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Q92045

- CP11A_DASAM

UniProt

Q92045 - CP11A_DASAM

Protein

Cholesterol side-chain cleavage enzyme, mitochondrial

Gene

CYP11A1

Organism
Dasyatis americana (Southern stingray)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.

    Catalytic activityi

    Cholesterol + 6 reduced adrenodoxin + 3 O2 = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.

    Cofactori

    Heme group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi461 – 4611Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. cholesterol monooxygenase (side-chain-cleaving) activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. C21-steroid hormone metabolic process Source: UniProtKB-UniPathway
    2. cholesterol metabolic process Source: UniProtKB-KW
    3. steroid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Steroidogenesis, Sterol metabolism

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00229.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cholesterol side-chain cleavage enzyme, mitochondrial (EC:1.14.15.6)
    Alternative name(s):
    CYPXIA1
    Cholesterol desmolase
    Cytochrome P450 11A1
    Cytochrome P450(scc)
    Gene namesi
    Name:CYP11A1
    OrganismiDasyatis americana (Southern stingray)
    Taxonomic identifieri50411 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaMyliobatiformesDasyatidaeDasyatis

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei‹1 – 39›39MitochondrionBy similarityAdd
    BLAST
    Chaini40 – 514475Cholesterol side-chain cleavage enzyme, mitochondrialPRO_0000003592Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ92045.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG051098.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q92045-1 [UniParc]FASTAAdd to Basket

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    SFRLSLSAST YAQRGSFTTP EHDFTLFPHR NHSVTSESRI PSEQTLKSLT    50
    DIPGNWRKNW LNVYYFWRSN GLNNAHQWML DNFNKYGPIY REKIAYYESI 100
    NIINPADAVI MNKSEGPFPK RIEMAPWVAY RDLRKENYGV QLLNGENWKR 150
    TRLILNNSIF AQSSIQRLVP LFNEVVLDFV SMVHKEVEKS RSDYWKTDLT 200
    NDLFKLALEV ICYILYGERL DLLQRKYNKA PQKFIDSIAT MFHSTPIMLY 250
    VPPSLLKSIN SKIWQQHVGS WDNIFEHADT YLKKAYRQFQ QGSKNEHAFP 300
    GVLTELLLQG ALPFEDIRAS IIDVMSGAID TTSTTVHWMM YELAKHPHIQ 350
    KNVRSEIMEA HQKTEGDPVK MLKSVPLLKC VVKETLRLYP VAISIQRYLN 400
    EDTVLQNYHI PAGTLVQLGL YAMGRNPKIF KNPEQYNPER WLKGEDTHFR 450
    HLGFGFGPRQ CIGRRIAETQ MVLLMIHMLQ NFKIETDPMT EVKSKFSLIL 500
    IPDKPINLKF TPIK 514
    Length:514
    Mass (Da):59,863
    Last modified:November 1, 1996 - v1
    Checksum:iD0F03E25D5534FB2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63299 mRNA. Translation: AAC60095.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63299 mRNA. Translation: AAC60095.1 .

    3D structure databases

    ProteinModelPortali Q92045.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG051098.

    Enzyme and pathway databases

    UniPathwayi UPA00229 .

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of the putative cDNA encoding cholesterol side chain cleavage cytochrome P450 (CYP11A) of the southern stingray (Dasyatis americana)."
      Nunez S., Trant J.M.
      Gene 187:123-129(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Interrenal gland.

    Entry informationi

    Entry nameiCP11A_DASAM
    AccessioniPrimary (citable) accession number: Q92045
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3