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Q92039

- CP1A1_CHACA

UniProt

Q92039 - CP1A1_CHACA

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Protein

Cytochrome P450 1A1

Gene
cyp1a1, cyp1a
Organism
Chaetodon capistratus (Four-eye butterflyfish)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei229 – 2291Substrate By similarity
Metal bindingi463 – 4631Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:cyp1a1
Synonyms:cyp1a
OrganismiChaetodon capistratus (Four-eye butterflyfish)
Taxonomic identifieri37949 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaChaetodontidaeChaetodon

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Cytochrome P450 1A1PRO_0000051634Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92039.
SMRiQ92039. Positions 38-512.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92039-1 [UniParc]FASTAAdd to Basket

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MALMILPFIG SVSVSESLVA LTAVCLVYLI LKFFRTEIPA GLRQLPGPKP    50
LPIIGNVLEV GSKPHLSLTA MSKRYGDVFQ IQIGMRPVVV LSGSETVRQA 100
LIKQGDEFSG RPDLYSFTFI NDGKSLAFST DQAGVCGACR KLAYSALRSF 150
STLDGTTPEY SCMLEEHICK EGECLINQLN TVMKADGSFD PFRHIVVSVA 200
NVICGMCFGR RYDHNDQDLL RLVNLSDEFG QVAGSGNPAD FINILRFLPS 250
TTMKKFMTIN ADFNTFVKKI VGEHYATFDK NNIRDITDSL IDHCEDRKLD 300
ENCNVQMSDE KIVGIVNDLF GAGFDTVSTA LSWSVMYLVA YPDIQERLFQ 350
EIKDNVGLDR TPLLSDRSKV PYLEAFILEL FRHSSFLPFT IPHCSAKDTS 400
LNGYFIPKDT CVFINQWQIN RDPELWKDPS SFNPDRFLSC NGTEVNKQEG 450
EKVMVFGMGK RRCIGEVIAR NEVYRGLAIL IQRLQFHEMP GELLDMTPEY 500
GLTMKHKRCH LRATMRARNE Q 521
Length:521
Mass (Da):58,653
Last modified:November 1, 1996 - v1
Checksum:i45FFA98CC37BE919
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19855 mRNA. Translation: AAA62123.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19855 mRNA. Translation: AAA62123.1 .

3D structure databases

ProteinModelPortali Q92039.
SMRi Q92039. Positions 38-512.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization and expression of a CYP1A gene from the tropical teleost, Chaetodon capistratus."
    Vrolijk N.H., Lin C., Chen T.T.
    Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A1_CHACA
AccessioniPrimary (citable) accession number: Q92039
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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