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Protein

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

Gene

pcmt

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei60By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-DRE-5676934 Protein repair

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (EC:2.1.1.77)
Short name:
PIMT
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferase
Protein L-isoaspartyl/D-aspartyl methyltransferase
Protein-beta-aspartate methyltransferase
Gene namesi
Name:pcmt
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990415-134 pcmt

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001118792 – 228Protein-L-isoaspartate(D-aspartate) O-methyltransferaseAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ92047
PRIDEiQ92047

Expressioni

Gene expression databases

BgeeiENSDARG00000015201
ExpressionAtlasiQ92047 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000119861

Structurei

3D structure databases

ProteinModelPortaliQ92047
SMRiQ92047
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1661 Eukaryota
COG2518 LUCA
HOVERGENiHBG004483
InParanoidiQ92047
KOiK00573

Family and domain databases

InterProiView protein in InterPro
IPR000682 PCMT
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11579 PTHR11579, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00080 pimt, 1 hit
PROSITEiView protein in PROSITE
PS01279 PCMT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92047-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWKSGGASH AELVNNLRKN GIIKSDRVYE VMLATDRSHF SRCNPYMDSP
60 70 80 90 100
QSIGYQATIS APHMHAYALE LLHDHLYEGA KALDVGSGSG ILSVCFSRMV
110 120 130 140 150
GPTGKVIGID HIKELVEDSI ANVKKDDPSL ITSGRIKLIV GDGRMGFTEE
160 170 180 190 200
APYDAIHVGA AAPTVPQALL DQLKPGGRLI LPVGPAGGNQ MLEQYDKLED
210 220
GSTKMKPLMG VIYVPLTDKD KQWSRDEL
Length:228
Mass (Da):24,725
Last modified:January 23, 2007 - v3
Checksum:i0266456304972562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37434 mRNA Translation: AAA96020.1
BC075735 mRNA Translation: AAH75735.1
RefSeqiNP_571540.1, NM_131465.3
UniGeneiDr.372

Genome annotation databases

GeneIDi30751
KEGGidre:30751

Similar proteinsi

Entry informationi

Entry nameiPIMT_DANRE
AccessioniPrimary (citable) accession number: Q92047
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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