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Q92030

- AT1A1_ANGAN

UniProt

Q92030 - AT1A1_ANGAN

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Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene
atp1a1
Organism
Anguilla anguilla (European freshwater eel) (Muraena anguilla)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei375 – 37514-aspartylphosphate intermediate By similarity
Binding sitei486 – 4861ATP By similarity
Metal bindingi716 – 7161Magnesium By similarity
Metal bindingi720 – 7201Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-1 subunit
Alternative name(s):
Sodium pump subunit alpha-1
Gene namesi
Name:atp1a1
OrganismiAnguilla anguilla (European freshwater eel) (Muraena anguilla)
Taxonomic identifieri7936 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiAnguilliformesAnguillidaeAnguilla

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini6 – 8681Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei87 – 10721Helical; Reviewed predictionAdd
BLAST
Topological domaini108 – 13023Extracellular Reviewed predictionAdd
BLAST
Transmembranei131 – 15121Helical; Reviewed predictionAdd
BLAST
Topological domaini152 – 287136Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei288 – 30720Helical; Reviewed predictionAdd
BLAST
Topological domaini308 – 31912Extracellular Reviewed predictionAdd
BLAST
Transmembranei320 – 33718Helical; Reviewed predictionAdd
BLAST
Topological domaini338 – 771434Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei772 – 79120Helical; Reviewed predictionAdd
BLAST
Topological domaini792 – 80110Extracellular Reviewed prediction
Transmembranei802 – 82221Helical; Reviewed predictionAdd
BLAST
Topological domaini823 – 84220Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei843 – 86523Helical; Reviewed predictionAdd
BLAST
Topological domaini866 – 91752Extracellular Reviewed predictionAdd
BLAST
Transmembranei918 – 93720Helical; Reviewed predictionAdd
BLAST
Topological domaini938 – 95013Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei951 – 96919Helical; Reviewed predictionAdd
BLAST
Topological domaini970 – 98415Extracellular Reviewed predictionAdd
BLAST
Transmembranei985 – 100521Helical; Reviewed predictionAdd
BLAST
Topological domaini1006 – 102217Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 55 By similarityPRO_0000002495
Chaini6 – 10221017Sodium/potassium-transporting ATPase subunit alpha-1PRO_0000002496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine; by PKC By similarity
Modified residuei942 – 9421Phosphoserine; by PKA By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ92030.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliQ92030.
SMRiQ92030. Positions 26-1022.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 833Interaction with phosphoinositide-3 kinase By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92030-1 [UniParc]FASTAAdd to Basket

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MGRGTGHDQY ELAATSEGGR KKKRDKKKKD MDDLKKEVDL DDHKLTLDEL     50
HRKYGTDLTR GLTSSRAAEI LARDGPNALT PPPTTPEWVK FCRQLFGGFS 100
MLLWIGAILC FLAYGIQAAS EDEPANDNLY LGVVLSAVVI ITGCFSYYQE 150
AKSSRIMDSF KNLVPQQALV IRDGEKKCIN AEEVVAGDLV EVKGGDRIPA 200
DLRVASAQGC KVDNSSLTGE SEPQTRSPDF SNENPLETRN IAFFSTNCVE 250
GTARGVVINT GDRTVMGRIA TLASSLEVGR TPISIEIEHF IHIITGVAVF 300
LGVSFFILSL ILGYAWLEAV IFLIGIIVAN VPEGLLATVT VCLTLTAKRM 350
AKKNCLVKNL EAVETLGSTS TICSDKTGTL TQNRMTVAHM WFDNQIHEAD 400
TTENQSGTSF DRSSATWAAL ARIAGLCNRA VFLAEQSNVP ILKRDVAGDA 450
SESALLKCIE LCCGSVNDMR DKHVKIAEIP FNSTNKYQLS IHKNANSEES 500
KHLLVMKGAP ERILDRCSTI MIHGKEQPLD DEMKDAFQNA YVELGGLGER 550
VLGFCHYFLP DDQFAEGFQF DTEEVNFPTE NLCFIGLMSM IDPPRAAVLD 600
AVGKCRSPGI KVIMVTGDHP ITAKAIAKGV GIISEGNETV EDIAARLNIP 650
INEVNPRDAK ACVVHGGELK DLTPEQLDDI LKHHTEIVFA RTSPQQKLII 700
VEGCQRQGAI VAVTGDGVND SPALKKADIG VAMGIAGSDV SKQAADMILL 750
DDNFASIVTG VEEGRLIFDN LKKSIAYTLT SNIPEITPFL LFIIANIPLP 800
LGTVTILCID LGTDMVPAIS LAYEAAESDI MKRQPRNPRT DKLVNERLIS 850
IAYGQIGMMQ ATAGFFTYFV ILAENGFLPS TLLGIRVKWD DKYVNDLEDS 900
YGQQWTYEQR KIVEYTCHTS FFASIVIVQW ADLIICKTRR NSIIQQGMKN 950
KILIFGLFEE TALAAFLSYC PGMDVALRMY PLKPSWWFCA FPYSLLIFLY 1000
DEARRFILRR NPDGWVERET YY 1022
Length:1,022
Mass (Da):112,716
Last modified:November 1, 1997 - v1
Checksum:i5186DBFBC70C3C5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76108 mRNA. Translation: CAA53714.1.
PIRiS49127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76108 mRNA. Translation: CAA53714.1 .
PIRi S49127.

3D structure databases

ProteinModelPortali Q92030.
SMRi Q92030. Positions 26-1022.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q92030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004298.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary sequence, tissue specificity and expression of the Na+,K(+)-ATPase alpha 1 subunit in the European eel (Anguilla anguilla)."
    Cutler C., Sanders I.L., Hazon N., Cramb G.
    Comp. Biochem. Physiol. 111B:567-573(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Gill.

Entry informationi

Entry nameiAT1A1_ANGAN
AccessioniPrimary (citable) accession number: Q92030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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