303SubstrateBy similarity1
Binding sitei307SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processMelatonin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00837; UER00815.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylserotonin O-methyltransferase (EC:2.1.1.4)
Alternative name(s):
Hydroxyindole O-methyltransferase
Short name:
HIOMT
Gene namesi
Name:ASMT
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000839811 – 346Acetylserotonin O-methyltransferaseAdd BLAST346

Proteomic databases

PaxDbiQ92056.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026872.

Structurei

3D structure databases

ProteinModelPortaliQ92056.
SMRiQ92056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni236 – 238S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3178. Eukaryota.
ENOG410XS7T. LUCA.
HOGENOMiHOG000247024.
HOVERGENiHBG001526.
InParanoidiQ92056.
KOiK00543.
PhylomeDBiQ92056.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR031725. ASMT_dimerisation.
IPR016461. O-MeTrfase_COMT.
IPR001077. O_MeTrfase_2.
IPR029063. SAM-dependent_MTases.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF16864. Dimerisation2. 1 hit.
PF00891. Methyltransf_2. 1 hit.
PIRSFiPIRSF005739. O-mtase. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS51683. SAM_OMT_II. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSTEDLDYP QIIFQYSNGF LVSKVMFTAC ELGVFDLLLQ SGRPLSLDVI
60 70 80 90 100
AARLGTSIMG MERLLDACVG LKLLAVELRR EGAFYRNTEI SNIYLTKSSP
110 120 130 140 150
KSQYHIMMYY SNTVYLCWHY LTDAVREGRN QYERAFGISS KDLFGARYRS
160 170 180 190 200
EEEMLKFLAG QNSIWSICGR DVLTAFDLSP FTQIYDLGGG GGALAQECVF
210 220 230 240 250
LYPNCTVTIY DLPKVVQVAK ERLVPPEERR IAFHEGDFFK DSIPEADLYI
260 270 280 290 300
LSKILHDWDD KKCRQLLAEV YKACRPGGGV LLVESLLSED RSGPVETQLY
310 320 330 340
SLNMLVQTEG KERTAVEYSE LLGAAGFREV QVRRTGKLYD AVLGRK
Length:346
Mass (Da):39,136
Last modified:November 1, 1997 - v1
Checksum:i3EB370E4488CC5E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62309 mRNA. Translation: CAA44189.1.
PIRiS21265.
RefSeqiNP_990674.1. NM_205343.1.
UniGeneiGga.1821.

Genome annotation databases

GeneIDi396286.
KEGGigga:396286.

Similar proteinsi

Entry informationi

Entry nameiASMT_CHICK
AccessioniPrimary (citable) accession number: Q92056
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families