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Q92045

- CP11A_DASAM

UniProt

Q92045 - CP11A_DASAM

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Protein

Cholesterol side-chain cleavage enzyme, mitochondrial

Gene

CYP11A1

Organism
Dasyatis americana (Southern stingray)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.By similarity

Catalytic activityi

Cholesterol + 6 reduced adrenodoxin + 3 O2 + 6 H+ = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.By similarity

Cofactori

hemeBy similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi461 – 4611Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. cholesterol monooxygenase (side-chain-cleaving) activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. C21-steroid hormone metabolic process Source: UniProtKB-UniPathway
  2. cholesterol metabolic process Source: UniProtKB-KW
  3. steroid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Steroidogenesis, Sterol metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00229.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholesterol side-chain cleavage enzyme, mitochondrial (EC:1.14.15.6)
Alternative name(s):
CYPXIA1
Cholesterol desmolase
Cytochrome P450 11A1
Cytochrome P450(scc)
Gene namesi
Name:CYP11A1
OrganismiDasyatis americana (Southern stingray)
Taxonomic identifieri50411 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaMyliobatiformesDasyatidaeDasyatis

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei‹1 – 39›39MitochondrionBy similarityAdd
BLAST
Chaini40 – 514475Cholesterol side-chain cleavage enzyme, mitochondrialPRO_0000003592Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92045.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051098.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92045-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SFRLSLSAST YAQRGSFTTP EHDFTLFPHR NHSVTSESRI PSEQTLKSLT
60 70 80 90 100
DIPGNWRKNW LNVYYFWRSN GLNNAHQWML DNFNKYGPIY REKIAYYESI
110 120 130 140 150
NIINPADAVI MNKSEGPFPK RIEMAPWVAY RDLRKENYGV QLLNGENWKR
160 170 180 190 200
TRLILNNSIF AQSSIQRLVP LFNEVVLDFV SMVHKEVEKS RSDYWKTDLT
210 220 230 240 250
NDLFKLALEV ICYILYGERL DLLQRKYNKA PQKFIDSIAT MFHSTPIMLY
260 270 280 290 300
VPPSLLKSIN SKIWQQHVGS WDNIFEHADT YLKKAYRQFQ QGSKNEHAFP
310 320 330 340 350
GVLTELLLQG ALPFEDIRAS IIDVMSGAID TTSTTVHWMM YELAKHPHIQ
360 370 380 390 400
KNVRSEIMEA HQKTEGDPVK MLKSVPLLKC VVKETLRLYP VAISIQRYLN
410 420 430 440 450
EDTVLQNYHI PAGTLVQLGL YAMGRNPKIF KNPEQYNPER WLKGEDTHFR
460 470 480 490 500
HLGFGFGPRQ CIGRRIAETQ MVLLMIHMLQ NFKIETDPMT EVKSKFSLIL
510
IPDKPINLKF TPIK
Length:514
Mass (Da):59,863
Last modified:November 1, 1996 - v1
Checksum:iD0F03E25D5534FB2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63299 mRNA. Translation: AAC60095.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63299 mRNA. Translation: AAC60095.1 .

3D structure databases

ProteinModelPortali Q92045.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG051098.

Enzyme and pathway databases

UniPathwayi UPA00229 .

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of the putative cDNA encoding cholesterol side chain cleavage cytochrome P450 (CYP11A) of the southern stingray (Dasyatis americana)."
    Nunez S., Trant J.M.
    Gene 187:123-129(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Interrenal gland.

Entry informationi

Entry nameiCP11A_DASAM
AccessioniPrimary (citable) accession number: Q92045
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3