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Q92045

- CP11A_DASAM

UniProt

Q92045 - CP11A_DASAM

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Protein
Cholesterol side-chain cleavage enzyme, mitochondrial
Gene
CYP11A1
Organism
Dasyatis americana (Southern stingray)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.

Catalytic activityi

Cholesterol + 6 reduced adrenodoxin + 3 O2 = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.

Cofactori

Heme group By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi461 – 4611Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. cholesterol monooxygenase (side-chain-cleaving) activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. C21-steroid hormone metabolic process Source: UniProtKB-UniPathway
  2. cholesterol metabolic process Source: UniProtKB-KW
  3. steroid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Steroidogenesis, Sterol metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00229.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholesterol side-chain cleavage enzyme, mitochondrial (EC:1.14.15.6)
Alternative name(s):
CYPXIA1
Cholesterol desmolase
Cytochrome P450 11A1
Cytochrome P450(scc)
Gene namesi
Name:CYP11A1
OrganismiDasyatis americana (Southern stingray)
Taxonomic identifieri50411 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaMyliobatiformesDasyatidaeDasyatis

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei‹1 – 39›39Mitochondrion By similarity
Add
BLAST
Chaini40 – 514475Cholesterol side-chain cleavage enzyme, mitochondrial
PRO_0000003592Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92045.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051098.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92045-1 [UniParc]FASTAAdd to Basket

« Hide

SFRLSLSAST YAQRGSFTTP EHDFTLFPHR NHSVTSESRI PSEQTLKSLT    50
DIPGNWRKNW LNVYYFWRSN GLNNAHQWML DNFNKYGPIY REKIAYYESI 100
NIINPADAVI MNKSEGPFPK RIEMAPWVAY RDLRKENYGV QLLNGENWKR 150
TRLILNNSIF AQSSIQRLVP LFNEVVLDFV SMVHKEVEKS RSDYWKTDLT 200
NDLFKLALEV ICYILYGERL DLLQRKYNKA PQKFIDSIAT MFHSTPIMLY 250
VPPSLLKSIN SKIWQQHVGS WDNIFEHADT YLKKAYRQFQ QGSKNEHAFP 300
GVLTELLLQG ALPFEDIRAS IIDVMSGAID TTSTTVHWMM YELAKHPHIQ 350
KNVRSEIMEA HQKTEGDPVK MLKSVPLLKC VVKETLRLYP VAISIQRYLN 400
EDTVLQNYHI PAGTLVQLGL YAMGRNPKIF KNPEQYNPER WLKGEDTHFR 450
HLGFGFGPRQ CIGRRIAETQ MVLLMIHMLQ NFKIETDPMT EVKSKFSLIL 500
IPDKPINLKF TPIK 514
Length:514
Mass (Da):59,863
Last modified:November 1, 1996 - v1
Checksum:iD0F03E25D5534FB2
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U63299 mRNA. Translation: AAC60095.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U63299 mRNA. Translation: AAC60095.1 .

3D structure databases

ProteinModelPortali Q92045.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG051098.

Enzyme and pathway databases

UniPathwayi UPA00229 .

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of the putative cDNA encoding cholesterol side chain cleavage cytochrome P450 (CYP11A) of the southern stingray (Dasyatis americana)."
    Nunez S., Trant J.M.
    Gene 187:123-129(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Interrenal gland.

Entry informationi

Entry nameiCP11A_DASAM
AccessioniPrimary (citable) accession number: Q92045
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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