Q92056 (ASMT_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylserotonin O-methyltransferase
EC=2.1.1.4

Alternative name(s):
Hydroxyindole O-methyltransferase
Short name=HIOMT

Gene names

Name:

ASMT

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Produces melatonin (N-acetyl-5-methoxytryptamine) from N-acetylserotonin By similarity.
Catalytic activity	S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine.
Pathway	Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
Sequence similarities	Belongs to the methyltransferase superfamily.

Ontologies

Keywords
Biological process	Melatonin biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	melatonin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acetylserotonin O-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Acetylserotonin O-methyltransferase		PRO_0000083981

Sequences

	Sequence		Length	Mass (Da)
	Q92056 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 3EB370E4488CC5E8	FASTA	346	39,136
	10 20 30 40 50 60 MDSTEDLDYP QIIFQYSNGF LVSKVMFTAC ELGVFDLLLQ SGRPLSLDVI AARLGTSIMG 70 80 90 100 110 120 MERLLDACVG LKLLAVELRR EGAFYRNTEI SNIYLTKSSP KSQYHIMMYY SNTVYLCWHY 130 140 150 160 170 180 LTDAVREGRN QYERAFGISS KDLFGARYRS EEEMLKFLAG QNSIWSICGR DVLTAFDLSP 190 200 210 220 230 240 FTQIYDLGGG GGALAQECVF LYPNCTVTIY DLPKVVQVAK ERLVPPEERR IAFHEGDFFK 250 260 270 280 290 300 DSIPEADLYI LSKILHDWDD KKCRQLLAEV YKACRPGGGV LLVESLLSED RSGPVETQLY 310 320 330 340 SLNMLVQTEG KERTAVEYSE LLGAAGFREV QVRRTGKLYD AVLGRK

References

[1]

"Molecular cloning and nucleotide sequence of a cDNA encoding hydroxyindole O-methyltransferase from chicken pineal gland." Voisin P., Guerlotte J., Bernard M., Collin J.P., Cogne M. Biochem. J. 282:571-576(1992) [PubMed: 1372168] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Hubbard. Tissue: Pineal gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X62309 mRNA. Translation: CAA44189.1.
IPI	IPI00581669.
PIR	S21265.
RefSeq	NP_990674.1. NM_205343.1.
UniGene	Gga.1821.
3D structure databases
ProteinModelPortal	Q92056.
ModBase	Search...
Protein-protein interaction databases
STRING	Q92056.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	396286.
KEGG	gga:396286.
Organism-specific databases
CTD	438.
Phylogenomic databases
eggNOG	veNOG10285.
GeneTree	ENSGT00530000064032.
HOGENOM	HBG652032.
HOVERGEN	HBG001526.
InParanoid	Q92056.
OrthoDB	EOG408N8H.
Family and domain databases
InterPro	IPR016461. O-MeTrfase_COMT_euk. IPR001077. O_MeTrfase_2. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
KO	K00543.
Pfam	PF00891. Methyltransf_2. 1 hit. [Graphical view]
PIRSF	PIRSF005739. O-mtase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ASMT_CHICK

Accession

Primary (citable) accession number: Q92056

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program