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Q92030

- AT1A1_ANGAN

UniProt

Q92030 - AT1A1_ANGAN

Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene

atp1a1

Organism
Anguilla anguilla (European freshwater eel) (Muraena anguilla)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

    Catalytic activityi

    ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei375 – 37514-aspartylphosphate intermediateBy similarity
    Binding sitei486 – 4861ATPBy similarity
    Metal bindingi716 – 7161MagnesiumBy similarity
    Metal bindingi720 – 7201MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

    GO - Biological processi

    1. ATP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
    Short name:
    Na(+)/K(+) ATPase alpha-1 subunit
    Alternative name(s):
    Sodium pump subunit alpha-1
    Gene namesi
    Name:atp1a1
    OrganismiAnguilla anguilla (European freshwater eel) (Muraena anguilla)
    Taxonomic identifieri7936 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiAnguilliformesAnguillidaeAnguilla

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 55By similarityPRO_0000002495
    Chaini6 – 10221017Sodium/potassium-transporting ATPase subunit alpha-1PRO_0000002496Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei16 – 161Phosphoserine; by PKCBy similarity
    Modified residuei942 – 9421Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ92030.

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92030.
    SMRiQ92030. Positions 26-1022.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini6 – 8681CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini108 – 13023ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini152 – 287136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini308 – 31912ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini338 – 771434CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini792 – 80110ExtracellularSequence Analysis
    Topological domaini823 – 84220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini866 – 91752ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini938 – 95013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini970 – 98415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1006 – 102217CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei320 – 33718HelicalSequence AnalysisAdd
    BLAST
    Transmembranei772 – 79120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei802 – 82221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei843 – 86523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei918 – 93720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei951 – 96919HelicalSequence AnalysisAdd
    BLAST
    Transmembranei985 – 100521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni81 – 833Interaction with phosphoinositide-3 kinaseBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004298.

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q92030-1 [UniParc]FASTAAdd to Basket

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    MGRGTGHDQY ELAATSEGGR KKKRDKKKKD MDDLKKEVDL DDHKLTLDEL     50
    HRKYGTDLTR GLTSSRAAEI LARDGPNALT PPPTTPEWVK FCRQLFGGFS 100
    MLLWIGAILC FLAYGIQAAS EDEPANDNLY LGVVLSAVVI ITGCFSYYQE 150
    AKSSRIMDSF KNLVPQQALV IRDGEKKCIN AEEVVAGDLV EVKGGDRIPA 200
    DLRVASAQGC KVDNSSLTGE SEPQTRSPDF SNENPLETRN IAFFSTNCVE 250
    GTARGVVINT GDRTVMGRIA TLASSLEVGR TPISIEIEHF IHIITGVAVF 300
    LGVSFFILSL ILGYAWLEAV IFLIGIIVAN VPEGLLATVT VCLTLTAKRM 350
    AKKNCLVKNL EAVETLGSTS TICSDKTGTL TQNRMTVAHM WFDNQIHEAD 400
    TTENQSGTSF DRSSATWAAL ARIAGLCNRA VFLAEQSNVP ILKRDVAGDA 450
    SESALLKCIE LCCGSVNDMR DKHVKIAEIP FNSTNKYQLS IHKNANSEES 500
    KHLLVMKGAP ERILDRCSTI MIHGKEQPLD DEMKDAFQNA YVELGGLGER 550
    VLGFCHYFLP DDQFAEGFQF DTEEVNFPTE NLCFIGLMSM IDPPRAAVLD 600
    AVGKCRSPGI KVIMVTGDHP ITAKAIAKGV GIISEGNETV EDIAARLNIP 650
    INEVNPRDAK ACVVHGGELK DLTPEQLDDI LKHHTEIVFA RTSPQQKLII 700
    VEGCQRQGAI VAVTGDGVND SPALKKADIG VAMGIAGSDV SKQAADMILL 750
    DDNFASIVTG VEEGRLIFDN LKKSIAYTLT SNIPEITPFL LFIIANIPLP 800
    LGTVTILCID LGTDMVPAIS LAYEAAESDI MKRQPRNPRT DKLVNERLIS 850
    IAYGQIGMMQ ATAGFFTYFV ILAENGFLPS TLLGIRVKWD DKYVNDLEDS 900
    YGQQWTYEQR KIVEYTCHTS FFASIVIVQW ADLIICKTRR NSIIQQGMKN 950
    KILIFGLFEE TALAAFLSYC PGMDVALRMY PLKPSWWFCA FPYSLLIFLY 1000
    DEARRFILRR NPDGWVERET YY 1022
    Length:1,022
    Mass (Da):112,716
    Last modified:November 1, 1997 - v1
    Checksum:i5186DBFBC70C3C5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76108 mRNA. Translation: CAA53714.1.
    PIRiS49127.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76108 mRNA. Translation: CAA53714.1 .
    PIRi S49127.

    3D structure databases

    ProteinModelPortali Q92030.
    SMRi Q92030. Positions 26-1022.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q92030.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG004298.

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary sequence, tissue specificity and expression of the Na+,K(+)-ATPase alpha 1 subunit in the European eel (Anguilla anguilla)."
      Cutler C., Sanders I.L., Hazon N., Cramb G.
      Comp. Biochem. Physiol. 111B:567-573(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Gill.

    Entry informationi

    Entry nameiAT1A1_ANGAN
    AccessioniPrimary (citable) accession number: Q92030
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3