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Q92047

- PIMT_DANRE

UniProt

Q92047 - PIMT_DANRE

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Protein
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Gene
pcmt
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins By similarity.

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601 By similarity

GO - Molecular functioni

  1. protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-L-isoaspartate(D-aspartate) O-methyltransferase (EC:2.1.1.77)
    Short name:
    PIMT
    Alternative name(s):
    L-isoaspartyl protein carboxyl methyltransferase
    Protein L-isoaspartyl/D-aspartyl methyltransferase
    Protein-beta-aspartate methyltransferase
    Gene namesi
    Name:pcmt
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 20

    Organism-specific databases

    ZFINiZDB-GENE-990415-134. pcmt.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed By similarity
    Chaini2 – 228227Protein-L-isoaspartate(D-aspartate) O-methyltransferase
    PRO_0000111879Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ92047.

    Expressioni

    Gene expression databases

    BgeeiQ92047.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92047.
    SMRiQ92047. Positions 3-225.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2518.
    GeneTreeiENSGT00510000046974.
    HOVERGENiHBG004483.
    InParanoidiQ92047.
    KOiK00573.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR000682. PCMT.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR11579. PTHR11579. 1 hit.
    PfamiPF01135. PCMT. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00080. pimt. 1 hit.
    PROSITEiPS01279. PCMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q92047-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWKSGGASH AELVNNLRKN GIIKSDRVYE VMLATDRSHF SRCNPYMDSP    50
    QSIGYQATIS APHMHAYALE LLHDHLYEGA KALDVGSGSG ILSVCFSRMV 100
    GPTGKVIGID HIKELVEDSI ANVKKDDPSL ITSGRIKLIV GDGRMGFTEE 150
    APYDAIHVGA AAPTVPQALL DQLKPGGRLI LPVGPAGGNQ MLEQYDKLED 200
    GSTKMKPLMG VIYVPLTDKD KQWSRDEL 228
    Length:228
    Mass (Da):24,725
    Last modified:January 23, 2007 - v3
    Checksum:i0266456304972562
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37434 mRNA. Translation: AAA96020.1.
    BC075735 mRNA. Translation: AAH75735.1.
    RefSeqiNP_571540.1. NM_131465.2.
    UniGeneiDr.372.

    Genome annotation databases

    EnsembliENSDART00000092718; ENSDARP00000087150; ENSDARG00000015201.
    GeneIDi30751.
    KEGGidre:30751.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37434 mRNA. Translation: AAA96020.1 .
    BC075735 mRNA. Translation: AAH75735.1 .
    RefSeqi NP_571540.1. NM_131465.2.
    UniGenei Dr.372.

    3D structure databases

    ProteinModelPortali Q92047.
    SMRi Q92047. Positions 3-225.
    ModBasei Search...

    Proteomic databases

    PRIDEi Q92047.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000092718 ; ENSDARP00000087150 ; ENSDARG00000015201 .
    GeneIDi 30751.
    KEGGi dre:30751.

    Organism-specific databases

    CTDi 30751.
    ZFINi ZDB-GENE-990415-134. pcmt.

    Phylogenomic databases

    eggNOGi COG2518.
    GeneTreei ENSGT00510000046974.
    HOVERGENi HBG004483.
    InParanoidi Q92047.
    KOi K00573.

    Miscellaneous databases

    NextBioi 20807097.
    PROi Q92047.

    Gene expression databases

    Bgeei Q92047.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR000682. PCMT.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR11579. PTHR11579. 1 hit.
    Pfami PF01135. PCMT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00080. pimt. 1 hit.
    PROSITEi PS01279. PCMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiPIMT_DANRE
    AccessioniPrimary (citable) accession number: Q92047
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: June 11, 2014
    This is version 89 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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