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Q92039

- CP1A1_CHACA

UniProt

Q92039 - CP1A1_CHACA

Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Chaetodon capistratus (Four-eye butterflyfish)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei229 – 2291SubstrateBy similarity
    Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:cyp1a1
    Synonyms:cyp1a
    OrganismiChaetodon capistratus (Four-eye butterflyfish)
    Taxonomic identifieri37949 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaChaetodontidaeChaetodon

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Cytochrome P450 1A1PRO_0000051634Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ92039.
    SMRiQ92039. Positions 38-512.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92039-1 [UniParc]FASTAAdd to Basket

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    MALMILPFIG SVSVSESLVA LTAVCLVYLI LKFFRTEIPA GLRQLPGPKP    50
    LPIIGNVLEV GSKPHLSLTA MSKRYGDVFQ IQIGMRPVVV LSGSETVRQA 100
    LIKQGDEFSG RPDLYSFTFI NDGKSLAFST DQAGVCGACR KLAYSALRSF 150
    STLDGTTPEY SCMLEEHICK EGECLINQLN TVMKADGSFD PFRHIVVSVA 200
    NVICGMCFGR RYDHNDQDLL RLVNLSDEFG QVAGSGNPAD FINILRFLPS 250
    TTMKKFMTIN ADFNTFVKKI VGEHYATFDK NNIRDITDSL IDHCEDRKLD 300
    ENCNVQMSDE KIVGIVNDLF GAGFDTVSTA LSWSVMYLVA YPDIQERLFQ 350
    EIKDNVGLDR TPLLSDRSKV PYLEAFILEL FRHSSFLPFT IPHCSAKDTS 400
    LNGYFIPKDT CVFINQWQIN RDPELWKDPS SFNPDRFLSC NGTEVNKQEG 450
    EKVMVFGMGK RRCIGEVIAR NEVYRGLAIL IQRLQFHEMP GELLDMTPEY 500
    GLTMKHKRCH LRATMRARNE Q 521
    Length:521
    Mass (Da):58,653
    Last modified:November 1, 1996 - v1
    Checksum:i45FFA98CC37BE919
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19855 mRNA. Translation: AAA62123.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19855 mRNA. Translation: AAA62123.1 .

    3D structure databases

    ProteinModelPortali Q92039.
    SMRi Q92039. Positions 38-512.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and expression of a CYP1A gene from the tropical teleost, Chaetodon capistratus."
      Vrolijk N.H., Lin C., Chen T.T.
      Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_CHACA
    AccessioniPrimary (citable) accession number: Q92039
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3