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Q92045 (CP11A_DASAM) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cholesterol side-chain cleavage enzyme, mitochondrial

EC=1.14.15.6
Alternative name(s):
CYPXIA1
Cholesterol desmolase
Cytochrome P450 11A1
Cytochrome P450(scc)
Gene names
Name:CYP11A1
OrganismDasyatis americana (Southern stingray)
Taxonomic identifier50411 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaMyliobatiformesDasyatidaeDasyatis

Protein attributes

Sequence length514 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.

Catalytic activity

Cholesterol + 6 reduced adrenodoxin + 3 O2 = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.

Cofactor

Heme group By similarity.

Pathway

Lipid metabolism; C21-steroid hormone metabolism.

Subcellular location

Mitochondrion membrane.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide‹1 – 39›39Mitochondrion By similarity
Chain40 – 514475Cholesterol side-chain cleavage enzyme, mitochondrial
PRO_0000003592

Sites

Metal binding4611Iron (heme axial ligand) By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q92045 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D0F03E25D5534FB2

FASTA51459,863
        10         20         30         40         50         60 
SFRLSLSAST YAQRGSFTTP EHDFTLFPHR NHSVTSESRI PSEQTLKSLT DIPGNWRKNW 

        70         80         90        100        110        120 
LNVYYFWRSN GLNNAHQWML DNFNKYGPIY REKIAYYESI NIINPADAVI MNKSEGPFPK 

       130        140        150        160        170        180 
RIEMAPWVAY RDLRKENYGV QLLNGENWKR TRLILNNSIF AQSSIQRLVP LFNEVVLDFV 

       190        200        210        220        230        240 
SMVHKEVEKS RSDYWKTDLT NDLFKLALEV ICYILYGERL DLLQRKYNKA PQKFIDSIAT 

       250        260        270        280        290        300 
MFHSTPIMLY VPPSLLKSIN SKIWQQHVGS WDNIFEHADT YLKKAYRQFQ QGSKNEHAFP 

       310        320        330        340        350        360 
GVLTELLLQG ALPFEDIRAS IIDVMSGAID TTSTTVHWMM YELAKHPHIQ KNVRSEIMEA 

       370        380        390        400        410        420 
HQKTEGDPVK MLKSVPLLKC VVKETLRLYP VAISIQRYLN EDTVLQNYHI PAGTLVQLGL 

       430        440        450        460        470        480 
YAMGRNPKIF KNPEQYNPER WLKGEDTHFR HLGFGFGPRQ CIGRRIAETQ MVLLMIHMLQ 

       490        500        510 
NFKIETDPMT EVKSKFSLIL IPDKPINLKF TPIK 

« Hide

References

[1]"Isolation of the putative cDNA encoding cholesterol side chain cleavage cytochrome P450 (CYP11A) of the southern stingray (Dasyatis americana)."
Nunez S., Trant J.M.
Gene 187:123-129(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Interrenal gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U63299 mRNA. Translation: AAC60095.1.

3D structure databases

ProteinModelPortalQ92045.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG051098.

Enzyme and pathway databases

UniPathwayUPA00229.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP11A_DASAM
AccessionPrimary (citable) accession number: Q92045
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways