Reviewed, UniProtKB/Swiss-Prot Q92051 (CAHZ_DANRE)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase
    EC=4.2.1.1
Alternative name(s):
    Carbonate dehydratase

Gene names

Name:	cahz
Synonyms:	cah-z

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	hypotonic salinity response Inferred from direct assay. Source: ZFIN one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Carbonic anhydrase		PRO_0000077442
Sites
	Metal binding	94	1	Zinc; catalytic By similarity
	Metal binding	96	1	Zinc; catalytic By similarity
	Metal binding	119	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92051-1 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: 35C0C871B13A6256	FASTA	260	28,677
	10 20 30 40 50 60 MAHAWGYGPA DGPESWAESF PIANGPRQSP IDIVPTQAQH DPSLKHLKLK YDPATTKSIL 70 80 90 100 110 120 NNGHSFQVDF VDDDNSSTLA GGPITGIYRL RQFHFHWGSS DDKGSEHTIA GTKFPCELHL 130 140 150 160 170 180 VHWNTKYPNF GEAASKPDGL AVVGVFLKIG AANPRLQKVL DALDDIKSKG RQTTFANFDP 190 200 210 220 230 240 KTLLPASLDY WTYEGSLTTP PLLESVTWIV LKEPISVSPA QMAKFRSLLF SSEGETPCCM 250 260 VDNYRPPQPL KGRKVRASFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a carbonic anhydrase homologue from the zebrafish (Danio rerio)." Peterson R.E., Tu C., Linser P.J. J. Mol. Evol. 44:432-439(1997) [PubMed: 9089083] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U55177 mRNA. Translation: AAB82303.1. BC065611 mRNA. Translation: AAH65611.1.
IPI	IPI00489033.
PIR	T08463.
RefSeq	NP_571185.1.
UniGene	Dr.32297
3D structure databases
HSSP	HSSP built from PDB template 1CIM based on UniProtKB P00918.
ModBase	Search...
Protein-protein interaction databases
STRING	Q92051.
Proteomic databases
PRIDE	Q92051.
Genome annotation databases
Ensembl	ENSDART00000013411; ENSDARP00000022592; ENSDARG00000011166; Danio rerio. [Genome view]
GeneID	30331.
KEGG	dre:30331.
Organism-specific databases
CTD	30331.
ZFIN	ZDB-GENE-980526-39. cahz.
Phylogenomic databases
HOGENOM	Q92051.
HOVERGEN	Q92051.
OMA	DSKGSEH.
Enzyme and pathway databases
BRENDA	4.2.1.1. 96826.
Gene expression databases
ArrayExpress	Q92051.
Bgee	Q92051.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018440. Carbonic_anhydrase_CA2. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF28. Carbonic_anhydrase_CA2. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
ProDom	PD000865. Euk_COanhd. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAHZ_DANRE

Accession

Primary (citable) accession number: Q92051

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 15, 1998
Last modified:	November 3, 2009
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project