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Protein

Protein Wnt-5b

Gene

wnt5b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

  • receptor binding Source: ZFIN

GO - Biological processi

  • ameboidal-type cell migration Source: ZFIN
  • angiogenesis Source: ZFIN
  • cell migration involved in gastrulation Source: ZFIN
  • chondrocyte differentiation Source: ZFIN
  • convergent extension Source: ZFIN
  • convergent extension involved in axis elongation Source: ZFIN
  • convergent extension involved in gastrulation Source: ZFIN
  • dorsal convergence Source: ZFIN
  • embryonic body morphogenesis Source: ZFIN
  • embryonic viscerocranium morphogenesis Source: ZFIN
  • endocrine pancreas development Source: ZFIN
  • fin regeneration Source: ZFIN
  • lymphangiogenesis Source: ZFIN
  • neuromast development Source: ZFIN
  • otolith development Source: ZFIN
  • regulation of Wnt signaling pathway, calcium modulating pathway Source: ZFIN
  • release of sequestered calcium ion into cytosol Source: ZFIN
  • skeletal system development Source: ZFIN
  • somite development Source: ZFIN
  • thrombocyte differentiation Source: ZFIN
  • unidimensional cell growth Source: ZFIN
  • Wnt signaling pathway, calcium modulating pathway Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-DRE-3238698. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5b
Gene namesi
Name:wnt5b
Synonyms:wnt-5, wnt5, wnt5a
ORF Names:si:ch73-211c7.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 4

Organism-specific databases

ZFINiZDB-GENE-980526-87. wnt5b.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: GOC
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 363342Protein Wnt-5bPRO_0000041438Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi87 ↔ 98By similarity
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi137 ↔ 145By similarity
Disulfide bondi147 ↔ 165By similarity
Disulfide bondi221 ↔ 235By similarity
Disulfide bondi223 ↔ 230By similarity
Lipidationi227 – 2271O-palmitoleyl serine; by PORCNBy similarity
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence analysis
Disulfide bondi308 ↔ 323By similarity
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence analysis
Disulfide bondi338 ↔ 353By similarity
Disulfide bondi340 ↔ 350By similarity
Disulfide bondi345 ↔ 346By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiQ92050.

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Zygotic expression begins during somitogenesis and is confined to the mesenchyme of the developing tailbud, the posterior 4-5 somites and the ventrolateral mesenchyme of the head. In later stages, expressed in the pharyngeal arch mesenchyme and pectoral finbuds. Not detected in mature chondrocytes.1 Publication

Gene expression databases

BgeeiQ92050.

Interactioni

GO - Molecular functioni

  • receptor binding Source: ZFIN

Protein-protein interaction databases

BioGridi78343. 6 interactions.
STRINGi7955.ENSDARP00000106303.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiQ92050.
KOiK00444.
OMAiQGQRKLC.
OrthoDBiEOG7C8GJ8.
PhylomeDBiQ92050.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026537. Wnt5b.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF87. PTHR12027:SF87. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVRMNQGHL LLAVTLIVCN SQLLVVANSW WSLAMNPIQR PEMYIIGAQP
60 70 80 90 100
LCSQLTGLSQ GQRKLCQLYQ DHMVYIGEGA KTGIKECQYQ FRQRRWNCST
110 120 130 140 150
VDNTSVFGRV MHIGSRETAF TYAVSAAGVV NAVSRACREG ELSTCGCSRA
160 170 180 190 200
ARPRDLPRDW LWGGCGDNVN YGYRFAREFV DAREREKNYP RGSVEHARTL
210 220 230 240 250
MNLQNNEAGR MAVYNLANVA CKCHGVSGSC SLKTCWLQLA DFRRVGEFLK
260 270 280 290 300
EKYDSAAAMR INRRGKLELV NNRFNPPTGE DLVYIDPSPD YCLRNETTGS
310 320 330 340 350
LGTQGRLCNK TSEGMDGCEL MCCGRGYDQF KTYKHERCHC KFHWCCYVKC
360
KRCTSLVDQF VCK
Length:363
Mass (Da):41,137
Last modified:November 1, 1997 - v1
Checksum:i86AC06DE20DCBBA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51268 mRNA. Translation: AAA96519.1.
CT025936 Genomic DNA. Translation: CAN88522.1.
RefSeqiNP_571012.1. NM_130937.1.
XP_005164595.1. XM_005164538.2.
XP_005164596.1. XM_005164539.2.
UniGeneiDr.389.

Genome annotation databases

EnsembliENSDART00000162065; ENSDARP00000134193; ENSDARG00000102464.
ENSDART00000165181; ENSDARP00000131042; ENSDARG00000102464.
GeneIDi30105.
KEGGidre:30105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51268 mRNA. Translation: AAA96519.1.
CT025936 Genomic DNA. Translation: CAN88522.1.
RefSeqiNP_571012.1. NM_130937.1.
XP_005164595.1. XM_005164538.2.
XP_005164596.1. XM_005164539.2.
UniGeneiDr.389.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi78343. 6 interactions.
STRINGi7955.ENSDARP00000106303.

Proteomic databases

PaxDbiQ92050.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000162065; ENSDARP00000134193; ENSDARG00000102464.
ENSDART00000165181; ENSDARP00000131042; ENSDARG00000102464.
GeneIDi30105.
KEGGidre:30105.

Organism-specific databases

CTDi81029.
ZFINiZDB-GENE-980526-87. wnt5b.

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiQ92050.
KOiK00444.
OMAiQGQRKLC.
OrthoDBiEOG7C8GJ8.
PhylomeDBiQ92050.

Enzyme and pathway databases

ReactomeiR-DRE-3238698. WNT ligand biogenesis and trafficking.

Miscellaneous databases

PROiQ92050.

Gene expression databases

BgeeiQ92050.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026537. Wnt5b.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF87. PTHR12027:SF87. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Three Wnt genes expressed in a wide variety of tissues during development of the zebrafish, Danio rerio: developmental and evolutionary perspectives."
    Blader P., Straehle U., Ingham P.W.
    Dev. Genes Evol. 206:3-13(1996)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Embryo.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.

Entry informationi

Entry nameiWNT5B_DANRE
AccessioniPrimary (citable) accession number: Q92050
Secondary accession number(s): A5WVR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 8, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.