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Q92039

- CP1A1_CHACA

UniProt

Q92039 - CP1A1_CHACA

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Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Chaetodon capistratus (Four-eye butterflyfish)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei229 – 2291SubstrateBy similarity
Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:cyp1a1
Synonyms:cyp1a
OrganismiChaetodon capistratus (Four-eye butterflyfish)
Taxonomic identifieri37949 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaChaetodontiformesChaetodontidaeChaetodon

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Cytochrome P450 1A1PRO_0000051634Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92039.
SMRiQ92039. Positions 38-512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92039-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALMILPFIG SVSVSESLVA LTAVCLVYLI LKFFRTEIPA GLRQLPGPKP
60 70 80 90 100
LPIIGNVLEV GSKPHLSLTA MSKRYGDVFQ IQIGMRPVVV LSGSETVRQA
110 120 130 140 150
LIKQGDEFSG RPDLYSFTFI NDGKSLAFST DQAGVCGACR KLAYSALRSF
160 170 180 190 200
STLDGTTPEY SCMLEEHICK EGECLINQLN TVMKADGSFD PFRHIVVSVA
210 220 230 240 250
NVICGMCFGR RYDHNDQDLL RLVNLSDEFG QVAGSGNPAD FINILRFLPS
260 270 280 290 300
TTMKKFMTIN ADFNTFVKKI VGEHYATFDK NNIRDITDSL IDHCEDRKLD
310 320 330 340 350
ENCNVQMSDE KIVGIVNDLF GAGFDTVSTA LSWSVMYLVA YPDIQERLFQ
360 370 380 390 400
EIKDNVGLDR TPLLSDRSKV PYLEAFILEL FRHSSFLPFT IPHCSAKDTS
410 420 430 440 450
LNGYFIPKDT CVFINQWQIN RDPELWKDPS SFNPDRFLSC NGTEVNKQEG
460 470 480 490 500
EKVMVFGMGK RRCIGEVIAR NEVYRGLAIL IQRLQFHEMP GELLDMTPEY
510 520
GLTMKHKRCH LRATMRARNE Q
Length:521
Mass (Da):58,653
Last modified:November 1, 1996 - v1
Checksum:i45FFA98CC37BE919
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19855 mRNA. Translation: AAA62123.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19855 mRNA. Translation: AAA62123.1 .

3D structure databases

ProteinModelPortali Q92039.
SMRi Q92039. Positions 38-512.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization and expression of a CYP1A gene from the tropical teleost, Chaetodon capistratus."
    Vrolijk N.H., Lin C., Chen T.T.
    Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A1_CHACA
AccessioniPrimary (citable) accession number: Q92039
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3