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Protein

Potassium-transporting ATPase alpha chain 2

Gene

ATP12A

Organism
Rhinella marina (Cane toad) (Bufo marinus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for potassium absorption in various tissues.

Catalytic activityi

ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei394 – 39414-aspartylphosphate intermediateBy similarity
Metal bindingi735 – 7351MagnesiumBy similarity
Metal bindingi739 – 7391MagnesiumBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase alpha chain 2 (EC:3.6.3.10)
Alternative name(s):
Non-gastric H(+)/K(+) ATPase subunit alpha
Proton pump
Gene namesi
Name:ATP12A
OrganismiRhinella marina (Cane toad) (Bufo marinus)
Taxonomic identifieri8386 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaBufonidaeRhinella

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 105105CytoplasmicSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Topological domaini127 – 14923LumenalSequence analysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence analysisAdd
BLAST
Topological domaini171 – 306136CytoplasmicSequence analysisAdd
BLAST
Transmembranei307 – 32620HelicalSequence analysisAdd
BLAST
Topological domaini327 – 33812LumenalSequence analysisAdd
BLAST
Transmembranei339 – 35618HelicalSequence analysisAdd
BLAST
Topological domaini357 – 790434CytoplasmicSequence analysisAdd
BLAST
Transmembranei791 – 81020HelicalSequence analysisAdd
BLAST
Topological domaini811 – 82010LumenalSequence analysis
Transmembranei821 – 84121HelicalSequence analysisAdd
BLAST
Topological domaini842 – 86120CytoplasmicSequence analysisAdd
BLAST
Transmembranei862 – 88423HelicalSequence analysisAdd
BLAST
Topological domaini885 – 93652LumenalSequence analysisAdd
BLAST
Transmembranei937 – 95620HelicalSequence analysisAdd
BLAST
Topological domaini957 – 97014CytoplasmicSequence analysisAdd
BLAST
Transmembranei971 – 98919HelicalSequence analysisAdd
BLAST
Topological domaini990 – 100415LumenalSequence analysisAdd
BLAST
Transmembranei1005 – 102521HelicalSequence analysisAdd
BLAST
Topological domaini1026 – 104217CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10421042Potassium-transporting ATPase alpha chain 2PRO_0000046264Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei961 – 9611Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ92036.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Structurei

3D structure databases

ProteinModelPortaliQ92036.
SMRiQ92036. Positions 46-1042.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR030318. Atp12a.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF282. PTHR24093:SF282. 2 hits.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92036-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTEANSDVY STAINGINEI GYPDKEKEED LGLEVQKKKE KKQKKKKGKN
60 70 80 90 100
VDDLKQELDL EDHKLSIEEL EAKYETSLQG LTSARAAEIL ARDGPNTLTP
110 120 130 140 150
PKGTPEIIKF LKQMIGGFSL LLWAGAILCW IAYGILYAQD HNTSRDNLYL
160 170 180 190 200
GIVLAVVVIL TGCFAYFQEA KSTNIMASFN QMIPQQAVVT RNGQKLEIPA
210 220 230 240 250
KDLVVGDLVD VKGGDRIPAD LRIIFAQGCK VDNSSLTGES EAQPRSSEFT
260 270 280 290 300
HENPLETKNI AFYSTTCLEG TARGFVINTG DQTIIGRIAS LASGVGNEKT
310 320 330 340 350
PIAVEIEHFV HIVAGVAVSV GVLFFIIAIC MGYSALNSII FLIGIIVANV
360 370 380 390 400
PEGLLATVTV TLSLTAKRMA KKNCLVKNLE AVETLGSTSI ICSDKTGTLT
410 420 430 440 450
QNRMTVAHLW FDDHIHIADT SEDQSHHSFE QTPETWNALC KIVSLCNRAE
460 470 480 490 500
FKAGQDDVPI MKKVAVGDAS ETALLKFSEV ITGNVMNIRS QNRKVCEIPF
510 520 530 540 550
NSTNKFQLSI HETDDPQDQR LLLVMKGAPE RILEKCSTIM IGGKELPLDE
560 570 580 590 600
SMKDSFQTAY MELGGLGERV LGFCHLYLPE EEYPSSYAFD IESMNFPTSN
610 620 630 640 650
LCFVGLLSMI DPPRSTVPDA VTKCRSAGIK VIMVTGDHPI TAKAIARSVG
660 670 680 690 700
IISAGSETVD DIAKRLNIPV EQVNKREAKA AVVNGGELKD MSSEELDDIL
710 720 730 740 750
TNHAEIVFAR TSPQQKLIIV EGCQRQNYVV AVTGDGVNDS PALKKADIGI
760 770 780 790 800
AMGIAGSDAA KNAADMILLD DNFASIVTGV EEGRLIFDNI KKSIGYTLTK
810 820 830 840 850
NVAELCPFLI YIIADIPLPI GTITILFIDL GTDIIPSVSF AYEKAERDIM
860 870 880 890 900
NRKPRRKNVD RLVNQQLALY AYLQIGIIQS VGAFLNYFTV MAEQGFLPHT
910 920 930 940 950
LVGIRIDWEK INNQDLEDSY GQEWTFSQRQ FLEWTGYTAF FVSIVVEQLA
960 970 980 990 1000
DLIIRKTRRN SVFQQGLFRN KFLLMGLASQ VIIAAFLSYC PEMPYALKFT
1010 1020 1030 1040
PLRAQYWFVA APYALLIFVY DEIRKLFIRR YPGSWWDKNM YY
Length:1,042
Mass (Da):115,349
Last modified:November 1, 1996 - v1
Checksum:i92AED15486957B94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25809 mRNA. Translation: CAA81058.1.
PIRiI50099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25809 mRNA. Translation: CAA81058.1.
PIRiI50099.

3D structure databases

ProteinModelPortaliQ92036.
SMRiQ92036. Positions 46-1042.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ92036.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR030318. Atp12a.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF282. PTHR24093:SF282. 2 hits.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT12A_RHIMB
AccessioniPrimary (citable) accession number: Q92036
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1996
Last modified: April 13, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.